The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis

Jie Zhou; Xinxin Duan; Ting Xiong; Aixia Sui

doi:doi:10.11648/j.crj.20221002.15

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The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis

Jie Zhou, Xinxin Duan, Ting Xiong, Aixia Sui

Published in Cancer Research Journal (Volume 10, Issue 2)

Received: 3 June 2022 Accepted: 17 June 2022 Published: 27 June 2022

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Abstract

Tumor angiogenesis is the center of tumor growth and metastasis, and it increases the supply of nutrients and oxygen to tumors, thereby supporting tumor growth and progression. Vascular endothelial growth factor (VEGF) is a stimulator of angiogenesis and also plays a key role in the process of angiogenesis. Overexpression of VEGF is associated with tumor angiogenesis, promotion of tumor growth and reduced survival rate of patients. Notch signaling is a key pathway that regulates the response to angiogenesis stimulation during embryonic vascular development and postnatal angiogenesis, and is involved in multiple steps of angiogenesis. Dll4 is the only Notch ligand mainly expressed in endothelial cells, which can propagate by activating Notch signal and regulate tumor angiogenesis. Notch signaling pathway and VEGF pathway have both independent and synergistic effects, and Notch is necessary for VEGF-mediated vascular remodeling. The pathways cross each other and jointly regulate tumor angiogenesis. This review reviews the relationship between dLL4-notch-VEGFR2 signaling pathway composition, transduction and regulation and tumor angiogenesis. Combined blocking of DLL4-notch-VEGFR2 signaling pathway can significantly reduce vascular perfusion, resulting in vascular degeneration and reduced tumor survival. It can destroy the vascular system and survival ability of the primary tumor more than blocking alone, thus providing a new idea for the treatment of tumor, which is of great significance for the future anti-angiogenesis therapy.

Published in	Cancer Research Journal (Volume 10, Issue 2)
DOI	10.11648/j.crj.20221002.15
Page(s)	46-50
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

DLL4, Notch, VEGF, Angiogenesis

References

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APA Style

Jie Zhou, Xinxin Duan, Ting Xiong, Aixia Sui. (2022). The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis. Cancer Research Journal, 10(2), 46-50. https://doi.org/10.11648/j.crj.20221002.15

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ACS Style

Jie Zhou; Xinxin Duan; Ting Xiong; Aixia Sui. The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis. Cancer Res. J. 2022, 10(2), 46-50. doi: 10.11648/j.crj.20221002.15

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AMA Style

Jie Zhou, Xinxin Duan, Ting Xiong, Aixia Sui. The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis. Cancer Res J. 2022;10(2):46-50. doi: 10.11648/j.crj.20221002.15

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@article{10.11648/j.crj.20221002.15,
  author = {Jie Zhou and Xinxin Duan and Ting Xiong and Aixia Sui},
  title = {The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis},
  journal = {Cancer Research Journal},
  volume = {10},
  number = {2},
  pages = {46-50},
  doi = {10.11648/j.crj.20221002.15},
  url = {https://doi.org/10.11648/j.crj.20221002.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.15},
  abstract = {Tumor angiogenesis is the center of tumor growth and metastasis, and it increases the supply of nutrients and oxygen to tumors, thereby supporting tumor growth and progression. Vascular endothelial growth factor (VEGF) is a stimulator of angiogenesis and also plays a key role in the process of angiogenesis. Overexpression of VEGF is associated with tumor angiogenesis, promotion of tumor growth and reduced survival rate of patients. Notch signaling is a key pathway that regulates the response to angiogenesis stimulation during embryonic vascular development and postnatal angiogenesis, and is involved in multiple steps of angiogenesis. Dll4 is the only Notch ligand mainly expressed in endothelial cells, which can propagate by activating Notch signal and regulate tumor angiogenesis. Notch signaling pathway and VEGF pathway have both independent and synergistic effects, and Notch is necessary for VEGF-mediated vascular remodeling. The pathways cross each other and jointly regulate tumor angiogenesis. This review reviews the relationship between dLL4-notch-VEGFR2 signaling pathway composition, transduction and regulation and tumor angiogenesis. Combined blocking of DLL4-notch-VEGFR2 signaling pathway can significantly reduce vascular perfusion, resulting in vascular degeneration and reduced tumor survival. It can destroy the vascular system and survival ability of the primary tumor more than blocking alone, thus providing a new idea for the treatment of tumor, which is of great significance for the future anti-angiogenesis therapy.},
 year = {2022}
}

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TY  - JOUR
T1  - The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis
AU  - Jie Zhou
AU  - Xinxin Duan
AU  - Ting Xiong
AU  - Aixia Sui
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.crj.20221002.15
DO  - 10.11648/j.crj.20221002.15
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 46
EP  - 50
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20221002.15
AB  - Tumor angiogenesis is the center of tumor growth and metastasis, and it increases the supply of nutrients and oxygen to tumors, thereby supporting tumor growth and progression. Vascular endothelial growth factor (VEGF) is a stimulator of angiogenesis and also plays a key role in the process of angiogenesis. Overexpression of VEGF is associated with tumor angiogenesis, promotion of tumor growth and reduced survival rate of patients. Notch signaling is a key pathway that regulates the response to angiogenesis stimulation during embryonic vascular development and postnatal angiogenesis, and is involved in multiple steps of angiogenesis. Dll4 is the only Notch ligand mainly expressed in endothelial cells, which can propagate by activating Notch signal and regulate tumor angiogenesis. Notch signaling pathway and VEGF pathway have both independent and synergistic effects, and Notch is necessary for VEGF-mediated vascular remodeling. The pathways cross each other and jointly regulate tumor angiogenesis. This review reviews the relationship between dLL4-notch-VEGFR2 signaling pathway composition, transduction and regulation and tumor angiogenesis. Combined blocking of DLL4-notch-VEGFR2 signaling pathway can significantly reduce vascular perfusion, resulting in vascular degeneration and reduced tumor survival. It can destroy the vascular system and survival ability of the primary tumor more than blocking alone, thus providing a new idea for the treatment of tumor, which is of great significance for the future anti-angiogenesis therapy.
VL  - 10
IS  - 2
ER  -

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Author Information

Jie Zhou

Graduate School, North China University of Science and Technology, Tangshan, China
Xinxin Duan

Graduate School, North China University of Science and Technology, Tangshan, China
Ting Xiong

Graduate School, North China University of Science and Technology, Tangshan, China
Aixia Sui

Department of Sixth Oncology, Hebei General Hospital, Shijiazhuang, China

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Plain Text BibTeX RIS

APA Style

Jie Zhou, Xinxin Duan, Ting Xiong, Aixia Sui. (2022). The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis. Cancer Research Journal, 10(2), 46-50. https://doi.org/10.11648/j.crj.20221002.15

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ACS Style

Jie Zhou; Xinxin Duan; Ting Xiong; Aixia Sui. The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis. Cancer Res. J. 2022, 10(2), 46-50. doi: 10.11648/j.crj.20221002.15

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AMA Style

Jie Zhou, Xinxin Duan, Ting Xiong, Aixia Sui. The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis. Cancer Res J. 2022;10(2):46-50. doi: 10.11648/j.crj.20221002.15

Copy | Download

@article{10.11648/j.crj.20221002.15,
  author = {Jie Zhou and Xinxin Duan and Ting Xiong and Aixia Sui},
  title = {The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis},
  journal = {Cancer Research Journal},
  volume = {10},
  number = {2},
  pages = {46-50},
  doi = {10.11648/j.crj.20221002.15},
  url = {https://doi.org/10.11648/j.crj.20221002.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221002.15},
  abstract = {Tumor angiogenesis is the center of tumor growth and metastasis, and it increases the supply of nutrients and oxygen to tumors, thereby supporting tumor growth and progression. Vascular endothelial growth factor (VEGF) is a stimulator of angiogenesis and also plays a key role in the process of angiogenesis. Overexpression of VEGF is associated with tumor angiogenesis, promotion of tumor growth and reduced survival rate of patients. Notch signaling is a key pathway that regulates the response to angiogenesis stimulation during embryonic vascular development and postnatal angiogenesis, and is involved in multiple steps of angiogenesis. Dll4 is the only Notch ligand mainly expressed in endothelial cells, which can propagate by activating Notch signal and regulate tumor angiogenesis. Notch signaling pathway and VEGF pathway have both independent and synergistic effects, and Notch is necessary for VEGF-mediated vascular remodeling. The pathways cross each other and jointly regulate tumor angiogenesis. This review reviews the relationship between dLL4-notch-VEGFR2 signaling pathway composition, transduction and regulation and tumor angiogenesis. Combined blocking of DLL4-notch-VEGFR2 signaling pathway can significantly reduce vascular perfusion, resulting in vascular degeneration and reduced tumor survival. It can destroy the vascular system and survival ability of the primary tumor more than blocking alone, thus providing a new idea for the treatment of tumor, which is of great significance for the future anti-angiogenesis therapy.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Role of DLL4-Notch-VEGFR2 Signaling Pathway in Tumor Angiogenesis
AU  - Jie Zhou
AU  - Xinxin Duan
AU  - Ting Xiong
AU  - Aixia Sui
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.crj.20221002.15
DO  - 10.11648/j.crj.20221002.15
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 46
EP  - 50
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20221002.15
AB  - Tumor angiogenesis is the center of tumor growth and metastasis, and it increases the supply of nutrients and oxygen to tumors, thereby supporting tumor growth and progression. Vascular endothelial growth factor (VEGF) is a stimulator of angiogenesis and also plays a key role in the process of angiogenesis. Overexpression of VEGF is associated with tumor angiogenesis, promotion of tumor growth and reduced survival rate of patients. Notch signaling is a key pathway that regulates the response to angiogenesis stimulation during embryonic vascular development and postnatal angiogenesis, and is involved in multiple steps of angiogenesis. Dll4 is the only Notch ligand mainly expressed in endothelial cells, which can propagate by activating Notch signal and regulate tumor angiogenesis. Notch signaling pathway and VEGF pathway have both independent and synergistic effects, and Notch is necessary for VEGF-mediated vascular remodeling. The pathways cross each other and jointly regulate tumor angiogenesis. This review reviews the relationship between dLL4-notch-VEGFR2 signaling pathway composition, transduction and regulation and tumor angiogenesis. Combined blocking of DLL4-notch-VEGFR2 signaling pathway can significantly reduce vascular perfusion, resulting in vascular degeneration and reduced tumor survival. It can destroy the vascular system and survival ability of the primary tumor more than blocking alone, thus providing a new idea for the treatment of tumor, which is of great significance for the future anti-angiogenesis therapy.
VL  - 10
IS  - 2
ER  -

Copy | Download