American Journal of Pediatrics

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The Clinical Characteristics and Magnetic Resonance Analysis of Children with Mild Encephalitis with Reversible Isolated Corpus Callosum

Received: May 04, 2018    Accepted: Jun. 07, 2018    Published: Jul. 16, 2018
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Abstract

Objective: To summarize the Magnetic Resonance Imaging (MRI) performance and clinical characteristics of children mild encephalitis with reversible isolated corpus callosum pressure (MERS), and analyze the possible etiology. Methods: The clinical data and MRI findings of 11 children with MERS in children's hospital of Shanxi Province from January 2012 to January 2015 were summarized, and then their clinical manifestations and characteristics were analyzed. Results: Among the 11 patients, 5 were male and 6 were female. The age range was 2- 14 years. Clinical manifestations include fever (7 cases, 63.6%), gastrointestinal symptoms (9 cases, 81.8%), drowsiness (5 cases, 45.5%), convulsions (6 cases, 54.5%), dizziness (2 cases, 18.2%), cervical positive resistance (1 case, 9.1%), carotid resistance suspicious (3 patients [27.3%]). The appearance of cerebrospinal fluid, white blood cell count, leukocyte classification, protein, glucose and chloride are all normal. MRI showed only abnormal signal in the corpus callosum pressure: a slightly longer T1 signal, a longer T2 signal, a high Diffusion Weighted Imaging (DWI) signal, and a low signal of Apparent Diffusion Coefficient (ADC). Has 4 cases of nuclear magnetic head of abnormal signal in the middle of corpus callosum and ovoid, 6 cases, in the middle and a wide belt of corpus callosum, 1 case was located in the corpus callosum and diffuse wide strip. Eleven children were treated with anti-infective agents and other symptomatic treatment. All of the 11 children were recovered and discharged. The duration of the course is 8 d and the longest is 21 d. The results of MRI follow - up showed that the callosal pressure lesion disappeared. Conclusion: The clinical manifestations of children's MERS include fever, gastrointestinal symptoms, drowsiness and convulsions, and their characteristic head MRI is a reversible cytotoxic edema with good prognosis.

DOI 10.11648/j.ajp.20180402.14
Published in American Journal of Pediatrics ( Volume 4, Issue 2, June 2018 )
Page(s) 36-40
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Encephalopathy, Splenium of Corpus Callosum, Magnetic Resonance Imaging, Children

References
[1] Tada H, Takanashi J, Barkovich AJ, et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology 2004; 63:1854–58.
[2] Malhotra HS, Garg RK, Vidhate MR, et al. Clinical significance of transient lesion in splenium of corpus callosum. Ann Indian Acad Neurol 2012; 15:151-57.
[3] Bulakbasi N, Kocaoglu M, Tayfun C, et al. Transient splenial lesion of the corpus callosum in clinically mild influenza-associated encephalitis/encephalopathy. AJNR 2006; 27:1983–86.
[4] Ganapathy S, Ey EH, Wolfson BJ, et al. Transient isolated lesion of the splenium associated with clinically mild influenza encephalitis. Pediatr Radiol 2008; 38:1243–45.
[5] Hoshino A, Saitoh M, Oka A, et al. Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes. Brain Dev 2012; 34:337–43.
[6] Takanashi J. Two newly proposed infectious encephalitis/encephalopathy syndromes [J]. Brain Dev 2009; 31:521–28.
[7] Takanashi J, Shirai K, Sugawara Y, et al. Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS). J Neurol Sci 2012; 315:167–69.
[8] Matsuoka T, Yodoshi T, Sugai M, et al. A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P Rotavirus Infection. Case Rep Pediatr. 2013; 2013:197163.
[9] T Okamoto, Y Sato, T Yamazaki, A Hayashi. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with febrile urinary tract infection. European Journal of Pediatrics 2014; 173:533.
[10] K Anneken, S Evers, S Mohammadi, W Schwindt, M Deppe. Transient lesion in the splenium related to antiepileptic drug: case report and new pathophysiological insights. Seizure European Journal of Epilepsy 2008; 17:654-57.
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    Li Chaoyang, Yang Jie, Guan Xiaoli, Li Chunhua, Jing Xiaowei, et al. (2018). The Clinical Characteristics and Magnetic Resonance Analysis of Children with Mild Encephalitis with Reversible Isolated Corpus Callosum. American Journal of Pediatrics, 4(2), 36-40. https://doi.org/10.11648/j.ajp.20180402.14

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    ACS Style

    Li Chaoyang; Yang Jie; Guan Xiaoli; Li Chunhua; Jing Xiaowei, et al. The Clinical Characteristics and Magnetic Resonance Analysis of Children with Mild Encephalitis with Reversible Isolated Corpus Callosum. Am. J. Pediatr. 2018, 4(2), 36-40. doi: 10.11648/j.ajp.20180402.14

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    AMA Style

    Li Chaoyang, Yang Jie, Guan Xiaoli, Li Chunhua, Jing Xiaowei, et al. The Clinical Characteristics and Magnetic Resonance Analysis of Children with Mild Encephalitis with Reversible Isolated Corpus Callosum. Am J Pediatr. 2018;4(2):36-40. doi: 10.11648/j.ajp.20180402.14

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  • @article{10.11648/j.ajp.20180402.14,
      author = {Li Chaoyang and Yang Jie and Guan Xiaoli and Li Chunhua and Jing Xiaowei and Li Wenling},
      title = {The Clinical Characteristics and Magnetic Resonance Analysis of Children with Mild Encephalitis with Reversible Isolated Corpus Callosum},
      journal = {American Journal of Pediatrics},
      volume = {4},
      number = {2},
      pages = {36-40},
      doi = {10.11648/j.ajp.20180402.14},
      url = {https://doi.org/10.11648/j.ajp.20180402.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajp.20180402.14},
      abstract = {Objective: To summarize the Magnetic Resonance Imaging (MRI) performance and clinical characteristics of children mild encephalitis with reversible isolated corpus callosum pressure (MERS), and analyze the possible etiology. Methods: The clinical data and MRI findings of 11 children with MERS in children's hospital of Shanxi Province from January 2012 to January 2015 were summarized, and then their clinical manifestations and characteristics were analyzed. Results: Among the 11 patients, 5 were male and 6 were female. The age range was 2- 14 years. Clinical manifestations include fever (7 cases, 63.6%), gastrointestinal symptoms (9 cases, 81.8%), drowsiness (5 cases, 45.5%), convulsions (6 cases, 54.5%), dizziness (2 cases, 18.2%), cervical positive resistance (1 case, 9.1%), carotid resistance suspicious (3 patients [27.3%]). The appearance of cerebrospinal fluid, white blood cell count, leukocyte classification, protein, glucose and chloride are all normal. MRI showed only abnormal signal in the corpus callosum pressure: a slightly longer T1 signal, a longer T2 signal, a high Diffusion Weighted Imaging (DWI) signal, and a low signal of Apparent Diffusion Coefficient (ADC). Has 4 cases of nuclear magnetic head of abnormal signal in the middle of corpus callosum and ovoid, 6 cases, in the middle and a wide belt of corpus callosum, 1 case was located in the corpus callosum and diffuse wide strip. Eleven children were treated with anti-infective agents and other symptomatic treatment. All of the 11 children were recovered and discharged. The duration of the course is 8 d and the longest is 21 d. The results of MRI follow - up showed that the callosal pressure lesion disappeared. Conclusion: The clinical manifestations of children's MERS include fever, gastrointestinal symptoms, drowsiness and convulsions, and their characteristic head MRI is a reversible cytotoxic edema with good prognosis.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Clinical Characteristics and Magnetic Resonance Analysis of Children with Mild Encephalitis with Reversible Isolated Corpus Callosum
    AU  - Li Chaoyang
    AU  - Yang Jie
    AU  - Guan Xiaoli
    AU  - Li Chunhua
    AU  - Jing Xiaowei
    AU  - Li Wenling
    Y1  - 2018/07/16
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ajp.20180402.14
    DO  - 10.11648/j.ajp.20180402.14
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 36
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20180402.14
    AB  - Objective: To summarize the Magnetic Resonance Imaging (MRI) performance and clinical characteristics of children mild encephalitis with reversible isolated corpus callosum pressure (MERS), and analyze the possible etiology. Methods: The clinical data and MRI findings of 11 children with MERS in children's hospital of Shanxi Province from January 2012 to January 2015 were summarized, and then their clinical manifestations and characteristics were analyzed. Results: Among the 11 patients, 5 were male and 6 were female. The age range was 2- 14 years. Clinical manifestations include fever (7 cases, 63.6%), gastrointestinal symptoms (9 cases, 81.8%), drowsiness (5 cases, 45.5%), convulsions (6 cases, 54.5%), dizziness (2 cases, 18.2%), cervical positive resistance (1 case, 9.1%), carotid resistance suspicious (3 patients [27.3%]). The appearance of cerebrospinal fluid, white blood cell count, leukocyte classification, protein, glucose and chloride are all normal. MRI showed only abnormal signal in the corpus callosum pressure: a slightly longer T1 signal, a longer T2 signal, a high Diffusion Weighted Imaging (DWI) signal, and a low signal of Apparent Diffusion Coefficient (ADC). Has 4 cases of nuclear magnetic head of abnormal signal in the middle of corpus callosum and ovoid, 6 cases, in the middle and a wide belt of corpus callosum, 1 case was located in the corpus callosum and diffuse wide strip. Eleven children were treated with anti-infective agents and other symptomatic treatment. All of the 11 children were recovered and discharged. The duration of the course is 8 d and the longest is 21 d. The results of MRI follow - up showed that the callosal pressure lesion disappeared. Conclusion: The clinical manifestations of children's MERS include fever, gastrointestinal symptoms, drowsiness and convulsions, and their characteristic head MRI is a reversible cytotoxic edema with good prognosis.
    VL  - 4
    IS  - 2
    ER  - 

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Author Information
  • Department of Neurology, Shanxi Province Children Hospital, Taiyuan, China

  • Department of Image Center, Shanxi Province Children Hospital, Taiyuan, China

  • Department of Image Center, Shanxi Province Children Hospital, Taiyuan, China

  • Department of Neurology, Shanxi Province Children Hospital, Taiyuan, China

  • Department of Neurology, Shanxi Province Children Hospital, Taiyuan, China

  • Department of Scientific Research Department, Shanxi Province Children Hospital, Taiyuan, China

  • Section