Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease

Matheus Pelinski da Silveira; Aline Mânica; João Victor Garcia de Souza; Cíntia Krilow; Pedro Augusto Cavagni Ambrosi; Cristiane Márcia Siepko; Beatriz Da Silva Rosa Bonadiman; Margarete Dulce Bagatini; Débora Tavares Resende e Silva

doi:doi:10.11648/j.ajss.20180604.17

Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease

Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, Cristiane Márcia Siepko, Beatriz Da Silva Rosa Bonadiman, Margarete Dulce Bagatini, Débora Tavares Resende e Silva

Published in American Journal of Sports Science (Volume 6, Issue 4)

Received: 19 October 2018 Accepted: 12 November 2018 Published: 20 December 2018

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Abstract

Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.

Published in	American Journal of Sports Science (Volume 6, Issue 4)
DOI	10.11648/j.ajss.20180604.17
Page(s)	175-181
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Chronic Kidney Disease (CKD), Purinergic Signaling, Oxidative Stress, Platelet Aggregation, Resistance Exercise

References

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APA Style

Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, et al. (2018). Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. American Journal of Sports Science, 6(4), 175-181. https://doi.org/10.11648/j.ajss.20180604.17

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ACS Style

Matheus Pelinski da Silveira; Aline Mânica; João Victor Garcia de Souza; Cíntia Krilow; Pedro Augusto Cavagni Ambrosi, et al. Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. Am. J. Sports Sci. 2018, 6(4), 175-181. doi: 10.11648/j.ajss.20180604.17

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AMA Style

Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, et al. Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. Am J Sports Sci. 2018;6(4):175-181. doi: 10.11648/j.ajss.20180604.17

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@article{10.11648/j.ajss.20180604.17,
  author = {Matheus Pelinski da Silveira and Aline Mânica and João Victor Garcia de Souza and Cíntia Krilow and Pedro Augusto Cavagni Ambrosi and Cristiane Márcia Siepko and Beatriz Da Silva Rosa Bonadiman and Margarete Dulce Bagatini and Débora Tavares Resende e Silva},
  title = {Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease},
  journal = {American Journal of Sports Science},
  volume = {6},
  number = {4},
  pages = {175-181},
  doi = {10.11648/j.ajss.20180604.17},
  url = {https://doi.org/10.11648/j.ajss.20180604.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20180604.17},
  abstract = {Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.},
 year = {2018}
}

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TY  - JOUR
T1  - Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease
AU  - Matheus Pelinski da Silveira
AU  - Aline Mânica
AU  - João Victor Garcia de Souza
AU  - Cíntia Krilow
AU  - Pedro Augusto Cavagni Ambrosi
AU  - Cristiane Márcia Siepko
AU  - Beatriz Da Silva Rosa Bonadiman
AU  - Margarete Dulce Bagatini
AU  - Débora Tavares Resende e Silva
Y1  - 2018/12/20
PY  - 2018
N1  - https://doi.org/10.11648/j.ajss.20180604.17
DO  - 10.11648/j.ajss.20180604.17
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 175
EP  - 181
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20180604.17
AB  - Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.
VL  - 6
IS  - 4
ER  -

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Author Information

Matheus Pelinski da Silveira

Department of Medicine, Federal University of South Frontier, Chapecó, Brazil
Aline Mânica
João Victor Garcia de Souza
Cíntia Krilow

Department of Medicine, Federal University of South Frontier, Chapecó, Brazil
Pedro Augusto Cavagni Ambrosi

Department of Medicine, Federal University of South Frontier, Chapecó, Brazil
Cristiane Márcia Siepko

Department of Health Sciences, Ibrate College, Curitiba, Brazil
Beatriz Da Silva Rosa Bonadiman

Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil
Margarete Dulce Bagatini

Academic Coordination, Federal University of South Frontier, Chapecó, Brazil
Débora Tavares Resende e Silva

Academic Coordination, Federal University of South Frontier, Chapecó, Brazil

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APA Style

Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, et al. (2018). Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. American Journal of Sports Science, 6(4), 175-181. https://doi.org/10.11648/j.ajss.20180604.17

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ACS Style

Matheus Pelinski da Silveira; Aline Mânica; João Victor Garcia de Souza; Cíntia Krilow; Pedro Augusto Cavagni Ambrosi, et al. Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. Am. J. Sports Sci. 2018, 6(4), 175-181. doi: 10.11648/j.ajss.20180604.17

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AMA Style

Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, et al. Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. Am J Sports Sci. 2018;6(4):175-181. doi: 10.11648/j.ajss.20180604.17

Copy | Download

@article{10.11648/j.ajss.20180604.17,
  author = {Matheus Pelinski da Silveira and Aline Mânica and João Victor Garcia de Souza and Cíntia Krilow and Pedro Augusto Cavagni Ambrosi and Cristiane Márcia Siepko and Beatriz Da Silva Rosa Bonadiman and Margarete Dulce Bagatini and Débora Tavares Resende e Silva},
  title = {Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease},
  journal = {American Journal of Sports Science},
  volume = {6},
  number = {4},
  pages = {175-181},
  doi = {10.11648/j.ajss.20180604.17},
  url = {https://doi.org/10.11648/j.ajss.20180604.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20180604.17},
  abstract = {Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease
AU  - Matheus Pelinski da Silveira
AU  - Aline Mânica
AU  - João Victor Garcia de Souza
AU  - Cíntia Krilow
AU  - Pedro Augusto Cavagni Ambrosi
AU  - Cristiane Márcia Siepko
AU  - Beatriz Da Silva Rosa Bonadiman
AU  - Margarete Dulce Bagatini
AU  - Débora Tavares Resende e Silva
Y1  - 2018/12/20
PY  - 2018
N1  - https://doi.org/10.11648/j.ajss.20180604.17
DO  - 10.11648/j.ajss.20180604.17
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 175
EP  - 181
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20180604.17
AB  - Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.
VL  - 6
IS  - 4
ER  -

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