Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. The failure rate of treatment for its subsets is still very high. CXC chemokine, secreted by a variety of cells, is a vital component in the immune process. It also participated in the growth, development, and metastasis of tumors. This study aimed to explore the prognosis of CXC chemokines in DLBCL and the relationship with immune infiltration through bioinformatics analysis. Methods: We systematically analyzed the expression level and prognostic value of CXC chemokines in DLBCL patients, and the correlation between CXC chemokines and tumor immune infiltration through databases, such as Oncomine, GEO, GEPIA, GeneMANIA, DAVID, HPA, GenomicScape, and TIMER2.0. Results: With the comprehensive analysis of different databases, we found that CXC chemokines (CXCL1/2/5/6/7/8/9/10/11/12/13/14) had significantly higher transcription levels in DLBCL patients vs. the control groups. The up-regulation mRNA levels of CXCL1/2/6/7/10/12 were associated with poor prognoses in DLBC patients. Further enrichment analysis of CXC chemokines and their receptors revealed that they were related to the infiltration and metastasis of immune cells. Besides, we found that the expression of CXCL9/10/11 were significantly correlated with tumor-infiltrating lymphocytes (TILs) (B cells, CD8+ T cells, CD4+ T cells, macrophages, Treg cells, and NK cells) and immune checkpoints in DLBCL. Conclusion: Our study may provide novel understandings for CXC chemokines as immunotherapeutic targets and prognostic biomarkers in diffuse large B-cell lymphoma through systematic analysis.
| Published in | Cancer Research Journal (Volume 10, Issue 1) |
| DOI | 10.11648/j.crj.20221001.11 |
| Page(s) | 1-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Diffuse Large B-cell Lymphoma (DLBCL), Immune Infiltration, Prognosis, Biomarker, Bioinformatics Analysis
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APA Style
Yuli Cao, Fenling Zhou, Cuilan Deng, Gexiu Liu. (2022). Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma. Cancer Research Journal, 10(1), 1-15. https://doi.org/10.11648/j.crj.20221001.11
ACS Style
Yuli Cao; Fenling Zhou; Cuilan Deng; Gexiu Liu. Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma. Cancer Res. J. 2022, 10(1), 1-15. doi: 10.11648/j.crj.20221001.11
AMA Style
Yuli Cao, Fenling Zhou, Cuilan Deng, Gexiu Liu. Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma. Cancer Res J. 2022;10(1):1-15. doi: 10.11648/j.crj.20221001.11
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Download@article{10.11648/j.crj.20221001.11,
author = {Yuli Cao and Fenling Zhou and Cuilan Deng and Gexiu Liu},
title = {Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma},
journal = {Cancer Research Journal},
volume = {10},
number = {1},
pages = {1-15},
doi = {10.11648/j.crj.20221001.11},
url = {https://doi.org/10.11648/j.crj.20221001.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221001.11},
abstract = {Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. The failure rate of treatment for its subsets is still very high. CXC chemokine, secreted by a variety of cells, is a vital component in the immune process. It also participated in the growth, development, and metastasis of tumors. This study aimed to explore the prognosis of CXC chemokines in DLBCL and the relationship with immune infiltration through bioinformatics analysis. Methods: We systematically analyzed the expression level and prognostic value of CXC chemokines in DLBCL patients, and the correlation between CXC chemokines and tumor immune infiltration through databases, such as Oncomine, GEO, GEPIA, GeneMANIA, DAVID, HPA, GenomicScape, and TIMER2.0. Results: With the comprehensive analysis of different databases, we found that CXC chemokines (CXCL1/2/5/6/7/8/9/10/11/12/13/14) had significantly higher transcription levels in DLBCL patients vs. the control groups. The up-regulation mRNA levels of CXCL1/2/6/7/10/12 were associated with poor prognoses in DLBC patients. Further enrichment analysis of CXC chemokines and their receptors revealed that they were related to the infiltration and metastasis of immune cells. Besides, we found that the expression of CXCL9/10/11 were significantly correlated with tumor-infiltrating lymphocytes (TILs) (B cells, CD8+ T cells, CD4+ T cells, macrophages, Treg cells, and NK cells) and immune checkpoints in DLBCL. Conclusion: Our study may provide novel understandings for CXC chemokines as immunotherapeutic targets and prognostic biomarkers in diffuse large B-cell lymphoma through systematic analysis.},
year = {2022}
}
TY - JOUR T1 - Comprehensive Analysis of the Prognosis and Correlations with Immune Infiltration of CXC Chemokine Family Members in Diffuse Large B-cell Lymphoma AU - Yuli Cao AU - Fenling Zhou AU - Cuilan Deng AU - Gexiu Liu Y1 - 2022/01/21 PY - 2022 N1 - https://doi.org/10.11648/j.crj.20221001.11 DO - 10.11648/j.crj.20221001.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 1 EP - 15 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20221001.11 AB - Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. The failure rate of treatment for its subsets is still very high. CXC chemokine, secreted by a variety of cells, is a vital component in the immune process. It also participated in the growth, development, and metastasis of tumors. This study aimed to explore the prognosis of CXC chemokines in DLBCL and the relationship with immune infiltration through bioinformatics analysis. Methods: We systematically analyzed the expression level and prognostic value of CXC chemokines in DLBCL patients, and the correlation between CXC chemokines and tumor immune infiltration through databases, such as Oncomine, GEO, GEPIA, GeneMANIA, DAVID, HPA, GenomicScape, and TIMER2.0. Results: With the comprehensive analysis of different databases, we found that CXC chemokines (CXCL1/2/5/6/7/8/9/10/11/12/13/14) had significantly higher transcription levels in DLBCL patients vs. the control groups. The up-regulation mRNA levels of CXCL1/2/6/7/10/12 were associated with poor prognoses in DLBC patients. Further enrichment analysis of CXC chemokines and their receptors revealed that they were related to the infiltration and metastasis of immune cells. Besides, we found that the expression of CXCL9/10/11 were significantly correlated with tumor-infiltrating lymphocytes (TILs) (B cells, CD8+ T cells, CD4+ T cells, macrophages, Treg cells, and NK cells) and immune checkpoints in DLBCL. Conclusion: Our study may provide novel understandings for CXC chemokines as immunotherapeutic targets and prognostic biomarkers in diffuse large B-cell lymphoma through systematic analysis. VL - 10 IS - 1 ER -
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