American Journal of Pediatrics

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Sensitivity and Resistant Pattern of Commonly Used Drugs in UTI in Younger Children: A Study in a Tertiary Care Level Hospital, Dhaka, Bangladesh

Received: Feb. 05, 2020    Accepted: Feb. 24, 2020    Published: Mar. 24, 2020
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Abstract

Urinary tract infections (UTIs) are one of the most common types of infections in children. Resistance to drug used in UTI is universal crisis in the present world. UTIs are usually caused by bacteria living on or in our bodies, and require treatment with antibiotics. A prospectively observational study was conducted in Kurmitola General Hospital (KGH) from January 2018 to December 2018. A total of 519 culture positive UTI children were considered for analysis. Colony counts for these samples were identified, and the profile of antibiotic resistance was identified. Here, samples with a colony count of ≥105 CFU/mL bacteria were considered positive. Among the children 416 children took antibiotics without prescription and among them 205 (49.2%) was culture positive. The most common pathogen was E-coli (74.31%) which prevailed that taking antibiotics without prescription is highly associated with the drug resistant UTI recurrent abdominal pain. Researcher took 19 antibiotics for susceptibility testing to identify the most resistant and safe drug for the UTI patients. According to the present study sensitive antibiotics were Cephradine 0%, Cefotaxim 0%, Imepenam 100%, Cotrimoxale 46%, amoxicillin and clavulanic acid 0%, Cefixime 36%, Cefuroxime 19%, Ceftriaxone 22%, Azithromycin 25%, Nitrofurantoin 66%, Ceftazidime 19%, Ciprofloxacin 47%, Nalidixic acid 36%, Levofloxacin 71% Colistin 79%, Gentamycin 80%, Netilmycin 80%, Amikacin 80% and Meropenam 40%. On the other hand, resistance was Cephradine 100%, Cefotaxim 100%, Imepenam 0%, Cotrimoxale 54%, Amoxicillin and clavulanic acid 100%, Cefixime 64%, Cefuroxime 81%, Ceftriaxone 78%, Azithromycin 75%, Nitrofurantoin 34%, Ceftazidime 81%, Ciprofloxacin 53%, Nalidixic acid 64%, Levofloxacin 29%, Colistin 21%, Gentamycin 20%, Netilmycin 20%, Amikacin 20% and Meropenam 60%. So, the most sensitive drug was Imepenam 100% and the most resistant drugs were Cephradine and Cefotaxim 100% resistance against urinary pathogens. Association between antibiotic use, drug resistance and use of with and without prescription in UTI patients was highly significant. We suggest that empirical antibiotic selection should be based on knowledge of the local prevalence of bacterial organism and their antibiotic resistance in a specific area rather than on universal or even national guidelines.

DOI 10.11648/j.ajp.20200602.25
Published in American Journal of Pediatrics ( Volume 6, Issue 2, June 2020 )
Page(s) 146-151
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

UTI, Antibiotic Resistance, Urinary Pathogens, Resistance

References
[1] Platt, R, Polk, BF, Murdock, B et al, Mortality associated with nosocomial urinary-tract infection. N Engl J Med. 1982; 307: 637–642.
[2] Adjei and Copoku, “Urinary tract infections in African infants,” International Journal of Antimicrobial Agents, 2004; 24 (1): S32–S34.
[3] F Mortazavi and NShahin, “Changing patterns in sensitivity of bacterial uropathogens to antibiotics in children,” Pakistan Journal of Medical Sciences, 2009; 25 (5): 801–805.
[4] Dulczak S, Kirk J Overview of the evaluation, diagnosis and management of urinary tract infections in infants and children. UrolNurs 2005; 25: 185–191.
[5] Winberg, J, Andersen, JH, Bergstrom, T et al, Epidemiology of symptomatic urinary tract infection in childhood. ActaPathol Scand. 1974; 252: 1–20.
[6] AlperAsscher, AW. Urinary tract infection in childhood J R Coll Physicians Lond. 1981; 15: 232–238.
[7] F. E. Abdullah, AA, Memon, MY, Bandukda, and M Jamil, “Increasing ciprofloxacin resistance of isolates from infected urines of a cross-section of patients in Karachi,” BMC Research Notes, 2012; 5 (1): 696–701.
[8] Alemu, F Moges, Y Shiferaw, K Tafess, AKassu, B. Anagaw, et al., “Bacterial profile and drug susceptibility pattern of urinary tract infection in pregnant women at University of Gondar Teaching Hospital, Northwest Ethiopia,” BMC Research Notes, 2012; 5 (1): 197–204.
[9] G. Schmiemann, I Gagyor, E Hummers-Pradier, and J. Bleidorn, “Resistance profiles of urinary tract infections in general practice-an observational study,” BMC Urology, 2012; 12 (1): 33–38.
[10] S. Farajnia, MY Alikhani, R Ghotaslou, B Naghili, and ANakhlband, “Causative agents and antimicrobial susceptibilities of urinary tract infections in the northwest of Iran,” International Journal of Infectious Diseases,, 2009; 13 (2): 140–144.
[11] N. Kashef, GE Djavid, and SShahbazi, “Antimicrobial susceptibility patterns of community-acquired uropathogens in Tehran, Iran,” Journal of Infection in Developing Countries, 2010; 4 (4): 202–206.
[12] Pieore RK, Patrice M. Lazre K. Antibiotic resistance in E. coli isolated from women genitila and tend of minimal inhibiting concentration in a semi-urban population. Current research journal biological science 2012: 4 (16). 696-701.
[13] Hryniewicz K, Szczypa K, SulikowskaA et al. Antibiotic Susceptibility of bacterial stains isolated from urinary tract infection in Polland. J. Antimicrobchemother 2001; 47 (6): 773-80.
[14] Farjana R, Sadia C, Mojibur R, Ahmed D, Anwar H. Antimicrobial resistance pattern of gram negative bacteria causing urinary tract infection, Stamford journal of Pharmaceuticals sci 2009; 2 (1): 44-50.
[15] Lizama CM, Luco IM, Reichhard TC, et al. Urinary tract infection in a pediatrics emergency department: frequency and clinical parameters. Rev ChilenaInfectol 2005; 22: 235–241.
[16] Lutter SA, Currie ML, Mitz LB, et al. Antibiotic resistance patterns in children hospitalized for urinary tract infections. Arch PediatrAdolesc Med 2005; 159: 924–928.
[17] Salah AA, Ahmed SS, Ahmed M, Naser A, Ruhul A M. Changing Trends in Uropathogens and their antimicrobial sensitivity pattern. Bangladesh J Med Microbial 2009; 03 (01); 9-12.
[18] Tantry BA, Rahiman S. Antibacterial resistance and trend of urinary tract pathogens in commonly used antibiotics in khasmir Valley; West Indian med J 2012; 61 (7): 43-44.
[19] Francesco MA, Ravizzola G, Peroni L, Negrini R, Manca N: Urinary tract infections in Brescia, Italy: Etiology of n uropathogens and antimicrobial resitance of common uropathogens. Med Sci Monit 2007, 6: 136–144.
[20] Mendo A, Antunes J, Costa M, Pereira PM, Monteiro C, Gomes CF, Gomes JF: Frequência de Infecções urinárias em Ambulatório - dados de um laboratório de Lisboa. Parte I. Revista Lusófona de Ciências e Tecnologia da Saúde 2008, 5: 216–223.
[21] Costa M, Pereira PM, Bolotinha C, Ferreira A, Cardoso R, Monteiro C, Gomes CF, Gomes JF: Frequência e Susceptibilidade Bacteriana em Infecções Urinárias –dados de um laboratório de Lisboa. Parte II. Rev Lusófona de Ciências e Tecnologias da Saúde 2009, 6: 87–103.
[22] Stephens GM, Akers S, Nguyen H, Woxland H. Evaluation and management of urinary tract infections in the school-aged child. Prim Care 2015; 42 (1): 33-41.
[23] Bonny AE, Brouhard BH. Urinary tract infections among adoles- cents. Adolesc Med 2005; 16 (1): 149-61.
[24] Williams GJ, Macaskill P, Chan SF, Turner RM, Hodson E, Craig JC. Absolute and relative accuracy of rapid urine tests for urinary tract infection in children: A meta-analysis. Lancet Infect Dis 2010; 10 (4): 240-50.
[25] Chang SL, Shortliffe LD. Pediatric urinary tract infections. Pediatr Clin North Am 2006; 53 (3): 379-400.
[26] Simões e Silva AC, Oliveira EA. Update on the approach of uri- nary tract infection in childhood. J Pediatr (Rio J) 2015; 91 (6 Suppl 1): S2-S10.
[27] Korbel L, Howell M, Spencer JD. The clinical diagnosis and man- agement of urinary tract infections in children and adolescents. Paediatr Int Child Health 2017; 37 (4): 273-9.
[28] Schlager TA. Urinary tract infections in infants and children. Mi- crobiol Spectr 2016; 4 (5). doi: 10.1128/microbiolspec. UTI-0022- 2016.
[29] Shaikh N, Hoberman A. Urinary tract infections in children: Epi- demiology and risk factors. In: Post TW, Ed. UpToDate. Waltham, MA. (Accessed on August 10, 2018).
[30] CLSI Clinical and Laboratory Standard Institute (CLSI), Performance standards for antimicrobial susceptibility testing, Wayne, A, USA. 2010.
[31] Nelson, Edition-21, chapter-553, page-2789.
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    Farhana Noman, Gulsan Ara Zahan, Ferdousi Hasnat, Md. Kariul Islam. (2020). Sensitivity and Resistant Pattern of Commonly Used Drugs in UTI in Younger Children: A Study in a Tertiary Care Level Hospital, Dhaka, Bangladesh. American Journal of Pediatrics, 6(2), 146-151. https://doi.org/10.11648/j.ajp.20200602.25

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    ACS Style

    Farhana Noman; Gulsan Ara Zahan; Ferdousi Hasnat; Md. Kariul Islam. Sensitivity and Resistant Pattern of Commonly Used Drugs in UTI in Younger Children: A Study in a Tertiary Care Level Hospital, Dhaka, Bangladesh. Am. J. Pediatr. 2020, 6(2), 146-151. doi: 10.11648/j.ajp.20200602.25

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    AMA Style

    Farhana Noman, Gulsan Ara Zahan, Ferdousi Hasnat, Md. Kariul Islam. Sensitivity and Resistant Pattern of Commonly Used Drugs in UTI in Younger Children: A Study in a Tertiary Care Level Hospital, Dhaka, Bangladesh. Am J Pediatr. 2020;6(2):146-151. doi: 10.11648/j.ajp.20200602.25

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  • @article{10.11648/j.ajp.20200602.25,
      author = {Farhana Noman and Gulsan Ara Zahan and Ferdousi Hasnat and Md. Kariul Islam},
      title = {Sensitivity and Resistant Pattern of Commonly Used Drugs in UTI in Younger Children: A Study in a Tertiary Care Level Hospital, Dhaka, Bangladesh},
      journal = {American Journal of Pediatrics},
      volume = {6},
      number = {2},
      pages = {146-151},
      doi = {10.11648/j.ajp.20200602.25},
      url = {https://doi.org/10.11648/j.ajp.20200602.25},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajp.20200602.25},
      abstract = {Urinary tract infections (UTIs) are one of the most common types of infections in children. Resistance to drug used in UTI is universal crisis in the present world. UTIs are usually caused by bacteria living on or in our bodies, and require treatment with antibiotics. A prospectively observational study was conducted in Kurmitola General Hospital (KGH) from January 2018 to December 2018. A total of 519 culture positive UTI children were considered for analysis. Colony counts for these samples were identified, and the profile of antibiotic resistance was identified. Here, samples with a colony count of ≥105 CFU/mL bacteria were considered positive. Among the children 416 children took antibiotics without prescription and among them 205 (49.2%) was culture positive. The most common pathogen was E-coli (74.31%) which prevailed that taking antibiotics without prescription is highly associated with the drug resistant UTI recurrent abdominal pain. Researcher took 19 antibiotics for susceptibility testing to identify the most resistant and safe drug for the UTI patients. According to the present study sensitive antibiotics were Cephradine 0%, Cefotaxim 0%, Imepenam 100%, Cotrimoxale 46%, amoxicillin and clavulanic acid 0%, Cefixime 36%, Cefuroxime 19%, Ceftriaxone 22%, Azithromycin 25%, Nitrofurantoin 66%, Ceftazidime 19%, Ciprofloxacin 47%, Nalidixic acid 36%, Levofloxacin 71% Colistin 79%, Gentamycin 80%, Netilmycin 80%, Amikacin 80% and Meropenam 40%. On the other hand, resistance was Cephradine 100%, Cefotaxim 100%, Imepenam 0%, Cotrimoxale 54%, Amoxicillin and clavulanic acid 100%, Cefixime 64%, Cefuroxime 81%, Ceftriaxone 78%, Azithromycin 75%, Nitrofurantoin 34%, Ceftazidime 81%, Ciprofloxacin 53%, Nalidixic acid 64%, Levofloxacin 29%, Colistin 21%, Gentamycin 20%, Netilmycin 20%, Amikacin 20% and Meropenam 60%. So, the most sensitive drug was Imepenam 100% and the most resistant drugs were Cephradine and Cefotaxim 100% resistance against urinary pathogens. Association between antibiotic use, drug resistance and use of with and without prescription in UTI patients was highly significant. We suggest that empirical antibiotic selection should be based on knowledge of the local prevalence of bacterial organism and their antibiotic resistance in a specific area rather than on universal or even national guidelines.},
     year = {2020}
    }
    

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    T1  - Sensitivity and Resistant Pattern of Commonly Used Drugs in UTI in Younger Children: A Study in a Tertiary Care Level Hospital, Dhaka, Bangladesh
    AU  - Farhana Noman
    AU  - Gulsan Ara Zahan
    AU  - Ferdousi Hasnat
    AU  - Md. Kariul Islam
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    DO  - 10.11648/j.ajp.20200602.25
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
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    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20200602.25
    AB  - Urinary tract infections (UTIs) are one of the most common types of infections in children. Resistance to drug used in UTI is universal crisis in the present world. UTIs are usually caused by bacteria living on or in our bodies, and require treatment with antibiotics. A prospectively observational study was conducted in Kurmitola General Hospital (KGH) from January 2018 to December 2018. A total of 519 culture positive UTI children were considered for analysis. Colony counts for these samples were identified, and the profile of antibiotic resistance was identified. Here, samples with a colony count of ≥105 CFU/mL bacteria were considered positive. Among the children 416 children took antibiotics without prescription and among them 205 (49.2%) was culture positive. The most common pathogen was E-coli (74.31%) which prevailed that taking antibiotics without prescription is highly associated with the drug resistant UTI recurrent abdominal pain. Researcher took 19 antibiotics for susceptibility testing to identify the most resistant and safe drug for the UTI patients. According to the present study sensitive antibiotics were Cephradine 0%, Cefotaxim 0%, Imepenam 100%, Cotrimoxale 46%, amoxicillin and clavulanic acid 0%, Cefixime 36%, Cefuroxime 19%, Ceftriaxone 22%, Azithromycin 25%, Nitrofurantoin 66%, Ceftazidime 19%, Ciprofloxacin 47%, Nalidixic acid 36%, Levofloxacin 71% Colistin 79%, Gentamycin 80%, Netilmycin 80%, Amikacin 80% and Meropenam 40%. On the other hand, resistance was Cephradine 100%, Cefotaxim 100%, Imepenam 0%, Cotrimoxale 54%, Amoxicillin and clavulanic acid 100%, Cefixime 64%, Cefuroxime 81%, Ceftriaxone 78%, Azithromycin 75%, Nitrofurantoin 34%, Ceftazidime 81%, Ciprofloxacin 53%, Nalidixic acid 64%, Levofloxacin 29%, Colistin 21%, Gentamycin 20%, Netilmycin 20%, Amikacin 20% and Meropenam 60%. So, the most sensitive drug was Imepenam 100% and the most resistant drugs were Cephradine and Cefotaxim 100% resistance against urinary pathogens. Association between antibiotic use, drug resistance and use of with and without prescription in UTI patients was highly significant. We suggest that empirical antibiotic selection should be based on knowledge of the local prevalence of bacterial organism and their antibiotic resistance in a specific area rather than on universal or even national guidelines.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Pediatrics, Kurmitola General Hospital, Cantonment, Dhaka, Bangladesh

  • Department of Pediatrics, Kurmitola General Hospital, Cantonment, Dhaka, Bangladesh

  • Department of Pediatrics, Kurmitola General Hospital, Cantonment, Dhaka, Bangladesh

  • International Online Journal Hub, Dhaka, Bangladesh

  • Section