Genetic Proclivities of Two-Component Modulated Aerobiosis

Hamzat Ibiyeye Tijani; Idris Abdulrahman; Bashir Mohammed Abubakar; Sulaiman Mohammed; Jibrin Ndejiko Mohammed; Haruna Saidu; Hindatu Yusuf

doi:doi:10.11648/j.cbb.20140201.11

Genetic Proclivities of Two-Component Modulated Aerobiosis

Hamzat Ibiyeye Tijani, Idris Abdulrahman, Bashir Mohammed Abubakar, Sulaiman Mohammed, Jibrin Ndejiko Mohammed, Haruna Saidu, Hindatu Yusuf

Published in Computational Biology and Bioinformatics (Volume 2, Issue 1)

Received: 11 December 2013 Published: 10 January 2014

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Abstract

Great advances have been made in the past five decades in understanding the molecular mechanics of the two-component signal transduction pathway in bacteria but its applications in Medicine and Food Industries are yet to be fully unravelled. We discuss the varying changes in the extracellular environment of bacteria and their possession of multiple Two-Component Systems with each being specialize to react to a specific environmental signal, such as pH, nutrient level, redox state, osmotic pressure, quorum signals, and antibiotics. The sensitivity of this response transmits information between different Two-Component Systems to form a complex signal transduction network. Bacteria’s signal transduction system, referred to as a two-component system, are essential for adaptation to external stimuli. These systems provides a signal transduction pathways widely employed from prokaryotes to eukaryotes. Typically, each two-component system composed of a sensor protein distinctively monitors an external signal(s) and a response regulator (RR) that controls gene expression and other physiological activities which are collectively assembled in a signal transduction pathway. This annex reviews the molecular mechanics underlying the signal transduction systems in prokaryotic organisms. It is not uncommon to hear, either explicitly or implicitly, the statement that “two component regulatory systems are well understood”. Therefore, we examine the current models of the mechanisms of the regulatory systems and provide viable suggestions to further expand its applications in drug efficiency and antibiotic resistance in humans as well as enhancing the shelf-life of products in the food industry. We also outline the challenges that might have quenched possible trials of this application to human health.

Published in	Computational Biology and Bioinformatics (Volume 2, Issue 1)
DOI	10.11648/j.cbb.20140201.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Signal Transduction, Two-Component Arc System, Aerobiosis, Antibiotics

References

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Hamzat Ibiyeye Tijani, Idris Abdulrahman, Bashir Mohammed Abubakar, Sulaiman Mohammed, Jibrin Ndejiko Mohammed, et al. (2014). Genetic Proclivities of Two-Component Modulated Aerobiosis. Computational Biology and Bioinformatics, 2(1), 1-6. https://doi.org/10.11648/j.cbb.20140201.11

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ACS Style

Hamzat Ibiyeye Tijani; Idris Abdulrahman; Bashir Mohammed Abubakar; Sulaiman Mohammed; Jibrin Ndejiko Mohammed, et al. Genetic Proclivities of Two-Component Modulated Aerobiosis. Comput. Biol. Bioinform. 2014, 2(1), 1-6. doi: 10.11648/j.cbb.20140201.11

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AMA Style

Hamzat Ibiyeye Tijani, Idris Abdulrahman, Bashir Mohammed Abubakar, Sulaiman Mohammed, Jibrin Ndejiko Mohammed, et al. Genetic Proclivities of Two-Component Modulated Aerobiosis. Comput Biol Bioinform. 2014;2(1):1-6. doi: 10.11648/j.cbb.20140201.11

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@article{10.11648/j.cbb.20140201.11,
  author = {Hamzat Ibiyeye Tijani and Idris Abdulrahman and Bashir Mohammed Abubakar and Sulaiman Mohammed and Jibrin Ndejiko Mohammed and Haruna Saidu and Hindatu Yusuf},
  title = {Genetic Proclivities of Two-Component Modulated Aerobiosis},
  journal = {Computational Biology and Bioinformatics},
  volume = {2},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.cbb.20140201.11},
  url = {https://doi.org/10.11648/j.cbb.20140201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cbb.20140201.11},
  abstract = {Great advances have been made in the past five decades in understanding the molecular mechanics of the two-component signal transduction pathway in bacteria but its applications in Medicine and Food Industries are yet to be fully unravelled. We discuss the varying changes in the extracellular environment of bacteria and their possession of multiple Two-Component Systems with each being specialize to react to a specific environmental signal, such as pH, nutrient level, redox state, osmotic pressure, quorum signals, and antibiotics. The sensitivity of this response transmits information between different Two-Component Systems to form a complex signal transduction network. Bacteria’s signal transduction system, referred to as a two-component system, are essential for adaptation to external stimuli. These systems provides a signal transduction pathways widely employed from prokaryotes to eukaryotes. Typically, each two-component system composed of a sensor protein distinctively monitors an external signal(s) and a response regulator (RR) that controls gene expression and other physiological activities which are collectively assembled in a signal transduction pathway. This annex reviews the molecular mechanics underlying the signal transduction systems in prokaryotic organisms. It is not uncommon to hear, either explicitly or implicitly, the statement that “two component regulatory systems are well understood”. Therefore, we examine the current models of the mechanisms of the regulatory systems and provide viable suggestions to further expand its applications in drug efficiency and antibiotic resistance in humans as well as enhancing the shelf-life of products in the food industry. We also outline the challenges that might have quenched possible trials of this application to human health.},
 year = {2014}
}

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TY  - JOUR
T1  - Genetic Proclivities of Two-Component Modulated Aerobiosis
AU  - Hamzat Ibiyeye Tijani
AU  - Idris Abdulrahman
AU  - Bashir Mohammed Abubakar
AU  - Sulaiman Mohammed
AU  - Jibrin Ndejiko Mohammed
AU  - Haruna Saidu
AU  - Hindatu Yusuf
Y1  - 2014/01/10
PY  - 2014
N1  - https://doi.org/10.11648/j.cbb.20140201.11
DO  - 10.11648/j.cbb.20140201.11
T2  - Computational Biology and Bioinformatics
JF  - Computational Biology and Bioinformatics
JO  - Computational Biology and Bioinformatics
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-8281
UR  - https://doi.org/10.11648/j.cbb.20140201.11
AB  - Great advances have been made in the past five decades in understanding the molecular mechanics of the two-component signal transduction pathway in bacteria but its applications in Medicine and Food Industries are yet to be fully unravelled. We discuss the varying changes in the extracellular environment of bacteria and their possession of multiple Two-Component Systems with each being specialize to react to a specific environmental signal, such as pH, nutrient level, redox state, osmotic pressure, quorum signals, and antibiotics. The sensitivity of this response transmits information between different Two-Component Systems to form a complex signal transduction network. Bacteria’s signal transduction system, referred to as a two-component system, are essential for adaptation to external stimuli. These systems provides a signal transduction pathways widely employed from prokaryotes to eukaryotes. Typically, each two-component system composed of a sensor protein distinctively monitors an external signal(s) and a response regulator (RR) that controls gene expression and other physiological activities which are collectively assembled in a signal transduction pathway. This annex reviews the molecular mechanics underlying the signal transduction systems in prokaryotic organisms. It is not uncommon to hear, either explicitly or implicitly, the statement that “two component regulatory systems are well understood”. Therefore, we examine the current models of the mechanisms of the regulatory systems and provide viable suggestions to further expand its applications in drug efficiency and antibiotic resistance in humans as well as enhancing the shelf-life of products in the food industry. We also outline the challenges that might have quenched possible trials of this application to human health.
VL  - 2
IS  - 1
ER  -

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Author Information

Hamzat Ibiyeye Tijani

Faculty of Bioscience & Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor-Bahru, Malaysia
Idris Abdulrahman

Department of Microbiology, Kaduna State University, P.M.B. 2339, Kaduna
Bashir Mohammed Abubakar

Department of Biological Sciences, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria
Sulaiman Mohammed

Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria
Jibrin Ndejiko Mohammed

Department of Microbiology, Ibrahim Badamasi Babangida University Lapai, P.M.B 011, Niger, Nigeria
Haruna Saidu

Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria
Hindatu Yusuf

Department of Biochemistry, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria

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APA Style

Hamzat Ibiyeye Tijani, Idris Abdulrahman, Bashir Mohammed Abubakar, Sulaiman Mohammed, Jibrin Ndejiko Mohammed, et al. (2014). Genetic Proclivities of Two-Component Modulated Aerobiosis. Computational Biology and Bioinformatics, 2(1), 1-6. https://doi.org/10.11648/j.cbb.20140201.11

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ACS Style

Hamzat Ibiyeye Tijani; Idris Abdulrahman; Bashir Mohammed Abubakar; Sulaiman Mohammed; Jibrin Ndejiko Mohammed, et al. Genetic Proclivities of Two-Component Modulated Aerobiosis. Comput. Biol. Bioinform. 2014, 2(1), 1-6. doi: 10.11648/j.cbb.20140201.11

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AMA Style

Hamzat Ibiyeye Tijani, Idris Abdulrahman, Bashir Mohammed Abubakar, Sulaiman Mohammed, Jibrin Ndejiko Mohammed, et al. Genetic Proclivities of Two-Component Modulated Aerobiosis. Comput Biol Bioinform. 2014;2(1):1-6. doi: 10.11648/j.cbb.20140201.11

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@article{10.11648/j.cbb.20140201.11,
  author = {Hamzat Ibiyeye Tijani and Idris Abdulrahman and Bashir Mohammed Abubakar and Sulaiman Mohammed and Jibrin Ndejiko Mohammed and Haruna Saidu and Hindatu Yusuf},
  title = {Genetic Proclivities of Two-Component Modulated Aerobiosis},
  journal = {Computational Biology and Bioinformatics},
  volume = {2},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.cbb.20140201.11},
  url = {https://doi.org/10.11648/j.cbb.20140201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cbb.20140201.11},
  abstract = {Great advances have been made in the past five decades in understanding the molecular mechanics of the two-component signal transduction pathway in bacteria but its applications in Medicine and Food Industries are yet to be fully unravelled. We discuss the varying changes in the extracellular environment of bacteria and their possession of multiple Two-Component Systems with each being specialize to react to a specific environmental signal, such as pH, nutrient level, redox state, osmotic pressure, quorum signals, and antibiotics. The sensitivity of this response transmits information between different Two-Component Systems to form a complex signal transduction network. Bacteria’s signal transduction system, referred to as a two-component system, are essential for adaptation to external stimuli. These systems provides a signal transduction pathways widely employed from prokaryotes to eukaryotes. Typically, each two-component system composed of a sensor protein distinctively monitors an external signal(s) and a response regulator (RR) that controls gene expression and other physiological activities which are collectively assembled in a signal transduction pathway. This annex reviews the molecular mechanics underlying the signal transduction systems in prokaryotic organisms. It is not uncommon to hear, either explicitly or implicitly, the statement that “two component regulatory systems are well understood”. Therefore, we examine the current models of the mechanisms of the regulatory systems and provide viable suggestions to further expand its applications in drug efficiency and antibiotic resistance in humans as well as enhancing the shelf-life of products in the food industry. We also outline the challenges that might have quenched possible trials of this application to human health.},
 year = {2014}
}

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TY  - JOUR
T1  - Genetic Proclivities of Two-Component Modulated Aerobiosis
AU  - Hamzat Ibiyeye Tijani
AU  - Idris Abdulrahman
AU  - Bashir Mohammed Abubakar
AU  - Sulaiman Mohammed
AU  - Jibrin Ndejiko Mohammed
AU  - Haruna Saidu
AU  - Hindatu Yusuf
Y1  - 2014/01/10
PY  - 2014
N1  - https://doi.org/10.11648/j.cbb.20140201.11
DO  - 10.11648/j.cbb.20140201.11
T2  - Computational Biology and Bioinformatics
JF  - Computational Biology and Bioinformatics
JO  - Computational Biology and Bioinformatics
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-8281
UR  - https://doi.org/10.11648/j.cbb.20140201.11
AB  - Great advances have been made in the past five decades in understanding the molecular mechanics of the two-component signal transduction pathway in bacteria but its applications in Medicine and Food Industries are yet to be fully unravelled. We discuss the varying changes in the extracellular environment of bacteria and their possession of multiple Two-Component Systems with each being specialize to react to a specific environmental signal, such as pH, nutrient level, redox state, osmotic pressure, quorum signals, and antibiotics. The sensitivity of this response transmits information between different Two-Component Systems to form a complex signal transduction network. Bacteria’s signal transduction system, referred to as a two-component system, are essential for adaptation to external stimuli. These systems provides a signal transduction pathways widely employed from prokaryotes to eukaryotes. Typically, each two-component system composed of a sensor protein distinctively monitors an external signal(s) and a response regulator (RR) that controls gene expression and other physiological activities which are collectively assembled in a signal transduction pathway. This annex reviews the molecular mechanics underlying the signal transduction systems in prokaryotic organisms. It is not uncommon to hear, either explicitly or implicitly, the statement that “two component regulatory systems are well understood”. Therefore, we examine the current models of the mechanisms of the regulatory systems and provide viable suggestions to further expand its applications in drug efficiency and antibiotic resistance in humans as well as enhancing the shelf-life of products in the food industry. We also outline the challenges that might have quenched possible trials of this application to human health.
VL  - 2
IS  - 1
ER  -

Copy | Download