Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review

Ting Xiong; Shihua Liu; Yuying Lei; Liangliang Zhang; Aixia Sui

doi:doi:10.11648/j.crj.20221002.13

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Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review

Ting Xiong, Shihua Liu, Yuying Lei, Liangliang Zhang, Aixia Sui

Published in Cancer Research Journal (Volume 10, Issue 2)

Received: 14 May 2022 Accepted: 2 June 2022 Published: 14 June 2022

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Abstract

Sarcomatoid carcinoma of the gallbladder is a highly malignant tumor originating from totipotent mesenchymal stem cells, accounting for only 4.1% of gallbladder cancers. Its clinical manifestations are very similar to adenocarcinoma of the gallbladder, mainly presenting in the digestive tract. Surgical resection is currently the only possible cure for sarcomatoid carcinoma of the gallbladder. Due to the lack of effective diagnostic means at early stage, many patients have reached the middle and late stage of diagnosis, and the prognosis is often poor. In this paper, we present a case of a 52-year-old woman with advanced and rapidly progressing sarcomatoid carcinoma of the gallbladder causing obstructive cholangitis. She developed bone marrow suppression after immunotherapy combined with chemotherapy. The patient died after symptomatic and supportive treatment. This paper reports the whole process of diagnosis and treatment in this case of gallbladder sarcomatoid carcinoma, thus carring out a discussion based on relevant literaturea and providing a reference for treatment.

Published in	Cancer Research Journal (Volume 10, Issue 2)
DOI	10.11648/j.crj.20221002.13
Page(s)	34-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Sarcomatoid Carcinoma of the Gallbladder, Diagnosis, Treatment, Obstructive Cholangitis

References

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[4]	Siddiqui Mehdi, Hegde Sheetal, Nguyen Tung, et al. Sarcomatoid carcinoma of the gallbladder: A rare form of gallbladder cancer. SAGE open medical case reports. 2020, 8: 2050313X20906739.
[5]	Song X, Hu Y, Li Y, et al. Overview of current targeted therapy in gallbladder cancer. Signal Transduct Target Ther. 2020, 5 (1): 230.
[6]	He Q Q. Clinicopathological and prognostic analysis of sarcomatoid carcinoma of digestive system [D]. Zhengzhou University Internal Medicine (Gastroenterology), 2017.
[7]	Toledo PF, Berger Z, Carreño L, et al. Sarcomatoid carcinoma of the pancreas - a rare tumor with an uncommon presentation and course: A case report and review of literature. World J Clin Cases. 2021, 9 (15): 3716-3725.
[8]	Li X P, Zhu C Y, Liu S L, et al. Diagnosis and treatment of sarcomatoid carcinoma of gallbladder: a report of 4 cases [J]. Hepatobiliary and pancreatic surgery, 2020, 32 (05): 307-309.
[9]	Qin Q, Liu M, Wang X. Gallbladder sarcomatoid carcinoma: Seven case reports. World J Clin Cases. 2020, 8 (17): 3881-3889.
[10]	Feng F, Cheng Q, Yang L, et al. Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing [J]. Oncotarget, 2017, 8 (3): 5349-5360.
[11]	Hu Z H, Li Z W, Shen L, et al. Surgical therapy and prognosis of sarcomatoid carcinoma of the gallbladder [J]. Hepatobiliary Pancreat Dis Int, 2010, 9 (2): 175-179.
[12]	Zou W, Wolchok J D, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations [J]. Sci Transl Med, 2016, 8 (328): 324r-328r.
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[15]	Song Z Q, Guo G F, Zhu Y M, et al. A case of super advanced sarcomatoid lung cancer induced by parbrizizumab [J]. Chin J Clin Lung, 2022, 27 (01): 150-153. 2022, 27 (01): 150-153.
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APA Style

Ting Xiong, Shihua Liu, Yuying Lei, Liangliang Zhang, Aixia Sui. (2022). Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review. Cancer Research Journal, 10(2), 34-37. https://doi.org/10.11648/j.crj.20221002.13

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ACS Style

Ting Xiong; Shihua Liu; Yuying Lei; Liangliang Zhang; Aixia Sui. Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review. Cancer Res. J. 2022, 10(2), 34-37. doi: 10.11648/j.crj.20221002.13

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AMA Style

Ting Xiong, Shihua Liu, Yuying Lei, Liangliang Zhang, Aixia Sui. Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review. Cancer Res J. 2022;10(2):34-37. doi: 10.11648/j.crj.20221002.13

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@article{10.11648/j.crj.20221002.13,
  author = {Ting Xiong and Shihua Liu and Yuying Lei and Liangliang Zhang and Aixia Sui},
  title = {Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review},
  journal = {Cancer Research Journal},
  volume = {10},
  number = {2},
  pages = {34-37},
  doi = {10.11648/j.crj.20221002.13},
  url = {https://doi.org/10.11648/j.crj.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.13},
  abstract = {Sarcomatoid carcinoma of the gallbladder is a highly malignant tumor originating from totipotent mesenchymal stem cells, accounting for only 4.1% of gallbladder cancers. Its clinical manifestations are very similar to adenocarcinoma of the gallbladder, mainly presenting in the digestive tract. Surgical resection is currently the only possible cure for sarcomatoid carcinoma of the gallbladder. Due to the lack of effective diagnostic means at early stage, many patients have reached the middle and late stage of diagnosis, and the prognosis is often poor. In this paper, we present a case of a 52-year-old woman with advanced and rapidly progressing sarcomatoid carcinoma of the gallbladder causing obstructive cholangitis. She developed bone marrow suppression after immunotherapy combined with chemotherapy. The patient died after symptomatic and supportive treatment. This paper reports the whole process of diagnosis and treatment in this case of gallbladder sarcomatoid carcinoma, thus carring out a discussion based on relevant literaturea and providing a reference for treatment.},
 year = {2022}
}

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TY  - JOUR
T1  - Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review
AU  - Ting Xiong
AU  - Shihua Liu
AU  - Yuying Lei
AU  - Liangliang Zhang
AU  - Aixia Sui
Y1  - 2022/06/14
PY  - 2022
N1  - https://doi.org/10.11648/j.crj.20221002.13
DO  - 10.11648/j.crj.20221002.13
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 34
EP  - 37
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20221002.13
AB  - Sarcomatoid carcinoma of the gallbladder is a highly malignant tumor originating from totipotent mesenchymal stem cells, accounting for only 4.1% of gallbladder cancers. Its clinical manifestations are very similar to adenocarcinoma of the gallbladder, mainly presenting in the digestive tract. Surgical resection is currently the only possible cure for sarcomatoid carcinoma of the gallbladder. Due to the lack of effective diagnostic means at early stage, many patients have reached the middle and late stage of diagnosis, and the prognosis is often poor. In this paper, we present a case of a 52-year-old woman with advanced and rapidly progressing sarcomatoid carcinoma of the gallbladder causing obstructive cholangitis. She developed bone marrow suppression after immunotherapy combined with chemotherapy. The patient died after symptomatic and supportive treatment. This paper reports the whole process of diagnosis and treatment in this case of gallbladder sarcomatoid carcinoma, thus carring out a discussion based on relevant literaturea and providing a reference for treatment.
VL  - 10
IS  - 2
ER  -

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Author Information

Ting Xiong

Hebei General Hospital, Shijiazhuang, China
Shihua Liu

Hebei General Hospital, Shijiazhuang, China
Yuying Lei

Hebei General Hospital, Shijiazhuang, China
Liangliang Zhang

Hebei General Hospital, Shijiazhuang, China
Aixia Sui

Hebei General Hospital, Shijiazhuang, China

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Plain Text BibTeX RIS

APA Style

Ting Xiong, Shihua Liu, Yuying Lei, Liangliang Zhang, Aixia Sui. (2022). Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review. Cancer Research Journal, 10(2), 34-37. https://doi.org/10.11648/j.crj.20221002.13

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ACS Style

Ting Xiong; Shihua Liu; Yuying Lei; Liangliang Zhang; Aixia Sui. Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review. Cancer Res. J. 2022, 10(2), 34-37. doi: 10.11648/j.crj.20221002.13

Copy | Download

AMA Style

Ting Xiong, Shihua Liu, Yuying Lei, Liangliang Zhang, Aixia Sui. Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review. Cancer Res J. 2022;10(2):34-37. doi: 10.11648/j.crj.20221002.13

Copy | Download

@article{10.11648/j.crj.20221002.13,
  author = {Ting Xiong and Shihua Liu and Yuying Lei and Liangliang Zhang and Aixia Sui},
  title = {Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review},
  journal = {Cancer Research Journal},
  volume = {10},
  number = {2},
  pages = {34-37},
  doi = {10.11648/j.crj.20221002.13},
  url = {https://doi.org/10.11648/j.crj.20221002.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.13},
  abstract = {Sarcomatoid carcinoma of the gallbladder is a highly malignant tumor originating from totipotent mesenchymal stem cells, accounting for only 4.1% of gallbladder cancers. Its clinical manifestations are very similar to adenocarcinoma of the gallbladder, mainly presenting in the digestive tract. Surgical resection is currently the only possible cure for sarcomatoid carcinoma of the gallbladder. Due to the lack of effective diagnostic means at early stage, many patients have reached the middle and late stage of diagnosis, and the prognosis is often poor. In this paper, we present a case of a 52-year-old woman with advanced and rapidly progressing sarcomatoid carcinoma of the gallbladder causing obstructive cholangitis. She developed bone marrow suppression after immunotherapy combined with chemotherapy. The patient died after symptomatic and supportive treatment. This paper reports the whole process of diagnosis and treatment in this case of gallbladder sarcomatoid carcinoma, thus carring out a discussion based on relevant literaturea and providing a reference for treatment.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Sarcomatoid Carcinoma of the Gallbladder: A Case Report and Literature Review
AU  - Ting Xiong
AU  - Shihua Liu
AU  - Yuying Lei
AU  - Liangliang Zhang
AU  - Aixia Sui
Y1  - 2022/06/14
PY  - 2022
N1  - https://doi.org/10.11648/j.crj.20221002.13
DO  - 10.11648/j.crj.20221002.13
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 34
EP  - 37
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20221002.13
AB  - Sarcomatoid carcinoma of the gallbladder is a highly malignant tumor originating from totipotent mesenchymal stem cells, accounting for only 4.1% of gallbladder cancers. Its clinical manifestations are very similar to adenocarcinoma of the gallbladder, mainly presenting in the digestive tract. Surgical resection is currently the only possible cure for sarcomatoid carcinoma of the gallbladder. Due to the lack of effective diagnostic means at early stage, many patients have reached the middle and late stage of diagnosis, and the prognosis is often poor. In this paper, we present a case of a 52-year-old woman with advanced and rapidly progressing sarcomatoid carcinoma of the gallbladder causing obstructive cholangitis. She developed bone marrow suppression after immunotherapy combined with chemotherapy. The patient died after symptomatic and supportive treatment. This paper reports the whole process of diagnosis and treatment in this case of gallbladder sarcomatoid carcinoma, thus carring out a discussion based on relevant literaturea and providing a reference for treatment.
VL  - 10
IS  - 2
ER  -

Copy | Download