The occurrence of hypercalcemia in a person with cancer always raises concerns about hypercalcemia of malignancy. A well-conducted diagnostic approach can rule out this possibility and find primary hyperparathyroidism, the other most common cause of hypercalcemia. Few cases of primary hyperparathyroidism have been reported in Madagascar. Our aim is to report a case of it by discussing the circumstances of discovery and its therapeutic management. We report a case of 56 years- old patient, with treated breast cancer in remission, hospitalized for symptomatic hypercalcemia at 3.14 mmol/l. Her serum intact PTH level was elevated to 270 ng/ml and images in favor of osteitis fibrosa cystica were present in the spine and pelvis. Cervical ultrasonography could not locate the pathological parathyroids. Cervico-thoracic CT scan revealed two bilateral para-esophageal parathyroid nodules which were removed by bilateral neck exploration parathyroidectomy and for which the anatomo-pathological examination was in favour of an adenoma. The postoperative course was simple. This observation illustrates that hypercalcemia in subjects with active cancer or cancer in remission is not always related to metastasis but may, indeed, be related to primary hyperparathyroidism. Its curative treatment is based on surgical removal of the pathological parathyroid(s).
| Published in | International Journal of Diabetes and Endocrinology (Volume 7, Issue 3) |
| DOI | 10.11648/j.ijde.20220703.12 |
| Page(s) | 54-58 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
CT Scan, Hypercalcemia, Osteitis Fibrosa Cystica, Parathyroidectomy, Primary Hyperparathyroidism, Scintigraphy
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APA Style
Rija Eric Raherison, Sitraka Angelo Raharinavalona, Tsikinirina Valisoa Randrianomanana, Thierry Razanamparany, Miora Maeva Arielle Andrianiaina, et al. (2022). Symptomatic Primary Hyperparathyroidism in a Woman in Remission from Breast Cancer: A Case Report from Antananarivo, Madagascar. International Journal of Diabetes and Endocrinology, 7(3), 54-58. https://doi.org/10.11648/j.ijde.20220703.12
ACS Style
Rija Eric Raherison; Sitraka Angelo Raharinavalona; Tsikinirina Valisoa Randrianomanana; Thierry Razanamparany; Miora Maeva Arielle Andrianiaina, et al. Symptomatic Primary Hyperparathyroidism in a Woman in Remission from Breast Cancer: A Case Report from Antananarivo, Madagascar. Int. J. Diabetes Endocrinol. 2022, 7(3), 54-58. doi: 10.11648/j.ijde.20220703.12
AMA Style
Rija Eric Raherison, Sitraka Angelo Raharinavalona, Tsikinirina Valisoa Randrianomanana, Thierry Razanamparany, Miora Maeva Arielle Andrianiaina, et al. Symptomatic Primary Hyperparathyroidism in a Woman in Remission from Breast Cancer: A Case Report from Antananarivo, Madagascar. Int J Diabetes Endocrinol. 2022;7(3):54-58. doi: 10.11648/j.ijde.20220703.12
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Download@article{10.11648/j.ijde.20220703.12,
author = {Rija Eric Raherison and Sitraka Angelo Raharinavalona and Tsikinirina Valisoa Randrianomanana and Thierry Razanamparany and Miora Maeva Arielle Andrianiaina and Radonirina Lazasoa Andrianasolo and Andrianirina Dave Patrick Rakotomalala},
title = {Symptomatic Primary Hyperparathyroidism in a Woman in Remission from Breast Cancer: A Case Report from Antananarivo, Madagascar},
journal = {International Journal of Diabetes and Endocrinology},
volume = {7},
number = {3},
pages = {54-58},
doi = {10.11648/j.ijde.20220703.12},
url = {https://doi.org/10.11648/j.ijde.20220703.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20220703.12},
abstract = {The occurrence of hypercalcemia in a person with cancer always raises concerns about hypercalcemia of malignancy. A well-conducted diagnostic approach can rule out this possibility and find primary hyperparathyroidism, the other most common cause of hypercalcemia. Few cases of primary hyperparathyroidism have been reported in Madagascar. Our aim is to report a case of it by discussing the circumstances of discovery and its therapeutic management. We report a case of 56 years- old patient, with treated breast cancer in remission, hospitalized for symptomatic hypercalcemia at 3.14 mmol/l. Her serum intact PTH level was elevated to 270 ng/ml and images in favor of osteitis fibrosa cystica were present in the spine and pelvis. Cervical ultrasonography could not locate the pathological parathyroids. Cervico-thoracic CT scan revealed two bilateral para-esophageal parathyroid nodules which were removed by bilateral neck exploration parathyroidectomy and for which the anatomo-pathological examination was in favour of an adenoma. The postoperative course was simple. This observation illustrates that hypercalcemia in subjects with active cancer or cancer in remission is not always related to metastasis but may, indeed, be related to primary hyperparathyroidism. Its curative treatment is based on surgical removal of the pathological parathyroid(s).},
year = {2022}
}
TY - JOUR T1 - Symptomatic Primary Hyperparathyroidism in a Woman in Remission from Breast Cancer: A Case Report from Antananarivo, Madagascar AU - Rija Eric Raherison AU - Sitraka Angelo Raharinavalona AU - Tsikinirina Valisoa Randrianomanana AU - Thierry Razanamparany AU - Miora Maeva Arielle Andrianiaina AU - Radonirina Lazasoa Andrianasolo AU - Andrianirina Dave Patrick Rakotomalala Y1 - 2022/08/04 PY - 2022 N1 - https://doi.org/10.11648/j.ijde.20220703.12 DO - 10.11648/j.ijde.20220703.12 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 54 EP - 58 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20220703.12 AB - The occurrence of hypercalcemia in a person with cancer always raises concerns about hypercalcemia of malignancy. A well-conducted diagnostic approach can rule out this possibility and find primary hyperparathyroidism, the other most common cause of hypercalcemia. Few cases of primary hyperparathyroidism have been reported in Madagascar. Our aim is to report a case of it by discussing the circumstances of discovery and its therapeutic management. We report a case of 56 years- old patient, with treated breast cancer in remission, hospitalized for symptomatic hypercalcemia at 3.14 mmol/l. Her serum intact PTH level was elevated to 270 ng/ml and images in favor of osteitis fibrosa cystica were present in the spine and pelvis. Cervical ultrasonography could not locate the pathological parathyroids. Cervico-thoracic CT scan revealed two bilateral para-esophageal parathyroid nodules which were removed by bilateral neck exploration parathyroidectomy and for which the anatomo-pathological examination was in favour of an adenoma. The postoperative course was simple. This observation illustrates that hypercalcemia in subjects with active cancer or cancer in remission is not always related to metastasis but may, indeed, be related to primary hyperparathyroidism. Its curative treatment is based on surgical removal of the pathological parathyroid(s). VL - 7 IS - 3 ER -
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