Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients

Soukaina Haddougui; Salma Bajjouk; Mounia Bouchaar; Mehdi Khamaily; Yassine Mouzari; Karim Reda; Abdelbarre Oubaaz

doi:doi:10.11648/j.ijovs.20220704.12

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Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, Karim Reda, Abdelbarre Oubaaz

Published in International Journal of Ophthalmology & Visual Science (Volume 7, Issue 4)

Received: 11 October 2022 Accepted: 31 October 2022 Published: 11 November 2022

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Abstract

Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.

Published in	International Journal of Ophthalmology & Visual Science (Volume 7, Issue 4)
DOI	10.11648/j.ijovs.20220704.12
Page(s)	106-110
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

POAG, RNFL, Ganglion Cells, Diabetes, Loss

References

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APA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. (2022). Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. International Journal of Ophthalmology & Visual Science, 7(4), 106-110. https://doi.org/10.11648/j.ijovs.20220704.12

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ACS Style

Soukaina Haddougui; Salma Bajjouk; Mounia Bouchaar; Mehdi Khamaily; Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int. J. Ophthalmol. Vis. Sci. 2022, 7(4), 106-110. doi: 10.11648/j.ijovs.20220704.12

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AMA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int J Ophthalmol Vis Sci. 2022;7(4):106-110. doi: 10.11648/j.ijovs.20220704.12

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@article{10.11648/j.ijovs.20220704.12,
  author = {Soukaina Haddougui and Salma Bajjouk and Mounia Bouchaar and Mehdi Khamaily and Yassine Mouzari and Karim Reda and Abdelbarre Oubaaz},
  title = {Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {7},
  number = {4},
  pages = {106-110},
  doi = {10.11648/j.ijovs.20220704.12},
  url = {https://doi.org/10.11648/j.ijovs.20220704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20220704.12},
  abstract = {Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.},
 year = {2022}
}

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TY  - JOUR
T1  - Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients
AU  - Soukaina Haddougui
AU  - Salma Bajjouk
AU  - Mounia Bouchaar
AU  - Mehdi Khamaily
AU  - Yassine Mouzari
AU  - Karim Reda
AU  - Abdelbarre Oubaaz
Y1  - 2022/11/11
PY  - 2022
N1  - https://doi.org/10.11648/j.ijovs.20220704.12
DO  - 10.11648/j.ijovs.20220704.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 106
EP  - 110
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20220704.12
AB  - Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.
VL  - 7
IS  - 4
ER  -

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Author Information

Soukaina Haddougui

Department of Ophthalmology, Cheikh Khalifa Ibn Zaid International University Hospital, Casablanca, Morocco
Salma Bajjouk

Department of Ophthalmology, Cheikh Khalifa Ibn Zaid International University Hospital, Casablanca, Morocco
Mounia Bouchaar

Department of Ophthalmology, Cheikh Khalifa Ibn Zaid International University Hospital, Casablanca, Morocco
Mehdi Khamaily

Faculty of Medicine, University Mohamed VI of Health Sciences, Casablanca, Morocco
Yassine Mouzari

Department of Ophtalmology of the Mohamed V Military Teaching Hospital, Rabat, Morocco
Karim Reda

Department of Ophtalmology of the Mohamed V Military Teaching Hospital, Rabat, Morocco
Abdelbarre Oubaaz

Department of Ophtalmology of the Mohamed V Military Teaching Hospital, Rabat, Morocco

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APA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. (2022). Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. International Journal of Ophthalmology & Visual Science, 7(4), 106-110. https://doi.org/10.11648/j.ijovs.20220704.12

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ACS Style

Soukaina Haddougui; Salma Bajjouk; Mounia Bouchaar; Mehdi Khamaily; Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int. J. Ophthalmol. Vis. Sci. 2022, 7(4), 106-110. doi: 10.11648/j.ijovs.20220704.12

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AMA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int J Ophthalmol Vis Sci. 2022;7(4):106-110. doi: 10.11648/j.ijovs.20220704.12

Copy | Download

@article{10.11648/j.ijovs.20220704.12,
  author = {Soukaina Haddougui and Salma Bajjouk and Mounia Bouchaar and Mehdi Khamaily and Yassine Mouzari and Karim Reda and Abdelbarre Oubaaz},
  title = {Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {7},
  number = {4},
  pages = {106-110},
  doi = {10.11648/j.ijovs.20220704.12},
  url = {https://doi.org/10.11648/j.ijovs.20220704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20220704.12},
  abstract = {Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients
AU  - Soukaina Haddougui
AU  - Salma Bajjouk
AU  - Mounia Bouchaar
AU  - Mehdi Khamaily
AU  - Yassine Mouzari
AU  - Karim Reda
AU  - Abdelbarre Oubaaz
Y1  - 2022/11/11
PY  - 2022
N1  - https://doi.org/10.11648/j.ijovs.20220704.12
DO  - 10.11648/j.ijovs.20220704.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 106
EP  - 110
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20220704.12
AB  - Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.
VL  - 7
IS  - 4
ER  -

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