The Role of Lama2 in Cancer: Current Perspectives

Jiamei Hu; Shaoying Li

doi:doi:10.11648/j.crj.20221004.13

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The Role of Lama2 in Cancer: Current Perspectives

Jiamei Hu, Shaoying Li

Published in Cancer Research Journal (Volume 10, Issue 4)

Received: 26 August 2022 Accepted: 7 September 2022 Published: 29 November 2022

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Abstract

Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.

Published in	Cancer Research Journal (Volume 10, Issue 4)
DOI	10.11648/j.crj.20221004.13
Page(s)	85-88
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lama2, Laminin, Gene, Gene Regulation, Epigenetic, Cancer

References

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APA Style

Jiamei Hu, Shaoying Li. (2022). The Role of Lama2 in Cancer: Current Perspectives. Cancer Research Journal, 10(4), 85-88. https://doi.org/10.11648/j.crj.20221004.13

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ACS Style

Jiamei Hu; Shaoying Li. The Role of Lama2 in Cancer: Current Perspectives. Cancer Res. J. 2022, 10(4), 85-88. doi: 10.11648/j.crj.20221004.13

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Jiamei Hu, Shaoying Li. The Role of Lama2 in Cancer: Current Perspectives. Cancer Res J. 2022;10(4):85-88. doi: 10.11648/j.crj.20221004.13

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@article{10.11648/j.crj.20221004.13,
  author = {Jiamei Hu and Shaoying Li},
  title = {The Role of Lama2 in Cancer: Current Perspectives},
  journal = {Cancer Research Journal},
  volume = {10},
  number = {4},
  pages = {85-88},
  doi = {10.11648/j.crj.20221004.13},
  url = {https://doi.org/10.11648/j.crj.20221004.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221004.13},
  abstract = {Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.},
 year = {2022}
}

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TY  - JOUR
T1  - The Role of Lama2 in Cancer: Current Perspectives
AU  - Jiamei Hu
AU  - Shaoying Li
Y1  - 2022/11/29
PY  - 2022
N1  - https://doi.org/10.11648/j.crj.20221004.13
DO  - 10.11648/j.crj.20221004.13
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 85
EP  - 88
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20221004.13
AB  - Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.
VL  - 10
IS  - 4
ER  -

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Author Information

Jiamei Hu

Department of Thyroid and Breast Surgery, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Sanming Project of Medicine in Shenzhen, Shenzhen, P. R. China
Shaoying Li

Department of Thyroid and Breast Surgery, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Sanming Project of Medicine in Shenzhen, Shenzhen, P. R. China

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Plain Text BibTeX RIS

APA Style

Jiamei Hu, Shaoying Li. (2022). The Role of Lama2 in Cancer: Current Perspectives. Cancer Research Journal, 10(4), 85-88. https://doi.org/10.11648/j.crj.20221004.13

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ACS Style

Jiamei Hu; Shaoying Li. The Role of Lama2 in Cancer: Current Perspectives. Cancer Res. J. 2022, 10(4), 85-88. doi: 10.11648/j.crj.20221004.13

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AMA Style

Jiamei Hu, Shaoying Li. The Role of Lama2 in Cancer: Current Perspectives. Cancer Res J. 2022;10(4):85-88. doi: 10.11648/j.crj.20221004.13

Copy | Download

@article{10.11648/j.crj.20221004.13,
  author = {Jiamei Hu and Shaoying Li},
  title = {The Role of Lama2 in Cancer: Current Perspectives},
  journal = {Cancer Research Journal},
  volume = {10},
  number = {4},
  pages = {85-88},
  doi = {10.11648/j.crj.20221004.13},
  url = {https://doi.org/10.11648/j.crj.20221004.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20221004.13},
  abstract = {Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Role of Lama2 in Cancer: Current Perspectives
AU  - Jiamei Hu
AU  - Shaoying Li
Y1  - 2022/11/29
PY  - 2022
N1  - https://doi.org/10.11648/j.crj.20221004.13
DO  - 10.11648/j.crj.20221004.13
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 85
EP  - 88
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20221004.13
AB  - Laminin is a large molecular glycoprotein heterotrimer assembled from different α, β, and γ chains. In 1979, Non-collagen glycoprotein were isolated from basement membrane-rich tumors and cells that produce basement membranes and purified into laminin. The LAMA2 gene encodes the subunit of Laminin α2 and is located on chromosome 6q22-q33. Recently, new evidence has emerged that LAMA2 is involved in the biological processes of extracellular matrix (ECM) tissue and adhesions, and is related to inflammatory breast cancer (IBC), pituitary adenoma (PitNET), ovarian cancer (OC), Laryngopharyngeal squamous cell carcinoma (L/P-SCC) and many other diseases. In addition, the role of LAMA2 gene in mutation, differential expression and in terms of signal pathways in many cancers and other diseases, as well as promoter DNA methylation, all show the important regulatory role of LAMA2 in molecular biological mechanisms. The review briefly generalizes the progress in deciphering this unique molecule in recent years, including molecular structure of Lama2 gene, Lama2 gene regulation and DNA methylation, Lama2 and its protein binding partners, clinical relevance of Lama2, prospective application in diagnosis and potential therapeutic application of Lama2, and summarizes the new frontiers of Lama2 research and predicts the new prospects of Lama2 as a diagnostic and prognostic indicator of cancer and other diseases.
VL  - 10
IS  - 4
ER  -

Copy | Download