Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine

Nahida Sultana; ABM Rashedul Amir; Hasina Momtaz; Md. Abu Taher

doi:doi:10.11648/j.ijacm.20210902.13

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Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine

Nahida Sultana, ABM Rashedul Amir, Hasina Momtaz, Md. Abu Taher

Published in International Journal of Anesthesia and Clinical Medicine (Volume 9, Issue 2)

Received: 13 February 2021 Accepted: 4 June 2021 Published: 11 August 2021

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Abstract

Introduction: Preeclampsia is one of the most commonly disorders of pregnancy. The pressor response to laryngoscopy is known to be exaggerated in patients with severe preeclampsia. The aim of this study was to assess the preoperative blood pressure control in severe preeclamptic mother with intravenous nitroglycerine is more effectively attenuate the haemodynamic response to laryngoscopy in comparison to treatment with intravenous hydralazine. Methods: This randomized fixed sealed envelope lottery method study was conducted in the Department of anaesthesiology of Dhaka Medical College Hospital, Dhaka, between October 2014 to March 2015 Total of 60 patients with severe preeclampsia and gestational age more than 36 weeks, who were presented for elective or urgent caesarean delivery under general anaesthesia were randomly divided into two groups, group A, n=30 received 50 mcg intravenous nitroglycerine. Group B received 5mg hydralazine intravenously very slowly. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were simultaneously recorded in the mother at pre-induction, pre-laryngoscopy, and at 1min, 3 min, and 5 min after laryngoscopy. Result: The patients in group A and group B showed no significant difference in HR, SAP, DAP and MAP at pre induction and pre laryngoscopy. But there is significant difference (P<0.05) at 1, 3, 5 min after laryngoscopy. The mean heart rate at 1, 3 and 5 minutes after laryngoscopy were significantly (p<0.05) higher in group B than group A. The mean SAP, DAP, MAP were also significantly (p<0.05) higher in group B than group A at 1, 3, 5 min after laryngoscopy. Conclusion: Women with severe preeclampsia who were preoperatively treated with intravenous nitroglycerine provides a safe and more effective prophylaxis for patients with severe preeclampsia undergoing cesarean delivery under general anesthesia, in attenuating haemodynamic responses to laryngoscopy.

Published in	International Journal of Anesthesia and Clinical Medicine (Volume 9, Issue 2)
DOI	10.11648/j.ijacm.20210902.13
Page(s)	32-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Attenuation, Pressor, Laryngoscopy, Preeclampsia, Intravenous Nitroglycerine & Hydralazine

References

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APA Style

Nahida Sultana, ABM Rashedul Amir, Hasina Momtaz, Md. Abu Taher. (2021). Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine. International Journal of Anesthesia and Clinical Medicine, 9(2), 32-37. https://doi.org/10.11648/j.ijacm.20210902.13

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ACS Style

Nahida Sultana; ABM Rashedul Amir; Hasina Momtaz; Md. Abu Taher. Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine. Int. J. Anesth. Clin. Med. 2021, 9(2), 32-37. doi: 10.11648/j.ijacm.20210902.13

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AMA Style

Nahida Sultana, ABM Rashedul Amir, Hasina Momtaz, Md. Abu Taher. Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine. Int J Anesth Clin Med. 2021;9(2):32-37. doi: 10.11648/j.ijacm.20210902.13

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@article{10.11648/j.ijacm.20210902.13,
  author = {Nahida Sultana and ABM Rashedul Amir and Hasina Momtaz and Md. Abu Taher},
  title = {Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {9},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijacm.20210902.13},
  url = {https://doi.org/10.11648/j.ijacm.20210902.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijacm.20210902.13},
  abstract = {Introduction: Preeclampsia is one of the most commonly disorders of pregnancy. The pressor response to laryngoscopy is known to be exaggerated in patients with severe preeclampsia. The aim of this study was to assess the preoperative blood pressure control in severe preeclamptic mother with intravenous nitroglycerine is more effectively attenuate the haemodynamic response to laryngoscopy in comparison to treatment with intravenous hydralazine. Methods: This randomized fixed sealed envelope lottery method study was conducted in the Department of anaesthesiology of Dhaka Medical College Hospital, Dhaka, between October 2014 to March 2015 Total of 60 patients with severe preeclampsia and gestational age more than 36 weeks, who were presented for elective or urgent caesarean delivery under general anaesthesia were randomly divided into two groups, group A, n=30 received 50 mcg intravenous nitroglycerine. Group B received 5mg hydralazine intravenously very slowly. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were simultaneously recorded in the mother at pre-induction, pre-laryngoscopy, and at 1min, 3 min, and 5 min after laryngoscopy. Result: The patients in group A and group B showed no significant difference in HR, SAP, DAP and MAP at pre induction and pre laryngoscopy. But there is significant difference (PConclusion: Women with severe preeclampsia who were preoperatively treated with intravenous nitroglycerine provides a safe and more effective prophylaxis for patients with severe preeclampsia undergoing cesarean delivery under general anesthesia, in attenuating haemodynamic responses to laryngoscopy.},
 year = {2021}
}

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TY  - JOUR
T1  - Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine
AU  - Nahida Sultana
AU  - ABM Rashedul Amir
AU  - Hasina Momtaz
AU  - Md. Abu Taher
Y1  - 2021/08/11
PY  - 2021
N1  - https://doi.org/10.11648/j.ijacm.20210902.13
DO  - 10.11648/j.ijacm.20210902.13
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 32
EP  - 37
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ijacm.20210902.13
AB  - Introduction: Preeclampsia is one of the most commonly disorders of pregnancy. The pressor response to laryngoscopy is known to be exaggerated in patients with severe preeclampsia. The aim of this study was to assess the preoperative blood pressure control in severe preeclamptic mother with intravenous nitroglycerine is more effectively attenuate the haemodynamic response to laryngoscopy in comparison to treatment with intravenous hydralazine. Methods: This randomized fixed sealed envelope lottery method study was conducted in the Department of anaesthesiology of Dhaka Medical College Hospital, Dhaka, between October 2014 to March 2015 Total of 60 patients with severe preeclampsia and gestational age more than 36 weeks, who were presented for elective or urgent caesarean delivery under general anaesthesia were randomly divided into two groups, group A, n=30 received 50 mcg intravenous nitroglycerine. Group B received 5mg hydralazine intravenously very slowly. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were simultaneously recorded in the mother at pre-induction, pre-laryngoscopy, and at 1min, 3 min, and 5 min after laryngoscopy. Result: The patients in group A and group B showed no significant difference in HR, SAP, DAP and MAP at pre induction and pre laryngoscopy. But there is significant difference (PConclusion: Women with severe preeclampsia who were preoperatively treated with intravenous nitroglycerine provides a safe and more effective prophylaxis for patients with severe preeclampsia undergoing cesarean delivery under general anesthesia, in attenuating haemodynamic responses to laryngoscopy.
VL  - 9
IS  - 2
ER  -

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Author Information

Nahida Sultana

Department of Anesthesiology, Prime Medical College Hospital, Rangpur, Bangladesh
ABM Rashedul Amir

Department of Anesthesiology, Prime Medical College Hospital, Rangpur, Bangladesh
Hasina Momtaz

Department of Community Medicine, Ibrahim Medical College, Dhaka, Bangladesh
Md. Abu Taher

Combined Military Hospital (CMH), Savar, Dhaka, Bangladesh

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Nahida Sultana, ABM Rashedul Amir, Hasina Momtaz, Md. Abu Taher. (2021). Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine. International Journal of Anesthesia and Clinical Medicine, 9(2), 32-37. https://doi.org/10.11648/j.ijacm.20210902.13

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ACS Style

Nahida Sultana; ABM Rashedul Amir; Hasina Momtaz; Md. Abu Taher. Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine. Int. J. Anesth. Clin. Med. 2021, 9(2), 32-37. doi: 10.11648/j.ijacm.20210902.13

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AMA Style

Nahida Sultana, ABM Rashedul Amir, Hasina Momtaz, Md. Abu Taher. Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine. Int J Anesth Clin Med. 2021;9(2):32-37. doi: 10.11648/j.ijacm.20210902.13

Copy | Download

@article{10.11648/j.ijacm.20210902.13,
  author = {Nahida Sultana and ABM Rashedul Amir and Hasina Momtaz and Md. Abu Taher},
  title = {Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {9},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijacm.20210902.13},
  url = {https://doi.org/10.11648/j.ijacm.20210902.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijacm.20210902.13},
  abstract = {Introduction: Preeclampsia is one of the most commonly disorders of pregnancy. The pressor response to laryngoscopy is known to be exaggerated in patients with severe preeclampsia. The aim of this study was to assess the preoperative blood pressure control in severe preeclamptic mother with intravenous nitroglycerine is more effectively attenuate the haemodynamic response to laryngoscopy in comparison to treatment with intravenous hydralazine. Methods: This randomized fixed sealed envelope lottery method study was conducted in the Department of anaesthesiology of Dhaka Medical College Hospital, Dhaka, between October 2014 to March 2015 Total of 60 patients with severe preeclampsia and gestational age more than 36 weeks, who were presented for elective or urgent caesarean delivery under general anaesthesia were randomly divided into two groups, group A, n=30 received 50 mcg intravenous nitroglycerine. Group B received 5mg hydralazine intravenously very slowly. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were simultaneously recorded in the mother at pre-induction, pre-laryngoscopy, and at 1min, 3 min, and 5 min after laryngoscopy. Result: The patients in group A and group B showed no significant difference in HR, SAP, DAP and MAP at pre induction and pre laryngoscopy. But there is significant difference (PConclusion: Women with severe preeclampsia who were preoperatively treated with intravenous nitroglycerine provides a safe and more effective prophylaxis for patients with severe preeclampsia undergoing cesarean delivery under general anesthesia, in attenuating haemodynamic responses to laryngoscopy.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Attenuation of Pressor Response to Laryngoscopy in Severe Preeclampsia: Comparison the Efficacies Between Intravenous Nitroglycerine and Intravenous Hydralazine
AU  - Nahida Sultana
AU  - ABM Rashedul Amir
AU  - Hasina Momtaz
AU  - Md. Abu Taher
Y1  - 2021/08/11
PY  - 2021
N1  - https://doi.org/10.11648/j.ijacm.20210902.13
DO  - 10.11648/j.ijacm.20210902.13
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 32
EP  - 37
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ijacm.20210902.13
AB  - Introduction: Preeclampsia is one of the most commonly disorders of pregnancy. The pressor response to laryngoscopy is known to be exaggerated in patients with severe preeclampsia. The aim of this study was to assess the preoperative blood pressure control in severe preeclamptic mother with intravenous nitroglycerine is more effectively attenuate the haemodynamic response to laryngoscopy in comparison to treatment with intravenous hydralazine. Methods: This randomized fixed sealed envelope lottery method study was conducted in the Department of anaesthesiology of Dhaka Medical College Hospital, Dhaka, between October 2014 to March 2015 Total of 60 patients with severe preeclampsia and gestational age more than 36 weeks, who were presented for elective or urgent caesarean delivery under general anaesthesia were randomly divided into two groups, group A, n=30 received 50 mcg intravenous nitroglycerine. Group B received 5mg hydralazine intravenously very slowly. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were simultaneously recorded in the mother at pre-induction, pre-laryngoscopy, and at 1min, 3 min, and 5 min after laryngoscopy. Result: The patients in group A and group B showed no significant difference in HR, SAP, DAP and MAP at pre induction and pre laryngoscopy. But there is significant difference (PConclusion: Women with severe preeclampsia who were preoperatively treated with intravenous nitroglycerine provides a safe and more effective prophylaxis for patients with severe preeclampsia undergoing cesarean delivery under general anesthesia, in attenuating haemodynamic responses to laryngoscopy.
VL  - 9
IS  - 2
ER  -

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