The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution

Yu Chuan; Liu Penggang; Yang Gang; Wu Qiang

doi:doi:10.11648/j.ijast.20210502.11

| Peer-Reviewed

The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang

Published in International Journal of Animal Science and Technology (Volume 5, Issue 2)

Received: 23 March 2021 Accepted: 10 April 2021 Published: 20 April 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.

Published in	International Journal of Animal Science and Technology (Volume 5, Issue 2)
DOI	10.11648/j.ijast.20210502.11
Page(s)	32-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Rabbit, Epidermis, Dermis, Hair Folliclaes, Sebaceous Glands, Pharmacokinetics

References

[1]	M. Honda, K. Namikawa, H. Hirata, S. Neo el. (2011) An Outbreak of Trixacarus caviae Infestation in Guinea Pigs at an Animal Petting Facility and an Evaluation of the Safety and Suitable Dose of Selamectin Treatment. American Society of Parasitologists, 4 (97), 731-734.
[2]	James W. Carpenter, Michael W Dryden, Butch KuKanich. (2012) Pharmacokinetics, efficacy, and adverse effects of selamectin following topical administration in flea-infested rabbits. American Journal of Veterinary Pharmacology and Therapeutics, 4 (73), 562-566.
[3]	Jennifer J. Grary WestD, Dawn M. (2007) Plasma pharmacokinetics of selamectin after a single topical andministration in the american bullfrog (Rana catesbeiana). American Journal of Zoo and Wildlife Medicine, 1 (38), 51-54.
[4]	Sang-Hum Kin, Jung-Youn Leet, Hyung-Kyou Jun et al. (2007) Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits. Chinese Journal of Veterinary dermatology, 19 (01), 26-27.
[5]	Arif Kurtdede, Zafar Karaert, Abuzer Acar et al. (2006) Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits. Chinese Journal of Veeterinary dermatology, 18 (01), 18-22.
[6]	Lara Olivieri, Giordano Nardini, Stefania Leopardi et al.(2015) Mitet infection in a masked palm civet (paguma larvata) treated by selamectin (stronghold, pfizer ltd). Journal of Zoo and Wildlife Medicine, 46 (03), 592-595.
[7]	Tom L. McTier, Aleah Pullins, Sara Chapin et al.(2019) The efficacy of a novel topical formulation of selamectin plus sarolaner (Revolution Plus/Stronghold Plus) in preventing the development of Dirofilaria immitis in cats. Journal of Veterinary Parasitology, 270 (06), 56-62.
[8]	Meng Yuelan. (2020) Comprehensive control of staphylococcal disease in rabbits. Chinese Journal of The Chinese Live stock and Poultry Breeding, 05 (16), 89-89.
[9]	Tian Dahong. (2014) Prevention and treatment of necrotic bacillosis in rabbits. Chinese Journal of The Chinese Zhong Guo Xu Mu Shou Yi Wen Zhai, 03 (30), 105-105.
[10]	Li Ming-yong, Mu Te, Liu Man etc. (2014) Isolation of Rabbit Dermatophytes and Analysis and Identification of their ITs Sequences. Chinese Journal of Rabbit Farming 06 (11), 11-14.
[11]	Xu Yanhong, Zhang Yu, Yang Zhenyan. (2017) Differentiation and Treatment of Common Rabbit Skin Diseases. Chinese Journal of Rabbit Farming 01 (2017), 45-7.
[12]	Wenrui Wei, Yongjun Ren, Nengxing Shen. (2019) Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds. Parasites & Vectors 12 (01), 382-387.
[13]	H Hernandez-Pigeon, J Besse, M Aries, S Bessou-Touya, et al. (2012) Interest of pentyl-rhamnoside in keratinocyte differentiation and cell junction for atopic dermatitis treatment [J]. Journal of Investigative Dermatology. 132: 723-748.
[14]	J Idkowiak-Baldys, C Hwang, S Yim, et al. (2007) Modulation of CPT-1 expression in primary human subcutaneous adipocytes with starfruit (Averrhoa carambola) leaf extract [J]. Journal of Investigative Dermatology. 13: 151-164.
[15]	M Hou, M Man, W Man, et al. (2012) Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin [J]. Journal of VA Med Ctr/UCSF. 21: 337-340.
[16]	G Baida, P Bhalla, I Budunova. (2015) Glucocorticoids induce epidermal atrophy via activation of REDD1 and inhibition of m-TOR activity [J]. journal of investigative dermatology. 07: 42-85.
[17]	TR Sutter, QTran, LH Kennedy, et al. (2012) EGFR regulation of epidermal barrier function [J]. Journal of physiological genomics. 03: 455-469.
[18]	M Gschwandtner, M Mildner, V Mlitz, et al. (2013) Histamine suppresses epidermal keratinocyte differentiation and impairs the inside-out barrier function of the epidermis – a new role for mast cells in inflammatory skin diseases [J]. Journal of Allergy Clinical Immunology. 15: 37-47.
[19]	R. C. Gupta, M. B. Masthay, T. D. Canerdy and T. M. Acosta, et al (2005) Human exposure to selamectin from dogs treated with revolution: methodological consideration for selamectin isolation [J]. Journal of Toxicology Mechanisms and Methods. 15 (04): 317-321.
[20]	Vlamir Bozzatto, Patricia Rosa De Oliveira, Karim Christina Scopinho Furquim, Maria Izabel Camargo-Mathias. (2020) The occurrence of autophagic cell death in the tegument of rabbits pre-infested with rhipicephalus sanguineus and exposed to selamectin (active principle of acaricide pfizer revolution) Jourinal of Microscopy Research Technique. 76: 1171-1176.
[21]	Vlamer Bozzatto, Patricia Rose de Oliveria Gervasio Henrique Bechara, et al.(2014) Morphological alterations of epidermis of rabbits infested by R. Sanguineus ticks and exposed to selamectin (active principle of pfizer revolution acaricide): A confocal microscopy study [J]. Journal of Contents lists available at Science Direct. 116: 534-538.
[22]	Vlamir Bozzatto. Patricia Rose de Oliveira, Maria Izabel Camargo-Mathias.(2013) Histopathology of the tegument of rabbits infested by Rhipicephalus sanguineus (acari: ixodidae) ticks and exposed to selamectin (active principle of acaricide revolution, pfizer). Journal of Parssitol Res 24 (112), 2551-2560.
[23]	R. G. Clemence a, P. Sarasola a, C. Genchi b, et al. (2000) Efficacy of selamectin in the prevention of adult heartworm (Dirofilaria immitis) infection in dogs in northern Italy. Journal of Veterinary Parasitology91: 251-258.
[24]	Alicia Hahn, D. V. M, Jennifer D’Agostino, D. V. M., Dipl. A. C. Z. M., et al. (2014) Pharmacokinetics of selamectin in helmeted guineafowl (numida meleagris) after topical administration. Journal of Zoo and Wildlife Medicine 45 (1): 176–178.
[25]	Sarasolap, Jerniganad, Walkerdk. (2002) Prmacokinetics of selamectin following intravenous oral and topical administration in catsanddogs. Journal of Veterinary Pharmacology and Therapeutics, 25 (4): 265-272.
[26]	Hideo Hasegawa, Hiroshi Sato, Eri Iwakiri, et al. (2008) Helminths Collected From Imported Pet Murids, with Special Reference to Concomitant Infection of the Golden Hamsters with Three Pinworm Species of the Genus Syphacia (Nematoda: Oxyuridae). Journal of American Society of Parasitologists, 94 (3): 752-754.

Cite This Article

Plain Text BibTeX RIS

APA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. (2021). The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. International Journal of Animal Science and Technology, 5(2), 32-37. https://doi.org/10.11648/j.ijast.20210502.11

Copy | Download

ACS Style

Yu Chuan; Liu Penggang; Yang Gang; Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int. J. Anim. Sci. Technol. 2021, 5(2), 32-37. doi: 10.11648/j.ijast.20210502.11

Copy | Download

AMA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int J Anim Sci Technol. 2021;5(2):32-37. doi: 10.11648/j.ijast.20210502.11

Copy | Download

@article{10.11648/j.ijast.20210502.11,
  author = {Yu Chuan and Liu Penggang and Yang Gang and Wu Qiang},
  title = {The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution},
  journal = {International Journal of Animal Science and Technology},
  volume = {5},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijast.20210502.11},
  url = {https://doi.org/10.11648/j.ijast.20210502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20210502.11},
  abstract = {Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.},
 year = {2021}
}

Copy | Download

TY - JOUR
T1 - The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution
AU - Yu Chuan
AU - Liu Penggang
AU - Yang Gang
AU - Wu Qiang
Y1 - 2021/04/20
PY - 2021
N1 - https://doi.org/10.11648/j.ijast.20210502.11
DO - 10.11648/j.ijast.20210502.11
T2 - International Journal of Animal Science and Technology
JF - International Journal of Animal Science and Technology
JO - International Journal of Animal Science and Technology
SP - 32
EP - 37
PB - Science Publishing Group
SN - 2640-1312
UR - https://doi.org/10.11648/j.ijast.20210502.11
AB - Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.
VL - 5
IS - 2
ER -

Copy | Download

Author Information

Yu Chuan

College of Agricultural, Yibin Vocation & Technical College, Yibin, China
Liu Penggang

College of Veterinary Medicine, Yang Zhou University, Yangzhou, China
Yang Gang

College of Agricultural, Yibin Vocation & Technical College, Yibin, China
Wu Qiang

College of Agricultural, Yibin Vocation & Technical College, Yibin, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. (2021). The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. International Journal of Animal Science and Technology, 5(2), 32-37. https://doi.org/10.11648/j.ijast.20210502.11

Copy | Download

ACS Style

Yu Chuan; Liu Penggang; Yang Gang; Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int. J. Anim. Sci. Technol. 2021, 5(2), 32-37. doi: 10.11648/j.ijast.20210502.11

Copy | Download

AMA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int J Anim Sci Technol. 2021;5(2):32-37. doi: 10.11648/j.ijast.20210502.11

Copy | Download

@article{10.11648/j.ijast.20210502.11,
  author = {Yu Chuan and Liu Penggang and Yang Gang and Wu Qiang},
  title = {The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution},
  journal = {International Journal of Animal Science and Technology},
  volume = {5},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijast.20210502.11},
  url = {https://doi.org/10.11648/j.ijast.20210502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20210502.11},
  abstract = {Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.},
 year = {2021}
}

Copy | Download