In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone.
| Published in | International Journal of Bioorganic Chemistry (Volume 2, Issue 3) |
| DOI | 10.11648/j.ijbc.20170203.11 |
| Page(s) | 83-86 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Microwave Irradiation (MWI), 2-thiobarbituric Acid Derivatives, Arylidene Acetophenone, Antimicrobial and Cytotoxic Activity
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APA Style
M. A. Sattar, Mst. Khodeza Khatun, Tapan K. Sarkar, Sharif M. Al-Reza. (2017). Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives. International Journal of Bioorganic Chemistry, 2(3), 83-86. https://doi.org/10.11648/j.ijbc.20170203.11
ACS Style
M. A. Sattar; Mst. Khodeza Khatun; Tapan K. Sarkar; Sharif M. Al-Reza. Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives. Int. J. Bioorg. Chem. 2017, 2(3), 83-86. doi: 10.11648/j.ijbc.20170203.11
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Download@article{10.11648/j.ijbc.20170203.11,
author = {M. A. Sattar and Mst. Khodeza Khatun and Tapan K. Sarkar and Sharif M. Al-Reza},
title = {Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives},
journal = {International Journal of Bioorganic Chemistry},
volume = {2},
number = {3},
pages = {83-86},
doi = {10.11648/j.ijbc.20170203.11},
url = {https://doi.org/10.11648/j.ijbc.20170203.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbc.20170203.11},
abstract = {In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone.},
year = {2017}
}
TY - JOUR T1 - Ecofriendly Synthesis of Bioactive 2-thiobarbituric Acid Derivatives AU - M. A. Sattar AU - Mst. Khodeza Khatun AU - Tapan K. Sarkar AU - Sharif M. Al-Reza Y1 - 2017/03/27 PY - 2017 N1 - https://doi.org/10.11648/j.ijbc.20170203.11 DO - 10.11648/j.ijbc.20170203.11 T2 - International Journal of Bioorganic Chemistry JF - International Journal of Bioorganic Chemistry JO - International Journal of Bioorganic Chemistry SP - 83 EP - 86 PB - Science Publishing Group SN - 2578-9392 UR - https://doi.org/10.11648/j.ijbc.20170203.11 AB - In this study, five derivatives of 2-thiobarbituric acid were prepared under microwave irradiation (MWI) and conventional heating method. It was found that the preparation time wasreduced from 24 hours to 5-10 minutes by using microwave irradiation method. In microwave irradiation, the yield also comparatively very high (97.50-98.32%) than conventional method (74-78%). FT-IR, 1H-NMR spectral data were used to determine the structures of the compounds. The antimicrobial activity of the synthesized compounds were investigated by using Staphylococcus aureus, Bacillus megaterium, Escherichia coli and Pseudomonas aeruginosa bacteia. The zone of inhibition of the compounds were found in the range of 8 to 14 mm. In cytotoxic analysis, the mortality 74-89% were appeared when sample concentration were (0.78-6.25) μg/ml and more than 6.25 μg/ml concentration showed 100% mortality. The antimicrobial and cytotoxic activity of synthesized compoundswas found due to the presence of a reactive and unsaturated ketone. VL - 2 IS - 3 ER -
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