American Journal of Laboratory Medicine
Volume 5, Issue 4, July 2020, Pages: 118-124
Received: Jul. 15, 2020;
Accepted: Jul. 28, 2020;
Published: Aug. 10, 2020
Views 160 Downloads 58
Asrat Endrias, Department of Biochemistry, Mekelle University, Mekelle, Ethiopia
Menakath Menon, Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Mihretu Wodeyes, Department of Dermatology, Addis Ababa University, Addis Ababa, Ethiopia
Tamrat Abebe, Department of Microbiology, Parasitology and Immunology, Addis Ababa University, Addis Ababa, Ethiopia
Mohammed Mehdi, Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Ezra Belay, Department of Biochemistry, Mekelle University, Mekelle, Ethiopia
Daniel Seifu, Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (p<0.001) as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
Oxidative Stress and Human Psoriasis Diseases, American Journal of Laboratory Medicine.
Vol. 5, No. 4,
2020, pp. 118-124.
Baur, B., Sarkar, J., Manna, N. and Bandyopadhyay, L.,. The pattern of dermatological disorders among patients attending the skin OPD of a tertiary care hospital in Kolkata, India. IOSR Journal of Dental and Medical Sciences (JDMS), 2013; 4 (3), pp. 04-09.
Prasanth, D., Masram, P., Paul, R. and Anup, T. A systemic analysis on psoriasis. WSR to EKAKUSHTA, Pharma Science Monitor 5 (3) Supl-1 July-Sep 2014. 333-347.
Chong, L. Is Psoriasis a Cutaneous Disease or Systemic Disease?. Medical Bulletin, 2010; 15 (11).
Dilnawaz, M., Sadiq, S., Shaikh, Z., Aziz, H., Khan, S. A. and Jawad, B. Clinical audit: baseline Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) assessment of psoriasis patients. Journal of Pakistan Association of Dermatologists, 2013; 23 (4), pp. 407-411.
Chandran, V. and Raychaudhuri, S. P. Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. Journal of autoimmunity, 2010; 34 (3), pp. J314-J321.
Diallo, M.,. Psoriasis Epidemiology. Journal of Clinical Case Reports, 2012.
Gimbel, D. C. and Legesse, T. B. Dermatopathology practice in Ethiopia. Archives of Pathology and Laboratory Medicine, 2013; 137 (6), pp. 798-804.
Balato, A., Ayala, F., Schiattarella, M., Megna, M., Balato, N. and Lembo, S. Pathogenesis of psoriasis: the role of pro-inflammatory cytokines produced by Keratinocytes. INTECH Open Access Publisher, 2012.
Mantovani, A., Gisondi, P., Lonardo, A. and Targher, G. Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis? International journal of molecular sciences, 2016; 17 (2), p. 217.
Wagener, F. A., Carels, C. E. and Lundvig, D. Targeting the redox balance in inflammatory skin conditions. International journal of molecular sciences, 2013; 14 (5), pp. 9126-9167.
Erel, O. A new automated colorimetric method for measuring total oxidant status. Clinicalbiochemistry, 2005; 38 (12), pp. 1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
Koracevic D., Koracevic G., Djordjevic V., Andrejevic S. And Cosic V. Method for the measurement of antioxidant activity in human fluids. J. Clin Pathol, 2001; 54, 356-361.
Zhou, Q., Mrowietz, U. and Rostami-Yazdi, M. Oxidative stress in the pathogenesis of psoriasis. Free Radical Biology and Medicine, 2009; 47 (7), pp. 891-905.
Nassiri, S., Malekzad, F., Sarlak, M., Saeedi, M., Hedayati, M. A. H. D. I. and Qaisari, M. Interplay among antioxidants and oxidants in psoriasis. Iranian Journal of Dermatology, 2009; 12 (2), pp. 56-59.
Guven, B., Can, M., Genc, M. and Koca, R. Serum prolidase activity in psoriasis patients. Archives of dermatological research, 2013; 305 (6), pp. 473-476.
Sürücü, H. A., Aksoy, N., Ozgöztas, O., Sezen, H., Yesilova, Y. and Turan, E. Prolidase activity in chronic plaque psoriasis patients. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 2015; 32 (2), p. 82.
Karababa, F., Yesilova, Y., Turan, E., Selek, S., Altun, H. and Selek, S.. Impact of depressive symptoms on oxidative stress in patients with psoriasis. Redox Report, 2013; 18 (2), pp. 51-55.
Gabr, S. A. and Al-Ghadir, A. H. Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis. Archives of dermatological research, 2012; 304 (6), pp. 451-457.
Hashemi, M., Mehrabifar, H., Daliri, M. and Ghavami, S. Adenosine deaminase activity, trypsin inhibitory capacity and total antioxidant capacity in psoriasis. Journal of the European Academy of Dermatology and Venereology, 2010; 24 (3), pp. 329-334.
Pujari, V. M., Ireddy, S., Itagi, I. and Kumar, S. The Serum Levels of Malondialdehyde, Vitamin E and Erythrocyte Catalase Activity in Psoriasis Patients. Journal of clinical and diagnostic research: JCDR, 2014; 8 (11), p. CC14.
Attwa, E. and Swelam, E. Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis. Journal of the European Academy of Dermatology and Venereology, 2011; 25 (7), pp. 782-787.
RS Jyothi, KS Govindswamy, K Gurupadappa - Psoriasis: An oxidative stress condition. J Clin Diagn Res, 2011.
Şikar Aktürk, A., Özdoğan, H. K., Bayramgürler, D., Çekmen, M. B., Bilen, N. and Kıran, R. Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients. Journal of the European Academy of Dermatology and Venereology, 2012; 26 (7), pp. 833-837.
Galassetti, P. Inflammation and oxidative stress in obesity, metabolic syndrome, and diabetes. Experimental Diabetes Research, 2012. Article ID 943706, 2 pages, doi: 10.1155/2012/943706.
Benedetti, S., Tagliamonte, M. C., Catalani, S., Primiterra, M., Canestrari, F., De Stefani, S., Palini, S. and Bulletti, C. Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality. Reproductive biomedicine online, 2012; 25 (3), pp. 300-306.
Shamsi, M. B., Venkatesh, S., Kumar, R., Gupta, N. P., Malhotra, N., Singh, N., et al.,. Antioxidant levels in blood and seminal plasma and their impact on sperm parameters in infertile men. Indian journal of biochemistry & biophysics, 2010; 47 (1), p. 38.
Kayar, A., Dokuzeylul, B., Kandemir, F. M., Kirbas, A., Bayrakal, A. and Or, M. E. Total oxidant and antioxidant capacities, nitric oxide and malondialdehyde levels in cats seropositive for the feline coronavirus. Veterinarni Medicina, 2015; 60 (5), pp. 274-281.
Kose, O., Canakci, V., Canakci, C. F., Yildirim, A., Kermen, E., Arabaci, T. and Gungor, A. The effect of obesity on total antioxidant/oxidant status and oxidative stress index in patients with chronic periodontitis. Oxidants and Antioxidants in Medical Science, 2014; 3 (2), pp. 153-159.