Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice

Gabrielle Yasmin Muller; André Henrique Ernandes de Amo; Karen Saar Vedovelli; Isabela Ramos Mariano; Giselle Cristina Bueno; Julia Pedrosa Furlan; Maria Montserrat Diaz Pedrosa

doi:doi:10.11648/j.ajss.20190702.12

Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice

Gabrielle Yasmin Muller, André Henrique Ernandes de Amo, Karen Saar Vedovelli, Isabela Ramos Mariano, Giselle Cristina Bueno, Julia Pedrosa Furlan, Maria Montserrat Diaz Pedrosa

Published in American Journal of Sports Science (Volume 7, Issue 2)

Received: 12 April 2019 Accepted: 23 May 2019 Published: 4 June 2019

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Abstract

High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.

Published in	American Journal of Sports Science (Volume 7, Issue 2)
DOI	10.11648/j.ajss.20190702.12
Page(s)	53-59
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Lactate, Resistance HIIT, Mouse, Liver, Performance

References

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APA Style

Gabrielle Yasmin Muller, André Henrique Ernandes de Amo, Karen Saar Vedovelli, Isabela Ramos Mariano, Giselle Cristina Bueno, et al. (2019). Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice. American Journal of Sports Science, 7(2), 53-59. https://doi.org/10.11648/j.ajss.20190702.12

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ACS Style

Gabrielle Yasmin Muller; André Henrique Ernandes de Amo; Karen Saar Vedovelli; Isabela Ramos Mariano; Giselle Cristina Bueno, et al. Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice. Am. J. Sports Sci. 2019, 7(2), 53-59. doi: 10.11648/j.ajss.20190702.12

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AMA Style

Gabrielle Yasmin Muller, André Henrique Ernandes de Amo, Karen Saar Vedovelli, Isabela Ramos Mariano, Giselle Cristina Bueno, et al. Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice. Am J Sports Sci. 2019;7(2):53-59. doi: 10.11648/j.ajss.20190702.12

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@article{10.11648/j.ajss.20190702.12,
  author = {Gabrielle Yasmin Muller and André Henrique Ernandes de Amo and Karen Saar Vedovelli and Isabela Ramos Mariano and Giselle Cristina Bueno and Julia Pedrosa Furlan and Maria Montserrat Diaz Pedrosa},
  title = {Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice},
  journal = {American Journal of Sports Science},
  volume = {7},
  number = {2},
  pages = {53-59},
  doi = {10.11648/j.ajss.20190702.12},
  url = {https://doi.org/10.11648/j.ajss.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20190702.12},
  abstract = {High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.},
 year = {2019}
}

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TY  - JOUR
T1  - Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice
AU  - Gabrielle Yasmin Muller
AU  - André Henrique Ernandes de Amo
AU  - Karen Saar Vedovelli
AU  - Isabela Ramos Mariano
AU  - Giselle Cristina Bueno
AU  - Julia Pedrosa Furlan
AU  - Maria Montserrat Diaz Pedrosa
Y1  - 2019/06/04
PY  - 2019
N1  - https://doi.org/10.11648/j.ajss.20190702.12
DO  - 10.11648/j.ajss.20190702.12
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 53
EP  - 59
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20190702.12
AB  - High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.
VL  - 7
IS  - 2
ER  -

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Author Information

Gabrielle Yasmin Muller

Department of Physical Education, State University of Maringá, Maringá, Brazil
André Henrique Ernandes de Amo

Department of Biological Sciences, State University of Maringá, Maringá, Brazil
Karen Saar Vedovelli

Specialization in Human Physiology, State University of Maringá, Maringá, Brazil
Isabela Ramos Mariano

Program of Graduate Studies in Physiological Sciences, State University of Maringá, Maringá, Brazil
Giselle Cristina Bueno

Program of Graduate Studies in Physical Education, State University of Maringá, Maringá, Brazil
Julia Pedrosa Furlan

Program of Graduate Studies in Physiological Sciences, State University of Maringá, Maringá, Brazil
Maria Montserrat Diaz Pedrosa

Department of Physiological Sciences, State University of Maringá, Maringá, Brazil

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APA Style

Gabrielle Yasmin Muller, André Henrique Ernandes de Amo, Karen Saar Vedovelli, Isabela Ramos Mariano, Giselle Cristina Bueno, et al. (2019). Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice. American Journal of Sports Science, 7(2), 53-59. https://doi.org/10.11648/j.ajss.20190702.12

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ACS Style

Gabrielle Yasmin Muller; André Henrique Ernandes de Amo; Karen Saar Vedovelli; Isabela Ramos Mariano; Giselle Cristina Bueno, et al. Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice. Am. J. Sports Sci. 2019, 7(2), 53-59. doi: 10.11648/j.ajss.20190702.12

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AMA Style

Gabrielle Yasmin Muller, André Henrique Ernandes de Amo, Karen Saar Vedovelli, Isabela Ramos Mariano, Giselle Cristina Bueno, et al. Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice. Am J Sports Sci. 2019;7(2):53-59. doi: 10.11648/j.ajss.20190702.12

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@article{10.11648/j.ajss.20190702.12,
  author = {Gabrielle Yasmin Muller and André Henrique Ernandes de Amo and Karen Saar Vedovelli and Isabela Ramos Mariano and Giselle Cristina Bueno and Julia Pedrosa Furlan and Maria Montserrat Diaz Pedrosa},
  title = {Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice},
  journal = {American Journal of Sports Science},
  volume = {7},
  number = {2},
  pages = {53-59},
  doi = {10.11648/j.ajss.20190702.12},
  url = {https://doi.org/10.11648/j.ajss.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20190702.12},
  abstract = {High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice
AU  - Gabrielle Yasmin Muller
AU  - André Henrique Ernandes de Amo
AU  - Karen Saar Vedovelli
AU  - Isabela Ramos Mariano
AU  - Giselle Cristina Bueno
AU  - Julia Pedrosa Furlan
AU  - Maria Montserrat Diaz Pedrosa
Y1  - 2019/06/04
PY  - 2019
N1  - https://doi.org/10.11648/j.ajss.20190702.12
DO  - 10.11648/j.ajss.20190702.12
T2  - American Journal of Sports Science
JF  - American Journal of Sports Science
JO  - American Journal of Sports Science
SP  - 53
EP  - 59
PB  - Science Publishing Group
SN  - 2330-8540
UR  - https://doi.org/10.11648/j.ajss.20190702.12
AB  - High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.
VL  - 7
IS  - 2
ER  -

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