Alzheimer's disease (AD) is a neurodegenerative disease with progressive loss of memory and cognitive function. Because its pathogenesis has not been fully elucidated, there is still a lack of understanding of its pathogenesis and effective treatment. Many studies have shown that Mesenchymal stem cells Exosomes (MSCs-Exo) can promote anti-inflammatory, regulate immune function, enhance amyloid (Aβ) degradation, and promote axon growth of nerve cells. Exosomes can effectively cross the blood-brain barrier, and have better biocompatibility and biosafety than nanomaterials, and more diverse ways to carry drugs. Adipose stem cell exosomes can not only treat AD by their own characteristics, but also regulate AD and other neurological diseases as A drug carrier that can efficiently and freely cross the blood-brain barrier: they can effectively reduce Aβ42 plaques and improve the neuronal microenvironment through microglia. In AD model mice, excessive activation of microglia demonstrated the formation of an inflammatory microenvironment in the brain. The inflammatory microenvironment erodes healthy neurons to a certain extent, forcing them to overactivate inflammatory signaling pathways so that they can't function normally, Adipose stem cell exosomes can effectively clear the expression of inflammatory factors in hypoxia-induced AD neuronal model and promote synaptic repair through microRNA/ phosphatase and tensin homolog (miR-223/PTEN) and phosphatidylinositol kinase (PI3K/Akt) pathways. It can promote the polarization of microglia towards anti-inflammatory phenotype and promote neuronal repair. Adipose stem cell exosomes can also be used to improve memory and cognitive dysfunction by alleviating Tau phosphating or delaying hippocampus volume decay, targeting the core pathological mechanism of AD to achieve therapeutic effects. This article mainly introduces the role of MSC exosomes in the pathogenesis and development of AD.
| Published in | Biomedical Sciences (Volume 10, Issue 1) |
| DOI | 10.11648/j.bs.20241001.12 |
| Page(s) | 6-13 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Mesenchymal Stem Cells, Exosomes, Alzheimer’s Disease
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APA Style
Tian, M., Yi, X. (2024). The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease. Biomedical Sciences, 10(1), 6-13. https://doi.org/10.11648/j.bs.20241001.12
ACS Style
Tian, M.; Yi, X. The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease. Biomed. Sci. 2024, 10(1), 6-13. doi: 10.11648/j.bs.20241001.12
AMA Style
Tian M, Yi X. The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease. Biomed Sci. 2024;10(1):6-13. doi: 10.11648/j.bs.20241001.12
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Download@article{10.11648/j.bs.20241001.12,
author = {Meng-Si Tian and Xi-Nan Yi},
title = {The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease},
journal = {Biomedical Sciences},
volume = {10},
number = {1},
pages = {6-13},
doi = {10.11648/j.bs.20241001.12},
url = {https://doi.org/10.11648/j.bs.20241001.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20241001.12},
abstract = {Alzheimer's disease (AD) is a neurodegenerative disease with progressive loss of memory and cognitive function. Because its pathogenesis has not been fully elucidated, there is still a lack of understanding of its pathogenesis and effective treatment. Many studies have shown that Mesenchymal stem cells Exosomes (MSCs-Exo) can promote anti-inflammatory, regulate immune function, enhance amyloid (Aβ) degradation, and promote axon growth of nerve cells. Exosomes can effectively cross the blood-brain barrier, and have better biocompatibility and biosafety than nanomaterials, and more diverse ways to carry drugs. Adipose stem cell exosomes can not only treat AD by their own characteristics, but also regulate AD and other neurological diseases as A drug carrier that can efficiently and freely cross the blood-brain barrier: they can effectively reduce Aβ42 plaques and improve the neuronal microenvironment through microglia. In AD model mice, excessive activation of microglia demonstrated the formation of an inflammatory microenvironment in the brain. The inflammatory microenvironment erodes healthy neurons to a certain extent, forcing them to overactivate inflammatory signaling pathways so that they can't function normally, Adipose stem cell exosomes can effectively clear the expression of inflammatory factors in hypoxia-induced AD neuronal model and promote synaptic repair through microRNA/ phosphatase and tensin homolog (miR-223/PTEN) and phosphatidylinositol kinase (PI3K/Akt) pathways. It can promote the polarization of microglia towards anti-inflammatory phenotype and promote neuronal repair. Adipose stem cell exosomes can also be used to improve memory and cognitive dysfunction by alleviating Tau phosphating or delaying hippocampus volume decay, targeting the core pathological mechanism of AD to achieve therapeutic effects. This article mainly introduces the role of MSC exosomes in the pathogenesis and development of AD.
},
year = {2024}
}
TY - JOUR T1 - The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease AU - Meng-Si Tian AU - Xi-Nan Yi Y1 - 2024/03/13 PY - 2024 N1 - https://doi.org/10.11648/j.bs.20241001.12 DO - 10.11648/j.bs.20241001.12 T2 - Biomedical Sciences JF - Biomedical Sciences JO - Biomedical Sciences SP - 6 EP - 13 PB - Science Publishing Group SN - 2575-3932 UR - https://doi.org/10.11648/j.bs.20241001.12 AB - Alzheimer's disease (AD) is a neurodegenerative disease with progressive loss of memory and cognitive function. Because its pathogenesis has not been fully elucidated, there is still a lack of understanding of its pathogenesis and effective treatment. Many studies have shown that Mesenchymal stem cells Exosomes (MSCs-Exo) can promote anti-inflammatory, regulate immune function, enhance amyloid (Aβ) degradation, and promote axon growth of nerve cells. Exosomes can effectively cross the blood-brain barrier, and have better biocompatibility and biosafety than nanomaterials, and more diverse ways to carry drugs. Adipose stem cell exosomes can not only treat AD by their own characteristics, but also regulate AD and other neurological diseases as A drug carrier that can efficiently and freely cross the blood-brain barrier: they can effectively reduce Aβ42 plaques and improve the neuronal microenvironment through microglia. In AD model mice, excessive activation of microglia demonstrated the formation of an inflammatory microenvironment in the brain. The inflammatory microenvironment erodes healthy neurons to a certain extent, forcing them to overactivate inflammatory signaling pathways so that they can't function normally, Adipose stem cell exosomes can effectively clear the expression of inflammatory factors in hypoxia-induced AD neuronal model and promote synaptic repair through microRNA/ phosphatase and tensin homolog (miR-223/PTEN) and phosphatidylinositol kinase (PI3K/Akt) pathways. It can promote the polarization of microglia towards anti-inflammatory phenotype and promote neuronal repair. Adipose stem cell exosomes can also be used to improve memory and cognitive dysfunction by alleviating Tau phosphating or delaying hippocampus volume decay, targeting the core pathological mechanism of AD to achieve therapeutic effects. This article mainly introduces the role of MSC exosomes in the pathogenesis and development of AD. VL - 10 IS - 1 ER -
Engineering Research Center of Tropical Medicine, Ministry of Education, The Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province Hainan Medical University, Haikou, China; Department of Anatomy and Department of Neurology of the First Afliated Hospital, Hainan Medical University, Haikou, China
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