Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms

Hejer Nusret Aliyeva; Mahira Firudin Kizi Amirova; Huseyn Azizulla Oglu Abıyev; Khaleddin Novruz Musayev; Javanshir Ali Rahimov

doi:doi:10.11648/j.acm.20251403.11

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Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms

Hejer Nusret Aliyeva

, Mahira Firudin Kizi Amirova^*

, Huseyn Azizulla Oglu Abıyev

, Khaleddin Novruz Musayev

, Javanshir Ali Rahimov

Published in Applied and Computational Mathematics (Volume 14, Issue 3)

Received: 5 April 2025 Accepted: 15 April 2025 Published: 29 May 2025

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Abstract

In recent years, breast cancer has emerged as one of the most critical challenges in modern medicine and remains the leading cause of cancer-related mortality among women, with invasive ductal carcinoma representing the predominant histological subtype responsible for death. Early detection and precise molecular subtyping are essential for the timely initiation of targeted therapies, which significantly improve prognosis and clinical outcomes. When ductal carcinoma is identified at the receptor expression stage, the therapeutic landscape becomes more favorable, often allowing for effective intervention with minimal risk of remission. In this context, we employed a diagnostic pathway beginning with ultrasonographic screening, followed by mammographic imaging and culminating in histopathological confirmation. This approach was applied to a patient presenting to our clinic in 2024 with severe systemic symptoms, including a 15 kg weight loss over one month and marked general fatigue. The study outlines a comprehensive diagnostic algorithm implemented at the Diagnostic Department of the National Oncology Center. It provides a detailed exploration of the synergistic roles of Doppler ultrasonography and mammography in the stepwise differential diagnosis of ductal carcinoma of mammary gland. The diagnostic accuracy was enhanced via high-precision Doppler system optimized for directional sound wave propagation. Special consideration was given to the constant velocity of acoustic wave transmission through biological tissues and the impact of the beam-to-tissue angle (conicity) on Doppler frequency shifts. Following surgical excision of the neoplasm, receptor-targeted adjuvant therapy was promptly initiated to mitigate the risk of recurrence. The article concludes with strategic recommendations for future research directions aimed at refining diagnostic methodologies and improving personalized treatment strategies in ductal breast carcinoma.

Published in	Applied and Computational Mathematics (Volume 14, Issue 3)
DOI	10.11648/j.acm.20251403.11
Page(s)	101-106
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Operational Mechanisms, Mammography, Doppler USG, USG Tru-cut Biopsy, Ductal İnvasive Carcinoma

References

[1]	Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, et al. Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2016 Mar; 14(3): 324-54. https://doi.org/10.6004/jnccn.2016.0037
[2]	Ernst MF, Voogd AC, Coebergh JW, Roukema JA. Breast carcinoma diagnosis, treatment, and prognosis before and after the introduction of mass mammographic screening. Cancer. 2004 Apr 1; 100(7): 1337-44. https://doi.org/10.1002/cncr.20139
[3]	Akhundova, J. N., Amirova, M. F., Gasimov, N. V. and Sultanova, M. J. (2024) Which Lymph Nodes Should Be Exactly Removed During Breast Cancer Surgery to Prevent Metastasis? Health, 16, 1013-1026. https://doi.org/10.4236/health.2024.1611069
[4]	Sorice G, Fornaro R, Parodi G, Belcastro E. Il trattamento del carcinoma della mammella. Nostra esperienza [Treatment of breast carcinoma. Our experience]. Ann Ital Chir. 1991 Sep-Oct; 62(5): 437-41. Italian.
[5]	Virnig BA, Tuttle TM, Shamliyan T, Kane RL. Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes. J Natl Cancer Inst. 2010 Feb 3; 102(3): 170-8. https://doi.org/10.1093/jnci/djp482 Epub 2010 Jan 13 .
[6]	Schnitt SJ. Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy. Mod Pathol. 2010 May; 23 Suppl 2: S60-4. https://doi.org/10.1038/modpathol.2010.33
[7]	Shea EKH, Koh VCY, Tan PH. Invasive breast cancer: Current perspectives and emerging views. Pathol Int. 2020 May; 70(5): 242-252. https://doi.org/10.1111/pin.12910 Epub 2020 Feb 10.
[8]	Yersal O, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World J Clin Oncol 2014; 5(3): 412-424 [PMID: 25114856 https://doi.org/10.5306/wjco.v5.i3.412
[9]	Russnes, Hege G. BГёrresen-Dale O. Ch, BГёrresen-Dale A-L, Caldas Cş Breast Cancer Molecular Stratification. The American Journal of Pathology, Elsevier, 0002-9440, Volume 187, Issue 10, 2152 – 2162. https://doi.org/10.1016/j.ajpath.2017.04.022
[10]	Tsang JYS, Tse GM. Molecular Classification of Breast Cancer. Adv Anat Pathol. 2020 Jan; 27(1): 27-35. https://doi.org/10.1097/PAP.0000000000000232
[11]	Crosby D, Bhatia S, Brindle KM, Coussens LM, Dive C, Emberton M, Esener S, Fitzgerald RC, Gambhir SS, Kuhn P, Rebbeck TR, Balasubramanian S. Early detection of cancer. Science. 2022 Mar 18; 375(6586): eaay9040. https://doi.org/10.1126/science.aay9040
[12]	J. N. Akhundova, M. F. Amirova, Lymph nodes morphological changes and breast cancer subtypes' prediction of metastases. eISSN 2079-8334. The world of medicine and biology. 2024. No. 4 (90): 15-9.
[13]	Caldarella A, Buzzoni C, Crocetti E, Bianchi S, Vezzosi V, Apicella P, Biancalani M, Giannini A, Urso C, Zolfanelli F, Paci E. Invasive breast cancer: a significant correlation between histological types and molecular subgroups. J Cancer Res Clin Oncol. 2013 Apr; 139(4): 617-23. https://doi.org/10.1007/s00432-012-1365-1 Epub 2012 Dec 27.
[14]	Petrelli F, Barni S. Response to neoadjuvant chemotherapy in ductal compared to lobular carcinoma of the breast: a meta-analysis of published trials including 1,764 lobular breast cancer. Breast Cancer Res Treat. 2013 Nov; 142(2): 227-35. https://doi.org/10.1007/s10549-013-2751-3 Epub 2013 Nov 1.
[15]	Zhang J, Lu CY, Chen HM, Wu SY. Neoadjuvant Chemotherapy or Endocrine Therapy for Invasive Ductal Carcinoma of the Breast With High Hormone Receptor Positivity and Human Epidermal Growth Factor Receptor 2 Negativity. JAMA Netw Open. 2021 Mar 1; 4(3): e211785. https://doi.org/10.1001/jamanetworkopen.2021.1785

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APA Style

Aliyeva, H. N., Amirova, M. F. K., Abıyev, H. A. O., Musayev, K. N., Rahimov, J. A. (2025). Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms. Applied and Computational Mathematics, 14(3), 101-106. https://doi.org/10.11648/j.acm.20251403.11

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ACS Style

Aliyeva, H. N.; Amirova, M. F. K.; Abıyev, H. A. O.; Musayev, K. N.; Rahimov, J. A. Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms. Appl. Comput. Math. 2025, 14(3), 101-106. doi: 10.11648/j.acm.20251403.11

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AMA Style

Aliyeva HN, Amirova MFK, Abıyev HAO, Musayev KN, Rahimov JA. Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms. Appl Comput Math. 2025;14(3):101-106. doi: 10.11648/j.acm.20251403.11

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@article{10.11648/j.acm.20251403.11,
  author = {Hejer Nusret Aliyeva and Mahira Firudin Kizi Amirova and Huseyn Azizulla Oglu Abıyev and Khaleddin Novruz Musayev and Javanshir Ali Rahimov},
  title = {Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms
},
  journal = {Applied and Computational Mathematics},
  volume = {14},
  number = {3},
  pages = {101-106},
  doi = {10.11648/j.acm.20251403.11},
  url = {https://doi.org/10.11648/j.acm.20251403.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.acm.20251403.11},
  abstract = {In recent years, breast cancer has emerged as one of the most critical challenges in modern medicine and remains the leading cause of cancer-related mortality among women, with invasive ductal carcinoma representing the predominant histological subtype responsible for death. Early detection and precise molecular subtyping are essential for the timely initiation of targeted therapies, which significantly improve prognosis and clinical outcomes. When ductal carcinoma is identified at the receptor expression stage, the therapeutic landscape becomes more favorable, often allowing for effective intervention with minimal risk of remission. In this context, we employed a diagnostic pathway beginning with ultrasonographic screening, followed by mammographic imaging and culminating in histopathological confirmation. This approach was applied to a patient presenting to our clinic in 2024 with severe systemic symptoms, including a 15 kg weight loss over one month and marked general fatigue. The study outlines a comprehensive diagnostic algorithm implemented at the Diagnostic Department of the National Oncology Center. It provides a detailed exploration of the synergistic roles of Doppler ultrasonography and mammography in the stepwise differential diagnosis of ductal carcinoma of mammary gland. The diagnostic accuracy was enhanced via high-precision Doppler system optimized for directional sound wave propagation. Special consideration was given to the constant velocity of acoustic wave transmission through biological tissues and the impact of the beam-to-tissue angle (conicity) on Doppler frequency shifts. Following surgical excision of the neoplasm, receptor-targeted adjuvant therapy was promptly initiated to mitigate the risk of recurrence. The article concludes with strategic recommendations for future research directions aimed at refining diagnostic methodologies and improving personalized treatment strategies in ductal breast carcinoma.
},
 year = {2025}
}

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TY  - JOUR
T1  - Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms

AU  - Hejer Nusret Aliyeva
AU  - Mahira Firudin Kizi Amirova
AU  - Huseyn Azizulla Oglu Abıyev
AU  - Khaleddin Novruz Musayev
AU  - Javanshir Ali Rahimov
Y1  - 2025/05/29
PY  - 2025
N1  - https://doi.org/10.11648/j.acm.20251403.11
DO  - 10.11648/j.acm.20251403.11
T2  - Applied and Computational Mathematics
JF  - Applied and Computational Mathematics
JO  - Applied and Computational Mathematics
SP  - 101
EP  - 106
PB  - Science Publishing Group
SN  - 2328-5613
UR  - https://doi.org/10.11648/j.acm.20251403.11
AB  - In recent years, breast cancer has emerged as one of the most critical challenges in modern medicine and remains the leading cause of cancer-related mortality among women, with invasive ductal carcinoma representing the predominant histological subtype responsible for death. Early detection and precise molecular subtyping are essential for the timely initiation of targeted therapies, which significantly improve prognosis and clinical outcomes. When ductal carcinoma is identified at the receptor expression stage, the therapeutic landscape becomes more favorable, often allowing for effective intervention with minimal risk of remission. In this context, we employed a diagnostic pathway beginning with ultrasonographic screening, followed by mammographic imaging and culminating in histopathological confirmation. This approach was applied to a patient presenting to our clinic in 2024 with severe systemic symptoms, including a 15 kg weight loss over one month and marked general fatigue. The study outlines a comprehensive diagnostic algorithm implemented at the Diagnostic Department of the National Oncology Center. It provides a detailed exploration of the synergistic roles of Doppler ultrasonography and mammography in the stepwise differential diagnosis of ductal carcinoma of mammary gland. The diagnostic accuracy was enhanced via high-precision Doppler system optimized for directional sound wave propagation. Special consideration was given to the constant velocity of acoustic wave transmission through biological tissues and the impact of the beam-to-tissue angle (conicity) on Doppler frequency shifts. Following surgical excision of the neoplasm, receptor-targeted adjuvant therapy was promptly initiated to mitigate the risk of recurrence. The article concludes with strategic recommendations for future research directions aimed at refining diagnostic methodologies and improving personalized treatment strategies in ductal breast carcinoma.

VL  - 14
IS  - 3
ER  -

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Author Information

Hejer Nusret Aliyeva

Diagnostics Department, The National Oncology Centre, Baku, Azerbaijan

Contact Email

http://orcid.org/0009-0000-3616-6828
Mahira Firudin Kizi Amirova

Biochemistry Department, Azerbaijan Medical University, Baku, Azerbaijan

Contact Email

http://orcid.org/0000-0001-5598-6995
Huseyn Azizulla Oglu Abıyev

Medical and Biological Physics Department, Azerbaijan Medical University, Baku, Azerbaijan

Contact Email

http://orcid.org/0009-0004-9319-5317
Khaleddin Novruz Musayev

II Surgery Department, Azerbaijan Medical University, Baku, Azerbaijan

Contact Email

http://orcid.org/0009-0007-7098-9167
Javanshir Ali Rahimov

Epidemiology and Biostatistics Department, Azerbaijan Medical University, Baku, Azerbaijan

Contact Email

http://orcid.org/0009-0003-7930-3775

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Plain Text BibTeX RIS

APA Style

Aliyeva, H. N., Amirova, M. F. K., Abıyev, H. A. O., Musayev, K. N., Rahimov, J. A. (2025). Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms. Applied and Computational Mathematics, 14(3), 101-106. https://doi.org/10.11648/j.acm.20251403.11

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ACS Style

Aliyeva, H. N.; Amirova, M. F. K.; Abıyev, H. A. O.; Musayev, K. N.; Rahimov, J. A. Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms. Appl. Comput. Math. 2025, 14(3), 101-106. doi: 10.11648/j.acm.20251403.11

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AMA Style

Aliyeva HN, Amirova MFK, Abıyev HAO, Musayev KN, Rahimov JA. Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms. Appl Comput Math. 2025;14(3):101-106. doi: 10.11648/j.acm.20251403.11

Copy | Download

@article{10.11648/j.acm.20251403.11,
  author = {Hejer Nusret Aliyeva and Mahira Firudin Kizi Amirova and Huseyn Azizulla Oglu Abıyev and Khaleddin Novruz Musayev and Javanshir Ali Rahimov},
  title = {Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms
},
  journal = {Applied and Computational Mathematics},
  volume = {14},
  number = {3},
  pages = {101-106},
  doi = {10.11648/j.acm.20251403.11},
  url = {https://doi.org/10.11648/j.acm.20251403.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.acm.20251403.11},
  abstract = {In recent years, breast cancer has emerged as one of the most critical challenges in modern medicine and remains the leading cause of cancer-related mortality among women, with invasive ductal carcinoma representing the predominant histological subtype responsible for death. Early detection and precise molecular subtyping are essential for the timely initiation of targeted therapies, which significantly improve prognosis and clinical outcomes. When ductal carcinoma is identified at the receptor expression stage, the therapeutic landscape becomes more favorable, often allowing for effective intervention with minimal risk of remission. In this context, we employed a diagnostic pathway beginning with ultrasonographic screening, followed by mammographic imaging and culminating in histopathological confirmation. This approach was applied to a patient presenting to our clinic in 2024 with severe systemic symptoms, including a 15 kg weight loss over one month and marked general fatigue. The study outlines a comprehensive diagnostic algorithm implemented at the Diagnostic Department of the National Oncology Center. It provides a detailed exploration of the synergistic roles of Doppler ultrasonography and mammography in the stepwise differential diagnosis of ductal carcinoma of mammary gland. The diagnostic accuracy was enhanced via high-precision Doppler system optimized for directional sound wave propagation. Special consideration was given to the constant velocity of acoustic wave transmission through biological tissues and the impact of the beam-to-tissue angle (conicity) on Doppler frequency shifts. Following surgical excision of the neoplasm, receptor-targeted adjuvant therapy was promptly initiated to mitigate the risk of recurrence. The article concludes with strategic recommendations for future research directions aimed at refining diagnostic methodologies and improving personalized treatment strategies in ductal breast carcinoma.
},
 year = {2025}
}

Copy | Download

TY  - JOUR
T1  - Operational Mechanisms as a Reliable Tool for the Challenging Task of Differentiating Neoplasms

AU  - Hejer Nusret Aliyeva
AU  - Mahira Firudin Kizi Amirova
AU  - Huseyn Azizulla Oglu Abıyev
AU  - Khaleddin Novruz Musayev
AU  - Javanshir Ali Rahimov
Y1  - 2025/05/29
PY  - 2025
N1  - https://doi.org/10.11648/j.acm.20251403.11
DO  - 10.11648/j.acm.20251403.11
T2  - Applied and Computational Mathematics
JF  - Applied and Computational Mathematics
JO  - Applied and Computational Mathematics
SP  - 101
EP  - 106
PB  - Science Publishing Group
SN  - 2328-5613
UR  - https://doi.org/10.11648/j.acm.20251403.11
AB  - In recent years, breast cancer has emerged as one of the most critical challenges in modern medicine and remains the leading cause of cancer-related mortality among women, with invasive ductal carcinoma representing the predominant histological subtype responsible for death. Early detection and precise molecular subtyping are essential for the timely initiation of targeted therapies, which significantly improve prognosis and clinical outcomes. When ductal carcinoma is identified at the receptor expression stage, the therapeutic landscape becomes more favorable, often allowing for effective intervention with minimal risk of remission. In this context, we employed a diagnostic pathway beginning with ultrasonographic screening, followed by mammographic imaging and culminating in histopathological confirmation. This approach was applied to a patient presenting to our clinic in 2024 with severe systemic symptoms, including a 15 kg weight loss over one month and marked general fatigue. The study outlines a comprehensive diagnostic algorithm implemented at the Diagnostic Department of the National Oncology Center. It provides a detailed exploration of the synergistic roles of Doppler ultrasonography and mammography in the stepwise differential diagnosis of ductal carcinoma of mammary gland. The diagnostic accuracy was enhanced via high-precision Doppler system optimized for directional sound wave propagation. Special consideration was given to the constant velocity of acoustic wave transmission through biological tissues and the impact of the beam-to-tissue angle (conicity) on Doppler frequency shifts. Following surgical excision of the neoplasm, receptor-targeted adjuvant therapy was promptly initiated to mitigate the risk of recurrence. The article concludes with strategic recommendations for future research directions aimed at refining diagnostic methodologies and improving personalized treatment strategies in ductal breast carcinoma.

VL  - 14
IS  - 3
ER  -

Copy | Download