To investigate the predictive value of Glasgow Prognostic Score (GPS) for the postoperative complications and survival in elderly patients with colorectal cancer (CRC) undergoing radical resection. These participants in Beijing Hospital between February 2009 and November 2011 were included and classified into three groups according to GPS. The GPS was constructed based on C-reactive protein and serum albumin. Univariate and multivariate analyses evaluating predictors of long-term survival were performed. 137 participants were enrolled, including 58 (42.3%) with GPS=0, 64 (46.7%) with GPS=1 and 15 (11.0%) with GPS=2. High GPS group patients were associated with older age (P < 0.001), higher levels of BMI (P = 0.002), higher rate of postoperative complications (P < 0.001), lymph node metastasis (P < 0.001), higher levels of CEA (P < 0.001), CA199 (P = 0.031), as well as more advanced tumor depth and TNM stage (P < 0.001). The 5-year survival rate was 40.9% and 5-year disease-free rate was 51.8%. Univariate and multivariate analyses revealed that GPS, CA199, TNM stage and BMI were independent risk factors of overall survival. Moreover GPS, CA199, TNM stage and BMI were independent risk factors of disease-free survival. The GPS was an independent biomarker to predict long-outcomes of elderly CRC patients undergoing radical resection.
| Published in | Cancer Research Journal (Volume 10, Issue 3) |
| DOI | 10.11648/j.crj.20221003.11 |
| Page(s) | 55-60 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Colorectal Cancer, Glasgow Prognostic Score, Elderly, Survival Outcomes
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APA Style
Zi-Jian Li, Qi An, Jian Cui, Tao Yu, Guo-Ju Wu. (2022). Glasgow Prognostic Score as a Prognostic Factor for Survival in Chinese Elderly Patients with Colorectal Cancer. Cancer Research Journal, 10(3), 55-60. https://doi.org/10.11648/j.crj.20221003.11
ACS Style
Zi-Jian Li; Qi An; Jian Cui; Tao Yu; Guo-Ju Wu. Glasgow Prognostic Score as a Prognostic Factor for Survival in Chinese Elderly Patients with Colorectal Cancer. Cancer Res. J. 2022, 10(3), 55-60. doi: 10.11648/j.crj.20221003.11
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Download@article{10.11648/j.crj.20221003.11,
author = {Zi-Jian Li and Qi An and Jian Cui and Tao Yu and Guo-Ju Wu},
title = {Glasgow Prognostic Score as a Prognostic Factor for Survival in Chinese Elderly Patients with Colorectal Cancer},
journal = {Cancer Research Journal},
volume = {10},
number = {3},
pages = {55-60},
doi = {10.11648/j.crj.20221003.11},
url = {https://doi.org/10.11648/j.crj.20221003.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221003.11},
abstract = {To investigate the predictive value of Glasgow Prognostic Score (GPS) for the postoperative complications and survival in elderly patients with colorectal cancer (CRC) undergoing radical resection. These participants in Beijing Hospital between February 2009 and November 2011 were included and classified into three groups according to GPS. The GPS was constructed based on C-reactive protein and serum albumin. Univariate and multivariate analyses evaluating predictors of long-term survival were performed. 137 participants were enrolled, including 58 (42.3%) with GPS=0, 64 (46.7%) with GPS=1 and 15 (11.0%) with GPS=2. High GPS group patients were associated with older age (P < 0.001), higher levels of BMI (P = 0.002), higher rate of postoperative complications (P < 0.001), lymph node metastasis (P < 0.001), higher levels of CEA (P < 0.001), CA199 (P = 0.031), as well as more advanced tumor depth and TNM stage (P < 0.001). The 5-year survival rate was 40.9% and 5-year disease-free rate was 51.8%. Univariate and multivariate analyses revealed that GPS, CA199, TNM stage and BMI were independent risk factors of overall survival. Moreover GPS, CA199, TNM stage and BMI were independent risk factors of disease-free survival. The GPS was an independent biomarker to predict long-outcomes of elderly CRC patients undergoing radical resection.},
year = {2022}
}
TY - JOUR T1 - Glasgow Prognostic Score as a Prognostic Factor for Survival in Chinese Elderly Patients with Colorectal Cancer AU - Zi-Jian Li AU - Qi An AU - Jian Cui AU - Tao Yu AU - Guo-Ju Wu Y1 - 2022/07/05 PY - 2022 N1 - https://doi.org/10.11648/j.crj.20221003.11 DO - 10.11648/j.crj.20221003.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 55 EP - 60 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20221003.11 AB - To investigate the predictive value of Glasgow Prognostic Score (GPS) for the postoperative complications and survival in elderly patients with colorectal cancer (CRC) undergoing radical resection. These participants in Beijing Hospital between February 2009 and November 2011 were included and classified into three groups according to GPS. The GPS was constructed based on C-reactive protein and serum albumin. Univariate and multivariate analyses evaluating predictors of long-term survival were performed. 137 participants were enrolled, including 58 (42.3%) with GPS=0, 64 (46.7%) with GPS=1 and 15 (11.0%) with GPS=2. High GPS group patients were associated with older age (P < 0.001), higher levels of BMI (P = 0.002), higher rate of postoperative complications (P < 0.001), lymph node metastasis (P < 0.001), higher levels of CEA (P < 0.001), CA199 (P = 0.031), as well as more advanced tumor depth and TNM stage (P < 0.001). The 5-year survival rate was 40.9% and 5-year disease-free rate was 51.8%. Univariate and multivariate analyses revealed that GPS, CA199, TNM stage and BMI were independent risk factors of overall survival. Moreover GPS, CA199, TNM stage and BMI were independent risk factors of disease-free survival. The GPS was an independent biomarker to predict long-outcomes of elderly CRC patients undergoing radical resection. VL - 10 IS - 3 ER -
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