| Peer-Reviewed

Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria

Received: 23 October 2020    Accepted: 3 November 2020    Published: 26 April 2021
Views:       Downloads:
Abstract

The knowledge, attitude and practice of genotype screening for sickle cell are very important in the control and prevention of sickle cell disease (SCD). The objectives of this study therefore are to determine the knowledge, attitude and practice of genotype screening among undergraduate students of the University of Abuja, Nigeria. The study was a descriptive cross-sectional study. A sample size of 256 was studied and multi-stage sampling technique was used to select the faculties, departments and participants. Data was collected by using self-administered, semi-structured questionnaire. Associations between variables and proportions were ascertained using Chi-square tests at 5% level of statistical significance. Most of the respondents were males (51.1%) and majority belong to age group of 21-25 years. About 98% of the students have good knowledge of genotype screening for sickle cell. Also, 93.8% of the students had positive attitude to genotype screening and 76.6% of the participants had ever had a genotype screening with 52.7% having AA genotype, 18.4% AS and 5.5% with SS genotype. In addition, the study revealed a statistically significant association between good knowledge of genotype screening and the practice (98.0% vs. 58.2%; p value <0.003). Since the students have good knowledge and positive attitude to genotype screening, increased awareness on genotype screening should be encouraged so as to increase the uptake of screening and reduce the burden of sickle cell disease.

Published in European Journal of Preventive Medicine (Volume 9, Issue 2)
DOI 10.11648/j.ejpm.20210902.16
Page(s) 63-70
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Genotype, Screening, Students, Knowledge, Attitude, Practice

References
[1] Angela Edna Rankine-Mullings, Twila Mae Logan, Lesley-Gaye King, Colette Andrea Cunningham-Myrie, Clive Robert Scott, Jennifer Marcelle Knight-Madden. The risk of acute events among patientswith sickle cell disease in relation to earlyor late initiation of care at a specialistcenter: evidence from a retrospectivecohort study. BMC Paed Rankine-Mullingset al. BMC Pediatrics (2020) 20: 373 https://doi.org/10.1186/s12887-020-02270-y.
[2] Amissah-Arthur, K. N., Mensah, E. The past, present and future management of sickle cell retinopathy within an African context. Eye 32, 1304–1314 (2018). https://doi.org/10.1038/s41433-018-0162-8.
[3] Boubacar Gueye, Cheikh Tacko Diop, Ndéye Marième Diagne, Aminata Paye, Ibrahima Diagne. Study of Prognostic Factors of Death in Children with Sickle Cell Diseases Followed at the Albert Royer National Children's Hospital Center, Dakar, Senegal. American Journal of Pediatrics Volume 6, Issue 1, March 2020, Pages: 1-11.
[4] Abubakar Y, Ahmad HR, Faruk JA. Hematological parameters of children with sickle cell anemia in steady and crisis states in Zaria, Nigeria. Ann Trop Pathol 2019; 10: 122-5.
[5] Lagunju I, Sodeinde O, Telfer P. Prevalence of transcranial Doppler abnormalities in Nigerian children with sickle cell disease. Am J Hematol 2012; 87: 544-7.
[6] Stephen N, Nden N, Gusen NJ, Kumzhi PR, Gaknung B, Auta DA, Bulndi LB, Mbursa C, Kumari VP, Nanvyat N. Prevalence of sickle cell disease among children attending plateau specialist hospital, Jos, Nigeria. Acta Med Int 2018; 5: 20-3.
[7] Traore MS, Zohoncon TM, Ouedraogo P, Ouattara AK, Obiri-Yeboah D, Tao I, Ganane G, Belemgnegre M, Boro T, Sanou F, Simpore J. Hemoglobin AE, AO-Arab and SO-Arab Genotypes in Burkina Faso: Hematological Parameters, Genotypic and Allelic Frequencies of Hemoglobinopathies. J Human Clin Gen. (2020); 2 (1): 23-30.
[8] Chandrashekar V, Soni M. Hemoglobin disorders in South India. ISRN Hematol 2011; 2011: 748939.
[9] Munshi A, Anandraj MP, Joseph J, Shafi G, Anila AN, Jyothy A. Inherited hemoglobin disorders in Andhra Pradesh, India: A population study. Clin Chim Acta 2009; 400: 117-9.
[10] Muhammad Umair, Majid Alfadhel. Prevention of hemoglobinopathies in Saudi Arabia: efficacy of national premarital screening and the feasibility of preimplantation genetic diagnosis. Umair and Alfadhel, 2020; 3 (2): 94–99. https://doi.org/10.24911/JBCGenetics/183-1595487640.
[11] Serjeant GR. Sickle Cell Disease. 3rd ed. New York: Oxford University Press; 2001. p. 772.
[12] Population distribution by sex, state, LGAs and senatorial districts: 2006 census priority tables. Accessed; 15th July, 2017. Available from: www.population.gov.ng/index.php/censuses.
[13] Araoye MO. Research Methodology with Statistics for Health and Social Sciences. Nathadex Publishers, Ilorin, Nigeria, 2004, pp 115-120. 15.
[14] Bazuaye GN and Olayemi EE. Knowledge and attitude of Senior Secondary School Students in Benin City Nigeria to Sickle Cell Disease. World Journal of Medical Sciences 2009; 4 (1): 46-49.
[15] Smith M, Brownell G. Knowledge, beliefs, attitudes, and behaviors regarding sickle cell disease: Implications for prevention. Soc Work Public Health. 2018; 33 (5): 299-316. doi: 10.1080/19371918.2018.1469064. Epub 2018 May 16. PMID: 29768104.
[16] Adewoyin AS, Alagbe AE, Adedokun BO, Isubor NT. Knowledge, attitude and control practice of sickle cell diseases among youth corps members in Benin city, Nigeria. Annals of Ibadan postgraduate medicine. 2015 Dec, 13 2): 100-7.
[17] Adeyemo Oyenike A, Omidiji, olusesan O. and Shabi, Oluwasola A. level of awareness of genetic counseling in lagos Nigeria. African journal of biotechnology vol 6 (24) pp. 2758-2765, 17 december 2007.
[18] Precious Kalamba Gbeneol, Seiyefa Funakpa Brisibe, Best Ordinioha. Knowledge, Attitude and Uptake of Premarital Screening for the Sickle Trait Among Married Couples in a Semi-Urban Community in South-South Nigeria. European Journal of Preventive Medicine. Vol. 3, No. 3, 2015, pp. 49-54. doi: 10.11648/j.ejpm.20150303.13. Assessed 25th Aug 2018.
[19] Oludare, Gabriel & C Ogili, Matthew. (2013). Knowledge, attitude and practice of premarital counseling for sickle cell disease among youth in Yaba, Nigeria. African journal of reproductive health. 17. 175-82.
[20] Grosse SD, Odame I, Atrash HK, Amendah DD, Piel FB, Williams TN. Sickle cell disease in Africa: a neglected cause of early childhood mortality. AM j prev Med. 2011 dec.
[21] Isah BA, Musa Y, Mohammed UK, Ibrahim MTO, Awosan KJ, Yunusa EU. Knowledge and Attitude Regarding Premarital Screening for Sickle Cell Disease among Students of State School of Nursing Sokoto. Ann. Int. Med. Den. Res. 2016; 2 (3): 29-34.
[22] Abioye-Kuteyi E. A., Oyegbade O., Bello I., Osakwe C. Sickle cell knowledge, premarital screening and marital decisions among local government workers in Ile-Ife, Nigeria. African Journal of Primary Health Care & Family Medicine, 1 (1) (2009), pp. 53-57.
[23] Olatona FA, Odeyemi KA, Onajole AT, Asuzu MC. Effect of health education on knowledge and attitude of youth corps members to sickle cell disease and its screening in Lagos. J community med health educ. 2012. Vol 2. issue 7. pg 163.
[24] Gbenol PK, Brisibe SF, Ordinioha B. Knowledge, attitude and uptake of premarital screening for the sickle trait among married couples in a semi urban community in South-South Nigeria. Eur J Prev Med 2015; 3: 49-54.
[25] Galadanci N, Wudil BJ, Balogun TM, Ogunrinde GO, Akinsulie A, Hasan-Hanga F, et al. Current sickle cell disease management practices in Nigeria. Int Health 2014; 6: 23-8.
[26] Adenike Funmilola Faremi, Matthew Idowu Olatubi, Yetunde Ruqoyat Lawal. Knowledge of Sickle Cell Disease and Pre Marital Genotype Screening among Students of a Tertiary Educational Institution in South Western Nigeria. International Journal of Caring Sciences January-April 2018 Volume 11 | Issue 1| Page 285.
[27] Ugwu N. I. Pre-marital screening for sickle cell haemoglobin and genetic counseling: awareness and acceptability among undergraduate students of a Nigerian University. International Journal of Medicine and Biomedical Research Volume 5 Issue 1 January – April 2016.
[28] Egbochukwu, E. O. &ImoGie, A. O. (2002). Knowledge and attitude of Nigerian Adolescents to premarital genotyping. Paper presented at the Biennial meeting of society for research on adolescence. New Orleans.
[29] Uche E, Olowoselu O, Augustine B, Ismail A, Akinbami A, Dosunmu A, Balogun A. An Assessment of Knowledge, Awareness, and Attitude of Undergraduates toward Sickle Cell Disease in Lagos, Nigeria. Niger Med J. 2017 Nov-Dec; 58 (6): 167-172. doi: 10.4103/nmj.NMJ_111_18. PMID: 31198270; PMCID: PMC6555223.
[30] Busari AA, Mufutau MA. High prevalence of complementary and alternative medicine use among patients with sickle cell disease in a tertiary hospital in Lagos, South West, Nigeria. BMC Complement Altern Med. 2017 Jun 7; 17 (1): 299. doi: 10.1186/s12906-017-1812-2. PMID: 28592256; PMCID: PMC5463406.
[31] Orelaru F, Bolanle G, Tolulope I, Ishmael J. Assessing Knowledge of Sickle Cell Trait/Disease Inheritance in Metropolitan Detroit. J Natl Med Assoc. 2019 Dec; 111 (6): 656-664. doi: 10.1016/j.jnma.2019.09.003. Epub 2019 Oct 26. PMID: 31662206.
[32] Bindhani BK, Devi NK, Nayak JK. Knowledge, awareness, and attitude of premarital screening with special focus on sickle cell disease: a study from Odisha. J Community Genet. 2020 Oct; 11 (4): 445-449. doi: 10.1007/s12687-020-00471-7. Epub 2020 Jun 18. PMID: 32557401; PMCID: PMC7475140.
Cite This Article
  • APA Style

    Ramsey Msheliza Yalma, Mary Mayowa Awodiji. (2021). Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria. European Journal of Preventive Medicine, 9(2), 63-70. https://doi.org/10.11648/j.ejpm.20210902.16

    Copy | Download

    ACS Style

    Ramsey Msheliza Yalma; Mary Mayowa Awodiji. Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria. Eur. J. Prev. Med. 2021, 9(2), 63-70. doi: 10.11648/j.ejpm.20210902.16

    Copy | Download

    AMA Style

    Ramsey Msheliza Yalma, Mary Mayowa Awodiji. Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria. Eur J Prev Med. 2021;9(2):63-70. doi: 10.11648/j.ejpm.20210902.16

    Copy | Download

  • @article{10.11648/j.ejpm.20210902.16,
      author = {Ramsey Msheliza Yalma and Mary Mayowa Awodiji},
      title = {Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria},
      journal = {European Journal of Preventive Medicine},
      volume = {9},
      number = {2},
      pages = {63-70},
      doi = {10.11648/j.ejpm.20210902.16},
      url = {https://doi.org/10.11648/j.ejpm.20210902.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejpm.20210902.16},
      abstract = {The knowledge, attitude and practice of genotype screening for sickle cell are very important in the control and prevention of sickle cell disease (SCD). The objectives of this study therefore are to determine the knowledge, attitude and practice of genotype screening among undergraduate students of the University of Abuja, Nigeria. The study was a descriptive cross-sectional study. A sample size of 256 was studied and multi-stage sampling technique was used to select the faculties, departments and participants. Data was collected by using self-administered, semi-structured questionnaire. Associations between variables and proportions were ascertained using Chi-square tests at 5% level of statistical significance. Most of the respondents were males (51.1%) and majority belong to age group of 21-25 years. About 98% of the students have good knowledge of genotype screening for sickle cell. Also, 93.8% of the students had positive attitude to genotype screening and 76.6% of the participants had ever had a genotype screening with 52.7% having AA genotype, 18.4% AS and 5.5% with SS genotype. In addition, the study revealed a statistically significant association between good knowledge of genotype screening and the practice (98.0% vs. 58.2%; p value <0.003). Since the students have good knowledge and positive attitude to genotype screening, increased awareness on genotype screening should be encouraged so as to increase the uptake of screening and reduce the burden of sickle cell disease.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria
    AU  - Ramsey Msheliza Yalma
    AU  - Mary Mayowa Awodiji
    Y1  - 2021/04/26
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ejpm.20210902.16
    DO  - 10.11648/j.ejpm.20210902.16
    T2  - European Journal of Preventive Medicine
    JF  - European Journal of Preventive Medicine
    JO  - European Journal of Preventive Medicine
    SP  - 63
    EP  - 70
    PB  - Science Publishing Group
    SN  - 2330-8230
    UR  - https://doi.org/10.11648/j.ejpm.20210902.16
    AB  - The knowledge, attitude and practice of genotype screening for sickle cell are very important in the control and prevention of sickle cell disease (SCD). The objectives of this study therefore are to determine the knowledge, attitude and practice of genotype screening among undergraduate students of the University of Abuja, Nigeria. The study was a descriptive cross-sectional study. A sample size of 256 was studied and multi-stage sampling technique was used to select the faculties, departments and participants. Data was collected by using self-administered, semi-structured questionnaire. Associations between variables and proportions were ascertained using Chi-square tests at 5% level of statistical significance. Most of the respondents were males (51.1%) and majority belong to age group of 21-25 years. About 98% of the students have good knowledge of genotype screening for sickle cell. Also, 93.8% of the students had positive attitude to genotype screening and 76.6% of the participants had ever had a genotype screening with 52.7% having AA genotype, 18.4% AS and 5.5% with SS genotype. In addition, the study revealed a statistically significant association between good knowledge of genotype screening and the practice (98.0% vs. 58.2%; p value <0.003). Since the students have good knowledge and positive attitude to genotype screening, increased awareness on genotype screening should be encouraged so as to increase the uptake of screening and reduce the burden of sickle cell disease.
    VL  - 9
    IS  - 2
    ER  - 

    Copy | Download

Author Information
  • Department of Community Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Abuja, Abuja Nigeria

  • Department of Community Medicine, Faculty of Clinical Sciences, College of Health Sciences, University of Abuja, Abuja Nigeria

  • Sections