Objective: To explore the active components of ginkgo biloba and the possible targets and pathways for treating glioma. Methods: The chemical components and corresponding targets of Ginkgo biloba were searched by TCMSP, and the "component-target" network map was constructed by Cytoscape. The GenCards database, OMIM database and Disgenet database were used to search for glioma-related genes. Ginkgo biloba targets and glioma gene intersections were extracted using R software, and Veen maps were drawn to obtain key targets. PPI network construction and GO and KEGG enrichment analysis were performed by key targets. Results: A total of 27 active ingredients in Ginkgo biloba leaves and 5770 glioma target genes were collected, and 48 key targets were obtained. PPI analysis showed that the core targets were IL6, ESR1, EGFR, PPARG, VEGFA, CYP3A4, AHR, AR, PGR, etc. GO enrichment analysis is mainly concentrated in nuclear receptor activity, neurotransmitter receptor activity, fatty acid metabolic processes, response to foreign stimuli, etc. KEGG enrichment pathways are mainly manifested in: cholinergic synapses, resistance to EGFR tyrosine kinase inhibitors, tumor necrosis factor signaling pathway PI3K-Akt signaling pathway, etc. Conclusion: Ginkgo biloba can treat glioma through multi-target and multi-pathway, which is in line with the characteristics of holistic treatment of diseases in traditional Chinese medicine.
| Published in | Cancer Research Journal (Volume 11, Issue 2) |
| DOI | 10.11648/j.crj.20231102.11 |
| Page(s) | 34-43 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ginkgo Biloba, Glioma, Network Pharmacology
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APA Style
Shihua Liu, Sen Yang, Xiaohui Han, Aixia Sui. (2023). The Mechanism of Ginkgo Biloba Extract in Treating Glioma. Cancer Research Journal, 11(2), 34-43. https://doi.org/10.11648/j.crj.20231102.11
ACS Style
Shihua Liu; Sen Yang; Xiaohui Han; Aixia Sui. The Mechanism of Ginkgo Biloba Extract in Treating Glioma. Cancer Res. J. 2023, 11(2), 34-43. doi: 10.11648/j.crj.20231102.11
AMA Style
Shihua Liu, Sen Yang, Xiaohui Han, Aixia Sui. The Mechanism of Ginkgo Biloba Extract in Treating Glioma. Cancer Res J. 2023;11(2):34-43. doi: 10.11648/j.crj.20231102.11
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Download@article{10.11648/j.crj.20231102.11,
author = {Shihua Liu and Sen Yang and Xiaohui Han and Aixia Sui},
title = {The Mechanism of Ginkgo Biloba Extract in Treating Glioma},
journal = {Cancer Research Journal},
volume = {11},
number = {2},
pages = {34-43},
doi = {10.11648/j.crj.20231102.11},
url = {https://doi.org/10.11648/j.crj.20231102.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20231102.11},
abstract = {Objective: To explore the active components of ginkgo biloba and the possible targets and pathways for treating glioma. Methods: The chemical components and corresponding targets of Ginkgo biloba were searched by TCMSP, and the "component-target" network map was constructed by Cytoscape. The GenCards database, OMIM database and Disgenet database were used to search for glioma-related genes. Ginkgo biloba targets and glioma gene intersections were extracted using R software, and Veen maps were drawn to obtain key targets. PPI network construction and GO and KEGG enrichment analysis were performed by key targets. Results: A total of 27 active ingredients in Ginkgo biloba leaves and 5770 glioma target genes were collected, and 48 key targets were obtained. PPI analysis showed that the core targets were IL6, ESR1, EGFR, PPARG, VEGFA, CYP3A4, AHR, AR, PGR, etc. GO enrichment analysis is mainly concentrated in nuclear receptor activity, neurotransmitter receptor activity, fatty acid metabolic processes, response to foreign stimuli, etc. KEGG enrichment pathways are mainly manifested in: cholinergic synapses, resistance to EGFR tyrosine kinase inhibitors, tumor necrosis factor signaling pathway PI3K-Akt signaling pathway, etc. Conclusion: Ginkgo biloba can treat glioma through multi-target and multi-pathway, which is in line with the characteristics of holistic treatment of diseases in traditional Chinese medicine.},
year = {2023}
}
TY - JOUR T1 - The Mechanism of Ginkgo Biloba Extract in Treating Glioma AU - Shihua Liu AU - Sen Yang AU - Xiaohui Han AU - Aixia Sui Y1 - 2023/04/27 PY - 2023 N1 - https://doi.org/10.11648/j.crj.20231102.11 DO - 10.11648/j.crj.20231102.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 34 EP - 43 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20231102.11 AB - Objective: To explore the active components of ginkgo biloba and the possible targets and pathways for treating glioma. Methods: The chemical components and corresponding targets of Ginkgo biloba were searched by TCMSP, and the "component-target" network map was constructed by Cytoscape. The GenCards database, OMIM database and Disgenet database were used to search for glioma-related genes. Ginkgo biloba targets and glioma gene intersections were extracted using R software, and Veen maps were drawn to obtain key targets. PPI network construction and GO and KEGG enrichment analysis were performed by key targets. Results: A total of 27 active ingredients in Ginkgo biloba leaves and 5770 glioma target genes were collected, and 48 key targets were obtained. PPI analysis showed that the core targets were IL6, ESR1, EGFR, PPARG, VEGFA, CYP3A4, AHR, AR, PGR, etc. GO enrichment analysis is mainly concentrated in nuclear receptor activity, neurotransmitter receptor activity, fatty acid metabolic processes, response to foreign stimuli, etc. KEGG enrichment pathways are mainly manifested in: cholinergic synapses, resistance to EGFR tyrosine kinase inhibitors, tumor necrosis factor signaling pathway PI3K-Akt signaling pathway, etc. Conclusion: Ginkgo biloba can treat glioma through multi-target and multi-pathway, which is in line with the characteristics of holistic treatment of diseases in traditional Chinese medicine. VL - 11 IS - 2 ER -
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