Background and Objective: Severe hemorrhage is a predominant cause of death among trauma patients. Conventional techniques often proved insufficient for hemostasis in junctional injuries. In this study, the hemostatic clamp was independently developed and its efficacy was evaluated using swine models. Methods: 10 healthy Bama miniature pigs aged 6-7 months were divided into two groups. After anesthesia, a femoral artery incision was performed to create model. Hemostatic procedures were preformed after free bleeding for 30 seconds. The control and experimental group were treated with bandages hemostatic clamps, respectively. Survival rate, survival time, hemostatic operation time and blood loss were recorded. After hemostasis, the local joints were repeatedly flexed to assess instruments’ stability. Physiological parameters were monitored and recorded. Ultrasound was used to observe distal blood flow perfusion. After the experiment, local skin was examined and the injured femoral arteries were taken for pathological staining. Results: 5 (100%) and 3 (60%) animals survived in experimental and control group, respectively. Survival time of experimental group was all >180 min, the median survival time and interquartile range of control group were 180 min and 68 min. The hemostatic operation time were 22.50±2.89 min and 57.25±13.60 min, and blood loss were 190±100 g and 549±195 g, respectively. Ultrasound showed the hemostatic clamp effectively reduced distal arterial blood flow and was well-fixed after joint movement, while bandages were relatively loose. No skin damage was observed. Hematoxylin-eosin staining of femoral artery in experimental group showed intravascular thrombosis, while no significant thrombosis in 2 control group. Conclusion: This study developed an effective hemostatic clamp and found it can significantly reduce blood loss, hemostatic operation time and maintain stable vital signs. It is rapid, stable without secondary injuries, demonstrating its potential in controlling severe prehospital hemorrhage.

Hemostatic Clamp, Junctional Bleeding, Hemorrhage Control, Trauma