Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia

Aurelian Udristioiu

doi:doi:10.11648/j.ajlm.20160102.13

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Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia

Aurelian Udristioiu

Published in American Journal of Laboratory Medicine (Volume 1, Issue 2)

Received: 27 August 2016 Accepted: 5 September 2016 Published: 24 September 2016

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Abstract

Objective of this study is to present the latest researches in the field of molecular medicine, in terms of Chronic Lymphocytic Leukemia (CLL), emerged from the P53 gene deletion in human lymphoma genome. Method In recent years proved that the best technique in the investigation of malignant lymphocytes is the Fluorescence in situ hybridization (FISH). This method is used as an alternative to chromosomal banding, a conventional application in molecular medicine. Previous Results: In the literature it was registered, in previous years, on an international study, conducted on 109 cases of CLL, 79 cases (72.5%) who had more genetic abnormalities; the remaining 30 cases (27.5%) had normal results, using the technique Florescence in situ Hybridization, (FISH). The majority of patients, 67% (53.79) had a single anomaly and the remaining 33% had two or three genetic abnormalities. The band 14q32 /17p translocations in LLC genome, which appeared similar to some common, had demonstrated abnormalities involving IGH gene, located on chromosome14q32. Discussions: Identification of P53 gene mutations in regions of 17 chromosome of hematological neoplasm is important because these mutations have an impact on the clinical course of patients and requires an attitude adjustment therapeutic adequate. Restoring function to p53 can induce lymphoma, apoptosis. Recent, endogenous somatic gene therapy research is a basic of trial clinical and therapeutic trial. The DNA, is used to treat a disease arising as a result of mutations in chromosomal regions. In the past few years, this method has been included in the treatment of CLL, acute lymphocytic leukemia, [ALL], or multiple myeloma [MM]. Conclusion: The frequencies of P53 gene mutations and deletion in CLL can be categorized as individual biomarkers in proteomic and genomic profile for this type of leukemia that can be implemented in targeted patient treatment of personalized medicine.

Published in	American Journal of Laboratory Medicine (Volume 1, Issue 2)
DOI	10.11648/j.ajlm.20160102.13
Page(s)	16-22
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

P-53 Gene, Lymphocytic Leukemia, Apoptosis, Fluorescence in Situ Hybridization

References

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APA Style

Aurelian Udristioiu. (2016). Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia. American Journal of Laboratory Medicine, 1(2), 16-22. https://doi.org/10.11648/j.ajlm.20160102.13

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Aurelian Udristioiu. Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia. Am. J. Lab. Med. 2016, 1(2), 16-22. doi: 10.11648/j.ajlm.20160102.13

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Aurelian Udristioiu. Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia. Am J Lab Med. 2016;1(2):16-22. doi: 10.11648/j.ajlm.20160102.13

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@article{10.11648/j.ajlm.20160102.13,
  author = {Aurelian Udristioiu},
  title = {Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia},
  journal = {American Journal of Laboratory Medicine},
  volume = {1},
  number = {2},
  pages = {16-22},
  doi = {10.11648/j.ajlm.20160102.13},
  url = {https://doi.org/10.11648/j.ajlm.20160102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20160102.13},
  abstract = {Objective of this study is to present the latest researches in the field of molecular medicine, in terms of Chronic Lymphocytic Leukemia (CLL), emerged from the P53 gene deletion in human lymphoma genome. Method In recent years proved that the best technique in the investigation of malignant lymphocytes is the Fluorescence in situ hybridization (FISH). This method is used as an alternative to chromosomal banding, a conventional application in molecular medicine. Previous Results: In the literature it was registered, in previous years, on an international study, conducted on 109 cases of CLL, 79 cases (72.5%) who had more genetic abnormalities; the remaining 30 cases (27.5%) had normal results, using the technique Florescence in situ Hybridization, (FISH). The majority of patients, 67% (53.79) had a single anomaly and the remaining 33% had two or three genetic abnormalities. The band 14q32 /17p translocations in LLC genome, which appeared similar to some common, had demonstrated abnormalities involving IGH gene, located on chromosome14q32. Discussions: Identification of P53 gene mutations in regions of 17 chromosome of hematological neoplasm is important because these mutations have an impact on the clinical course of patients and requires an attitude adjustment therapeutic adequate. Restoring function to p53 can induce lymphoma, apoptosis. Recent, endogenous somatic gene therapy research is a basic of trial clinical and therapeutic trial. The DNA, is used to treat a disease arising as a result of mutations in chromosomal regions. In the past few years, this method has been included in the treatment of CLL, acute lymphocytic leukemia, [ALL], or multiple myeloma [MM]. Conclusion: The frequencies of P53 gene mutations and deletion in CLL can be categorized as individual biomarkers in proteomic and genomic profile for this type of leukemia that can be implemented in targeted patient treatment of personalized medicine.},
 year = {2016}
}

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TY  - JOUR
T1  - Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia
AU  - Aurelian Udristioiu
Y1  - 2016/09/24
PY  - 2016
N1  - https://doi.org/10.11648/j.ajlm.20160102.13
DO  - 10.11648/j.ajlm.20160102.13
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 16
EP  - 22
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20160102.13
AB  - Objective of this study is to present the latest researches in the field of molecular medicine, in terms of Chronic Lymphocytic Leukemia (CLL), emerged from the P53 gene deletion in human lymphoma genome. Method In recent years proved that the best technique in the investigation of malignant lymphocytes is the Fluorescence in situ hybridization (FISH). This method is used as an alternative to chromosomal banding, a conventional application in molecular medicine. Previous Results: In the literature it was registered, in previous years, on an international study, conducted on 109 cases of CLL, 79 cases (72.5%) who had more genetic abnormalities; the remaining 30 cases (27.5%) had normal results, using the technique Florescence in situ Hybridization, (FISH). The majority of patients, 67% (53.79) had a single anomaly and the remaining 33% had two or three genetic abnormalities. The band 14q32 /17p translocations in LLC genome, which appeared similar to some common, had demonstrated abnormalities involving IGH gene, located on chromosome14q32. Discussions: Identification of P53 gene mutations in regions of 17 chromosome of hematological neoplasm is important because these mutations have an impact on the clinical course of patients and requires an attitude adjustment therapeutic adequate. Restoring function to p53 can induce lymphoma, apoptosis. Recent, endogenous somatic gene therapy research is a basic of trial clinical and therapeutic trial. The DNA, is used to treat a disease arising as a result of mutations in chromosomal regions. In the past few years, this method has been included in the treatment of CLL, acute lymphocytic leukemia, [ALL], or multiple myeloma [MM]. Conclusion: The frequencies of P53 gene mutations and deletion in CLL can be categorized as individual biomarkers in proteomic and genomic profile for this type of leukemia that can be implemented in targeted patient treatment of personalized medicine.
VL  - 1
IS  - 2
ER  -

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Aurelian Udristioiu

Molecular Biology, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania

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Aurelian Udristioiu. (2016). Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia. American Journal of Laboratory Medicine, 1(2), 16-22. https://doi.org/10.11648/j.ajlm.20160102.13

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ACS Style

Aurelian Udristioiu. Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia. Am. J. Lab. Med. 2016, 1(2), 16-22. doi: 10.11648/j.ajlm.20160102.13

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Aurelian Udristioiu. Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia. Am J Lab Med. 2016;1(2):16-22. doi: 10.11648/j.ajlm.20160102.13

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@article{10.11648/j.ajlm.20160102.13,
  author = {Aurelian Udristioiu},
  title = {Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia},
  journal = {American Journal of Laboratory Medicine},
  volume = {1},
  number = {2},
  pages = {16-22},
  doi = {10.11648/j.ajlm.20160102.13},
  url = {https://doi.org/10.11648/j.ajlm.20160102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20160102.13},
  abstract = {Objective of this study is to present the latest researches in the field of molecular medicine, in terms of Chronic Lymphocytic Leukemia (CLL), emerged from the P53 gene deletion in human lymphoma genome. Method In recent years proved that the best technique in the investigation of malignant lymphocytes is the Fluorescence in situ hybridization (FISH). This method is used as an alternative to chromosomal banding, a conventional application in molecular medicine. Previous Results: In the literature it was registered, in previous years, on an international study, conducted on 109 cases of CLL, 79 cases (72.5%) who had more genetic abnormalities; the remaining 30 cases (27.5%) had normal results, using the technique Florescence in situ Hybridization, (FISH). The majority of patients, 67% (53.79) had a single anomaly and the remaining 33% had two or three genetic abnormalities. The band 14q32 /17p translocations in LLC genome, which appeared similar to some common, had demonstrated abnormalities involving IGH gene, located on chromosome14q32. Discussions: Identification of P53 gene mutations in regions of 17 chromosome of hematological neoplasm is important because these mutations have an impact on the clinical course of patients and requires an attitude adjustment therapeutic adequate. Restoring function to p53 can induce lymphoma, apoptosis. Recent, endogenous somatic gene therapy research is a basic of trial clinical and therapeutic trial. The DNA, is used to treat a disease arising as a result of mutations in chromosomal regions. In the past few years, this method has been included in the treatment of CLL, acute lymphocytic leukemia, [ALL], or multiple myeloma [MM]. Conclusion: The frequencies of P53 gene mutations and deletion in CLL can be categorized as individual biomarkers in proteomic and genomic profile for this type of leukemia that can be implemented in targeted patient treatment of personalized medicine.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Role of P53 Gene in Oncogenesis from Chronic Lymphocytic Leukemia
AU  - Aurelian Udristioiu
Y1  - 2016/09/24
PY  - 2016
N1  - https://doi.org/10.11648/j.ajlm.20160102.13
DO  - 10.11648/j.ajlm.20160102.13
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 16
EP  - 22
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20160102.13
AB  - Objective of this study is to present the latest researches in the field of molecular medicine, in terms of Chronic Lymphocytic Leukemia (CLL), emerged from the P53 gene deletion in human lymphoma genome. Method In recent years proved that the best technique in the investigation of malignant lymphocytes is the Fluorescence in situ hybridization (FISH). This method is used as an alternative to chromosomal banding, a conventional application in molecular medicine. Previous Results: In the literature it was registered, in previous years, on an international study, conducted on 109 cases of CLL, 79 cases (72.5%) who had more genetic abnormalities; the remaining 30 cases (27.5%) had normal results, using the technique Florescence in situ Hybridization, (FISH). The majority of patients, 67% (53.79) had a single anomaly and the remaining 33% had two or three genetic abnormalities. The band 14q32 /17p translocations in LLC genome, which appeared similar to some common, had demonstrated abnormalities involving IGH gene, located on chromosome14q32. Discussions: Identification of P53 gene mutations in regions of 17 chromosome of hematological neoplasm is important because these mutations have an impact on the clinical course of patients and requires an attitude adjustment therapeutic adequate. Restoring function to p53 can induce lymphoma, apoptosis. Recent, endogenous somatic gene therapy research is a basic of trial clinical and therapeutic trial. The DNA, is used to treat a disease arising as a result of mutations in chromosomal regions. In the past few years, this method has been included in the treatment of CLL, acute lymphocytic leukemia, [ALL], or multiple myeloma [MM]. Conclusion: The frequencies of P53 gene mutations and deletion in CLL can be categorized as individual biomarkers in proteomic and genomic profile for this type of leukemia that can be implemented in targeted patient treatment of personalized medicine.
VL  - 1
IS  - 2
ER  -

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