Microsporidia are obligate intracellular parasitic fungi causing chronic diarrhea, particularly among immunocompromised patients. Microsporidial infections have been recognized as an increasingly important infection, particularly among those hospitalised with HIV/AIDS infected patients at the federal medical centre (FMC), Keffi, Nasarawa State. One health facility was used to engage HIV/AIDS infected patient accessing antiretroviral therapy (ART) to identify the presence of microsporidium and to determine the associated risk factors. 252 stool samples were examined for microsporidial spores by modified giemsa staining technique. The overall prevalence rate of 15.08% was recorded. Based on age group, microsporidia infection was common among patients aged between 61-70years 15.0% while sex-related, the male had 30.43% rate of infection. Though, marital status, occupation, and widow/widower had 15.79% and artisans (33.33%) respectively. The vulnerability was determined by their fate and status. However, chi-square result showed no significant relationship observed (P>0.05) between the age, and sex- distribution of microsporidium. The proportion among occupation and marital related distribution of microsporidium among HIV/AIDS infected patients were diarrhoic. In relation to viral load, all positive HIV/AIDS infected patients with microsporidia spore had viral load above normal. Twenty-five (25) HIV/AIDS infected patients had 10,000ml/viral load in replicates. Microsporidium is therefore, identified and recognized as an invasive opportunistic infection among HIV/AIDS infected patients which should be considered in a routine checks among HIV/AIDS infected patients.
| Published in | Advances (Volume 4, Issue 3) |
| DOI | 10.11648/j.advances.20230403.14 |
| Page(s) | 111-115 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2023. Published by Science Publishing Group |
Current Microsporidium Status, Among Hospitalised, Hiv/Aids, Infected Patients, Medical Centre
| [1] | Anane, S. and Attouchi, H. (2010) Microsporidiosis: Epidemiology, clinical data and therapy. Gastroenterology and Clinical Biology (34) 450–464. |
| [2] | Anuar TS; Al-Mekhlafi HM; Salleh FM and Moktar N (2013). New insights of microsporidial infection among asymptomatic Aboriginal population in Malaysia. Plos one 8: 1-8. |
| [3] | Daar ES (2021). Evaluation of the treatment-experienced patient failing HIV therapy. In: Sax PE, ed. Up to date. |
| [4] | Deng, L. et al. (2017) Multi-locus genotypes of Enterocytozoon bieneusi in captive Asiatic black bears in southwestern China: High genetic diversity, broad host range, and zoonotic potential. Plos One. (12). |
| [5] | Didier ES, Weiss LM. (2011); Microsporidiosis: current status,. Current Opinion Infectious Disease. 19 (5): 485-492. |
| [6] | Didier ES. (2005); Microsporidiosis: an emerging and opportunistic infection in humans and animals. Acta Tropica. 94 (1): 61–76. |
| [7] | Eligio-Garcia L, Cano-Estrada A, Cruz C, Jimenez-CardosoE. (2016). Association of viral load and CD4+ count with infection of intestinal emerging parasites in HIV patients. Journal of AIDS and Clinical Research. 7: 644. |
| [8] | Ghoyounchi, R. et al. (2017) Microsporidiosis in Iran: A systematic review and meta-analysis. Asian Pac J Trop Med. (10) 341–350. |
| [9] | Han B, Weiss LM. (2017); Microsporidia: Obligate Intracellular Pathogens within the Fungal Kingdom. Microbiology Spectrum. 5 10.1128 [Google Scholar]. |
| [10] | Ikeh EL, Obadofin MO, Brindeiro B, Baugherb C, Frost F. (2007). Intestinal parasitism in Magama Gumau rural village and Jos township in North Central, Nigeria. Nigerian Post Graduate Medical Journal. 14 (4): 290-295 [pub med] [Google scholar]. |
| [11] | Li W, Feng Y, Santin M. (2019). Host specificity of Enterocytozoon bieneusi and public health implications. Trends in parasitology. 35 (6): 436-51. |
| [12] | Lono A; Kumar GS; Chye TT. (2010). Prevalence of microsporidia in an indigenous among Asli community in Pahang, Malaysia. Trang R. soc trop med hug 104: 214-218. |
| [13] | Maggi P, Larocca AM, Quarto M, Serio G, Brandonisio O, Angarano G, Pastore G (2000). Effect of antiretroviral therapy on cryptosporidiosis and microsporidiosis in patients infected with human immunodeficiency virus type 1. Europian Journal of Clinical Microbiology and Infectious Disease 19: 213-217. |
| [14] | Matos, O., Lobo, M. L. & Xiao, L. (2012). Epidemiology of Enterocytozoon bieneusi Infection in Humans. Journal of Parasitology Research. 981424. |
| [15] | Norhayati M; Al-Mekhlafi HM; Azlin M; Nor Aini U; Shaik A (2007). Intestinal microsporidial infections among orang Asli (aborigine) children from Malaysia. Annals of tropical medicine and parasitology. 101: 547-550. |
| [16] | Nur-Amira Hassan, Yvonne AL Lim, and Romano Ngui (2018). Molecular diagnosis of microsporidia among immunocompramised patients in Kuala Lumpur, Malaysia. American Journal of Tropical Medicine and Hyegiene. 99 (6): 1562-1566. |
| [17] | Nyamngee A, Edungbola LD, Agbede OO, Salami AK, Nwabuisi C, Akanbi AA 2nd, Ibrahim OOK, Tilahun M, Moser DB. (2013). Prevalence, intensity and coplictions of microsporidium spores amongs HIV-positive hospital patients in Ilorin, Nigeria; original research. African Journal of Laboratory Medicine. 2: 66. |
| [18] | Samie A, Patricia RM, Tanih N, Elbakri A. (2021). Molecular Epidemiology of Microsporidia among HIV-positive and HIV-negative patients in the Limpopo Province, South Africa. Journal of infection in developing countries; 15 (5): 710-718. |
| [19] | Speich B, Croll D, Furst T, Utzinger J, Keiser J. (2016). Effect of sanitation and water on intestinal protozoa infection: a systematic review and meta-analysis. Lancet Infectious Diseases. 16: 87-99. |
APA Style
Juliana Bitrus, Yako Andrew Bmibmitawuza, Ombugadu Ruth Jamila, Tongjura Joseph. (2023). Current Status of Microsporidium Among Hospitalised Human Immunodeficiency Virus (HIV/AIDS) Infected Patients, Federal Medical Centre, Keffi, Nigeria. Advances, 4(3), 111-115. https://doi.org/10.11648/j.advances.20230403.14
ACS Style
Juliana Bitrus; Yako Andrew Bmibmitawuza; Ombugadu Ruth Jamila; Tongjura Joseph. Current Status of Microsporidium Among Hospitalised Human Immunodeficiency Virus (HIV/AIDS) Infected Patients, Federal Medical Centre, Keffi, Nigeria. Advances. 2023, 4(3), 111-115. doi: 10.11648/j.advances.20230403.14
AMA Style
Juliana Bitrus, Yako Andrew Bmibmitawuza, Ombugadu Ruth Jamila, Tongjura Joseph. Current Status of Microsporidium Among Hospitalised Human Immunodeficiency Virus (HIV/AIDS) Infected Patients, Federal Medical Centre, Keffi, Nigeria. Advances. 2023;4(3):111-115. doi: 10.11648/j.advances.20230403.14
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Download@article{10.11648/j.advances.20230403.14,
author = {Juliana Bitrus and Yako Andrew Bmibmitawuza and Ombugadu Ruth Jamila and Tongjura Joseph},
title = {Current Status of Microsporidium Among Hospitalised Human Immunodeficiency Virus (HIV/AIDS) Infected Patients, Federal Medical Centre, Keffi, Nigeria},
journal = {Advances},
volume = {4},
number = {3},
pages = {111-115},
doi = {10.11648/j.advances.20230403.14},
url = {https://doi.org/10.11648/j.advances.20230403.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.advances.20230403.14},
abstract = {Microsporidia are obligate intracellular parasitic fungi causing chronic diarrhea, particularly among immunocompromised patients. Microsporidial infections have been recognized as an increasingly important infection, particularly among those hospitalised with HIV/AIDS infected patients at the federal medical centre (FMC), Keffi, Nasarawa State. One health facility was used to engage HIV/AIDS infected patient accessing antiretroviral therapy (ART) to identify the presence of microsporidium and to determine the associated risk factors. 252 stool samples were examined for microsporidial spores by modified giemsa staining technique. The overall prevalence rate of 15.08% was recorded. Based on age group, microsporidia infection was common among patients aged between 61-70years 15.0% while sex-related, the male had 30.43% rate of infection. Though, marital status, occupation, and widow/widower had 15.79% and artisans (33.33%) respectively. The vulnerability was determined by their fate and status. However, chi-square result showed no significant relationship observed (P>0.05) between the age, and sex- distribution of microsporidium. The proportion among occupation and marital related distribution of microsporidium among HIV/AIDS infected patients were diarrhoic. In relation to viral load, all positive HIV/AIDS infected patients with microsporidia spore had viral load above normal. Twenty-five (25) HIV/AIDS infected patients had 10,000ml/viral load in replicates. Microsporidium is therefore, identified and recognized as an invasive opportunistic infection among HIV/AIDS infected patients which should be considered in a routine checks among HIV/AIDS infected patients.},
year = {2023}
}
TY - JOUR T1 - Current Status of Microsporidium Among Hospitalised Human Immunodeficiency Virus (HIV/AIDS) Infected Patients, Federal Medical Centre, Keffi, Nigeria AU - Juliana Bitrus AU - Yako Andrew Bmibmitawuza AU - Ombugadu Ruth Jamila AU - Tongjura Joseph Y1 - 2023/09/25 PY - 2023 N1 - https://doi.org/10.11648/j.advances.20230403.14 DO - 10.11648/j.advances.20230403.14 T2 - Advances JF - Advances JO - Advances SP - 111 EP - 115 PB - Science Publishing Group SN - 2994-7200 UR - https://doi.org/10.11648/j.advances.20230403.14 AB - Microsporidia are obligate intracellular parasitic fungi causing chronic diarrhea, particularly among immunocompromised patients. Microsporidial infections have been recognized as an increasingly important infection, particularly among those hospitalised with HIV/AIDS infected patients at the federal medical centre (FMC), Keffi, Nasarawa State. One health facility was used to engage HIV/AIDS infected patient accessing antiretroviral therapy (ART) to identify the presence of microsporidium and to determine the associated risk factors. 252 stool samples were examined for microsporidial spores by modified giemsa staining technique. The overall prevalence rate of 15.08% was recorded. Based on age group, microsporidia infection was common among patients aged between 61-70years 15.0% while sex-related, the male had 30.43% rate of infection. Though, marital status, occupation, and widow/widower had 15.79% and artisans (33.33%) respectively. The vulnerability was determined by their fate and status. However, chi-square result showed no significant relationship observed (P>0.05) between the age, and sex- distribution of microsporidium. The proportion among occupation and marital related distribution of microsporidium among HIV/AIDS infected patients were diarrhoic. In relation to viral load, all positive HIV/AIDS infected patients with microsporidia spore had viral load above normal. Twenty-five (25) HIV/AIDS infected patients had 10,000ml/viral load in replicates. Microsporidium is therefore, identified and recognized as an invasive opportunistic infection among HIV/AIDS infected patients which should be considered in a routine checks among HIV/AIDS infected patients. VL - 4 IS - 3 ER -
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