How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report

Min Han; Xuelan Li

doi:doi:10.11648/j.jgo.20180604.12

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How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report

Min Han, Xuelan Li

Published in Journal of Gynecology and Obstetrics (Volume 6, Issue 4)

Received: 7 July 2018 Accepted: 26 July 2018 Published: 16 August 2018

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Abstract

Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.

Published in	Journal of Gynecology and Obstetrics (Volume 6, Issue 4)
DOI	10.11648/j.jgo.20180604.12
Page(s)	80-85
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pre-eclampsia, IVF-ET, Intrahepatic Cholestasis of Pregnancy

References

[1]	Laganà AS, Favilli A, Triolo O, Granese R, Gerli S (2015) Early serum markers of pre-eclampsia: are we stepping forward? J Matern Fetal Neonatal Med 29: 3019-23.
[2]	WHO (2004) The Global Burden of Disease, Geneva.
[3]	Brown M A, Magee L A, Kenny L C, et al. The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice [J]. Pregnancy Hypertension, 2018, 72(1):24-43.
[4]	Pastore L M. Assisted reproductive technology and pregnancy outcome.[J]. Digest of the World Core Medical Journals, 2016, 107(4):953-4.
[5]	Miyake H, Iwasaki N, Nakai A, Suzuki S and Takeshita T: The influence of assisted reproductive technology on women with pregnancy-induced hypertension: A retrospective study at a Japanese Regional Perinatal Center. J Nippon Med Sch 77: 312-317, 2010.
[6]	Miyake H, Iwasaki N, Nakai A, et al. The influence of assisted reproductive technology on women with pregnancy-induced hypertension: a retrospective study at a Japanese Regional Perinatal Center.[J]. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2010, 77(6):312.
[7]	Buzzi P J, Zappacosta M P, Auge L, et al. Beneficial effect of local injury to the endometrium in intracytoplasmic sperm injection (ICSI) patients with recurrent implantation failure [J]. Fertility & Sterility, 2014, 102(3):e293-e293.
[8]	Redman C W G, Jacobson S, Russell R. Hypertension in Pregnancy [M]// de Swiet's Medical Disorders in Obstetric Practice, Fifth Edition. Wiley‐Blackwell, 2010:153-181.
[9]	Mahande M, Dalveit A, Mmbaga B, et al. 646: The recurrence risk of preeclampsia in subsequent pregnancies in northern Tanzania: a registry–based prospective cohort study [J]. American Journal of Obstetrics & Gynecology, 2013, 208(1):S273-S273.
[10]	Raymond D, Peterson E: A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv 2011, 66(8):497–506.
[11]	Jackson RA, Gibson KA, Wu YW, Croughan MS: Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 2004, 103(3):551–563.
[12]	Shevell T, Malone FD, Vidaver J, Porter TF, Luthy DA, Comstock CH, Hankins GD, Eddleman K, Dolan S, Dugoff L, et al: Assisted reproductive technology and pregnancy outcome. Obstet Gynecol 2005, 106(5 Pt 1):1039–1045.
[13]	Chen XK, Wen SW, Bottomley J, Smith GN, Leader A, Walker MC: In vitro fertilization is associated with an increased risk for preeclampsia. Hypertension Pregnancy 2009, 28(1):1–12.
[14]	Thomopoulos C, Tsioufis C, Michalopoulou H, Makris T, Papademetriou V, Stefanadis C: Assisted reproductive technology and pregnancy-related hypertensive complications: a systematic review. J Hum Hypertens 2013, 27(3):148–157.
[15]	Woldringh G. P-16: Decreased ovarian reserve relates to preeclampsia in IVF/ ICSI pregnancies [J]. Fertility & Sterility, 2006, 86(3):S134-S1
[16]	Myers ER, McCrory DC, Mills AA, Price TM, Swamy GK, Tantibhedhyangkul J, Wu JM and Matchar DB: Effectiveness of assisted reproductive technology (ART). Evid Rep Technol Assess (Full Rep) 167: 1-195, 2008.
[17]	Makkonen N, Heinonen S, Kirkinen P. Obstetric prognosis in second pregnancy after preeclampsia in first pregnancy. Hypertens Pregnancy 2000; 19:173-81.
[18]	Hnat MD, Sibai BM, Caritis S, et al. Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas. Am J Obstet Gynecol 2002; 186:422-6.
[19]	Trogstad L, Skrondal A, Stoltenberg C, Magnus P, Nesheim BI, Eskild A. Recurrence risk of preeclampsia in twin and singleton pregnancies. Am J Med Genet A 2004; 126A:41-5.
[20]	Hjartardottir S, Leifsson BG, Geirsson RT, Steinthorsdottir V. Recurrence of hypertensive disorder in second pregnancy. Am J Obstet Gynecol 2006; 194:916-20.
[21]	Brown MA, Mackenzie C, Dunsmuir W, et al. Can we predict recurrence of pre-eclampsia or gestational hypertension? BJOG 2007; 114:984-93.
[22]	van Rijn BB, Hoeks LB, Bots ML, Franx A, Bruinse HW. Outcomes of subsequent pregnancy after first pregnancy with early-onset preeclampsia. Am J Obstet Gynecol 2006; 195:723-8.
[23]	Costa M L. Preeclampsia: Reflections on How to Counsel About Preventing Recurrence [J]. Journal of Obstetrics & Gynaecology Canada, 2015, 37(10):887-893.
[24]	Iii G A D, Belfort M A, Smulian J C. Preeclampsia Recurrence and Prevention [J]. Seminars in Perinatology, 2007, 31(3):135-141.
[25]	Xiong F, Hu L, Zhang Y, et al. Correlation of hypertensive disorders in pregnancy with procedures ofin vitrofertilization and pregnancy outcomes:[J]. Experimental & Therapeutic Medicine, 2017, 14(6):5405-5410.
[26]	Kurki T, Hiilesmaa V, Raitasalo R, et al. Depression and anxiety in early pregnancy and risk of preeclampsia [J]. Obstetrics & Gynecology, 2000, 95(4):487-490.
[27]	Sebire NJ, Jolly M, Harris J, Nicolaides KH, Regan L. Risks of obstetric complications in multiple pregnancies: an analysis of more than 400,000 pregnancies in the UK. Prenat Neonatal Med 2001; 6:89–94.
[28]	Morris R K, Kilby M D. Multi‐fetal Pregnancy Reduction after ART [M]// Assisted Reproduction Techniques: Challenges and Management Options. Wiley‐Blackwell, 2012:400-404
[29]	Cheang C U, Huang L S, Lee T H, et al. A comparison of the outcomes between twin and reduced twin pregnancies produced through assisted reproduction.[J]. Fertility & Sterility, 2007, 88(1):47-52.
[30]	Gelbaya TA, Tsoumpou I, Nardo LG. The likelihood of live birth and multiple births after single versus double embryo transfer at the cleavage stage:a systematic review and meta-analysis. Fertil Steril 2010; 94:936–45.
[31]	Lee A M, Connell M T, Csokmay J M, et al. Elective single embryo transfer- the power of one [J]. Contraception & Reproductive Medicine, 2016, 1(1):11.

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APA Style

Min Han, Xuelan Li. (2018). How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report. Journal of Gynecology and Obstetrics, 6(4), 80-85. https://doi.org/10.11648/j.jgo.20180604.12

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ACS Style

Min Han; Xuelan Li. How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report. J. Gynecol. Obstet. 2018, 6(4), 80-85. doi: 10.11648/j.jgo.20180604.12

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AMA Style

Min Han, Xuelan Li. How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report. J Gynecol Obstet. 2018;6(4):80-85. doi: 10.11648/j.jgo.20180604.12

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@article{10.11648/j.jgo.20180604.12,
  author = {Min Han and Xuelan Li},
  title = {How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {6},
  number = {4},
  pages = {80-85},
  doi = {10.11648/j.jgo.20180604.12},
  url = {https://doi.org/10.11648/j.jgo.20180604.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20180604.12},
  abstract = {Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.},
 year = {2018}
}

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TY  - JOUR
T1  - How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report
AU  - Min Han
AU  - Xuelan Li
Y1  - 2018/08/16
PY  - 2018
N1  - https://doi.org/10.11648/j.jgo.20180604.12
DO  - 10.11648/j.jgo.20180604.12
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 80
EP  - 85
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20180604.12
AB  - Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.
VL  - 6
IS  - 4
ER  -

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Author Information

Min Han

The First Affiliated Hospital of Xi’an Jiaotong Medical University, Xi’an, China
Xuelan Li

The First Affiliated Hospital of Xi’an Jiaotong Medical University, Xi’an, China

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APA Style

Min Han, Xuelan Li. (2018). How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report. Journal of Gynecology and Obstetrics, 6(4), 80-85. https://doi.org/10.11648/j.jgo.20180604.12

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ACS Style

Min Han; Xuelan Li. How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report. J. Gynecol. Obstet. 2018, 6(4), 80-85. doi: 10.11648/j.jgo.20180604.12

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AMA Style

Min Han, Xuelan Li. How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report. J Gynecol Obstet. 2018;6(4):80-85. doi: 10.11648/j.jgo.20180604.12

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@article{10.11648/j.jgo.20180604.12,
  author = {Min Han and Xuelan Li},
  title = {How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {6},
  number = {4},
  pages = {80-85},
  doi = {10.11648/j.jgo.20180604.12},
  url = {https://doi.org/10.11648/j.jgo.20180604.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20180604.12},
  abstract = {Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - How Many Embryos Should Be Transplanted After IVF Having Previous Pre-Eclampsia: A Case Report
AU  - Min Han
AU  - Xuelan Li
Y1  - 2018/08/16
PY  - 2018
N1  - https://doi.org/10.11648/j.jgo.20180604.12
DO  - 10.11648/j.jgo.20180604.12
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 80
EP  - 85
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20180604.12
AB  - Pre-eclampsia is a pregnancy-induced hypertensive disorder which affect multiple organ functions, it is one of the main factors increasing the morbidity and mortality of the maternal and neonatal. Furthermore, with the increasing rate of infertility or sub-fertility, more and more couples are conceiving assisted reproductive therapies, especially in vitro fertilization (IVF), which brings high possibility of multiple pregnancy due to its unique process and the patients demands. As is well known that multiple pregnancy may face great challenges of complications such as pre-eclampsia, gestational diabetes, intrahepatic cholestasis of pregnancy etc. If pre-eclampsia is not treated and monitored very well on time the mothers perhaps will have eclampsia, placental abruption or multiple organ dysfunction leading to death, likewise those fetus whose mother suffered from Pre-eclampsia also face the risks of fetus growth restriction, fetal stress or even stillbirth. We represent a patient in our clinic who had done twice in vitro fertilization-embryo transplantation(IVF-ET) with several high risks of pre-eclampsia and followed by recurrent Pre-eclampsia and Intrahepatic Cholestasis of Pregnancy, we fully recognize her risks in her second pregnancy and give a close antenatal surveillance, and she finally have two alive babies, but a large amount of money was spend for the two preterm babies in hospitalization in NICU and also the mother herself became exhausted and almost lost her hope. It reminds us that before conceiving IVF technology for patients, the indication must be clear, the adverse effect must be brought into consideration, cooperation must be obtained from both the reproductive clinicians and obstetrician to fully balance the benefit and adverse effect, attention must be paid to choose the best method during the assisted reproductive therapies and acquire the utmost benefit and avoid the side effect as possible.
VL  - 6
IS  - 4
ER  -

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