Breast cancer ranks as the number one cancer among Indian females with survival as low as 66.1%. Relationship between cholesterol and breast cancer has triggered special interest due to their role in important cellular processes that steer toward carcinogenesis. The interplay between cholesterol and tumor development have been studied in experimental breast cancer models. However, epidemiological data reveal conflicting results, that need to be integrated and put into appropriate viewpoint. This study aims to investigate and corroborate the impact of total cholesterol (TC), triglyceride (TG), VLDL, LDL and HDL cholesterol on the disease-free and overall survival of patients with breast cancer. This study retrospectively analyzed 50 breast cancer patients who underwent radical surgery and attended follow-up visits at KIMS Hospitals. The blood lipid levels such as TC, TG, VLDL, LDL and HDL cholesterol were collected and analyzed from the database of Department of Laboratory Medicine. Potential prognostic factors including age, menopause, grade, receptor status, systemic cholesterol profile etc., were analyzed by univariate and multivariate analysis. TC less than 180mg/dL was associated with disease relapse in univariate analysis. TG, VLDL, LDL and HDL cholesterol were not significantly correlated either to disease-free or overall survival. Low systemic cholesterol level could be a significant prognostic factor for a shorter disease-free survival.
| Published in | Cancer Research Journal (Volume 10, Issue 2) |
| DOI | 10.11648/j.crj.20221002.12 |
| Page(s) | 30-33 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Carcinogenesis, Lipoprotein, Cholesterol, Prognosis, Survival
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APA Style
Radhika Chowdary, Raghu Ram Pillarisetti, Vinod Kumar Verma, Radhika Korabathina, Syed Sultan Beevi. (2022). Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer. Cancer Research Journal, 10(2), 30-33. https://doi.org/10.11648/j.crj.20221002.12
ACS Style
Radhika Chowdary; Raghu Ram Pillarisetti; Vinod Kumar Verma; Radhika Korabathina; Syed Sultan Beevi. Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer. Cancer Res. J. 2022, 10(2), 30-33. doi: 10.11648/j.crj.20221002.12
AMA Style
Radhika Chowdary, Raghu Ram Pillarisetti, Vinod Kumar Verma, Radhika Korabathina, Syed Sultan Beevi. Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer. Cancer Res J. 2022;10(2):30-33. doi: 10.11648/j.crj.20221002.12
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Download@article{10.11648/j.crj.20221002.12,
author = {Radhika Chowdary and Raghu Ram Pillarisetti and Vinod Kumar Verma and Radhika Korabathina and Syed Sultan Beevi},
title = {Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer},
journal = {Cancer Research Journal},
volume = {10},
number = {2},
pages = {30-33},
doi = {10.11648/j.crj.20221002.12},
url = {https://doi.org/10.11648/j.crj.20221002.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.12},
abstract = {Breast cancer ranks as the number one cancer among Indian females with survival as low as 66.1%. Relationship between cholesterol and breast cancer has triggered special interest due to their role in important cellular processes that steer toward carcinogenesis. The interplay between cholesterol and tumor development have been studied in experimental breast cancer models. However, epidemiological data reveal conflicting results, that need to be integrated and put into appropriate viewpoint. This study aims to investigate and corroborate the impact of total cholesterol (TC), triglyceride (TG), VLDL, LDL and HDL cholesterol on the disease-free and overall survival of patients with breast cancer. This study retrospectively analyzed 50 breast cancer patients who underwent radical surgery and attended follow-up visits at KIMS Hospitals. The blood lipid levels such as TC, TG, VLDL, LDL and HDL cholesterol were collected and analyzed from the database of Department of Laboratory Medicine. Potential prognostic factors including age, menopause, grade, receptor status, systemic cholesterol profile etc., were analyzed by univariate and multivariate analysis. TC less than 180mg/dL was associated with disease relapse in univariate analysis. TG, VLDL, LDL and HDL cholesterol were not significantly correlated either to disease-free or overall survival. Low systemic cholesterol level could be a significant prognostic factor for a shorter disease-free survival.},
year = {2022}
}
TY - JOUR T1 - Prognostic Significance of Systemic Cholesterol Profile in Patients with Breast Cancer AU - Radhika Chowdary AU - Raghu Ram Pillarisetti AU - Vinod Kumar Verma AU - Radhika Korabathina AU - Syed Sultan Beevi Y1 - 2022/04/25 PY - 2022 N1 - https://doi.org/10.11648/j.crj.20221002.12 DO - 10.11648/j.crj.20221002.12 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 30 EP - 33 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20221002.12 AB - Breast cancer ranks as the number one cancer among Indian females with survival as low as 66.1%. Relationship between cholesterol and breast cancer has triggered special interest due to their role in important cellular processes that steer toward carcinogenesis. The interplay between cholesterol and tumor development have been studied in experimental breast cancer models. However, epidemiological data reveal conflicting results, that need to be integrated and put into appropriate viewpoint. This study aims to investigate and corroborate the impact of total cholesterol (TC), triglyceride (TG), VLDL, LDL and HDL cholesterol on the disease-free and overall survival of patients with breast cancer. This study retrospectively analyzed 50 breast cancer patients who underwent radical surgery and attended follow-up visits at KIMS Hospitals. The blood lipid levels such as TC, TG, VLDL, LDL and HDL cholesterol were collected and analyzed from the database of Department of Laboratory Medicine. Potential prognostic factors including age, menopause, grade, receptor status, systemic cholesterol profile etc., were analyzed by univariate and multivariate analysis. TC less than 180mg/dL was associated with disease relapse in univariate analysis. TG, VLDL, LDL and HDL cholesterol were not significantly correlated either to disease-free or overall survival. Low systemic cholesterol level could be a significant prognostic factor for a shorter disease-free survival. VL - 10 IS - 2 ER -
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