The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

Zekine Punduk; Adnan Adil Hismiogullari; Ozlem Yavuz; Khalid Rahman

doi:doi:10.11648/j.ajss.20150302.11

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The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman

Published in American Journal of Sports Science (Volume 3, Issue 2)

Received: 15 February 2015 Accepted: 27 February 2015 Published: 4 March 2015

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Abstract

The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.

Published in	American Journal of Sports Science (Volume 3, Issue 2)
DOI	10.11648/j.ajss.20150302.11
Page(s)	29-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

NGAL, IL6, Cycling performance, Quercetin, Resveratrol

References

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APA Style

Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman. (2015). The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. American Journal of Sports Science, 3(2), 29-35. https://doi.org/10.11648/j.ajss.20150302.11

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ACS Style

Zekine Punduk; Adnan Adil Hismiogullari; Ozlem Yavuz; Khalid Rahman. The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. Am. J. Sports Sci. 2015, 3(2), 29-35. doi: 10.11648/j.ajss.20150302.11

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AMA Style

Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman. The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. Am J Sports Sci. 2015;3(2):29-35. doi: 10.11648/j.ajss.20150302.11

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@article{10.11648/j.ajss.20150302.11,
  author = {Zekine Punduk and Adnan Adil Hismiogullari and Ozlem Yavuz and Khalid Rahman},
  title = {The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response},
  journal = {American Journal of Sports Science},
  volume = {3},
  number = {2},
  pages = {29-35},
  doi = {10.11648/j.ajss.20150302.11},
  url = {https://doi.org/10.11648/j.ajss.20150302.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20150302.11},
  abstract = {The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.},
 year = {2015}
}

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TY  - JOUR
T1  - The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response
AU  - Zekine Punduk
AU  - Adnan Adil Hismiogullari
AU  - Ozlem Yavuz
AU  - Khalid Rahman
Y1  - 2015/03/04
PY  - 2015
N1  - https://doi.org/10.11648/j.ajss.20150302.11
DO  - 10.11648/j.ajss.20150302.11
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 29
EP  - 35
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20150302.11
AB  - The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.
VL  - 3
IS  - 2
ER  -

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Author Information

Zekine Punduk

University of Balikesir, Physical Education and Sports, Balikesir, Turkey
Adnan Adil Hismiogullari

University of Balikesir, Faculty of Medicine, Department of Medical Biochemistry, Balikesir Turkey
Ozlem Yavuz

University of Balikesir, Faculty of Medicine, Department of Medical Biochemistry, Balikesir Turkey
Khalid Rahman

Liverpool John Moores University, Faculty of Science, Schoool of Pharmacy and Biomolecular Sciences, Liverpool, England (UK)

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Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman. (2015). The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. American Journal of Sports Science, 3(2), 29-35. https://doi.org/10.11648/j.ajss.20150302.11

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ACS Style

Zekine Punduk; Adnan Adil Hismiogullari; Ozlem Yavuz; Khalid Rahman. The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. Am. J. Sports Sci. 2015, 3(2), 29-35. doi: 10.11648/j.ajss.20150302.11

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AMA Style

Zekine Punduk, Adnan Adil Hismiogullari, Ozlem Yavuz, Khalid Rahman. The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response. Am J Sports Sci. 2015;3(2):29-35. doi: 10.11648/j.ajss.20150302.11

Copy | Download

@article{10.11648/j.ajss.20150302.11,
  author = {Zekine Punduk and Adnan Adil Hismiogullari and Ozlem Yavuz and Khalid Rahman},
  title = {The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response},
  journal = {American Journal of Sports Science},
  volume = {3},
  number = {2},
  pages = {29-35},
  doi = {10.11648/j.ajss.20150302.11},
  url = {https://doi.org/10.11648/j.ajss.20150302.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20150302.11},
  abstract = {The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.},
 year = {2015}
}

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TY  - JOUR
T1  - The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response
AU  - Zekine Punduk
AU  - Adnan Adil Hismiogullari
AU  - Ozlem Yavuz
AU  - Khalid Rahman
Y1  - 2015/03/04
PY  - 2015
N1  - https://doi.org/10.11648/j.ajss.20150302.11
DO  - 10.11648/j.ajss.20150302.11
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 29
EP  - 35
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20150302.11
AB  - The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or un-trained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.
VL  - 3
IS  - 2
ER  -

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