Research Article | | Peer-Reviewed

Exploring the Diagnostic Challenges of Pseudotumoral Peritoneal Tuberculosis That Mimics Advanced Ovarian Cancer in Women: The Role of Laparoscopy in a Case Study

Received: 11 September 2024     Accepted: 29 September 2024     Published: 18 October 2024
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Abstract

This case involves a 63-year-old multiparous woman with no significant medical history and no known exposure to tuberculosis. She presented with chronic abdominal pain and weight loss, anorexia, and subjective fevers. During the clinical examination, the patient was found to have ascites, bilateral pleural effusion, fever, and a general deterioration in her condition. Blood tests revealed normochromic normocytic anemia. The C-reactive protein was elevated, and the erythrocyte sedimentation rate was accelerated. Ferritin levels were raised. Her blood sugar, hepatic and renal functions were normals. The electrolyte panel showed no abnormalities. Serologies for hepatitis B, C, and HIV were negative, and the immunological profile was normal. The ascitic tap yielded a citrine-yellow fluid, and the cytochemical analysis indicated that the ascites were exudative. Analysis of the ascitic fluid revealed that the DNA test for Mycobacterium tuberculosis was negative, but the adenosine deaminase (ADA) level was elevated. Additionally, the CA125 level was significantly elevated, exceeding 600 UI/ml. A pelvic ultrasound identified a cystic pelvic mass with thick septations but without any solid tissue component, measuring 92x69 mm. The complementary CT (Computed Tomography) scan revealed enlarged ovaries, heterogeneous on the left, associated with a moderately abundant peritoneal effusion. The laparoscopic exploration revealed inflammatory peritoneal nodules, parietal adhesions, and serous ascites. Anatomopathology confirmed peritoneal tuberculosis. The peritoneal form, particularly in its pseudotumoral manifestation, can mimic ovarian cancer. Definitive diagnosis often requires invasive procedures.

Published in American Journal of Internal Medicine (Volume 12, Issue 5)
DOI 10.11648/j.ajim.20241205.13
Page(s) 78-81
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Tuberculosis, Laparoscopy, Ovarian, Cancer, CA125

References
[1] Trigui M, Ben Ayed H, Koubaa M, et al. Multifocal tuberculosis in Southern Tunisia: what is Specific With? J Tuberc. 2018; 2: 1006.
[2] Zaman K. Tuberculosis: a global health problem. J Health PopulNutr. 2010; 28(2): 111–113.
[3] Lantheaume S, Soler S, Issartel B, et al. Disseminated peritoneal tuberculosis simulating ovarian cancer: about a case. Obs, Gyn and Fertility. 2003; 31(7-8): 624–626.
[4] Abdallah M, Larbi T, Hamzaoui S, et al. Tuberculose abdominale: étude retrospective de 90 cas. La revue de medecine interne. 2011 Apr; 32(4): 212–217.
[5] Oge T, Ozalp S, Yalcin OT, Kabukcuoglu S, Kebapci M, Arik D, et al. Peritoneal tuberculosis mimicking ovarian cancer. European journal of obstetrics & gynecology and reproductive bio. 2012; 162(1): 105–108.
[6] Eghdami L, Kwon J. Tuberculose péritonéale se présentant sous forme d´une ascite persistante. J Obstet Gynaecol Can. 2015; 37(4): 296.
[7] Pommier J-D, Joly V. Complications following intravesical Bacillus Calmette-Guérin therapy: Epidemiology, clinical features and medical care. Anti-infectives journal. 2016; 18: 106–116.
[8] Saadi H, Mamouni M, Errarhay S, et al. Pseudotumoral pelvoperitoneal tuberculosis: about four cases. PAMJ. 2012; 13: 52. PMID: 23330043.
[9] Vardareli E, Kebapci M, Saricam T, et al. Tuberculous peritonitis of the wet ascitic type: clinical features and diagnostic value of image-guided peritoneal biopsy. Dig Liver Dis. 2004; 36(3): 199–204.
[10] Daaloul W, Gharbi H, Ouerdiane N, et al. Tuberculose péritonéale disséminée simulant un cancer ovarien. La tunisie méd. 2012; 90(04): 333–335. PMID: 22535355.
[11] Amouri A, Boudabbous M, Mnif L, Tahri N. Current profile of peritoneal tuberculosis: study of a Tunisian series of 42 cases and review of the literature.. J int med. 2009; 30: 215-220.
[12] Marshall JB. Tuberculosis of the gastrointestinal tract and peritoneum. Am J Gastroenterol. 1993; 88(7): 989–999. PMID: 8317433.
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  • APA Style

    Ndour, J. N. D., Diallo, B. M., Ndiaye, Y., Faye, F. A., Nana, M. B., et al. (2024). Exploring the Diagnostic Challenges of Pseudotumoral Peritoneal Tuberculosis That Mimics Advanced Ovarian Cancer in Women: The Role of Laparoscopy in a Case Study. American Journal of Internal Medicine, 12(5), 78-81. https://doi.org/10.11648/j.ajim.20241205.13

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    ACS Style

    Ndour, J. N. D.; Diallo, B. M.; Ndiaye, Y.; Faye, F. A.; Nana, M. B., et al. Exploring the Diagnostic Challenges of Pseudotumoral Peritoneal Tuberculosis That Mimics Advanced Ovarian Cancer in Women: The Role of Laparoscopy in a Case Study. Am. J. Intern. Med. 2024, 12(5), 78-81. doi: 10.11648/j.ajim.20241205.13

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    AMA Style

    Ndour JND, Diallo BM, Ndiaye Y, Faye FA, Nana MB, et al. Exploring the Diagnostic Challenges of Pseudotumoral Peritoneal Tuberculosis That Mimics Advanced Ovarian Cancer in Women: The Role of Laparoscopy in a Case Study. Am J Intern Med. 2024;12(5):78-81. doi: 10.11648/j.ajim.20241205.13

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  • @article{10.11648/j.ajim.20241205.13,
      author = {Jean Noel Diokel Ndour and Bachir Mansour Diallo and Yanidou Ndiaye and Fulgence Abdou Faye and Mamoudou Baba Nana and Atoumane Faye and Adama Berthé and Papa Souleymane Touré and Madoky Magatte Diop and Mamadou Mourtalla Ka},
      title = {Exploring the Diagnostic Challenges of Pseudotumoral Peritoneal Tuberculosis That Mimics Advanced Ovarian Cancer in Women: The Role of Laparoscopy in a Case Study
    },
      journal = {American Journal of Internal Medicine},
      volume = {12},
      number = {5},
      pages = {78-81},
      doi = {10.11648/j.ajim.20241205.13},
      url = {https://doi.org/10.11648/j.ajim.20241205.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20241205.13},
      abstract = {This case involves a 63-year-old multiparous woman with no significant medical history and no known exposure to tuberculosis. She presented with chronic abdominal pain and weight loss, anorexia, and subjective fevers. During the clinical examination, the patient was found to have ascites, bilateral pleural effusion, fever, and a general deterioration in her condition. Blood tests revealed normochromic normocytic anemia. The C-reactive protein was elevated, and the erythrocyte sedimentation rate was accelerated. Ferritin levels were raised. Her blood sugar, hepatic and renal functions were normals. The electrolyte panel showed no abnormalities. Serologies for hepatitis B, C, and HIV were negative, and the immunological profile was normal. The ascitic tap yielded a citrine-yellow fluid, and the cytochemical analysis indicated that the ascites were exudative. Analysis of the ascitic fluid revealed that the DNA test for Mycobacterium tuberculosis was negative, but the adenosine deaminase (ADA) level was elevated. Additionally, the CA125 level was significantly elevated, exceeding 600 UI/ml. A pelvic ultrasound identified a cystic pelvic mass with thick septations but without any solid tissue component, measuring 92x69 mm. The complementary CT (Computed Tomography) scan revealed enlarged ovaries, heterogeneous on the left, associated with a moderately abundant peritoneal effusion. The laparoscopic exploration revealed inflammatory peritoneal nodules, parietal adhesions, and serous ascites. Anatomopathology confirmed peritoneal tuberculosis. The peritoneal form, particularly in its pseudotumoral manifestation, can mimic ovarian cancer. Definitive diagnosis often requires invasive procedures.
    },
     year = {2024}
    }
    

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    AB  - This case involves a 63-year-old multiparous woman with no significant medical history and no known exposure to tuberculosis. She presented with chronic abdominal pain and weight loss, anorexia, and subjective fevers. During the clinical examination, the patient was found to have ascites, bilateral pleural effusion, fever, and a general deterioration in her condition. Blood tests revealed normochromic normocytic anemia. The C-reactive protein was elevated, and the erythrocyte sedimentation rate was accelerated. Ferritin levels were raised. Her blood sugar, hepatic and renal functions were normals. The electrolyte panel showed no abnormalities. Serologies for hepatitis B, C, and HIV were negative, and the immunological profile was normal. The ascitic tap yielded a citrine-yellow fluid, and the cytochemical analysis indicated that the ascites were exudative. Analysis of the ascitic fluid revealed that the DNA test for Mycobacterium tuberculosis was negative, but the adenosine deaminase (ADA) level was elevated. Additionally, the CA125 level was significantly elevated, exceeding 600 UI/ml. A pelvic ultrasound identified a cystic pelvic mass with thick septations but without any solid tissue component, measuring 92x69 mm. The complementary CT (Computed Tomography) scan revealed enlarged ovaries, heterogeneous on the left, associated with a moderately abundant peritoneal effusion. The laparoscopic exploration revealed inflammatory peritoneal nodules, parietal adhesions, and serous ascites. Anatomopathology confirmed peritoneal tuberculosis. The peritoneal form, particularly in its pseudotumoral manifestation, can mimic ovarian cancer. Definitive diagnosis often requires invasive procedures.
    
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Author Information
  • Internal Medicine Department, Mamadou Diop Health Center, Dakar, Senegal

  • Internal Medicine Department, Abdou Aziz Sy Dabakh Hospital, Tivaouane, Senegal

  • Internal Medicine Department, Regional Hospital of Thiès, Thies, Senegal

  • School of Medecine, Alioune Diop University of Bambey, Bambey, Senegal

  • Internal Medicine Department, Regional Hospital of Thiès, Thies, Senegal

  • Internal Medicine Department, Mamadou Diop Health Center, Dakar, Senegal; School of Medecine, Cheikh Anta Diop University of Dakar, Dakar, Senegal

  • Internal Medicine Department, Abdou Aziz Sy Dabakh Hospital, Tivaouane, Senegal

  • Internal Medicine Department, Mamadou Diop Health Center, Dakar, Senegal

  • Internal Medicine Department, Abdou Aziz Sy Dabakh Hospital, Tivaouane, Senegal

  • School of Medecine, Iba Der Thiam University of Thiès, Thies, Senegal

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