Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function

Rongqin Dai; Qian Xu; Yang Chen; Ying Li; Chao Shen Zhang; Jinbiao Zhang

doi:doi:10.11648/j.sjph.20210903.16

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Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function

Rongqin Dai, Qian Xu, Yang Chen, Ying Li, Chao Shen Zhang, Jinbiao Zhang

Published in Science Journal of Public Health (Volume 9, Issue 3)

Received: 13 April 2021 Accepted: Published: 24 May 2021

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Abstract

Objective: To assess the relationship between thyroid function and renal injury in Patients with Hashimoto's Thyroiditis. Method: To select 156 diagnosed HT patients as the research object, according to whether there is renal injury, they were divided into renal injury group with 21 cases and non-renal injury group with 135 cases. According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, Serum cystatin C and 24-hour urinary microalbumin were measured by immunoturbidimetry, serum creatinine was measured by creatine oxidase method, and the endogenous creatinine clearance rate was calculated. Result: TSH, TPOAb and TGAb in renal injury group were distinctly higher than those in non-renal injury group, while FT3 and FT4 were distinctly lower than those in non-renal injury group; Comparison of serum creatinine in Hashimoto groups, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group B is obviously higher than Group A, Group A is significantly lower than other groups; Comparison of cystatin C and creatinine clearance of each group, Group D is significantly lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, Group B is obviously lower than Group A, Group A is significantly higher than other groups; Comparison of 24-hour urinary microalbumin of each group, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, and the differences have statistic significance (P<0.05). The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance; TSH, TPOAb, TGAb is in positive correlation with 24-hour urinary microalbumin. Conclusion: There are obvious differences in renal function indexes of HT patients with different thyroid function states, which may be related to the effect of thyroid hormones and autoantibodies.

Published in	Science Journal of Public Health (Volume 9, Issue 3)
DOI	10.11648/j.sjph.20210903.16
Page(s)	98-102
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hashimoto's Thyroiditis, Thyroid Function, Renal Injury

References

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[17]	Das G, Taylor PN, Abusahmin H, et al. Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes [J]. Ann Clin Biochem, 2019, 56 (1): 155 162.
[18]	Li Di, Li Yan, PengRui. Study of renal damage associated with Graves disease [J]. Laboratory Medicine and Clinic, 2017, 14 (10): 1397-1398, 1401.
[19]	Rongqin Dai, Yuzhi Liu, Jinbiao Zhang. The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis [J]. American Journal of Life Sciences, 2020, 8 (2): 19-22.

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APA Style

Rongqin Dai, Qian Xu, Yang Chen, Ying Li, Chao Shen Zhang, et al. (2021). Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function. Science Journal of Public Health, 9(3), 98-102. https://doi.org/10.11648/j.sjph.20210903.16

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ACS Style

Rongqin Dai; Qian Xu; Yang Chen; Ying Li; Chao Shen Zhang, et al. Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function. Sci. J. Public Health 2021, 9(3), 98-102. doi: 10.11648/j.sjph.20210903.16

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AMA Style

Rongqin Dai, Qian Xu, Yang Chen, Ying Li, Chao Shen Zhang, et al. Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function. Sci J Public Health. 2021;9(3):98-102. doi: 10.11648/j.sjph.20210903.16

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@article{10.11648/j.sjph.20210903.16,
  author = {Rongqin Dai and Qian Xu and Yang Chen and Ying Li and Chao Shen Zhang and Jinbiao Zhang},
  title = {Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function},
  journal = {Science Journal of Public Health},
  volume = {9},
  number = {3},
  pages = {98-102},
  doi = {10.11648/j.sjph.20210903.16},
  url = {https://doi.org/10.11648/j.sjph.20210903.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20210903.16},
  abstract = {Objective: To assess the relationship between thyroid function and renal injury in Patients with Hashimoto's Thyroiditis. Method: To select 156 diagnosed HT patients as the research object, according to whether there is renal injury, they were divided into renal injury group with 21 cases and non-renal injury group with 135 cases. According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, Serum cystatin C and 24-hour urinary microalbumin were measured by immunoturbidimetry, serum creatinine was measured by creatine oxidase method, and the endogenous creatinine clearance rate was calculated. Result: TSH, TPOAb and TGAb in renal injury group were distinctly higher than those in non-renal injury group, while FT3 and FT4 were distinctly lower than those in non-renal injury group; Comparison of serum creatinine in Hashimoto groups, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group B is obviously higher than Group A, Group A is significantly lower than other groups; Comparison of cystatin C and creatinine clearance of each group, Group D is significantly lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, Group B is obviously lower than Group A, Group A is significantly higher than other groups; Comparison of 24-hour urinary microalbumin of each group, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, and the differences have statistic significance (P<0.05). The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance; TSH, TPOAb, TGAb is in positive correlation with 24-hour urinary microalbumin. Conclusion: There are obvious differences in renal function indexes of HT patients with different thyroid function states, which may be related to the effect of thyroid hormones and autoantibodies.},
 year = {2021}
}

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TY  - JOUR
T1  - Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function
AU  - Rongqin Dai
AU  - Qian Xu
AU  - Yang Chen
AU  - Ying Li
AU  - Chao Shen Zhang
AU  - Jinbiao Zhang
Y1  - 2021/05/24
PY  - 2021
N1  - https://doi.org/10.11648/j.sjph.20210903.16
DO  - 10.11648/j.sjph.20210903.16
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 98
EP  - 102
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20210903.16
AB  - Objective: To assess the relationship between thyroid function and renal injury in Patients with Hashimoto's Thyroiditis. Method: To select 156 diagnosed HT patients as the research object, according to whether there is renal injury, they were divided into renal injury group with 21 cases and non-renal injury group with 135 cases. According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, Serum cystatin C and 24-hour urinary microalbumin were measured by immunoturbidimetry, serum creatinine was measured by creatine oxidase method, and the endogenous creatinine clearance rate was calculated. Result: TSH, TPOAb and TGAb in renal injury group were distinctly higher than those in non-renal injury group, while FT3 and FT4 were distinctly lower than those in non-renal injury group; Comparison of serum creatinine in Hashimoto groups, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group B is obviously higher than Group A, Group A is significantly lower than other groups; Comparison of cystatin C and creatinine clearance of each group, Group D is significantly lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, Group B is obviously lower than Group A, Group A is significantly higher than other groups; Comparison of 24-hour urinary microalbumin of each group, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, and the differences have statistic significance (P<0.05). The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance; TSH, TPOAb, TGAb is in positive correlation with 24-hour urinary microalbumin. Conclusion: There are obvious differences in renal function indexes of HT patients with different thyroid function states, which may be related to the effect of thyroid hormones and autoantibodies.
VL  - 9
IS  - 3
ER  -

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Author Information

Rongqin Dai

Department of Medical Technology Laboratory, Cangzhou Medical College, Cangzhou, China
Qian Xu

Department of Medical Technology Laboratory, Cangzhou Medical College, Cangzhou, China
Yang Chen

Department of Medical Technology Laboratory, Cangzhou Medical College, Cangzhou, China
Ying Li

Department of Medical Technology Laboratory, Cangzhou Medical College, Cangzhou, China
Chao Shen Zhang

Department of Medical Technology Laboratory, Cangzhou Medical College, Cangzhou, China
Jinbiao Zhang

Laboratory Diagnostics Division, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

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Plain Text BibTeX RIS

APA Style

Rongqin Dai, Qian Xu, Yang Chen, Ying Li, Chao Shen Zhang, et al. (2021). Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function. Science Journal of Public Health, 9(3), 98-102. https://doi.org/10.11648/j.sjph.20210903.16

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ACS Style

Rongqin Dai; Qian Xu; Yang Chen; Ying Li; Chao Shen Zhang, et al. Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function. Sci. J. Public Health 2021, 9(3), 98-102. doi: 10.11648/j.sjph.20210903.16

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AMA Style

Rongqin Dai, Qian Xu, Yang Chen, Ying Li, Chao Shen Zhang, et al. Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function. Sci J Public Health. 2021;9(3):98-102. doi: 10.11648/j.sjph.20210903.16

Copy | Download

@article{10.11648/j.sjph.20210903.16,
  author = {Rongqin Dai and Qian Xu and Yang Chen and Ying Li and Chao Shen Zhang and Jinbiao Zhang},
  title = {Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function},
  journal = {Science Journal of Public Health},
  volume = {9},
  number = {3},
  pages = {98-102},
  doi = {10.11648/j.sjph.20210903.16},
  url = {https://doi.org/10.11648/j.sjph.20210903.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20210903.16},
  abstract = {Objective: To assess the relationship between thyroid function and renal injury in Patients with Hashimoto's Thyroiditis. Method: To select 156 diagnosed HT patients as the research object, according to whether there is renal injury, they were divided into renal injury group with 21 cases and non-renal injury group with 135 cases. According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, Serum cystatin C and 24-hour urinary microalbumin were measured by immunoturbidimetry, serum creatinine was measured by creatine oxidase method, and the endogenous creatinine clearance rate was calculated. Result: TSH, TPOAb and TGAb in renal injury group were distinctly higher than those in non-renal injury group, while FT3 and FT4 were distinctly lower than those in non-renal injury group; Comparison of serum creatinine in Hashimoto groups, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group B is obviously higher than Group A, Group A is significantly lower than other groups; Comparison of cystatin C and creatinine clearance of each group, Group D is significantly lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, Group B is obviously lower than Group A, Group A is significantly higher than other groups; Comparison of 24-hour urinary microalbumin of each group, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, and the differences have statistic significance (P<0.05). The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance; TSH, TPOAb, TGAb is in positive correlation with 24-hour urinary microalbumin. Conclusion: There are obvious differences in renal function indexes of HT patients with different thyroid function states, which may be related to the effect of thyroid hormones and autoantibodies.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Research on Renal Injury in Hashimoto's Thyroiditis Patients with Different Thyroid Function
AU  - Rongqin Dai
AU  - Qian Xu
AU  - Yang Chen
AU  - Ying Li
AU  - Chao Shen Zhang
AU  - Jinbiao Zhang
Y1  - 2021/05/24
PY  - 2021
N1  - https://doi.org/10.11648/j.sjph.20210903.16
DO  - 10.11648/j.sjph.20210903.16
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 98
EP  - 102
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20210903.16
AB  - Objective: To assess the relationship between thyroid function and renal injury in Patients with Hashimoto's Thyroiditis. Method: To select 156 diagnosed HT patients as the research object, according to whether there is renal injury, they were divided into renal injury group with 21 cases and non-renal injury group with 135 cases. According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, Serum cystatin C and 24-hour urinary microalbumin were measured by immunoturbidimetry, serum creatinine was measured by creatine oxidase method, and the endogenous creatinine clearance rate was calculated. Result: TSH, TPOAb and TGAb in renal injury group were distinctly higher than those in non-renal injury group, while FT3 and FT4 were distinctly lower than those in non-renal injury group; Comparison of serum creatinine in Hashimoto groups, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group B is obviously higher than Group A, Group A is significantly lower than other groups; Comparison of cystatin C and creatinine clearance of each group, Group D is significantly lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, Group B is obviously lower than Group A, Group A is significantly higher than other groups; Comparison of 24-hour urinary microalbumin of each group, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, and the differences have statistic significance (P<0.05). The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance; TSH, TPOAb, TGAb is in positive correlation with 24-hour urinary microalbumin. Conclusion: There are obvious differences in renal function indexes of HT patients with different thyroid function states, which may be related to the effect of thyroid hormones and autoantibodies.
VL  - 9
IS  - 3
ER  -

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