Indiscriminate use of anabolic steroids is associated with cardiovascular diseases, such as myocardial infarction, thrombosis, and arterial obstruction. Furthermore, high levels of androgens increase hepatic toxicity and the risk of cancer. Contrastingly, green tea prevents and controls cardiovascular and hepatic diseases, as it can improve the lipid profile and reduce inflammation and effects of oxidative stress. This study will evaluate benefits of green tea consumption, to attenuate systemic damage caused by supraphysiological doses of testosterone, by analyzing the lipid, biochemical, and hematological profiles of 28 42-day-old male Wistar rats. Silicone pellets containing testosterone in proportion were surgically implanted and replaced in these rats every four weeks, and they received casein-based control feed and water or green tea for hydration. After 20 weeks, all the male rats were anesthetized and their blood samples collected for the analysis of their biochemical and hematological profiles. Although the high hormone concentration had a negative influence on the lipid profile of these animals, the groups that consumed green tea exhibited a reduction in serum triglycerides (62%), Low Density Lipoprotein (76%), and Very Low Density Lipoprotein (45%). Tea consumption also led to a significant reduction in total cholesterol (32% in the green tea control group and 45% in the green tea-induced group), without changing the High Density Lipoprotein fraction. Only the green tea-induced group manifested a reduction in the total concentration of serum proteins. A fall in serum albumin was observed in the green tea-induced groups (2.3 g/dL) compared to control groups (2.9 g/dL). The induced group presented elevation in hematocrit, erythrocytosis, and leukocytosis in contrast to the green tea-induced group. The green tea control group maintained erythrocytosis, but without any other potentially harmful effect. A 30% increase in lymphocyte population in the induced group was observed. There was no difference in the platelet count of these rodents. Hepatic enzymes were also shown to have increased in the induced group, indicating hepatic injury in this group due to exposure to testosterone. This effect was reversed in the tea groups. From this, its possible to reach the conclusion that consumption of green tea shields the lipid profile, proteins, liver enzymes and hematological profile, thus reducing risk factors related to the supraphysiological doses of testosterone.
| Published in | American Journal of Sports Science (Volume 6, Issue 4) |
| DOI | 10.11648/j.ajss.20180604.15 |
| Page(s) | 162-168 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Testosterone Green, Tea, Cardiovascular Diseases, Lipid Profile, Hematological Profile, Hepatic Cancer
| [1] | Maravelias C., Dona A., Stefanidou M., Spiliopoulou C. Adverse effects of anabolic steroids in athletes. A constant threat. Toxicology letters. Vol. 158, No. 3, 2005, pp. 167-175. |
| [2] | Razavi Z., Moeini B., Shafiei Y., Bazmamoun H. Prevalence of anabolic steroid use and associated factors among body-builders in hamadan, west province of iran. Journal of research in health sciences. Vol. 14, No. 2, 2014, pp. 163-166. |
| [3] | Luijkx T., Velthuis B. K., Backx F. J., Buckens C. F., Prakken N. H., Rienks R. Anabolic androgenic steroid use is associated with ventricular dysfunction on cardiac mri in strength trained athletes. International journal of cardiology. Vol. 167, No. 3, 2013, pp. 664-668. |
| [4] | Piacentino D., Kotzalidis G. D., Longo L., Pavan A., Stivali L., Stivali G. Body image and eating disorders are common among professional and amateur athletes using performance and image enhancing drugs: A cross-sectional study. Journal of psychoactive drugs. Vol. 49, No. 5, 2017, pp. 373-384. |
| [5] | Nicholls A. R., Cope E., Bailey R., Koenen K., Dumon D., Theodorou N. C. Children's first experience of taking anabolic-androgenic steroids can occur before their 10th birthday: A systematic review identifying 9 factors that predicted doping among young people. Frontiers in psychology. Vol. 8, No. 2017, pp. 1015. |
| [6] | Lichtenfeld J., Deal B. J., Crawford S. Sudden cardiac arrest following ventricular fibrillation attributed to anabolic steroid use in an adolescent. Cardiology in the young. Vol. 26, No. 5, 2016, pp. 996-998. |
| [7] | dos Santos R. L., da Silva F. B., Ribeiro R. F., Jr., Stefanon I. Sex hormones in the cardiovascular system. Hormone molecular biology and clinical investigation. Vol. 18, No. 2, 2014, pp. 89-103. |
| [8] | Kasikcioglu E., Oflaz H., Arslan A., Topcu B., Kasikcioglu H. A., Umman B. Aortic elastic properties in athletes using anabolic-androgenic steroids. International journal of cardiology. Vol. 114, No. 1, 2007, pp. 132-134. |
| [9] | Sader M. A., Griffiths K. A., McCredie R. J., Handelsman D. J., Celermajer D. S. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. Journal of the American College of Cardiology. Vol. 37, No. 1, 2001, pp. 224-230. |
| [10] | Hartgens F., Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports medicine. Vol. 34, No. 8, 2004, pp. 513-554. |
| [11] | Yeap B. B. Sex steroids and cardiovascular disease. Asian journal of andrology. Vol. 16, No. 2, 2014, pp. 239-247. |
| [12] | Di Paolo M., Agozzino M., Toni C., Luciani A. B., Molendini L., Scaglione M. Sudden anabolic steroid abuse-related death in athletes. International journal of cardiology. Vol. 114, No. 1, 2007, pp. 114-117. |
| [13] | Montisci M., El Mazloum R., Cecchetto G., Terranova C., Ferrara S. D., Thiene G. Anabolic androgenic steroids abuse and cardiac death in athletes: Morphological and toxicological findings in four fatal cases. Forensic science international. Vol. 217, No. 1-3, 2012, pp. 13-18. |
| [14] | Yokozawa T., Noh J. S., Park C. H. Green tea polyphenols for the protection against renal damage caused by oxidative stress. Evidence-based complementary and alternative medicine. No. 845917, 2012. |
| [15] | Mostafa T., Sabry D., Abdelaal A. M., Mostafa I., Taymour M. Cavernous antioxidant effect of green tea, epigallocatechin-3-gallate with/without sildenafil citrate intake in aged diabetic rats. Andrologia. Vol. 45, No. 4, 2013, pp. 272-277. |
| [16] | Cheng H., Xu N., Zhao W., Su J., Liang M., Xie Z. (-)-epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high-fat diet. Molecular nutrition & food research. Vol. 61, No. 11, 2017, 1700303. |
| [17] | Grant P., Ramasamy S. An update on plant derived anti-androgens. International journal of endocrinology and metabolism. Vol. 10, No. 2, 2012, pp. 497-502. |
| [18] | Hiipakka R. A., Zhang H. Z., Dai W., Dai Q., Liao S. Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols. Biochemical pharmacology. Vol. 63, No. 6, 2002, pp. 1165-1176. |
| [19] | Ribeiro I. C. d. A., da Costa C. A., da Silva V. A., Correa L. B., Boaventura G. T., Chagas M. A. Flaxseed reduces epithelial proliferation but does not affect basal cells in induced benign prostatic hyperplasia in rats. European journal of nutrition. Vol. No. 2016, pp. 1201-1210. |
| [20] | Reeves P., Nielsen F., Gahey G. Ain-93 purified diets for laboratory rodents: Final report of the american institute of nutrition ad hoc writing committee on the reformation of the ain-76a rodent diet. Journal of Nutrition. Vol. 132, No. 1993, pp. 1939-1931. |
| [21] | Orner G. A., Dashwood W. M., Dashwood R. H. Tumor-suppressing effects of antioxidants from tea. The Journal of nutrition. Vol. 134, No. 11, 2004, pp. 3177-3178. |
| [22] | Melo M. G. D. d., Dória G. A. A., Serafini M. R., Araújo A. A. d. S. Hematological and biochemical reference values of wistar rats (rattus novergicus) from the central laboratory of the federal of sergipe university. Valores de referência hematológicos e bioquímicos de ratos (rattus novergicus linhagem wistar) provenientes do biotério central da Universidade Federal de Sergipe. Scientia plena. Vol. 8, No. 9, 2012, pp. 1-6. |
| [23] | Sharp P., Villano J. S., The laboratory rat. CRC press, 2012. |
| [24] | Figueiroa M. S., Cesar Vieira J. S., Leite D. S., Filho R. C., Ferreira F., Gouveia P. S. Green tea polyphenols inhibit testosterone production in rat leydig cells. Asian journal of andrology. Vol. 11, No. 3, 2009, pp. 362-370. |
| [25] | Jenkinson C., Petroczi A., Naughton D. P. Effects of dietary components on testosterone metabolism via udp-glucuronosyltransferase. Frontiers in endocrinology. Vol. 4, No. 2013, pp. 80. |
| [26] | Venâncio D. P., Nóbrega A. C. L. d., Tufik S., Mello M. T. d. Descriptive assessment on the use of anabolic steroids and their effect on the biochemical and neuroendocrine variables in practitioners of resisted exercise. Revista Brasileira de Medicina do Esporte. Vol. 16, No. 3, 2010, pp. 191-195. |
| [27] | Hartgens F., Rietjens G., Keizer H. A., Kuipers H., Wolffenbuttel B. H. R. Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a). British Journal of Sports Medicine. Vol. 38, No. 3, 2004, pp. 253-259. |
| [28] | Bhasin S. Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression. Clinical Infectious Diseases. Vol. 37, No. suppl. 2, 2003, pp. 142-149. |
| [29] | Glazer G. Atherogenic effects of anabolic steroids on serum lipid levels: A literature review. Archives of Internal Medicine. Vol. 151, No. 10, 1991, pp. 1925-1933. |
| [30] | Zheng X. X., Xu Y. L., Li S. H., Liu X. X., Hui R., Huang X. H. Green tea intake lowers fasting serum total and ldl cholesterol in adults: A meta-analysis of 14 randomized controlled trials. The American journal of clinical nutrition. Vol. 94, No. 2, 2011, pp. 601-610. |
| [31] | Craig W. J. Health-promoting properties of common herbs. The American journal of clinical nutrition. Vol. 70, No. Suppl. 3 Suppl, 1999, pp. 491S-499S. |
| [32] | Bose M., Lambert J. D., Ju J., Reuhl K. R., Shapses S. A., Yang C. S. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat–fed mice. The Journal of nutrition. Vol. 138, No. 9, 2008, pp. 1677-1683. |
| [33] | Wang S., Huang Y., Xu H., Zhu Q., Lu H., Zhang M. Oxidized tea polyphenols prevent lipid accumulation in liver and visceral white adipose tissue in rats. European journal of nutrition. Vol. 56 No. 6 2016, pp. 2037-2048. |
| [34] | Snoussi C., Ducroc R., Hamdaoui M. H., Dhaouadi K., Abaidi H., Cluzeaud F. Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet. The Journal of nutritional biochemistry. Vol. 25, No. 5, 2014, pp. 557-564. |
| [35] | Rosenblat M., Volkova N., Coleman R., Almagor Y., Aviram M. Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-e-deficient mice: Enhanced macrophage cholesterol efflux. The Journal of nutritional biochemistry. Vol. 19, No. 8, 2008, pp. 514-523. |
| [36] | Riezzo I., Turillazzi E., Bello S., Cantatore S., Cerretani D., Di Paolo M. Chronic nandrolone administration promotes oxidative stress, induction of pro-inflammatory cytokine and tnf-α mediated apoptosis in the kidneys of cd1 treated mice. Toxicology and Applied Pharmacology. Vol. 280, No. 1, 2014, pp. 97-106. |
| [37] | Fijak M., Damm L. J., Wenzel J. P., Aslani F., Walecki M., Wahle E. Influence of testosterone on inflammatory response in testicular cells and expression of transcription factor foxp3 in t cells. American journal of reproductive immunology (New York, NY: 1989). Vol. 74, No. 1, 2015, pp. 12-25. |
| [38] | Chignalia A. Z., Oliveira M. A., Debbas V., Dull R. O., Laurindo F. R., Touyz R. M. Testosterone induces leucocyte migration by nadph oxidase-driven ros- and cox2-dependent mechanisms. Clinical science (London, England: 1979). Vol. 129, No. 1, 2015, pp. 39-48. |
| [39] | Hsu A., Bruno R. S., Löhr C. V., Taylor A. W., Dashwood R. H., Bray T. M. Dietary soy and tea mitigate chronic inflammation and prostate cancer via nfκb pathway in the noble rat model. Journal of Nutritional Biochemistry. Vol. 22, No. 5, 2011, pp. 502-510. |
| [40] | Stimac D., Milic S., Dintinjana R. D., Kovac D., Ristic S. Androgenic/anabolic steroid-induced toxic hepatitis. Journal of clinical gastroenterology. Vol. 35, No. 4, 2002, pp. 350-352. |
| [41] | Welder A. A., Robertson J. W., Melchert R. B. Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. Journal of pharmacological and toxicological methods. Vol. 33, No. 4, 1995, pp. 187-195. |
| [42] | Tan Y., Kim J., Cheng J., Ong M., Lao W. G., Jin X. L. Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating ampk activation in high fat fed zucker fatty rats. World journal of gastroenterology. Vol. 23, No. 21, 2017, pp. 3805-3814. |
| [43] | Kesler T., Sandhu R. S., Krishnamoorthy S. Hepatology: Hepatocellular carcinoma in a young man secondary to androgenic anabolic steroid abuse. Journal of gastroenterology and hepatology. Vol. 29, No. 11, 2014, pp. 1852. |
| [44] | Gupta S., Naini B. V., Munoz R., Graham R. P., Kipp B. R., Torbenson M. S. Hepatocellular neoplasms arising in association with androgen use. The American journal of surgical pathology. Vol. 40, No. 4, 2016, pp. 454-461. |
| [45] | Darvesh A. S., Bishayee A. Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer. Nutr Cancer. Vol. 65, No. 3, 2013, pp. 329-344. |
| [46] | Gardner F. H., Pringle J. C., Jr. Androgens and erythropoiesis: I. Preliminary clinical observations. Archives of Internal Medicine. Vol. 107, No. 6, 1961, pp. 846-862. |
| [47] | Beggs L. A., Yarrow J. F., Conover C. F., Meuleman J. R., Beck D. T., Morrow M. Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone. American journal of physiology Endocrinology and metabolism. Vol. 307, No. 5, 2014, pp. 456-461. |
| [48] | Malgor L. A., Barrios L., de Albarenque M. E., Verges E., de Markowsky E. E., Montiel E. Erythropoietic effects of triiodothyronine on the anemia of renal failure in rats: Comparative studies with testosterone and erythropoietin. Experimental hematology. Vol. 14, No. 4, 1986, pp. 250-256. |
| [49] | Marouani N., Chahed A., Hédhili A., Hamdaoui M. H. Both aluminum and polyphenols in green tea decoction (camellia sinensis) affect iron status and hematological parameters in rats. European journal of nutrition. Vol. 46, No. 8, 2007, pp. 453-459. |
| [50] | Kennedy M., Lawrence C. Anabolic steroid abuse and cardiac death. The Medical journal of Australia. Vol. 158, No. 5, 1993, pp. 346-348. |
| [51] | Rockhold R. Cardiovascular toxicity of anabolic steroids. Annual review of pharmacology and toxicology. Vol. 33, No. 1, 1993, pp. 497-520. |
| [52] | Daher E. F., Júnior G. B. S., Queiroz A. L., Ramos L. M., Santos S. Q., Barreto D. M. Acute kidney injury due to anabolic steroid and vitamin supplement abuse: Report of two cases and a literature review. International urology and nephrology. Vol. 41, No. 3, 2009, pp. 717-723. |
| [53] | Štimac D., Milic S., Dintinjana R. D., Kovac D., Ristic S. Androgenic/anabolic steroid-induced toxic hepatitis. Journal of clinical gastroenterology. Vol. 35, No. 4, 2002, pp. 350-352. |
| [54] | Frey-Wettstein M., Craddock C. G. Testosterone-induced depletion of thymus and marrow lymphocytes as related to lymphopoiesis and hematopoiesis. Blood. Vol. 35, No. 3, 1970, pp. 257-271. |
| [55] | Fijak M., Schneider E., Klug J., Bhushan S., Hackstein H., Schuler G. Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: Evidence for a direct role of testosterone on regulatory t cell expansion. The Journal of Immunology. Vol. 186, No. 9, 2011, pp. 5162-5172. |
| [56] | Molina N., Bolin A. P., Otton R. Green tea polyphenols change the profile of inflammatory cytokine release from lymphocytes of obese and lean rats and protect against oxidative damage. International immunopharmacology. Vol. 28, No. 2, 2015, pp. 985-996. |
| [57] | Albuquerque K. F., Marinovic M. P., Morandi A. C., Bolin A. P., Otton R. Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats. European journal of nutrition. Vol. 55, No. 3, 2016, pp. 1261-1274. |
APA Style
Vivian Alves Pereira Silva, Gilson Teles Boaventura, Renato Souza Abboud, José Antônio Silva Ribas, Mauricio Alves Chagas. (2018). Consumption of Green Tea (Camellia sinensis) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation. American Journal of Sports Science, 6(4), 162-168. https://doi.org/10.11648/j.ajss.20180604.15
ACS Style
Vivian Alves Pereira Silva; Gilson Teles Boaventura; Renato Souza Abboud; José Antônio Silva Ribas; Mauricio Alves Chagas. Consumption of Green Tea (Camellia sinensis) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation. Am. J. Sports Sci. 2018, 6(4), 162-168. doi: 10.11648/j.ajss.20180604.15
AMA Style
Vivian Alves Pereira Silva, Gilson Teles Boaventura, Renato Souza Abboud, José Antônio Silva Ribas, Mauricio Alves Chagas. Consumption of Green Tea (Camellia sinensis) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation. Am J Sports Sci. 2018;6(4):162-168. doi: 10.11648/j.ajss.20180604.15
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Download@article{10.11648/j.ajss.20180604.15,
author = {Vivian Alves Pereira Silva and Gilson Teles Boaventura and Renato Souza Abboud and José Antônio Silva Ribas and Mauricio Alves Chagas},
title = {Consumption of Green Tea (Camellia sinensis) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation},
journal = {American Journal of Sports Science},
volume = {6},
number = {4},
pages = {162-168},
doi = {10.11648/j.ajss.20180604.15},
url = {https://doi.org/10.11648/j.ajss.20180604.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20180604.15},
abstract = {Indiscriminate use of anabolic steroids is associated with cardiovascular diseases, such as myocardial infarction, thrombosis, and arterial obstruction. Furthermore, high levels of androgens increase hepatic toxicity and the risk of cancer. Contrastingly, green tea prevents and controls cardiovascular and hepatic diseases, as it can improve the lipid profile and reduce inflammation and effects of oxidative stress. This study will evaluate benefits of green tea consumption, to attenuate systemic damage caused by supraphysiological doses of testosterone, by analyzing the lipid, biochemical, and hematological profiles of 28 42-day-old male Wistar rats. Silicone pellets containing testosterone in proportion were surgically implanted and replaced in these rats every four weeks, and they received casein-based control feed and water or green tea for hydration. After 20 weeks, all the male rats were anesthetized and their blood samples collected for the analysis of their biochemical and hematological profiles. Although the high hormone concentration had a negative influence on the lipid profile of these animals, the groups that consumed green tea exhibited a reduction in serum triglycerides (62%), Low Density Lipoprotein (76%), and Very Low Density Lipoprotein (45%). Tea consumption also led to a significant reduction in total cholesterol (32% in the green tea control group and 45% in the green tea-induced group), without changing the High Density Lipoprotein fraction. Only the green tea-induced group manifested a reduction in the total concentration of serum proteins. A fall in serum albumin was observed in the green tea-induced groups (2.3 g/dL) compared to control groups (2.9 g/dL). The induced group presented elevation in hematocrit, erythrocytosis, and leukocytosis in contrast to the green tea-induced group. The green tea control group maintained erythrocytosis, but without any other potentially harmful effect. A 30% increase in lymphocyte population in the induced group was observed. There was no difference in the platelet count of these rodents. Hepatic enzymes were also shown to have increased in the induced group, indicating hepatic injury in this group due to exposure to testosterone. This effect was reversed in the tea groups. From this, its possible to reach the conclusion that consumption of green tea shields the lipid profile, proteins, liver enzymes and hematological profile, thus reducing risk factors related to the supraphysiological doses of testosterone.},
year = {2018}
}
TY - JOUR T1 - Consumption of Green Tea (Camellia sinensis) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation AU - Vivian Alves Pereira Silva AU - Gilson Teles Boaventura AU - Renato Souza Abboud AU - José Antônio Silva Ribas AU - Mauricio Alves Chagas Y1 - 2018/10/29 PY - 2018 N1 - https://doi.org/10.11648/j.ajss.20180604.15 DO - 10.11648/j.ajss.20180604.15 T2 - American Journal of Sports Science JF - American Journal of Sports Science JO - American Journal of Sports Science SP - 162 EP - 168 PB - Science Publishing Group SN - 2330-8540 UR - https://doi.org/10.11648/j.ajss.20180604.15 AB - Indiscriminate use of anabolic steroids is associated with cardiovascular diseases, such as myocardial infarction, thrombosis, and arterial obstruction. Furthermore, high levels of androgens increase hepatic toxicity and the risk of cancer. Contrastingly, green tea prevents and controls cardiovascular and hepatic diseases, as it can improve the lipid profile and reduce inflammation and effects of oxidative stress. This study will evaluate benefits of green tea consumption, to attenuate systemic damage caused by supraphysiological doses of testosterone, by analyzing the lipid, biochemical, and hematological profiles of 28 42-day-old male Wistar rats. Silicone pellets containing testosterone in proportion were surgically implanted and replaced in these rats every four weeks, and they received casein-based control feed and water or green tea for hydration. After 20 weeks, all the male rats were anesthetized and their blood samples collected for the analysis of their biochemical and hematological profiles. Although the high hormone concentration had a negative influence on the lipid profile of these animals, the groups that consumed green tea exhibited a reduction in serum triglycerides (62%), Low Density Lipoprotein (76%), and Very Low Density Lipoprotein (45%). Tea consumption also led to a significant reduction in total cholesterol (32% in the green tea control group and 45% in the green tea-induced group), without changing the High Density Lipoprotein fraction. Only the green tea-induced group manifested a reduction in the total concentration of serum proteins. A fall in serum albumin was observed in the green tea-induced groups (2.3 g/dL) compared to control groups (2.9 g/dL). The induced group presented elevation in hematocrit, erythrocytosis, and leukocytosis in contrast to the green tea-induced group. The green tea control group maintained erythrocytosis, but without any other potentially harmful effect. A 30% increase in lymphocyte population in the induced group was observed. There was no difference in the platelet count of these rodents. Hepatic enzymes were also shown to have increased in the induced group, indicating hepatic injury in this group due to exposure to testosterone. This effect was reversed in the tea groups. From this, its possible to reach the conclusion that consumption of green tea shields the lipid profile, proteins, liver enzymes and hematological profile, thus reducing risk factors related to the supraphysiological doses of testosterone. VL - 6 IS - 4 ER -
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