American Journal of Clinical and Experimental Medicine

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Nocturnal Enuresis as a Specific Compensatory Syndrome

Received: Aug. 22, 2017    Accepted: Sep. 06, 2017    Published: Oct. 09, 2017
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Abstract

The pathophysiological nature of the monosymptomatic primary nocturnal enuresis (PNE) in children is still the unresolved problem. The most hypotheses of pathogenesis of nocturnal enuresis are limited within anatomical, biochemical and physiological regulation of the urinary control. Based on our own observations as well as the data reported in the literature, we have concluded that in addition to described biological causes of this disorder, we should focus on the common clinical and developmental features observed in the majority of cases of the monosymptomatic primary nocturnal enuresis that could be united as “enuretic syndrome”. In attempt to move “outside of the box” of the urinary control we have put forward a hypothesis that enuresis is a specific compensatory syndrome which is self-developed by the child’s organism to “offset” the deviated sleep–wake mechanisms. This concept is based on the general “control system theory” and offers the explanations of the majority of symptoms. From the compensatory “offset” concept the treatment of PNE should be focused not on the suppression of the act of enuresis but on the stabilization of circadian sleep-wake mechanisms. Further investigations are needed to evaluate the validity of this concept.

DOI 10.11648/j.ajcem.20170506.13
Published in American Journal of Clinical and Experimental Medicine ( Volume 5, Issue 6, November 2017 )
Page(s) 197-204
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Enuresis, Bedwetting, Adaptation Syndrome, Compensatory Model, Etiology of Enuresis

References
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    Alexander Zaler Golbin, Anastasiia Tsarenko. (2017). Nocturnal Enuresis as a Specific Compensatory Syndrome. American Journal of Clinical and Experimental Medicine, 5(6), 197-204. https://doi.org/10.11648/j.ajcem.20170506.13

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    ACS Style

    Alexander Zaler Golbin; Anastasiia Tsarenko. Nocturnal Enuresis as a Specific Compensatory Syndrome. Am. J. Clin. Exp. Med. 2017, 5(6), 197-204. doi: 10.11648/j.ajcem.20170506.13

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    AMA Style

    Alexander Zaler Golbin, Anastasiia Tsarenko. Nocturnal Enuresis as a Specific Compensatory Syndrome. Am J Clin Exp Med. 2017;5(6):197-204. doi: 10.11648/j.ajcem.20170506.13

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  • @article{10.11648/j.ajcem.20170506.13,
      author = {Alexander Zaler Golbin and Anastasiia Tsarenko},
      title = {Nocturnal Enuresis as a Specific Compensatory Syndrome},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {5},
      number = {6},
      pages = {197-204},
      doi = {10.11648/j.ajcem.20170506.13},
      url = {https://doi.org/10.11648/j.ajcem.20170506.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20170506.13},
      abstract = {The pathophysiological nature of the monosymptomatic primary nocturnal enuresis (PNE) in children is still the unresolved problem. The most hypotheses of pathogenesis of nocturnal enuresis are limited within anatomical, biochemical and physiological regulation of the urinary control. Based on our own observations as well as the data reported in the literature, we have concluded that in addition to described biological causes of this disorder, we should focus on the common clinical and developmental features observed in the majority of cases of the monosymptomatic primary nocturnal enuresis that could be united as “enuretic syndrome”. In attempt to move “outside of the box” of the urinary control we have put forward a hypothesis that enuresis is a specific compensatory syndrome which is self-developed by the child’s organism to “offset” the deviated sleep–wake mechanisms. This concept is based on the general “control system theory” and offers the explanations of the majority of symptoms. From the compensatory “offset” concept the treatment of PNE should be focused not on the suppression of the act of enuresis but on the stabilization of circadian sleep-wake mechanisms. Further investigations are needed to evaluate the validity of this concept.},
     year = {2017}
    }
    

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    AB  - The pathophysiological nature of the monosymptomatic primary nocturnal enuresis (PNE) in children is still the unresolved problem. The most hypotheses of pathogenesis of nocturnal enuresis are limited within anatomical, biochemical and physiological regulation of the urinary control. Based on our own observations as well as the data reported in the literature, we have concluded that in addition to described biological causes of this disorder, we should focus on the common clinical and developmental features observed in the majority of cases of the monosymptomatic primary nocturnal enuresis that could be united as “enuretic syndrome”. In attempt to move “outside of the box” of the urinary control we have put forward a hypothesis that enuresis is a specific compensatory syndrome which is self-developed by the child’s organism to “offset” the deviated sleep–wake mechanisms. This concept is based on the general “control system theory” and offers the explanations of the majority of symptoms. From the compensatory “offset” concept the treatment of PNE should be focused not on the suppression of the act of enuresis but on the stabilization of circadian sleep-wake mechanisms. Further investigations are needed to evaluate the validity of this concept.
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Author Information
  • Sleep and Behavior Medicine Institute, Chicago, USA

  • Sleep and Behavior Medicine Institute, Chicago, USA

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