BACKGROUND: Chronic kidney disease (CKD) is a major global health concern, often complicated by pulmonary dysfunction. As cardiorespiratory dysfunction progresses, respiratory symptoms in CKD patients may also reflect this. In this study, respiratory symptoms in pre-dialysis CKD patients in southeast Nigeria were evaluated for prevalence and clinical correlations. A total of 240 participants—120 pre-dialysis CKD patients and 120 matched controls—were assessed in this hospital-based cross-sectional investigation. The St. George's Respiratory Questionnaire were used to gather sociodemographic, and clinical data. Respiratory symptoms were compared across stages of chronic kidney disease. Multivariate logistic regression was used to examine relationships between clinical factors and pulmonary function. The results indicated that, there was a substantial increase in respiratory symptoms among CKD patients (60%) compared to controls (11.7%) (OR = 10.5; 95% CI: 5.47-20.17; p < 0.001). The most frequent symptoms were cough (40%) and dyspnea (31.7%). Respiratory symptoms were associated with anemia, edema, and prolonged disease duration. It was concluded that; as CKD progresses, respiratory symptoms and pulmonary dysfunction become more severe. The treatment of CKD prior to dialysis should include routine respiratory evaluations, such as spirometry and symptom monitoring. It takes a multidisciplinary management approach to reduce respiratory morbidity and enhance clinical results.
| Published in | Central African Journal of Public Health (Volume 11, Issue 6) |
| DOI | 10.11648/j.cajph.20251106.18 |
| Page(s) | 396-400 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Nigeria, South-east, Spirometry, Pre-dialysis, Respiratory Symptoms, Chronic Kidney Disease, And Pulmonary Function
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APA Style
Ahamefule, O. C., Charles, U., Tochukwu, E. V., Chinyere, P. (2025). Prevalence and Clinical Correlates of Respiratory Symptoms in Pre-Dialysis Patients with Chronic Kidney Disease in a Tertiary Hospital in Southeastern Nigeria. Central African Journal of Public Health, 11(6), 396-400. https://doi.org/10.11648/j.cajph.20251106.18
ACS Style
Ahamefule, O. C.; Charles, U.; Tochukwu, E. V.; Chinyere, P. Prevalence and Clinical Correlates of Respiratory Symptoms in Pre-Dialysis Patients with Chronic Kidney Disease in a Tertiary Hospital in Southeastern Nigeria. Cent. Afr. J. Public Health 2025, 11(6), 396-400. doi: 10.11648/j.cajph.20251106.18
AMA Style
Ahamefule OC, Charles U, Tochukwu EV, Chinyere P. Prevalence and Clinical Correlates of Respiratory Symptoms in Pre-Dialysis Patients with Chronic Kidney Disease in a Tertiary Hospital in Southeastern Nigeria. Cent Afr J Public Health. 2025;11(6):396-400. doi: 10.11648/j.cajph.20251106.18
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Download@article{10.11648/j.cajph.20251106.18,
author = {Ordu Collins Ahamefule and Ugwuunze Charles and Ezeifeh Victor Tochukwu and Patrick-Iwuanyanwu Chinyere},
title = {Prevalence and Clinical Correlates of Respiratory Symptoms in Pre-Dialysis Patients with Chronic Kidney Disease in a Tertiary Hospital in Southeastern Nigeria},
journal = {Central African Journal of Public Health},
volume = {11},
number = {6},
pages = {396-400},
doi = {10.11648/j.cajph.20251106.18},
url = {https://doi.org/10.11648/j.cajph.20251106.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20251106.18},
abstract = {BACKGROUND: Chronic kidney disease (CKD) is a major global health concern, often complicated by pulmonary dysfunction. As cardiorespiratory dysfunction progresses, respiratory symptoms in CKD patients may also reflect this. In this study, respiratory symptoms in pre-dialysis CKD patients in southeast Nigeria were evaluated for prevalence and clinical correlations. A total of 240 participants—120 pre-dialysis CKD patients and 120 matched controls—were assessed in this hospital-based cross-sectional investigation. The St. George's Respiratory Questionnaire were used to gather sociodemographic, and clinical data. Respiratory symptoms were compared across stages of chronic kidney disease. Multivariate logistic regression was used to examine relationships between clinical factors and pulmonary function. The results indicated that, there was a substantial increase in respiratory symptoms among CKD patients (60%) compared to controls (11.7%) (OR = 10.5; 95% CI: 5.47-20.17; p < 0.001). The most frequent symptoms were cough (40%) and dyspnea (31.7%). Respiratory symptoms were associated with anemia, edema, and prolonged disease duration. It was concluded that; as CKD progresses, respiratory symptoms and pulmonary dysfunction become more severe. The treatment of CKD prior to dialysis should include routine respiratory evaluations, such as spirometry and symptom monitoring. It takes a multidisciplinary management approach to reduce respiratory morbidity and enhance clinical results.},
year = {2025}
}
TY - JOUR T1 - Prevalence and Clinical Correlates of Respiratory Symptoms in Pre-Dialysis Patients with Chronic Kidney Disease in a Tertiary Hospital in Southeastern Nigeria AU - Ordu Collins Ahamefule AU - Ugwuunze Charles AU - Ezeifeh Victor Tochukwu AU - Patrick-Iwuanyanwu Chinyere Y1 - 2025/12/09 PY - 2025 N1 - https://doi.org/10.11648/j.cajph.20251106.18 DO - 10.11648/j.cajph.20251106.18 T2 - Central African Journal of Public Health JF - Central African Journal of Public Health JO - Central African Journal of Public Health SP - 396 EP - 400 PB - Science Publishing Group SN - 2575-5781 UR - https://doi.org/10.11648/j.cajph.20251106.18 AB - BACKGROUND: Chronic kidney disease (CKD) is a major global health concern, often complicated by pulmonary dysfunction. As cardiorespiratory dysfunction progresses, respiratory symptoms in CKD patients may also reflect this. In this study, respiratory symptoms in pre-dialysis CKD patients in southeast Nigeria were evaluated for prevalence and clinical correlations. A total of 240 participants—120 pre-dialysis CKD patients and 120 matched controls—were assessed in this hospital-based cross-sectional investigation. The St. George's Respiratory Questionnaire were used to gather sociodemographic, and clinical data. Respiratory symptoms were compared across stages of chronic kidney disease. Multivariate logistic regression was used to examine relationships between clinical factors and pulmonary function. The results indicated that, there was a substantial increase in respiratory symptoms among CKD patients (60%) compared to controls (11.7%) (OR = 10.5; 95% CI: 5.47-20.17; p < 0.001). The most frequent symptoms were cough (40%) and dyspnea (31.7%). Respiratory symptoms were associated with anemia, edema, and prolonged disease duration. It was concluded that; as CKD progresses, respiratory symptoms and pulmonary dysfunction become more severe. The treatment of CKD prior to dialysis should include routine respiratory evaluations, such as spirometry and symptom monitoring. It takes a multidisciplinary management approach to reduce respiratory morbidity and enhance clinical results. VL - 11 IS - 6 ER -
Department of Internal Medicine, University of Port Harcourt Teaching Hospital. Port Harcourt, Nigeria
Department of Internal Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Amaku Awka, Nigeria
Department of Internal Medicine, University of Port Harcourt Teaching Hospital. Port Harcourt, Nigeria
Department of Internal Medicine, University of Port Harcourt Teaching Hospital. Port Harcourt, Nigeria
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