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Oxidative Stress and Human Psoriasis Diseases
American Journal of Laboratory Medicine
Volume 5, Issue 4, July 2020, Pages: 118-124
Received: Jul. 15, 2020; Accepted: Jul. 28, 2020; Published: Aug. 10, 2020
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Asrat Endrias, Department of Biochemistry, Mekelle University, Mekelle, Ethiopia
Menakath Menon, Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Mihretu Wodeyes, Department of Dermatology, Addis Ababa University, Addis Ababa, Ethiopia
Tamrat Abebe, Department of Microbiology, Parasitology and Immunology, Addis Ababa University, Addis Ababa, Ethiopia
Mohammed Mehdi, Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Ezra Belay, Department of Biochemistry, Mekelle University, Mekelle, Ethiopia
Daniel Seifu, Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
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Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (p<0.001) as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
Total Oxidant Capacity, Total Antioxidant Capacity, Oxidative Stress Index, Psoriasis
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Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, Ezra Belay, Daniel Seifu, Oxidative Stress and Human Psoriasis Diseases, American Journal of Laboratory Medicine. Vol. 5, No. 4, 2020, pp. 118-124. doi: 10.11648/j.ajlm.20200504.16
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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