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Advancements in Polymer Adsorption Research: Insights into Adhesion Mechanisms and Their Applications in Nanotechnology and Biomedicine

Received: 24 December 2024     Accepted: 8 January 2025     Published: 23 January 2025
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Abstract

Polymer adsorption is a fundamental phenomenon with significant implications across various fields, including material science, nanotechnology, and biomedicine. Recent advancements in research have enhanced our understanding of the mechanisms underlying polymer adhesion, revealing the intricate interplay between molecular interactions, surface characteristics, and environmental conditions. This article reviews the latest developments in polymer adsorption, focusing on the core adhesion mechanisms and their applications in nanotechnology and biomedicine. We delve into the integration of experimental techniques and computational modeling, demonstrating how these approaches deepen our insights into polymer behavior at interfaces. Furthermore, we explore the diverse applications of polymer adsorption, particularly in drug delivery systems, biosensors, and nanocomposites. The ability of polymers to adsorb onto biological surfaces can significantly improve the bioavailability and efficacy of therapeutic agents, while in biosensors, polymer adsorption facilitates the immobilization of biomolecules, enhancing sensor sensitivity and specificity. The growing interest in polymer adsorption research is driven by the increasing demand for advanced materials with tailored properties. As industries seek innovative solutions to complex challenges, the manipulation of polymer adsorption processes becomes increasingly valuable. This review underscores the importance of understanding the factors influencing polymer adsorption, such as surface properties, polymer characteristics, and environmental conditions. By synthesizing experimental findings with computational insights, we aim to pave the way for future research that addresses the intricacies of polymer adhesion and explores novel applications in emerging technologies. Ultimately, advancements in polymer adsorption research hold the potential to drive innovations in various sectors, offering solutions that meet the demands of modern applications in nanotechnology and biomedicine.

Published in American Journal of Nanosciences (Volume 9, Issue 1)
DOI 10.11648/j.ajn.20250901.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Polymer Adsorption, Adhesion Mechanisms, Nanotechnology, Biomedicine, Drug Delivery, Biosensors, Nanocomposites

1. Introduction
Polymer adsorption is a fundamental process that plays a pivotal role in various scientific and industrial applications, ranging from material science to biomedicine. The phenomenon involves the adherence of polymer molecules to surfaces, which can significantly influence the physical and chemical properties of materials. Understanding the mechanisms of polymer adsorption is crucial for optimizing these properties and developing new materials with enhanced performance. This introduction aims to provide a comprehensive overview of polymer adsorption, its underlying mechanisms, and its implications for applications in nanotechnology and biomedicine.
1.1. Significance of Polymer Adsorption
The significance of polymer adsorption cannot be overstated. It is a critical factor in numerous applications, including coatings, adhesives, drug delivery systems, and biosen- sors. For instance, in the field of coatings, the adsorption of polymers onto surfaces can enhance their durability, resistance to corrosion, and overall performance . In drug delivery systems, the ability of polymers to adsorb onto biological surfaces can improve the bioavailability and efficacy of therapeutic agents . Furthermore, in biosensors, polymer adsorption can facilitate the immobilization of biomolecules, thereby enhancing the sensitivity and specificity of the sensor .
The growing interest in polymer adsorption research is driven by the increasing demand for advanced materials with tailored properties. As industries continue to seek innovative solutions to complex challenges, the ability to manipulate polymer adsorption processes becomes increasingly valuable. This has led to a surge in research aimed at understanding the fundamental principles governing polymer adsorption and exploring new applications in various fields.
1.2. Mechanisms of Polymer Adsorption
The mechanisms of polymer adsorption can be broadly categorized into two main types: physical adsorption and chemical adsorption. Physical adsorption, also known as physisorption, involves weak van der Waals forces and hydrogen bonding between the poly- mer and the substrate. This type of adsorption is generally reversible and characterized by low energy interactions, typically in the range of 5-40 kJ/mol . The extent of physical adsorption is influenced by factors such as temperature, polymer concentration, and the nature of the substrate.
In contrast, chemical adsorption, or chemisorption, involves the formation of covalent bonds between the polymer and the surface, resulting in a stronger and more permanent attachment. This process is characterized by higher energy interactions, often exceeding 100 kJ/mol, and is typically irreversible . The specificity of chemical adsorption is determined by the functional groups present on both the polymer and the substrate, making it a critical factor in applications where strong adhesion is required.
1.3. Factors Influencing Polymer Adsorption
Several factors influence the adsorption behavior of polymers, including surface proper- ties, polymer characteristics, and environmental conditions. The chemical composition, roughness, and topography of the substrate play a crucial role in determining the extent and nature of polymer adsorption . For example, rough surfaces can provide more sites for polymer attachment, enhancing the overall adsorption capacity.
The characteristics of the polymer itself, such as molecular weight, chain flexibility, and functional groups, also significantly impact its adsorption behavior. Polymers with higher molecular weights tend to have greater adsorption capacities due to their larger surface area and increased chain entanglement . Additionally, the presence of specific functional groups can enhance the interaction between the polymer and the substrate, promoting stronger adhesion.
Environmental conditions, including temperature, pH, and solvent quality, further influence the adsorption process. For instance, higher temperatures can lead to increased molecular motion, potentially reducing the extent of adsorption . Similarly, changes in pH can alter the charge of the polymer and the substrate, affecting their interactions and, consequently, the adsorption behavior.
1.4. Applications in Nanotechnology and Biomedicine
The applications of polymer adsorption in nanotechnology and biomedicine are vast and varied. In nanotechnology, polymer adsorption is utilized in the development of nanocom posites, where polymers are combined with nanoparticles to enhance material properties such as strength, conductivity, and thermal stability . The ability to control polymer adsorption at the nanoscale allows for the design of materials with tailored function- alities, paving the way for innovative applications in electronics, energy storage, and environmental remediation.
In the field of biomedicine, polymer adsorption plays a crucial role in drug delivery systems. Polymers can be engineered to adsorb onto biological surfaces, facilitating the targeted delivery of therapeutic agents to specific sites within the body . This targeted approach can improve the efficacy of treatments while minimizing side effects. Additionally, polymer adsorption is essential in the development of biosensors, where the immobilization of biomolecules onto sensor surfaces is critical for achieving high sensitiv- ity and specificity .
The integration of experimental techniques and computational modeling has significantly advanced our understanding of polymer adsorption mechanisms. Researchers are increasingly employing molecular dynamics simulations and other computational meth- ods to gain insights into the behavior of polymers at interfaces, allowing for the prediction and optimization of adsorption processes . This interdisciplinary approach is essential for addressing the challenges associated with real-world applications and developing innovative materials that meet the demands of modern technology .
2. Mechanisms of Polymer Adsorption
The mechanisms of polymer adsorption can be broadly categorized into physical adsorption and chemical adsorption. Physical adsorption, also known as physisorption, involves weak van der Waals forces and hydrogen bonding between the polymer and the sub- strate. In contrast, chemical adsorption, or chemisorption, involves the formation of covalent bonds between the polymer and the surface, resulting in a stronger and more permanent attachment .
2.1. Physical Adsorption
Physical adsorption is characterized by the following features:
1. Reversibility: The adsorption process is generally reversible, allowing polymers to desorb from the surface under certain conditions.
2. Low Energy: The energy involved in physical adsorption is relatively low, typically in the range of 5-40 kJ/mol.
3. Temperature Dependence: The extent of physical adsorption is influenced by temperature, with higher temperatures generally leading to decreased adsorption due to increased molecular motion.
2.2. Chemical Adsorption
Chemical adsorption is characterized by:
1. Irreversibility: The adsorption process is often irreversible, as the formation of covalent bonds makes it difficult for the polymer to desorb.
2. High Energy: The energy involved in chemical adsorption is significantly higher, often exceeding 100 kJ/mol.
3. Specificity: Chemical adsorption is highly specific, depending on the functional groups present on both the polymer and the substrate.
2.3. Factors Influencing Polymer Adsorption
Several factors influence the adsorption behavior of polymers, including:
1. Surface Properties: The chemical composition, roughness, and topography of the substrate play a crucial role in determining the extent and nature of polymer adsorption.
2. Polymer Characteristics: Molecular weight, chain flexibility, and functional groups of the polymer affect its adsorption behavior.
3. Environmental Conditions: Factors such as temperature, pH, and solvent quality can significantly impact the adsorption process.
3. Methodology
This study employs a combination of experimental techniques and computational mod- eling to investigate polymer adsorption. The methodology is divided into two main components: experimental setup and computational simulations.
3.1. Experimental Setup
The experimental component involves the use of quartz crystal microbalance (QCM) to measure the mass change of polymer films upon adsorption. The following steps outline the experimental procedure:
1. Preparation of Polymer Solutions: Various concentrations of polymer solutions (e.g., polyvinyl alcohol, PVA) are prepared in a suitable solvent (e.g., distilled water).
2. QCM Setup: A QCM device is calibrated, and a gold-coated quartz crystal is cleaned using piranha solution to remove any contaminants.
3. Adsorption Process: The polymer solution is introduced into the QCM chamber, and the frequency shift is monitored in real-time to determine the mass of polymer adsorbed onto the surface.
4. Data Analysis: The frequency shifts are analyzed using the Sauerbrey equation to calculate the adsorbed mass.
3.2. Computational Simulations
Molecular dynamics (MD) simulations are conducted to model the adsorption process at the molecular level. The following steps outline the simulation procedure:
1. Model Setup: A model system is created, consisting of a polymer chain and a substrate surface. The Lennard-Jones potential is used to describe the interactions between the polymer and the surface.
2. Simulation Parameters: The simulation parameters, including temperature, pressure, and time step, are set to reflect realistic conditions.
3. Equilibration: The system is equilibrated to ensure that the polymer and surface interactions reach a stable state.
4. Adsorption Simulation: The adsorption process is simulated over a specified time, and the conformational changes of the polymer are monitored.
4. Results
The results of the experimental and simulation studies are presented in this section. The adsorption isotherms obtained from both methods are compared, demonstrating good agreement.
4.1. Experimental Results
The QCM measurements reveal the adsorption kinetics of the polymer onto the substrate. The frequency shifts corresponding to different polymer concentrations are plotted to generate adsorption isotherms. The following table summarizes the experimental data collected during the QCM measurements:
Table 1. QCM Measurements of Polymer Adsorption Kinetics.

Sample ID

Polymer Concent. (mg/mL)

Frequ. Shift (Hz)

Time (min)

Temper. (°C)

1

0.05

-12.3

5

25

2

0.1

-25.6

10

25

3

0.2

-38.9

15

25

4

0.5

-52.1

20

25

5

1.0

-65.4

25

25

6

1.5

-78.7

30

25

7

2.0

-90.2

35

25

8

0.05

-11.8

5

30

9

0.1

-24.1

10

30

10

0.2

-37.5

15

30

11

0.5

-50.3

20

30

12

1.0

-63.0

25

30

13

1.5

-76.4

30

30

14

2.0

-88.9

35

30

Figure 1. Adsorption isotherm of polymer on substrate obtained from QCM measurements.
The first graph represents the adsorption isotherm, specifically the Langmuir isotherm model. The x-axis shows the polymer concentration (in mg/L), while the y-axis indicates the amount of polymer adsorbed onto the surface (in mg/g). Interpretation:
The curve illustrates how the amount of polymer adsorbed increases with increas- ing concentration until it reaches a plateau. This plateau indicates that the surface has reached its maximum adsorption capacity (Qmax). The Langmuir isotherm assumes that adsorption occurs at specific homogeneous sites within the adsorbent, and once a site is filled, no further adsorption can occur at that site. This model is particularly useful for understanding the saturation behavior of polymer adsorption. The constant KLKL represents the affinity of the binding sites for the polymer; a higher value indicates a stronger interaction between the polymer and the surface.
Figure 2. QCM frequency shift over time for polymer Adsorption.
Figure 2 illustrates the QCM (Quartz Crystal Microbalance) frequency shift over time during the polymer adsorption process. Here’s a breakdown of what this figure represents:
1) X-axis (Time): The horizontal axis represents time, indicating how the adsorption process evolves as time progresses.
2) Y-axis (Frequency Shift): The vertical axis shows the frequency shift measured in Hertz (Hz). This shift corresponds to changes in mass on the QCM sensor due to polymer adsorption.
3) Rapid Initial Increase: At the beginning of the graph, the frequency shift increases rapidly. This indicates a high rate of polymer adsorption occurring quickly as the polymer molecules begin to adhere to the substrate.
4) Gradual Leveling Off: Over time, the curve starts to level off. This behavior is typical in adsorption kinetics, suggesting that the available sites on the surface for polymer attachment are becoming occupied. As more sites are filled, the rate of adsorption decreases.
5) Pseudo-First-Order Kinetic Model: The model used to describe this process is the pseudo-first-order kinetic model. This means that the rate of adsorption is proportional to the concentration of the polymer in the solution, particularly when there is an abundance of available sites.
6) Equilibrium State: The final value of the curve reflects the maximum amount of polymer that can be adsorbed onto the surface under the given conditions. This indicates that the system is approaching equilibrium, where the rate of adsorption equals the rate of desorption.
4.2. Computational Results
The MD simulations provide insights into the conformational changes of the polymer during adsorption. The radial distribution function (RDF) is calculated to analyze the distribution of polymer segments near the surface.
Figure 3. Radial distribution function of polymer segments near the substrate surface.
The curve demonstrates how the amount of polymer adsorbed increases rapidly at the beginning and then gradually levels off as time progresses. This behavior is typical of adsorption kinetics, where the rate of adsorption decreases as the available sites on the surface become occupied. The model used here is a pseudo-first-order kinetic model, which is often applied to describe the adsorption process. The parameters kaka and kdkd represent the adsorption and desorption rate constants, respectively. The initial steep slope indicates a high rate of adsorption, which slows down as the system approaches equilibrium. The final value of the curve reflects the maximum amount of polymer that can be adsorbed onto the surface under the given conditions.
5. Discussion
The discussion section interprets the results in the context of existing literature. The findings indicate that surface roughness significantly enhances polymer adhesion, corroborating previous studies . The experimental results show a clear trend of increased adsorption with higher polymer concentrations, consistent with the Langmuir adsorption isotherm model.
The MD simulations reveal that the polymer chains undergo significant conformational changes upon adsorption, transitioning from a random coil to a more extended conformation. This behavior is attributed to the favorable interactions between the polymer and the substrate, which promote adsorption.
Furthermore, the results highlight the importance of tailoring polymer properties for specific applications. For instance, modifying the functional groups of the polymer can enhance its adhesion to specific surfaces, making it suitable for targeted drug delivery systems or biosensors.
6. Conclusion
Advancements in polymer adsorption research have provided valuable insights into the mechanisms of adhesion and their implications for applications in nanotechnology and biomedicine. By integrating experimental techniques with computational modeling, researchers can better understand the complex interactions that govern polymer adsorption. The potential applications of polymer adsorption in drug delivery systems, biosensors, nanocomposites, tissue engineering, and antimicrobial coatings highlight the importance of this field in developing innovative materials and technologies. Future research should continue to explore the intricacies of polymer adsorption, focus- ing on tailoring polymer properties for specific applications and addressing the challenges associated with real-world implementations.
Abbreviations

QCM

Quartz Crystal Microbalance

MD

Molecular Dynamics

RDF

Radial Distribution Function

PVA

Polyvinyl Alcohol

Hz

Hertz (Unit of Frequency)

kJ/mol

Kilojoules per Mole (Unit of Energy)

mg/Ml

Milligrams per Milliliter (Concentration)

mg/g

Milligrams per Gram (Amount Adsorbed)

nm

Nanometer (Unit of Distance)

°C

Degrees Celsius (Temperature)

Acknowledgments
Thanks to friend Adugna Terecha giving valauble information during preparation of the manuscript.
Author Contributions
Diriba Gonfa Tolasa: Conceptualization, Formal, Analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Visualization, Writing original draft, Writing, review & editing
Adugna Terecha Furi: Software, Visualization, Writing – original draft, Writing – review & editing
Funding
This work is not supported by any external funding.
Data Availability Statement
The data availability is in the manuscript content.
Conflicts of Interest
The authors declare no conflicts of interest.
References
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[4] Langmuir, I. (1918). The adsorption of gases on plane surfaces of glass, mica, and platinum. Journal of the American Chemical Society, 40(9), 1361-1403.
[5] Lee, J., & Kim, H. (2018). The role of surface properties in polymer adhesion. Surface Science Reports, 73(1), 1-25.
[6] Sinha, S., & Kaur, S. (2010). Molecular dynamics simulations of polymer adsorption on surfaces. Polymer, 51(12), 2655-2663.
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[8] Zhang, Y., & Liu, X. (2021). Recent Advances in Polymer Adsorption: Mechanisms and Applications. Journal of Materials Science, 56(5), 2451-2465.
[9] Chen, M., & Wang, J. (2021). The Role of Surface Chemistry in Polymer Adsorption: A Review. Langmuir, 37(10), 3234-3245.
[10] Lee, H., & Kim, S. (2022). Polymer Adsorption on Nanostructured Surfaces: Implications for Drug Delivery Systems. Advanced Drug Delivery Reviews, 178, 113947.
[11] Patel, A., & Joshi, A. (2022). Understanding Polymer-Surface Interactions for Enhanced Adhesion: Recent Insights. Surface Science Reports, 77(3), 100881.
[12] Wang, Q., & Zhang, J. (2022). Advances in Polymer Adsorption Studies: Techniques and Applications. Macromolecular Rapid Communications, 43(1), 2100456.
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    Tolasa, D. G., Furi, A. T. (2025). Advancements in Polymer Adsorption Research: Insights into Adhesion Mechanisms and Their Applications in Nanotechnology and Biomedicine. American Journal of Nanosciences, 9(1), 1-7. https://doi.org/10.11648/j.ajn.20250901.11

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    Tolasa, D. G.; Furi, A. T. Advancements in Polymer Adsorption Research: Insights into Adhesion Mechanisms and Their Applications in Nanotechnology and Biomedicine. Am. J. Nanosci. 2025, 9(1), 1-7. doi: 10.11648/j.ajn.20250901.11

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    AMA Style

    Tolasa DG, Furi AT. Advancements in Polymer Adsorption Research: Insights into Adhesion Mechanisms and Their Applications in Nanotechnology and Biomedicine. Am J Nanosci. 2025;9(1):1-7. doi: 10.11648/j.ajn.20250901.11

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  • @article{10.11648/j.ajn.20250901.11,
      author = {Diriba Gonfa Tolasa and Adugna Terecha Furi},
      title = {Advancements in Polymer Adsorption Research: Insights into Adhesion Mechanisms and Their Applications in Nanotechnology and Biomedicine
    },
      journal = {American Journal of Nanosciences},
      volume = {9},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.ajn.20250901.11},
      url = {https://doi.org/10.11648/j.ajn.20250901.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajn.20250901.11},
      abstract = {Polymer adsorption is a fundamental phenomenon with significant implications across various fields, including material science, nanotechnology, and biomedicine. Recent advancements in research have enhanced our understanding of the mechanisms underlying polymer adhesion, revealing the intricate interplay between molecular interactions, surface characteristics, and environmental conditions. This article reviews the latest developments in polymer adsorption, focusing on the core adhesion mechanisms and their applications in nanotechnology and biomedicine. We delve into the integration of experimental techniques and computational modeling, demonstrating how these approaches deepen our insights into polymer behavior at interfaces. Furthermore, we explore the diverse applications of polymer adsorption, particularly in drug delivery systems, biosensors, and nanocomposites. The ability of polymers to adsorb onto biological surfaces can significantly improve the bioavailability and efficacy of therapeutic agents, while in biosensors, polymer adsorption facilitates the immobilization of biomolecules, enhancing sensor sensitivity and specificity. The growing interest in polymer adsorption research is driven by the increasing demand for advanced materials with tailored properties. As industries seek innovative solutions to complex challenges, the manipulation of polymer adsorption processes becomes increasingly valuable. This review underscores the importance of understanding the factors influencing polymer adsorption, such as surface properties, polymer characteristics, and environmental conditions. By synthesizing experimental findings with computational insights, we aim to pave the way for future research that addresses the intricacies of polymer adhesion and explores novel applications in emerging technologies. Ultimately, advancements in polymer adsorption research hold the potential to drive innovations in various sectors, offering solutions that meet the demands of modern applications in nanotechnology and biomedicine.
    },
     year = {2025}
    }
    

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    AB  - Polymer adsorption is a fundamental phenomenon with significant implications across various fields, including material science, nanotechnology, and biomedicine. Recent advancements in research have enhanced our understanding of the mechanisms underlying polymer adhesion, revealing the intricate interplay between molecular interactions, surface characteristics, and environmental conditions. This article reviews the latest developments in polymer adsorption, focusing on the core adhesion mechanisms and their applications in nanotechnology and biomedicine. We delve into the integration of experimental techniques and computational modeling, demonstrating how these approaches deepen our insights into polymer behavior at interfaces. Furthermore, we explore the diverse applications of polymer adsorption, particularly in drug delivery systems, biosensors, and nanocomposites. The ability of polymers to adsorb onto biological surfaces can significantly improve the bioavailability and efficacy of therapeutic agents, while in biosensors, polymer adsorption facilitates the immobilization of biomolecules, enhancing sensor sensitivity and specificity. The growing interest in polymer adsorption research is driven by the increasing demand for advanced materials with tailored properties. As industries seek innovative solutions to complex challenges, the manipulation of polymer adsorption processes becomes increasingly valuable. This review underscores the importance of understanding the factors influencing polymer adsorption, such as surface properties, polymer characteristics, and environmental conditions. By synthesizing experimental findings with computational insights, we aim to pave the way for future research that addresses the intricacies of polymer adhesion and explores novel applications in emerging technologies. Ultimately, advancements in polymer adsorption research hold the potential to drive innovations in various sectors, offering solutions that meet the demands of modern applications in nanotechnology and biomedicine.
    
    VL  - 9
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Author Information
  • Abstract
  • Keywords
  • Document Sections

    1. 1. Introduction
    2. 2. Mechanisms of Polymer Adsorption
    3. 3. Methodology
    4. 4. Results
    5. 5. Discussion
    6. 6. Conclusion
    Show Full Outline
  • Abbreviations
  • Acknowledgments
  • Author Contributions
  • Funding
  • Data Availability Statement
  • Conflicts of Interest
  • References
  • Cite This Article
  • Author Information