Type 2 Diabetes and Vitamin D Status

Rachidi Meriem; Tali Abdelali; Zahire Hanane; El Ansari Nawal; Chabaa Laila

doi:doi:10.11648/j.ajlm.20190404.11

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Type 2 Diabetes and Vitamin D Status

Rachidi Meriem, Tali Abdelali, Zahire Hanane, El Ansari Nawal, Chabaa Laila

Received: 31 January 2019 Accepted: 3 July 2019 Published: 19 July 2019

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Abstract

Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D < 10 ng / ml objectified in 37 patients (44%); group 2: 25 (OH) D between 10 and < 29 ng / ml in 43 patients (51.2%) and group 3: 25 (OH) D > 30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.

DOI	10.11648/j.ajlm.20190404.11
Published in	American Journal of Laboratory Medicine (Volume 4, Issue 4, July 2019)
Page(s)	70-73
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Vitamin D, Type 2 Diabetes, Insulin Resistance

References

[1]	T. Mezza, G. Muscogiuri, G. P. Sorice, A. Prioletta, E. Salomone, A. Pontecorvi, A. Giaccari. Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes?Ann Nutr Metab 2012; 61: 337–348.
[2]	S. Safi, H. Ouleghzal, I. Khaldouni, H. Hassikou, L. Ballouch, Y. Bamou, L. Hadri. Statut de la vitamine D chez les patients diabétiques de type 2 marocains. Médecine des maladies Métaboliques - Février 2015 - Vol. 9 - N°1.
[3]	Mitri J, Pittas AG. 25 (OH) D: 25-hydroxy-vitamin D. Endocrinol Metab Clin North Am 2014; 43: 205-32.
[4]	Pilz S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diabetes Rep 2013; 13: 261-70.
[5]	P. E. Norman and J. T. Powell. Vitamin D and Cardiovascular Disease. Circ Res. 2014; 114: 379-393.
[6]	Christy S Maxwell and Richard J Wood. Update on vitamin D and type 2 diabetes. Nutrition Reviews 2011; Vol. 69 (5): 291–295.
[7]	Cavalier E, Delanaye P, Souberbielle JC, Radermecker RP. Vitamin D and type 2 diabetes mellitus: where do we stand? Diabetes Metab. 2011; 37: 265-72.
[8]	Nobécourt E, Diedisheim M, Radu A, et al. Carence en vitamine D chez les diabétiques. Conséquences sur le métabolisme phosphocalcique. Diabetes Metab 2010; 36 (Special issue 1): A62 [Abstract P95].
[9]	Lee JI, Oh SJ, Ha WC, et al. Serum25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes. Diabetes Res Clin Pract 2012; 95: 42-7.
[10]	Yu JR, Lee SA, Lee JG, et al. Serum vitamin D status and its relationship to metabolic parameters in patients with type 2 diabetes mellitus. Chonnam Med J 2012; 48: 108-15.
[11]	Kos E, Liszek MJ, Emanuele MA, et al. The effect of metformin therapy on vitamin D and vitamin B12 levels in patients with type 2 diabetes mellitus. EndocrPract 2012; 18: 179-84.
[12]	Payne JF, Ray R, Watson DG, et al. Vitamin D insufficiency in diabetic retinopathy. EndocrPract 2012; 18: 185-93.
[13]	Suzuki A, Kotake M, Ono Y, et al. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocr J 2006; 53: 503-10.
[14]	Al-Timimi DJ, Ali AF. Serum 25(OH) D in diabetes mellitus type 2: relation to glycaemic control. J Clin Diagn Res 2013; 7: 2686-8.
[15]	Yilmaz H, Kaya M, Sahin M, Delibasi T. Is vitamin D status a predictor glycaemic regulation and cardiac complication in type 2 diabetes mellitus patients? Diabetes MetabSyndr 2012; 6: 28-31.

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APA Style

Rachidi Meriem, Tali Abdelali, Zahire Hanane, El Ansari Nawal, Chabaa Laila. (2019). Type 2 Diabetes and Vitamin D Status. American Journal of Laboratory Medicine, 4(4), 70-73. https://doi.org/10.11648/j.ajlm.20190404.11

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ACS Style

Rachidi Meriem; Tali Abdelali; Zahire Hanane; El Ansari Nawal; Chabaa Laila. Type 2 Diabetes and Vitamin D Status. Am. J. Lab. Med. 2019, 4(4), 70-73. doi: 10.11648/j.ajlm.20190404.11

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AMA Style

Rachidi Meriem, Tali Abdelali, Zahire Hanane, El Ansari Nawal, Chabaa Laila. Type 2 Diabetes and Vitamin D Status. Am J Lab Med. 2019;4(4):70-73. doi: 10.11648/j.ajlm.20190404.11

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@article{10.11648/j.ajlm.20190404.11,
  author = {Rachidi Meriem and Tali Abdelali and Zahire Hanane and El Ansari Nawal and Chabaa Laila},
  title = {Type 2 Diabetes and Vitamin D Status},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {4},
  pages = {70-73},
  doi = {10.11648/j.ajlm.20190404.11},
  url = {https://doi.org/10.11648/j.ajlm.20190404.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190404.11},
  abstract = {Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D  30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.},
 year = {2019}
}

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TY  - JOUR
T1  - Type 2 Diabetes and Vitamin D Status
AU  - Rachidi Meriem
AU  - Tali Abdelali
AU  - Zahire Hanane
AU  - El Ansari Nawal
AU  - Chabaa Laila
Y1  - 2019/07/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190404.11
DO  - 10.11648/j.ajlm.20190404.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 70
EP  - 73
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190404.11
AB  - Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D  30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.
VL  - 4
IS  - 4
ER  -

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Author Information

Rachidi Meriem

Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Tali Abdelali

Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Zahire Hanane

Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
El Ansari Nawal

Departement of Endocrinology, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Chabaa Laila

Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco

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APA Style

Rachidi Meriem, Tali Abdelali, Zahire Hanane, El Ansari Nawal, Chabaa Laila. (2019). Type 2 Diabetes and Vitamin D Status. American Journal of Laboratory Medicine, 4(4), 70-73. https://doi.org/10.11648/j.ajlm.20190404.11

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ACS Style

Rachidi Meriem; Tali Abdelali; Zahire Hanane; El Ansari Nawal; Chabaa Laila. Type 2 Diabetes and Vitamin D Status. Am. J. Lab. Med. 2019, 4(4), 70-73. doi: 10.11648/j.ajlm.20190404.11

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AMA Style

Rachidi Meriem, Tali Abdelali, Zahire Hanane, El Ansari Nawal, Chabaa Laila. Type 2 Diabetes and Vitamin D Status. Am J Lab Med. 2019;4(4):70-73. doi: 10.11648/j.ajlm.20190404.11

Copy | Download

@article{10.11648/j.ajlm.20190404.11,
  author = {Rachidi Meriem and Tali Abdelali and Zahire Hanane and El Ansari Nawal and Chabaa Laila},
  title = {Type 2 Diabetes and Vitamin D Status},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {4},
  pages = {70-73},
  doi = {10.11648/j.ajlm.20190404.11},
  url = {https://doi.org/10.11648/j.ajlm.20190404.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190404.11},
  abstract = {Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D  30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.},
 year = {2019}
}

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TY  - JOUR
T1  - Type 2 Diabetes and Vitamin D Status
AU  - Rachidi Meriem
AU  - Tali Abdelali
AU  - Zahire Hanane
AU  - El Ansari Nawal
AU  - Chabaa Laila
Y1  - 2019/07/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190404.11
DO  - 10.11648/j.ajlm.20190404.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 70
EP  - 73
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190404.11
AB  - Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D  30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.
VL  - 4
IS  - 4
ER  -

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