Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma

Xiaohui Han; Jie Zhou; Shihua Liu; Sen Yang; Aixia Sui

doi:doi:10.11648/j.crj.20231102.15

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Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma

Xiaohui Han, Jie Zhou, Shihua Liu, Sen Yang, Aixia Sui

Published in Cancer Research Journal (Volume 11, Issue 2)

Received: 4 May 2023 Accepted: 22 May 2023 Published: 29 May 2023

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Abstract

Glioma is the most common fatal primary malignant brain tumor in the central nervous system (CNS). Currently, the main standard treatment is the combination of tumor resection, chemotherapy and radiotherapy. The World Health Organization (WHO) classifies glioma into four grades. Glioblastoma (GBM, WHO Grade 4) is the most aggressive type of glioma, characterized by cell heterogeneity, high proliferation rate, diffuse infiltration ability, and high resistance to chemotherapy drugs. Since the five-year survival rate is extremely low and the recurrence rate is high, some new effective treatment strategies are expected. Pyroptosis is an inflammatory programmed cell death mode. Compared with apoptosis, pyroptosis occurs faster and is accompanied by the release of a large number of pro-inflammatory factors. A large amount of evidence shows that pyrodeath can affect the development of tumor, and has both promoting and inhibiting effects on the development of glioma. In order to further understand the influence of pyroptosis on the glioma, this paper discussed the related studies of pyroptosis and glioma, in order to provide potential tumor treatment strategies based on pyroptosis for glioma patients.

Published in	Cancer Research Journal (Volume 11, Issue 2)
DOI	10.11648/j.crj.20231102.15
Page(s)	70-74
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Glioma, Pyroptosis, Programmed Death, Molecular Mechanism

References

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APA Style

Xiaohui Han, Jie Zhou, Shihua Liu, Sen Yang, Aixia Sui. (2023). Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma. Cancer Research Journal, 11(2), 70-74. https://doi.org/10.11648/j.crj.20231102.15

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ACS Style

Xiaohui Han; Jie Zhou; Shihua Liu; Sen Yang; Aixia Sui. Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma. Cancer Res. J. 2023, 11(2), 70-74. doi: 10.11648/j.crj.20231102.15

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AMA Style

Xiaohui Han, Jie Zhou, Shihua Liu, Sen Yang, Aixia Sui. Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma. Cancer Res J. 2023;11(2):70-74. doi: 10.11648/j.crj.20231102.15

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@article{10.11648/j.crj.20231102.15,
  author = {Xiaohui Han and Jie Zhou and Shihua Liu and Sen Yang and Aixia Sui},
  title = {Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma},
  journal = {Cancer Research Journal},
  volume = {11},
  number = {2},
  pages = {70-74},
  doi = {10.11648/j.crj.20231102.15},
  url = {https://doi.org/10.11648/j.crj.20231102.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20231102.15},
  abstract = {Glioma is the most common fatal primary malignant brain tumor in the central nervous system (CNS). Currently, the main standard treatment is the combination of tumor resection, chemotherapy and radiotherapy. The World Health Organization (WHO) classifies glioma into four grades. Glioblastoma (GBM, WHO Grade 4) is the most aggressive type of glioma, characterized by cell heterogeneity, high proliferation rate, diffuse infiltration ability, and high resistance to chemotherapy drugs. Since the five-year survival rate is extremely low and the recurrence rate is high, some new effective treatment strategies are expected. Pyroptosis is an inflammatory programmed cell death mode. Compared with apoptosis, pyroptosis occurs faster and is accompanied by the release of a large number of pro-inflammatory factors. A large amount of evidence shows that pyrodeath can affect the development of tumor, and has both promoting and inhibiting effects on the development of glioma. In order to further understand the influence of pyroptosis on the glioma, this paper discussed the related studies of pyroptosis and glioma, in order to provide potential tumor treatment strategies based on pyroptosis for glioma patients.},
 year = {2023}
}

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TY - JOUR
T1 - Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma
AU - Xiaohui Han
AU - Jie Zhou
AU - Shihua Liu
AU - Sen Yang
AU - Aixia Sui
Y1 - 2023/05/29
PY - 2023
N1 - https://doi.org/10.11648/j.crj.20231102.15
DO - 10.11648/j.crj.20231102.15
T2 - Cancer Research Journal
JF - Cancer Research Journal
JO - Cancer Research Journal
SP - 70
EP - 74
PB - Science Publishing Group
SN - 2330-8214
UR - https://doi.org/10.11648/j.crj.20231102.15
AB - Glioma is the most common fatal primary malignant brain tumor in the central nervous system (CNS). Currently, the main standard treatment is the combination of tumor resection, chemotherapy and radiotherapy. The World Health Organization (WHO) classifies glioma into four grades. Glioblastoma (GBM, WHO Grade 4) is the most aggressive type of glioma, characterized by cell heterogeneity, high proliferation rate, diffuse infiltration ability, and high resistance to chemotherapy drugs. Since the five-year survival rate is extremely low and the recurrence rate is high, some new effective treatment strategies are expected. Pyroptosis is an inflammatory programmed cell death mode. Compared with apoptosis, pyroptosis occurs faster and is accompanied by the release of a large number of pro-inflammatory factors. A large amount of evidence shows that pyrodeath can affect the development of tumor, and has both promoting and inhibiting effects on the development of glioma. In order to further understand the influence of pyroptosis on the glioma, this paper discussed the related studies of pyroptosis and glioma, in order to provide potential tumor treatment strategies based on pyroptosis for glioma patients.
VL - 11
IS - 2
ER -

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Author Information

Xiaohui Han

Department of Oncology, Hebei General Hospital, Shijiazhuang, China
Jie Zhou

Department of Oncology, Hebei General Hospital, Shijiazhuang, China
Shihua Liu

Department of Oncology, Hebei General Hospital, Shijiazhuang, China
Sen Yang

Department of Oncology, Hebei General Hospital, Shijiazhuang, China
Aixia Sui

Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Plain Text BibTeX RIS

APA Style

Xiaohui Han, Jie Zhou, Shihua Liu, Sen Yang, Aixia Sui. (2023). Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma. Cancer Research Journal, 11(2), 70-74. https://doi.org/10.11648/j.crj.20231102.15

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ACS Style

Xiaohui Han; Jie Zhou; Shihua Liu; Sen Yang; Aixia Sui. Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma. Cancer Res. J. 2023, 11(2), 70-74. doi: 10.11648/j.crj.20231102.15

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AMA Style

Xiaohui Han, Jie Zhou, Shihua Liu, Sen Yang, Aixia Sui. Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma. Cancer Res J. 2023;11(2):70-74. doi: 10.11648/j.crj.20231102.15

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@article{10.11648/j.crj.20231102.15,
  author = {Xiaohui Han and Jie Zhou and Shihua Liu and Sen Yang and Aixia Sui},
  title = {Research Progress on the Mechanism and Treatment of Pyroptosis in Brain Glioma},
  journal = {Cancer Research Journal},
  volume = {11},
  number = {2},
  pages = {70-74},
  doi = {10.11648/j.crj.20231102.15},
  url = {https://doi.org/10.11648/j.crj.20231102.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20231102.15},
  abstract = {Glioma is the most common fatal primary malignant brain tumor in the central nervous system (CNS). Currently, the main standard treatment is the combination of tumor resection, chemotherapy and radiotherapy. The World Health Organization (WHO) classifies glioma into four grades. Glioblastoma (GBM, WHO Grade 4) is the most aggressive type of glioma, characterized by cell heterogeneity, high proliferation rate, diffuse infiltration ability, and high resistance to chemotherapy drugs. Since the five-year survival rate is extremely low and the recurrence rate is high, some new effective treatment strategies are expected. Pyroptosis is an inflammatory programmed cell death mode. Compared with apoptosis, pyroptosis occurs faster and is accompanied by the release of a large number of pro-inflammatory factors. A large amount of evidence shows that pyrodeath can affect the development of tumor, and has both promoting and inhibiting effects on the development of glioma. In order to further understand the influence of pyroptosis on the glioma, this paper discussed the related studies of pyroptosis and glioma, in order to provide potential tumor treatment strategies based on pyroptosis for glioma patients.},
 year = {2023}
}

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