Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes

Emese Pálovics; Elemér Fogassy

doi:doi:10.11648/j.ajche.20180604.15

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Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes

Emese Pálovics, Elemér Fogassy

Published in American Journal of Chemical Engineering (Volume 6, Issue 4)

Received: 15 May 2018 Accepted: 10 August 2018 Published: 21 September 2018

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Abstract

The preparation of pure enantiomers has an increasing demand both for academic and industrial (pharmaceutical) practice. This is not surprising, because the active ingredients of a main part of medicines (about 70-80%) are pure enantiomers. Several selective methods are known for preparation of pure enantiomers but the more economical and usual method is the resolution, when the pure enantiomers are obtained from diastereomeric salts formed due the reaction of the racemic compound and resolving agent in adequate conditions (solvent, temperature crystallization time). Since the first resolution effectuated by Pasteur the researchers have tried to explain what is happening during resolution, but this has not yet been fully accomplished, it is still a mystery. In this paper is described our proposal for resolution’s mechanism, based on systematization of our results and observations made during the resolution, taking into consideration the principal characteristics of enantiomeric mixtures, namely the eutectic composition and their helicity. We suppose that the enantiomers have a memory and they used it during the resolution processes, tending to form their stable symmetric conformation.

Published in	American Journal of Chemical Engineering (Volume 6, Issue 4)
DOI	10.11648/j.ajche.20180604.15
Page(s)	65-71
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Resolution, Enantiomers, Diastereomers, Eutectic composition, Homo- and Heterochiral Associates, Helical Structure

References

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APA Style

Emese Pálovics, Elemér Fogassy. (2018). Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes. American Journal of Chemical Engineering, 6(4), 65-71. https://doi.org/10.11648/j.ajche.20180604.15

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ACS Style

Emese Pálovics; Elemér Fogassy. Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes. Am. J. Chem. Eng. 2018, 6(4), 65-71. doi: 10.11648/j.ajche.20180604.15

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AMA Style

Emese Pálovics, Elemér Fogassy. Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes. Am J Chem Eng. 2018;6(4):65-71. doi: 10.11648/j.ajche.20180604.15

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@article{10.11648/j.ajche.20180604.15,
  author = {Emese Pálovics and Elemér Fogassy},
  title = {Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes},
  journal = {American Journal of Chemical Engineering},
  volume = {6},
  number = {4},
  pages = {65-71},
  doi = {10.11648/j.ajche.20180604.15},
  url = {https://doi.org/10.11648/j.ajche.20180604.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20180604.15},
  abstract = {The preparation of pure enantiomers has an increasing demand both for academic and industrial (pharmaceutical) practice. This is not surprising, because the active ingredients of a main part of medicines (about 70-80%) are pure enantiomers. Several selective methods are known for preparation of pure enantiomers but the more economical and usual method is the resolution, when the pure enantiomers are obtained from diastereomeric salts formed due the reaction of the racemic compound and resolving agent in adequate conditions (solvent, temperature crystallization time). Since the first resolution effectuated by Pasteur the researchers have tried to explain what is happening during resolution, but this has not yet been fully accomplished, it is still a mystery. In this paper is described our proposal for resolution’s mechanism, based on systematization of our results and observations made during the resolution, taking into consideration the principal characteristics of enantiomeric mixtures, namely the eutectic composition and their helicity. We suppose that the enantiomers have a memory and they used it during the resolution processes, tending to form their stable symmetric conformation.},
 year = {2018}
}

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TY  - JOUR
T1  - Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes
AU  - Emese Pálovics
AU  - Elemér Fogassy
Y1  - 2018/09/21
PY  - 2018
N1  - https://doi.org/10.11648/j.ajche.20180604.15
DO  - 10.11648/j.ajche.20180604.15
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 65
EP  - 71
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20180604.15
AB  - The preparation of pure enantiomers has an increasing demand both for academic and industrial (pharmaceutical) practice. This is not surprising, because the active ingredients of a main part of medicines (about 70-80%) are pure enantiomers. Several selective methods are known for preparation of pure enantiomers but the more economical and usual method is the resolution, when the pure enantiomers are obtained from diastereomeric salts formed due the reaction of the racemic compound and resolving agent in adequate conditions (solvent, temperature crystallization time). Since the first resolution effectuated by Pasteur the researchers have tried to explain what is happening during resolution, but this has not yet been fully accomplished, it is still a mystery. In this paper is described our proposal for resolution’s mechanism, based on systematization of our results and observations made during the resolution, taking into consideration the principal characteristics of enantiomeric mixtures, namely the eutectic composition and their helicity. We suppose that the enantiomers have a memory and they used it during the resolution processes, tending to form their stable symmetric conformation.
VL  - 6
IS  - 4
ER  -

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Author Information

Emese Pálovics

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary
Elemér Fogassy

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, Hungary

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Emese Pálovics, Elemér Fogassy. (2018). Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes. American Journal of Chemical Engineering, 6(4), 65-71. https://doi.org/10.11648/j.ajche.20180604.15

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ACS Style

Emese Pálovics; Elemér Fogassy. Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes. Am. J. Chem. Eng. 2018, 6(4), 65-71. doi: 10.11648/j.ajche.20180604.15

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AMA Style

Emese Pálovics, Elemér Fogassy. Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes. Am J Chem Eng. 2018;6(4):65-71. doi: 10.11648/j.ajche.20180604.15

Copy | Download

@article{10.11648/j.ajche.20180604.15,
  author = {Emese Pálovics and Elemér Fogassy},
  title = {Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes},
  journal = {American Journal of Chemical Engineering},
  volume = {6},
  number = {4},
  pages = {65-71},
  doi = {10.11648/j.ajche.20180604.15},
  url = {https://doi.org/10.11648/j.ajche.20180604.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20180604.15},
  abstract = {The preparation of pure enantiomers has an increasing demand both for academic and industrial (pharmaceutical) practice. This is not surprising, because the active ingredients of a main part of medicines (about 70-80%) are pure enantiomers. Several selective methods are known for preparation of pure enantiomers but the more economical and usual method is the resolution, when the pure enantiomers are obtained from diastereomeric salts formed due the reaction of the racemic compound and resolving agent in adequate conditions (solvent, temperature crystallization time). Since the first resolution effectuated by Pasteur the researchers have tried to explain what is happening during resolution, but this has not yet been fully accomplished, it is still a mystery. In this paper is described our proposal for resolution’s mechanism, based on systematization of our results and observations made during the resolution, taking into consideration the principal characteristics of enantiomeric mixtures, namely the eutectic composition and their helicity. We suppose that the enantiomers have a memory and they used it during the resolution processes, tending to form their stable symmetric conformation.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Memory of Chiral Molecules Define Their Interactions and the Results of Resolution Processes
AU  - Emese Pálovics
AU  - Elemér Fogassy
Y1  - 2018/09/21
PY  - 2018
N1  - https://doi.org/10.11648/j.ajche.20180604.15
DO  - 10.11648/j.ajche.20180604.15
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 65
EP  - 71
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20180604.15
AB  - The preparation of pure enantiomers has an increasing demand both for academic and industrial (pharmaceutical) practice. This is not surprising, because the active ingredients of a main part of medicines (about 70-80%) are pure enantiomers. Several selective methods are known for preparation of pure enantiomers but the more economical and usual method is the resolution, when the pure enantiomers are obtained from diastereomeric salts formed due the reaction of the racemic compound and resolving agent in adequate conditions (solvent, temperature crystallization time). Since the first resolution effectuated by Pasteur the researchers have tried to explain what is happening during resolution, but this has not yet been fully accomplished, it is still a mystery. In this paper is described our proposal for resolution’s mechanism, based on systematization of our results and observations made during the resolution, taking into consideration the principal characteristics of enantiomeric mixtures, namely the eutectic composition and their helicity. We suppose that the enantiomers have a memory and they used it during the resolution processes, tending to form their stable symmetric conformation.
VL  - 6
IS  - 4
ER  -

Copy | Download