Science Journal of Clinical Medicine

| Peer-Reviewed |

Prostate carcinoma: correlation of histopathology with serum prostate specific antigen

Received: Jan. 14, 2015    Accepted: Jan. 19, 2015    Published: Aug. 03, 2015
Views:       Downloads:

Share This Article

Abstract

Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value < 0.05 was considered significant. Patients were aged predominantly between 60 to 70 yrs. Majority (66.7%) had poorly differentiated adenocarcinoma. 84.3% had high values of PSA (>10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant (‘p’ value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer.

DOI 10.11648/j.sjcm.s.2015040401.11
Published in Science Journal of Clinical Medicine ( Volume 4, Issue 4-1, July 2015 )

This article belongs to the Special Issue Latest Different Concepts of Gynaecology

Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gleason Grade, Prostate Cancer, PSA

References
[1] http://www.cdc.gov/dcpc/data/men.htm. Accessed on 29/08/2013.
[2] Dubey D. The early use of prostate specific antigen for early detection of cancer prostate in India: Is it justified? Indian J Urol 2009;25:177-84.
[3] Karazanashvili G, Abrahamsson PA. Prostate specific antigen and human glandular kallikrein 2 in early detection of prostate cancer. J Urol 2003;169:445-57.
[4] Loeb S, Kettermann A, Carter HB, Ferrucci L, Metter EJ, Walsh PC. Does prostate growth confound PSA velocity? Data from the Baltimore longitudinal study of aging.J Urol 2008;180:1314-7.
[5] Partin AW, Oesterling JE. The clinical usefulness of prostate specific antigen: update 1994. J Urol 1994;152:1358-68.
[6] Mawakyoma H A, Mabandi J L. Prostate cancer; Correlation of Gleason’s score and pretreatment prostate specific antigen in patients. Professional Med J 2010;17:235-40.
[7] Jackson LA , McGrowder DA, Lindo RA. Prostate specific antigen and Gleason score in men with prostate cancer at a private diagnostic radiology centre in western Jamaica. Asian Pacific J Cancer Prev 2012;13:1453–6.
[8] Okolo CA, Akinosun OM, Shittu OB, Olaopa OO, Okeke LI, Akang EU. Correlation of serum PSA and Gleason score in Nigerian men with Prostate Cancer. African journal of urology 2008;14:15-22.
[9] Shirley SE, Escoffery CT, Sargeant LA, Tulloch T. Clinicopathological features of prostate cancer in Jamaican men. BJU International 2002; 89:390-5.
[10] Zivkovic S.Correlation between prostate specific antigen and histopathological difference of prostate carcinoma. ArchOncol 2004;12:148-51.
[11] Mulay K, Swain M, Jaiman S. Gleason’s scoring of prostatic carcinoma: Impact of a web based tutorial on inter and intra observer variability. Indian J Pathol Microbiol 2008;51:22-5.
[12] Corcoran NM, Hong MKH, Casey RG. Upgrade in Gleason score between prostate biopsies and pathology following radical prostatectomy significantly impacts upon the risk of biochemical recurrence.BJU International 2010;108:E202-10.
[13] Horninger W, Volgger H, Rogatsch H, Strohmeyer D, Steiner H, Hobisch A et al. Predictive value of total and percent free PSA in high grade prostatic intraepithelial lesion: Results of tyrol prostate specific antigen screening project. J Urol 2001;165:1143-5.
[14] Zynger DL, Yang X. High grade prostatic intraepithelial neoplasia of the prostate: The precursor lesion of Prostate Cancer.Int J Clin Exp Pathol 2009;2:327-38.
[15] Harnden P, Shelley MD, Clements H, Coles B, Tyndale-Biscoe RS, Naylor B et al. The prognostic significance of perineural invasion in prostatic cancer biopsies: a systematic review. Cancer 2007;109:13-24.
[16] Abdellatif J, Hajji F, Elonodo JC, Ghadouane M, Ameur A, Abbar M. Update the Indicator Role of Serum PSA Level and Gleason Score of the Biopsy for the Presence of Bony Metastases: Bone Scan Findings in a North African Ethnic Group. J Cancer Sci Ther 2011;3:112-5.
[17] McGuire BB, Helfand BT, Loeb S, Hu Q, O’Brien D, Cooper P. Outcomes in patients with Gleason score 8-10 prostate cancer : relation to preoperative PSA level. BJU International 2011;109:1764-9.
[18] Weir EG, Partin AW, Epstein JI. Correlation of serum prostate specific antigen and quantitative immunohistochemistry. J Urol 2000;163:1739–42.
[19] Shih WJ, Gross K, Mitchell B, Collins J, Wierzbinski B, Maqoun S et al. Prostate adenocarcinoma using Gleason scores correlates with prostate specific antigen and prostate acid phosphatase measurements. J Natl Med Assoc 1992;84:1049-50.
[20] Schroder FH, Crvijsen VD, Koeter I, De Koning HJ,Vis AN, Hoedemaeker RF. Prostate cancer detection at low prostate-specific antigen. J Urol 2000;163:806-12.
Cite This Article
  • APA Style

    Deepika Gurumurthy, Rangaswamy Maggad, Sapna Patel. (2015). Prostate carcinoma: correlation of histopathology with serum prostate specific antigen. Science Journal of Clinical Medicine, 4(4-1), 1-5. https://doi.org/10.11648/j.sjcm.s.2015040401.11

    Copy | Download

    ACS Style

    Deepika Gurumurthy; Rangaswamy Maggad; Sapna Patel. Prostate carcinoma: correlation of histopathology with serum prostate specific antigen. Sci. J. Clin. Med. 2015, 4(4-1), 1-5. doi: 10.11648/j.sjcm.s.2015040401.11

    Copy | Download

    AMA Style

    Deepika Gurumurthy, Rangaswamy Maggad, Sapna Patel. Prostate carcinoma: correlation of histopathology with serum prostate specific antigen. Sci J Clin Med. 2015;4(4-1):1-5. doi: 10.11648/j.sjcm.s.2015040401.11

    Copy | Download

  • @article{10.11648/j.sjcm.s.2015040401.11,
      author = {Deepika Gurumurthy and Rangaswamy Maggad and Sapna Patel},
      title = {Prostate carcinoma: correlation of histopathology with serum prostate specific antigen},
      journal = {Science Journal of Clinical Medicine},
      volume = {4},
      number = {4-1},
      pages = {1-5},
      doi = {10.11648/j.sjcm.s.2015040401.11},
      url = {https://doi.org/10.11648/j.sjcm.s.2015040401.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjcm.s.2015040401.11},
      abstract = {Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value 10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant (‘p’ value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Prostate carcinoma: correlation of histopathology with serum prostate specific antigen
    AU  - Deepika Gurumurthy
    AU  - Rangaswamy Maggad
    AU  - Sapna Patel
    Y1  - 2015/08/03
    PY  - 2015
    N1  - https://doi.org/10.11648/j.sjcm.s.2015040401.11
    DO  - 10.11648/j.sjcm.s.2015040401.11
    T2  - Science Journal of Clinical Medicine
    JF  - Science Journal of Clinical Medicine
    JO  - Science Journal of Clinical Medicine
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2327-2732
    UR  - https://doi.org/10.11648/j.sjcm.s.2015040401.11
    AB  - Prostate Specific Antigen (PSA) is the first line test in screening of prostate cancer. The increase in PSA depends on differentiation of tumour cells. Gleason grading is one of the most powerful predictors of biological behaviour and influential factors used to determine treatment. PSA, when combined with Gleason score and clinical stage, improves the prediction of pathological stage for prostate carcinoma. Aims of this study were to study the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate pretreatment PSA levels with Gleason grade. The study was undertaken in a tertiary care hospital over a period of two years.Fifty one cases of prostatic carcinoma were studied. Grading done by Gleason grading system, was correlated with serum PSA levels. Software statistical package for social sciences (SPSS), version 16 was used. P value 10ng/ml). 5.9 % had PSA value in normal range (< 4 ng/ml). Though there was a comparative increase in PSA level with increase in Gleason grade, it was not statistically significant (‘p’ value = 0.75). To conclude, a proportion of tumours with Gleason score 8-10 are so poorly differentiated that they produce relatively little PSA. Refinement in estimation and interpretation of PSA values may be considered to improve the sensitivity and specificity of PSA. Gleason grading is a better predictor of biological behaviour of prostate cancer.
    VL  - 4
    IS  - 4-1
    ER  - 

    Copy | Download

Author Information
  • Department of Pathology, Apollo BGS, Mysore, India

  • Department of Pathology, JSS Medical College and Hospital, Mysore, India

  • Department of Pathology, JSS Medical College and Hospital, Mysore, India

  • Section