Background. Metal complexes of biologically active ligands had considerable interests. L-cysteinate residue, L-Cys, is a biologically abundant and important versatile binding site of proteins. Diphenylamine, DPA, is an important aromatic amine containing two phenyl groups. Complexation equilibria of the divalent metal ions, Ca2+ and Zn2+ with the bio- relevant α-amino acid, L-cysteine and the nitrogen-containing diphenylamine ligand were investigated by means of the potentiometric technique at 25.0 ± 0.1°C and constant ionic strength of 0.200 ± 0.001 mol·dm-3 NaNO3. Objective. The stability constants and standard free energy changes of the α-amino acid, L-cysteine and diphenylamine complex species were determined at 0.200 ± 0.001 mol·dm-3ionic strength. Methods. The formation of the different 1:1 and 1:2 binary complexes and 1:1:1 ternary complexes were inferred from the potentiometric titrations. Results. The concentration distribution of L-cysteine species formed in solution was evaluated. The dissociation constants of the α-amino acid and diphenylamine were determined at different ionic strength. The stability constants of these binary and ternary systems were calculated. The values of ∆ log10 K, percent relative stabilization, %R.S. and log10 X for the ternary systems were evaluated and discussed. Concussion. The ternary complex formation occurred in a stepwise manner with L-cysteine acting as the primary ligand. The obtained values of ∆ G0 indicated that Complex formation reactions are spontaneous. Also, for all systems studied, the ternary complexes formed are more thermodynamically stable than the binary complexes.
| Published in | American Journal of Chemical Engineering (Volume 10, Issue 2) |
| DOI | 10.11648/j.ajche.20221002.12 |
| Page(s) | 23-31 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Potentiometric Studies, Metal (II) Ions, L-Cysteine, Ternary Systems
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APA Style
Abdelatty Mohamed Radalla. (2022). Complexation Equilibria and Determination of Stability Constants of Some Divalent Metal Ion Complexes of L-Cysteine and Diphenylamine in Aqueous Media. American Journal of Chemical Engineering, 10(2), 23-31. https://doi.org/10.11648/j.ajche.20221002.12
ACS Style
Abdelatty Mohamed Radalla. Complexation Equilibria and Determination of Stability Constants of Some Divalent Metal Ion Complexes of L-Cysteine and Diphenylamine in Aqueous Media. Am. J. Chem. Eng. 2022, 10(2), 23-31. doi: 10.11648/j.ajche.20221002.12
AMA Style
Abdelatty Mohamed Radalla. Complexation Equilibria and Determination of Stability Constants of Some Divalent Metal Ion Complexes of L-Cysteine and Diphenylamine in Aqueous Media. Am J Chem Eng. 2022;10(2):23-31. doi: 10.11648/j.ajche.20221002.12
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Download@article{10.11648/j.ajche.20221002.12,
author = {Abdelatty Mohamed Radalla},
title = {Complexation Equilibria and Determination of Stability Constants of Some Divalent Metal Ion Complexes of L-Cysteine and Diphenylamine in Aqueous Media},
journal = {American Journal of Chemical Engineering},
volume = {10},
number = {2},
pages = {23-31},
doi = {10.11648/j.ajche.20221002.12},
url = {https://doi.org/10.11648/j.ajche.20221002.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20221002.12},
abstract = {Background. Metal complexes of biologically active ligands had considerable interests. L-cysteinate residue, L-Cys, is a biologically abundant and important versatile binding site of proteins. Diphenylamine, DPA, is an important aromatic amine containing two phenyl groups. Complexation equilibria of the divalent metal ions, Ca2+ and Zn2+ with the bio- relevant α-amino acid, L-cysteine and the nitrogen-containing diphenylamine ligand were investigated by means of the potentiometric technique at 25.0 ± 0.1°C and constant ionic strength of 0.200 ± 0.001 mol·dm-3 NaNO3. Objective. The stability constants and standard free energy changes of the α-amino acid, L-cysteine and diphenylamine complex species were determined at 0.200 ± 0.001 mol·dm-3ionic strength. Methods. The formation of the different 1:1 and 1:2 binary complexes and 1:1:1 ternary complexes were inferred from the potentiometric titrations. Results. The concentration distribution of L-cysteine species formed in solution was evaluated. The dissociation constants of the α-amino acid and diphenylamine were determined at different ionic strength. The stability constants of these binary and ternary systems were calculated. The values of ∆ log10 K, percent relative stabilization, %R.S. and log10 X for the ternary systems were evaluated and discussed. Concussion. The ternary complex formation occurred in a stepwise manner with L-cysteine acting as the primary ligand. The obtained values of ∆ G0 indicated that Complex formation reactions are spontaneous. Also, for all systems studied, the ternary complexes formed are more thermodynamically stable than the binary complexes.},
year = {2022}
}
TY - JOUR T1 - Complexation Equilibria and Determination of Stability Constants of Some Divalent Metal Ion Complexes of L-Cysteine and Diphenylamine in Aqueous Media AU - Abdelatty Mohamed Radalla Y1 - 2022/03/29 PY - 2022 N1 - https://doi.org/10.11648/j.ajche.20221002.12 DO - 10.11648/j.ajche.20221002.12 T2 - American Journal of Chemical Engineering JF - American Journal of Chemical Engineering JO - American Journal of Chemical Engineering SP - 23 EP - 31 PB - Science Publishing Group SN - 2330-8613 UR - https://doi.org/10.11648/j.ajche.20221002.12 AB - Background. Metal complexes of biologically active ligands had considerable interests. L-cysteinate residue, L-Cys, is a biologically abundant and important versatile binding site of proteins. Diphenylamine, DPA, is an important aromatic amine containing two phenyl groups. Complexation equilibria of the divalent metal ions, Ca2+ and Zn2+ with the bio- relevant α-amino acid, L-cysteine and the nitrogen-containing diphenylamine ligand were investigated by means of the potentiometric technique at 25.0 ± 0.1°C and constant ionic strength of 0.200 ± 0.001 mol·dm-3 NaNO3. Objective. The stability constants and standard free energy changes of the α-amino acid, L-cysteine and diphenylamine complex species were determined at 0.200 ± 0.001 mol·dm-3ionic strength. Methods. The formation of the different 1:1 and 1:2 binary complexes and 1:1:1 ternary complexes were inferred from the potentiometric titrations. Results. The concentration distribution of L-cysteine species formed in solution was evaluated. The dissociation constants of the α-amino acid and diphenylamine were determined at different ionic strength. The stability constants of these binary and ternary systems were calculated. The values of ∆ log10 K, percent relative stabilization, %R.S. and log10 X for the ternary systems were evaluated and discussed. Concussion. The ternary complex formation occurred in a stepwise manner with L-cysteine acting as the primary ligand. The obtained values of ∆ G0 indicated that Complex formation reactions are spontaneous. Also, for all systems studied, the ternary complexes formed are more thermodynamically stable than the binary complexes. VL - 10 IS - 2 ER -
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