The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers

L. Nefyodov; N. Karavay

doi:doi:10.11648/j.pst.20170101.14

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The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers

L. Nefyodov, N. Karavay

Published in Pharmaceutical Science and Technology (Volume 1, Issue 1)

Received: 11 October 2016 Accepted: 9 February 2017 Published: 1 March 2017

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Abstract

On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.

Published in	Pharmaceutical Science and Technology (Volume 1, Issue 1)
DOI	10.11648/j.pst.20170101.14
Page(s)	10-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Free Amino Acids, Regulatory Effects, Oncology

References

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APA Style

L. Nefyodov, N. Karavay. (2017). The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharmaceutical Science and Technology, 1(1), 10-12. https://doi.org/10.11648/j.pst.20170101.14

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ACS Style

L. Nefyodov; N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm. Sci. Technol. 2017, 1(1), 10-12. doi: 10.11648/j.pst.20170101.14

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AMA Style

L. Nefyodov, N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm Sci Technol. 2017;1(1):10-12. doi: 10.11648/j.pst.20170101.14

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@article{10.11648/j.pst.20170101.14,
  author = {L. Nefyodov and N. Karavay},
  title = {The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers},
  journal = {Pharmaceutical Science and Technology},
  volume = {1},
  number = {1},
  pages = {10-12},
  doi = {10.11648/j.pst.20170101.14},
  url = {https://doi.org/10.11648/j.pst.20170101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20170101.14},
  abstract = {On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.},
 year = {2017}
}

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TY  - JOUR
T1  - The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers
AU  - L. Nefyodov
AU  - N. Karavay
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.pst.20170101.14
DO  - 10.11648/j.pst.20170101.14
T2  - Pharmaceutical Science and Technology
JF  - Pharmaceutical Science and Technology
JO  - Pharmaceutical Science and Technology
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EP  - 12
PB  - Science Publishing Group
SN  - 2640-4540
UR  - https://doi.org/10.11648/j.pst.20170101.14
AB  - On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
VL  - 1
IS  - 1
ER  -

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Author Information

L. Nefyodov

Department of Biochemistry, Yanka Kupala State University of Grodno, Grodno, Belarus
N. Karavay

Department of Hyperbaric Oxygenation, Grodno State Medical Hospital, Grodno, Belarus

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APA Style

L. Nefyodov, N. Karavay. (2017). The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharmaceutical Science and Technology, 1(1), 10-12. https://doi.org/10.11648/j.pst.20170101.14

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ACS Style

L. Nefyodov; N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm. Sci. Technol. 2017, 1(1), 10-12. doi: 10.11648/j.pst.20170101.14

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AMA Style

L. Nefyodov, N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm Sci Technol. 2017;1(1):10-12. doi: 10.11648/j.pst.20170101.14

Copy | Download

@article{10.11648/j.pst.20170101.14,
  author = {L. Nefyodov and N. Karavay},
  title = {The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers},
  journal = {Pharmaceutical Science and Technology},
  volume = {1},
  number = {1},
  pages = {10-12},
  doi = {10.11648/j.pst.20170101.14},
  url = {https://doi.org/10.11648/j.pst.20170101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20170101.14},
  abstract = {On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers
AU  - L. Nefyodov
AU  - N. Karavay
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.pst.20170101.14
DO  - 10.11648/j.pst.20170101.14
T2  - Pharmaceutical Science and Technology
JF  - Pharmaceutical Science and Technology
JO  - Pharmaceutical Science and Technology
SP  - 10
EP  - 12
PB  - Science Publishing Group
SN  - 2640-4540
UR  - https://doi.org/10.11648/j.pst.20170101.14
AB  - On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
VL  - 1
IS  - 1
ER  -

Copy | Download