Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression

Heng Zhang; Binxia Zhu; Runfeng Zhang

doi:doi:10.11648/j.ajcem.20241204.13

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Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression

Heng Zhang

, Binxia Zhu

, Runfeng Zhang^*

Published in American Journal of Clinical and Experimental Medicine (Volume 12, Issue 4)

Received: 10 September 2024 Accepted: 19 November 2024 Published: 28 November 2024

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Abstract

To investigate the effects of psycho-cardiology combined with fastigial nucleus stimulation (FNS) on patients with stable coronary artery disease (SCAD) complicated with depression, we observed the changes of concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP), tumor necrosis factor-α(TNF-α), 5-hydroxytryptamine (5-HT), dopamine (DA) and depressive symptoms in these patients. One hundred and fifty patients, who were hospitalized the Department of Cardiology at the Third People's Hospital of Mianyang from February 2020 to October 2021 with a confirmed diagnosis of SCAD combined with depression, were selected as study subjects. Patients were randomly divided into a control group, a psycho-cardiology treatment group and a combined treatment group. The control group was given conventional treatment of SCAD and pseudo-stimulation of the fastigial nucleus, the psycho-cardiology treatment group was given conventional treatment of SCAD, psychological interventions and pseudo-stimulation of the fastigial nucleus, and the combined treatment group was given conventional treatment of SCAD, psychological intervention and FNS. The changes of concentrations of TNF-α, NT-proBNP, 5-HT and DA were observed in the three groups of patients, and the changes of the state of depression were assessed by Hamilton Depression Scale (HAMD). Serum NT-proBNP and TNF-α concentrations decreased significantly after treatment in the three groups. Especially, the decrease in the combined treatment group was the most significant(p<0.05). Serum 5-HT and DA concentrations were not statistically different in the three groups before and after treatment (p>0.05). However, they were significantly higher in the psycho-cardiology treatment group and the combined treatment group(p<0.05) and the increase in the combined treatment group was more significant than in the psycho-cardiology treatment group. In the control group, the difference of HAMD scores was not statistically significant before and after treatment (p>0.05), in the psycho-cardiology treatment group and the combined treatment group, the scores decreased significantly after treatment compared to before treatment (p<0.05). Furthermore, compared to the psycho-cardiology treatment group, the decrease was more significant in the combined treatment group (p<0.05). Our data suggested that Psycho-cardiology medicine combined with FNS can effectively reduce the level of serum NT-proBNP and TNF-α, increase the serum concentrations of 5-HT and DA and improve the symptoms of depression in patients with SCAD complicated with depression.

Published in	American Journal of Clinical and Experimental Medicine (Volume 12, Issue 4)
DOI	10.11648/j.ajcem.20241204.13
Page(s)	52-60
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Psycho-cardiology Treatment, Fastigial Nucleus Stimulation, Stable Coronary Artery Disease, Depression

References

[1]	Liu MB, He XY, Yang XH, et al. Interpretation of the Key Points of China Cardiovascular Health and Disease Report 2023 [J]. Journal of Clinical Cardiology, 2024,40(08):599-616. https://doi.org/10.13201/j.issn.1001-1439.2024.08.002
[2]	Wu Y, Zhu B, Chen Z, Duan J, Luo A, Yang L, Yang C. New Insights into the Comorbidity of Coronary Heart Disease and Depression. Curr Probl Cardiol. 2021 Mar; 46(3): 100413. https://doi.org/10.1016/j.cpcardiol.2019.03.002
[3]	Vaccarino V, Sullivan S, Hammadah M, et al. Mental Stress-Induced-Myocardial Ischemia in Young Patients ith Recent Myocardial Infarction: Sex Differences and Mechanisms [J]. Circulation, 2018, 137(8): 794-805. https://doi.org/10.1161/CIRCULATIONAHA.117.030849
[4]	Wen Y, Yang Y, Shen J, et al. Anxiety and prognosis of patients with myocardial infarction: A meta-analysis [J]. Clin Cardiol, 2021, 44(6): 761-770. https://doi.org/10.1002/clc.23605
[5]	Gao Yang, Zhou Hongdan, Yang Yutong, et al. Research progress of anxiety and depression in patients with coronary heart disease [J]. Primary Health Care in China, 2019, 33, 12: 74-77. https://doi.org/10.3969/j.issn.1001-568X.2019.12.0024
[6]	Ghosh RK, Ball S, Prasad V, et al. Depression in heart failure: Intricate relationship, pathophysiology and most updated evidence of interventions from recent clinical studies [J]. Int J Cardiol, 2016, 224: 170-177. https://doi.org/10.1016/j.ijcard.2016.09.063
[7]	Liu Jian, Wu Jue, Wang Tongyu, et al. Effect of sertraline on elderly patients with coronary heart disease with anxiety and depression after percutaneous coronary intervention [J]. Chinese Journal of Clinical Pharmacology, 2020536(06): 613-616. https://doi.org/10.13699/j.cnki.1001-6821.2020.06.006
[8]	Yang J, Hu H, Li Y. Effect of Dual-track Interactive Nursing Intervention Model on Anxiety and Depression in Patients with Coronary Heart Disease. Psychiatr Danub. 2020 Summer; 32(2): 197-204. https://doi.org/10.24869/psyd.2020.197
[9]	Davidson KW, Alcántara C, Miller GE. Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities. Am Psychol. 2018 Nov; 73(8): 1019-1030. https://doi.org/10.1037/amp0000239
[10]	Zhang XY, Wang JJ, Zhu JN. Cerebellar fastigial nucleus: from anatomic construction to physiological functions. Cerebellum Ataxias. 2016 May 3; 3: 9. https://doi.org/10.1186/s40673-016-0047-1
[11]	Miura, M, and D J Reis. “Cerebellum: a pressor response elicited from the fastigial nucleus and its efferent pathway in brainstem.” Brain research vol. 13,3(1969): 595-9. https://doi.org/10.1016/0006-8993(69)90269-8
[12]	Golanov EV, Zhou P. Neurogenic neuroprotection. Cell Mol Neurobiol.2003Oct; 23(4-5): 651-63. https://doi.org/10.1023/a:1025088516742
[13]	Yu, Jiang et al. “Cerebellar fastigial nucleus electrostimulation attenuates inflammation in a Post-Infarction rat model by activating cholinergic anti-inflammatory pathway.” Neuroscience letters vol. 788(2022): 136860. https://doi.org/10.1016/j.neulet.2022.136860
[14]	Su, Mouxiao et al. “Effects of fastigial nucleus electrostimulation on cardiac nerve regeneration, neurotransmitter release, and malignant arrhythmia inducibility in a post-infarction rat model.” The European journal of neuroscience vol. 54,11 (2021): 8006-8019. https://doi.org/10.1111/ejn.15521
[15]	Zhang Runfeng, Li Xia, Hu Dayi, et al. Effect of cerebellar fastigial nucleus stimulation on serotonin content in brain tissue of rats with myocardial infarction [J]. Journal of Shanxi Medical University, 2011 42nd (8): 613-616. https://doi.org/10.3969/J.ISSN.1007-6611.2011.08.001
[16]	Lei Xin. Effect of cerebellar fastigial nucleus stimulation on autonomic nervous function in patients with coronary heart disease [D]. North Sichuan Medical College, 2019 https://doi.org/10.27755/d.cnki.gcbyx.2019.000075
[17]	Liu Xiaoju. Effect of cerebellar fastigial nucleus stimulation on oxidative stress injury in patients with coronary heart disease [D]. North Sichuan Medical College, 2020. https://doi.org/10.27755/d.cnki.gcbyx.2020.000153
[18]	Li Wensong. Effect of cerebellar fastigial nucleus stimulation on serum inflammatory factors in patients with coronary heart disease [D]. Southwest Medical University, 2020. https://doi.org/10.27215/d.cnki.glzyu.2020.000301
[19]	Helgers SOA, Al Krinawe Y, Alam M, Krauss JK, Schwabe K, Hermann EJ, Al-Afif S. Lesion of the Fastigial Nucleus in Juvenile Rats Deteriorates Rat Behavior in Adulthood, Accompanied by Altered Neuronal Activity in the Medial Prefrontal Cortex. Neuroscience. 2020 Aug 21; 442: 29-40. https://doi.org/10.1016/j.neuroscience.2020.06.035
[20]	Li Y, Zhang X, Chen L, Yang B, Sui R. Cerebellar fastigial nucleus is involved in post-stroke depression through direct cerebellar-hypothalamic GABAergic and glutamatergic projections. Exp Ther Med. 2019 Oct; 18(4): 2885-2892. https://doi.org/10.3892/etm.2019.7913
[21]	You Zhixing, Zhou Shaohua, Xi Gangming. Effects of cerebellar fastigial nucleus stimulation on post-stroke depression and daily activity ability [J]. Western Medicine, 2009. 21(11): 1909-1911. https://doi.org/10.3969/j.issn.1672-3511.2009.11.032
[22]	Guo Ganghua, Li Zhe, Le Lin, et al. Effects of cerebellar fastigial nucleus stimulation on post-stroke depression and activities of daily living [J]. Nerve injury and functional Reconstruction, 2008, (4): 248250. https://doi.org/10.3870/j.issn.1001-117X.2008.04.010
[23]	Penninx BW. Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms [J]. Neurosci Biobehav Rev, 2017, 74(Pt B): 277-286. https://doi.org/10.1016/j.neubiorev.2016.07.003
[24]	Farquhar JM, Stonerock GL, Blumenthal JA. Treatment of Anxiety in Patients With Coronary Heart Disease: A Systematic Review [J]. Psychosomatics, 2018, 59(4): 318-332. https://doi.org/10.1016/j.psym.2018.03.008
[25]	De Hert M, Detraux J, Vancampfort D. The intriguing relationship between coronary heart disease and mental disorders [J]. Dialogues Clin Neurosci, 2018, 20(1): 31-40. https://doi.org/10.31887/DCNS.2018.20.1/mdehert
[26]	Chow SL, Maisel AS, Anand I, et al. Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement from the American Heart Association [J]. Circulation, 2017, 135(22): e1054-e1091. https://doi.org/10.1161/CIR.0000000000000490
[27]	Pitsavos C, Panagiotakos DB, Papageorgiou C, et al. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study [J]. Atherosclerosis, 2006, 185(2): 320-326. https://doi.org/10.1016/j.atherosclerosis.2005.06.001
[28]	Jin XZ, Zhuang XS, Ning B, et al. Application of psycho-cardiology medical mode in patients with coronary artery disease (CAD) and hypertension complicated with depression [J]. Anhui Medical Journal, 2014, 0(8): 1031-1033. https://doi.org/10.3969/j.issn.1000-0399.2014.08.003
[29]	Huang Zheng, Lou Xiaoping, Zheng Xiao, et al. Construction and implementation of rehabilitation model for patients after percutaneous coronary stent implantation based on bicardiac medicine [J]. Nursing Education in China, 2019. 16(3): 178-182. https://doi.org/10.3761/j.issn.1672-9234.2019.03.003
[30]	Zhang Heng, Zhang Runfeng. Research progress of cerebellar fastigial nucleus electrical stimulation against myocardial ischemia [J]. Sichuan Medicine, 2021, 42(8): 843,846. https://doi.org/10.16252/j.cnki.issn1004-0501-2021.08.018
[31]	Wang M, Guo J, Dong LN, et al. Cerebellar Fastigial Nucleus Stimulation in a Chronic Unpredictable Mild Stress Rat Model Reduces Post-Stroke Depression by Suppressing Brain Inflammation via the microRNA-29c/TNFRSF1A Signaling Pathway [J]. Med Sci Monit, 2019, 25: 5594-5605. https://doi.org/10.12659/MSM.911835
[32]	Kotchabhakdi N, Walberg F. Cerebeller afferents from neurons in motor nuclei of cranial nerves demonstrated by retrograde axonal transport of horseradish peroxidase [J]. BrainRes,1977, 137(1): 158-163. https://doi.org/10.1016/0006-8993(77)91020-4
[33]	Nathan MA. Vasomotor projections of the nucleus fastigii to the medulla [J]. Brain Res, 1972, 41(1): 194-198. https://doi.org/10.1016/0006-8993(72)90628-2
[34]	Hein, Ernst et al. “Auricular transcutaneous electrical nerve stimulation in depressed patients: a randomized controlled pilot study.” Journal of neural transmission (Vienna, Austria: 1996) vol. 120,5(2013): 821-7. https://doi.org/10.1007/s00702-012-0908-6.
[35]	D'Urso G, Brunoni AR, Anastasia A, Micillo M, de Bartolomeis A, Mantovani A. Polarity-dependent effects of transcranial direct current stimulation in obsessive-compulsive disorder. Neurocase. 2016; 22(1): 60-4. https://doi.org/10.1080/13554794.2015.1045522.
[36]	Cimpianu, Camelia-Lucia et al. “Vagus nerve stimulation in psychiatry: a systematic review of the available evidence.” Journal of neural transmission (Vienna, Austria: 1996) vol. 124,1(2017): 145-158. https://doi.org/10.1007/s00702-016-1642-2
[37]	Yang Xianrong, Song Xiaopan, Zeng Chengbi, et al. Physiological characteristics and detection pathway of serotonin in brain [J]. Sichuan Jingshen Health, 2017, 30(2): 196,200. https://doi.org/10.11886/j.issn.1007-3256.2017.02.024
[38]	Amigó J, Díaz A, Pilar-Cuéllar F, et al. The absence of 5-HT (4) receptors modulates depression- and anxiety-like responses and influences the response of fluoxetine in olfactory bulbectomised mice: Adaptive changes in hippocampal neuroplasticity markers and 5-HT(1A) autoreceptor [J]. Neuropharmcolgy, 2016, 111: 47-58. https://doi.org/10.1016/j.neuropharm.2016.08.037
[39]	Fernandes N, Prada L, Rosa MM, et al. The impact of SSRIs on mortality and cardiovascular events in patients with coronary artery disease and depression: systematic review and meta-analysis. Clin Res Cardiol. 2021; 110(2): 183-193. https://doi.org/10.1007/s00392-020-01697-8
[40]	Liu JL, Li JP, Dong WW. Clinical Discussion on theTreatment of Post-stroke Depression with Fastigial Nucleus Stimulation [J]. Chinese Journal of Tissue Engineering Reasrch,2003,7(13): 1926-1927. https://doi.org/10.3321/j.issn:1673-8225.2003.13.007
[41]	Wu Jing, Deng Zhikuan. Effect of electrical stimulation of cerebellar fastigial nucleus on the content of monoamine transmitters in frontal lobe of depressed rats [J]. Chinese Journal of physical Medicine and Rehabilitation, 2009, 31(2): 78-81. https://doi.org/10.3760/cma.j.issn.0254-1424.2009.02.002
[42]	Huguet G, Kadar E, Temel Y, et al. Electrical Stimulation Normalizes c-Fos Expression in the Deep Cerebellar Nuclei of Depressive-like Rats: Implication of Antidepressant Activity [J]. Cerebellum, 2017, 16(2): 398-410. https://doi.org/10.1007/s12311-016-0812-y
[43]	Esler, Murray. “Mental stress and human cardiovascular disease.” Neuroscience and biobehavioral reviews vol. 74, Pt B (2017): 269-276. https://doi.org/10.1016/j.neubiorev.2016.10.011
[44]	Stapelberg NJ, Hamilton-Craig I, Neumann DL, et al. Mind and heart: heart rate variability in major depressive disorder and coronary heart disease - a review and recommendations [J]. Aust N Z J Psychiatry, 2012, 46(10): 946-957. https://doi.org/10.1177/0004867412444624
[45]	Kidwell M, Ellenbroek BA. Heart and soul: heart rate variability and major depression [J]. Behav Pharmacol, 2018, 29(2and3-SpecIssue):152-164. https://doi.org/10.1097/FBP.0000000000000387

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APA Style

Zhang, H., Zhu, B., Zhang, R. (2024). Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression. American Journal of Clinical and Experimental Medicine, 12(4), 52-60. https://doi.org/10.11648/j.ajcem.20241204.13

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ACS Style

Zhang, H.; Zhu, B.; Zhang, R. Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression. Am. J. Clin. Exp. Med. 2024, 12(4), 52-60. doi: 10.11648/j.ajcem.20241204.13

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AMA Style

Zhang H, Zhu B, Zhang R. Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression. Am J Clin Exp Med. 2024;12(4):52-60. doi: 10.11648/j.ajcem.20241204.13

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@article{10.11648/j.ajcem.20241204.13,
  author = {Heng Zhang and Binxia Zhu and Runfeng Zhang},
  title = {Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression
},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {12},
  number = {4},
  pages = {52-60},
  doi = {10.11648/j.ajcem.20241204.13},
  url = {https://doi.org/10.11648/j.ajcem.20241204.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20241204.13},
  abstract = {To investigate the effects of psycho-cardiology combined with fastigial nucleus stimulation (FNS) on patients with stable coronary artery disease (SCAD) complicated with depression, we observed the changes of concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP), tumor necrosis factor-α(TNF-α), 5-hydroxytryptamine (5-HT), dopamine (DA) and depressive symptoms in these patients. One hundred and fifty patients, who were hospitalized the Department of Cardiology at the Third People's Hospital of Mianyang from February 2020 to October 2021 with a confirmed diagnosis of SCAD combined with depression, were selected as study subjects. Patients were randomly divided into a control group, a psycho-cardiology treatment group and a combined treatment group. The control group was given conventional treatment of SCAD and pseudo-stimulation of the fastigial nucleus, the psycho-cardiology treatment group was given conventional treatment of SCAD, psychological interventions and pseudo-stimulation of the fastigial nucleus, and the combined treatment group was given conventional treatment of SCAD, psychological intervention and FNS. The changes of concentrations of TNF-α, NT-proBNP, 5-HT and DA were observed in the three groups of patients, and the changes of the state of depression were assessed by Hamilton Depression Scale (HAMD). Serum NT-proBNP and TNF-α concentrations decreased significantly after treatment in the three groups. Especially, the decrease in the combined treatment group was the most significant(p). Serum 5-HT and DA concentrations were not statistically different in the three groups before and after treatment (p>0.05). However, they were significantly higher in the psycho-cardiology treatment group and the combined treatment group(p) and the increase in the combined treatment group was more significant than in the psycho-cardiology treatment group. In the control group, the difference of HAMD scores was not statistically significant before and after treatment (p>0.05), in the psycho-cardiology treatment group and the combined treatment group, the scores decreased significantly after treatment compared to before treatment (p). Furthermore, compared to the psycho-cardiology treatment group, the decrease was more significant in the combined treatment group (p). Our data suggested that Psycho-cardiology medicine combined with FNS can effectively reduce the level of serum NT-proBNP and TNF-α, increase the serum concentrations of 5-HT and DA and improve the symptoms of depression in patients with SCAD complicated with depression.
},
 year = {2024}
}

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TY  - JOUR
T1  - Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression

AU  - Heng Zhang
AU  - Binxia Zhu
AU  - Runfeng Zhang
Y1  - 2024/11/28
PY  - 2024
N1  - https://doi.org/10.11648/j.ajcem.20241204.13
DO  - 10.11648/j.ajcem.20241204.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 52
EP  - 60
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20241204.13
AB  - To investigate the effects of psycho-cardiology combined with fastigial nucleus stimulation (FNS) on patients with stable coronary artery disease (SCAD) complicated with depression, we observed the changes of concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP), tumor necrosis factor-α(TNF-α), 5-hydroxytryptamine (5-HT), dopamine (DA) and depressive symptoms in these patients. One hundred and fifty patients, who were hospitalized the Department of Cardiology at the Third People's Hospital of Mianyang from February 2020 to October 2021 with a confirmed diagnosis of SCAD combined with depression, were selected as study subjects. Patients were randomly divided into a control group, a psycho-cardiology treatment group and a combined treatment group. The control group was given conventional treatment of SCAD and pseudo-stimulation of the fastigial nucleus, the psycho-cardiology treatment group was given conventional treatment of SCAD, psychological interventions and pseudo-stimulation of the fastigial nucleus, and the combined treatment group was given conventional treatment of SCAD, psychological intervention and FNS. The changes of concentrations of TNF-α, NT-proBNP, 5-HT and DA were observed in the three groups of patients, and the changes of the state of depression were assessed by Hamilton Depression Scale (HAMD). Serum NT-proBNP and TNF-α concentrations decreased significantly after treatment in the three groups. Especially, the decrease in the combined treatment group was the most significant(p). Serum 5-HT and DA concentrations were not statistically different in the three groups before and after treatment (p>0.05). However, they were significantly higher in the psycho-cardiology treatment group and the combined treatment group(p) and the increase in the combined treatment group was more significant than in the psycho-cardiology treatment group. In the control group, the difference of HAMD scores was not statistically significant before and after treatment (p>0.05), in the psycho-cardiology treatment group and the combined treatment group, the scores decreased significantly after treatment compared to before treatment (p). Furthermore, compared to the psycho-cardiology treatment group, the decrease was more significant in the combined treatment group (p). Our data suggested that Psycho-cardiology medicine combined with FNS can effectively reduce the level of serum NT-proBNP and TNF-α, increase the serum concentrations of 5-HT and DA and improve the symptoms of depression in patients with SCAD complicated with depression.

VL  - 12
IS  - 4
ER  -

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Heng Zhang

Department of Cardiology, Ziyang People's Hospital, Ziyang, China

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http://orcid.org/0000-0001-5174-9749
Binxia Zhu

Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

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http://orcid.org/0009-0001-4880-7212
Runfeng Zhang

Department of Cardiology, Mianyang 404 Hospital, Mianyang, China

Contact Email

http://orcid.org/0000-0002-7435-1159

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APA Style

Zhang, H., Zhu, B., Zhang, R. (2024). Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression. American Journal of Clinical and Experimental Medicine, 12(4), 52-60. https://doi.org/10.11648/j.ajcem.20241204.13

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ACS Style

Zhang, H.; Zhu, B.; Zhang, R. Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression. Am. J. Clin. Exp. Med. 2024, 12(4), 52-60. doi: 10.11648/j.ajcem.20241204.13

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AMA Style

Zhang H, Zhu B, Zhang R. Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression. Am J Clin Exp Med. 2024;12(4):52-60. doi: 10.11648/j.ajcem.20241204.13

Copy | Download

@article{10.11648/j.ajcem.20241204.13,
  author = {Heng Zhang and Binxia Zhu and Runfeng Zhang},
  title = {Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression
},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {12},
  number = {4},
  pages = {52-60},
  doi = {10.11648/j.ajcem.20241204.13},
  url = {https://doi.org/10.11648/j.ajcem.20241204.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20241204.13},
  abstract = {To investigate the effects of psycho-cardiology combined with fastigial nucleus stimulation (FNS) on patients with stable coronary artery disease (SCAD) complicated with depression, we observed the changes of concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP), tumor necrosis factor-α(TNF-α), 5-hydroxytryptamine (5-HT), dopamine (DA) and depressive symptoms in these patients. One hundred and fifty patients, who were hospitalized the Department of Cardiology at the Third People's Hospital of Mianyang from February 2020 to October 2021 with a confirmed diagnosis of SCAD combined with depression, were selected as study subjects. Patients were randomly divided into a control group, a psycho-cardiology treatment group and a combined treatment group. The control group was given conventional treatment of SCAD and pseudo-stimulation of the fastigial nucleus, the psycho-cardiology treatment group was given conventional treatment of SCAD, psychological interventions and pseudo-stimulation of the fastigial nucleus, and the combined treatment group was given conventional treatment of SCAD, psychological intervention and FNS. The changes of concentrations of TNF-α, NT-proBNP, 5-HT and DA were observed in the three groups of patients, and the changes of the state of depression were assessed by Hamilton Depression Scale (HAMD). Serum NT-proBNP and TNF-α concentrations decreased significantly after treatment in the three groups. Especially, the decrease in the combined treatment group was the most significant(p). Serum 5-HT and DA concentrations were not statistically different in the three groups before and after treatment (p>0.05). However, they were significantly higher in the psycho-cardiology treatment group and the combined treatment group(p) and the increase in the combined treatment group was more significant than in the psycho-cardiology treatment group. In the control group, the difference of HAMD scores was not statistically significant before and after treatment (p>0.05), in the psycho-cardiology treatment group and the combined treatment group, the scores decreased significantly after treatment compared to before treatment (p). Furthermore, compared to the psycho-cardiology treatment group, the decrease was more significant in the combined treatment group (p). Our data suggested that Psycho-cardiology medicine combined with FNS can effectively reduce the level of serum NT-proBNP and TNF-α, increase the serum concentrations of 5-HT and DA and improve the symptoms of depression in patients with SCAD complicated with depression.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Clinical Study of Psycho-cardiology Combined with FNS in the Treatment of SCAD with Depression

AU  - Heng Zhang
AU  - Binxia Zhu
AU  - Runfeng Zhang
Y1  - 2024/11/28
PY  - 2024
N1  - https://doi.org/10.11648/j.ajcem.20241204.13
DO  - 10.11648/j.ajcem.20241204.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 52
EP  - 60
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20241204.13
AB  - To investigate the effects of psycho-cardiology combined with fastigial nucleus stimulation (FNS) on patients with stable coronary artery disease (SCAD) complicated with depression, we observed the changes of concentrations of N-terminal pro-B type natriuretic peptide (NT-proBNP), tumor necrosis factor-α(TNF-α), 5-hydroxytryptamine (5-HT), dopamine (DA) and depressive symptoms in these patients. One hundred and fifty patients, who were hospitalized the Department of Cardiology at the Third People's Hospital of Mianyang from February 2020 to October 2021 with a confirmed diagnosis of SCAD combined with depression, were selected as study subjects. Patients were randomly divided into a control group, a psycho-cardiology treatment group and a combined treatment group. The control group was given conventional treatment of SCAD and pseudo-stimulation of the fastigial nucleus, the psycho-cardiology treatment group was given conventional treatment of SCAD, psychological interventions and pseudo-stimulation of the fastigial nucleus, and the combined treatment group was given conventional treatment of SCAD, psychological intervention and FNS. The changes of concentrations of TNF-α, NT-proBNP, 5-HT and DA were observed in the three groups of patients, and the changes of the state of depression were assessed by Hamilton Depression Scale (HAMD). Serum NT-proBNP and TNF-α concentrations decreased significantly after treatment in the three groups. Especially, the decrease in the combined treatment group was the most significant(p). Serum 5-HT and DA concentrations were not statistically different in the three groups before and after treatment (p>0.05). However, they were significantly higher in the psycho-cardiology treatment group and the combined treatment group(p) and the increase in the combined treatment group was more significant than in the psycho-cardiology treatment group. In the control group, the difference of HAMD scores was not statistically significant before and after treatment (p>0.05), in the psycho-cardiology treatment group and the combined treatment group, the scores decreased significantly after treatment compared to before treatment (p). Furthermore, compared to the psycho-cardiology treatment group, the decrease was more significant in the combined treatment group (p). Our data suggested that Psycho-cardiology medicine combined with FNS can effectively reduce the level of serum NT-proBNP and TNF-α, increase the serum concentrations of 5-HT and DA and improve the symptoms of depression in patients with SCAD complicated with depression.

VL  - 12
IS  - 4
ER  -

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