International Journal of Genetics and Genomics

Volume 2, Issue 5, October 2014

  • Helicobacter Pylori vacA Gene Detection in Saliva of Patients with Upper Gastrointestinal Disorders in Accra, Ghana

    Richard H. Asmah, Timothy Archampong, Charles A. Brown, Samuel B. Ntiamoah, Ebenezer K. Aidoo, Richard Gyasi, Edwin K. Wiredu

    Issue: Volume 2, Issue 5, October 2014
    Pages: 80-83
    Received: Jun. 18, 2014
    Accepted: Jul. 09, 2014
    Published: Nov. 10, 2014
    Downloads:
    Views:
    Abstract: Helicobacter pylori play an essential role in the pathogenesis of upper gastrointestinal disorders. The diagnostic role of the bacterium thus has been a subject of intense investigations. In this study we used an immune-chromatographic method and the polymerase chain reaction (PCR) to detect H. pylori in the saliva of patients with clinically diagn... Show More
  • Modifier Genes in Hypertrophic Cardiomyopathy Patients of South Indian Cohort

    Advithi Rangaraju, Satyanarayana Matsa.Lova, Narasimhan Calambur, Pratibha Nallari

    Issue: Volume 2, Issue 5, October 2014
    Pages: 84-91
    Received: Mar. 25, 2014
    Accepted: Apr. 18, 2014
    Published: Nov. 10, 2014
    Downloads:
    Views:
    Abstract: Hypertrophic cardiomyopathy is an autosomal dominant disorder, characterized by thickening of the myocardium with a variable clinical course. Mutations in 14 sarcomeric genes have been implicated resulting in phenotypic and genotypic heterogeneity. The phenotypic expression of HCM is not only determined by the sarcomeric gene mutations but the gene... Show More
  • Non-Syndromic Autosomal Recessive Deafness in Gaza Strip: A Study of Five GJB2 Gene Mutations

    Badria F. Essammak, Mohammed J. Ashour, Fadel A. Sharif

    Issue: Volume 2, Issue 5, October 2014
    Pages: 92-96
    Received: Nov. 05, 2014
    Accepted: Nov. 12, 2014
    Published: Nov. 20, 2014
    Downloads:
    Views:
    Abstract: Hearing loss is a common, pan-ethnic and highly heterogeneous sensory disorder with an incidence of around 1 in 1000 infants. Genetic causes are thought to be responsible for more than 60% of the cases with the majority of non-syndromic hearing impairment being inherited in an autosomal recessive pattern. The gene that is most frequently mutated in... Show More