Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro

Ruslan Valerievich Savchuk; Dmitriy Aleksandrovich Zhukovsky; Natalya Vladimirovna Shmatkova

doi:doi:10.11648/j.ijpc.20170305.11

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Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro

Ruslan Valerievich Savchuk, Dmitriy Aleksandrovich Zhukovsky, Natalya Vladimirovna Shmatkova

Published in International Journal of Pharmacy and Chemistry (Volume 3, Issue 5)

Received: 29 May 2017 Accepted: 5 September 2017 Published: 17 October 2017

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Abstract

Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3- (dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10^-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.

Published in	International Journal of Pharmacy and Chemistry (Volume 3, Issue 5)
DOI	10.11648/j.ijpc.20170305.11
Page(s)	62-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Radical Cystectomy, Neobladder, New Chemical Compounds, Proserin, Gynipral

References

[1]	Park J. 1. Radical cystectomy and orthotopic bladder substitution using ileum. Ahn H. Korean J Urol. 2011 Apr; 52(4):233-40. Epub 2011 Apr 22.
[2]	Stein J. P. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1054 patients /G. Lieskovsky, R. Cote [et al.] // J. Clin. Oncol. – 2001. – Vol. 19. – P. 666–775; 486–492; discussion 491–492.
[3]	Hautmann R. E. 25 years of experience with 1,000 neobladders: long-term complications / R. E. Hautmann, R. C. de Petriconi, B. G. Volkmer // J. Urol. – 2011. – Vol. 185. – P. 2207–2212.
[4]	Stein J. P., Skinner D. G. Application of the T-mechanism to an orthotopic (T-pouch) neobladder: a new era of urinary diversion. World J Urol. 2000;18:315–323.
[5]	Campbell’s Urology / Edited by P. C. Walsh [et al.]. – 8th ed. – Philadelphia : W. B. Saunders Co., 2002. – Vol. 3. – 3420 p.
[6]	Cystectomy for transitional cell carcinoma of the bladder: results of a surgery only series in the neobladder era / R. E. Hautmann, J. E. Gschwend, de Petriconi R. C. [et al. // J. Urol. – 2006. – Vol. 176. – P.486–492.
[7]	Hollenbeck BK, Miller DC, et al. Aggressive treatment for bladder cancer is associated with improved overall survival among patients 80 years old or older. Urology. 2004;64:292–7.
[8]	Singh V. 1. Urodynamic and continence assessment of orthotropic neobladder reconstruction following radical cystectomy in bladder cancer; a prospective, blinded North Indian tertiary care experience. /Mandal S.1., Patil S.1., Sinha R. J. et all. / South Asian J. Cancer. 2014 Oct;3(4):223-6.
[9]	Hautmann R. E. ICUD-EAU International Consultation on Bladder Cancer 2012: Urinary diversion Abol-Enein H, Davidsson T, Gudjonsson S, Hautmann SH, Eur Urol. 2013 Jan; 63(1):67-80. Epub 2012 Aug 31.
[10]	Blair P. J., Rhee P.-L., Sanders K. M., Ward S. M. The Significance of Interstitial Cells in Neurogastroenterology. J. Neurogastroenterol. Motil, 2014; 20, 3: 294–317.

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APA Style

Ruslan Valerievich Savchuk, Dmitriy Aleksandrovich Zhukovsky, Natalya Vladimirovna Shmatkova. (2017). Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro. International Journal of Pharmacy and Chemistry, 3(5), 62-66. https://doi.org/10.11648/j.ijpc.20170305.11

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ACS Style

Ruslan Valerievich Savchuk; Dmitriy Aleksandrovich Zhukovsky; Natalya Vladimirovna Shmatkova. Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro. Int. J. Pharm. Chem. 2017, 3(5), 62-66. doi: 10.11648/j.ijpc.20170305.11

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AMA Style

Ruslan Valerievich Savchuk, Dmitriy Aleksandrovich Zhukovsky, Natalya Vladimirovna Shmatkova. Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro. Int J Pharm Chem. 2017;3(5):62-66. doi: 10.11648/j.ijpc.20170305.11

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@article{10.11648/j.ijpc.20170305.11,
  author = {Ruslan Valerievich Savchuk and Dmitriy Aleksandrovich Zhukovsky and Natalya Vladimirovna Shmatkova},
  title = {Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {3},
  number = {5},
  pages = {62-66},
  doi = {10.11648/j.ijpc.20170305.11},
  url = {https://doi.org/10.11648/j.ijpc.20170305.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20170305.11},
  abstract = {Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3- (dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.},
 year = {2017}
}

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TY  - JOUR
T1  - Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro
AU  - Ruslan Valerievich Savchuk
AU  - Dmitriy Aleksandrovich Zhukovsky
AU  - Natalya Vladimirovna Shmatkova
Y1  - 2017/10/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ijpc.20170305.11
DO  - 10.11648/j.ijpc.20170305.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 62
EP  - 66
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20170305.11
AB  - Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3- (dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.
VL  - 3
IS  - 5
ER  -

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Author Information

Ruslan Valerievich Savchuk

Department of Urology and Nephrology, Odessa National Medical University, Odessa, Ukraine
Dmitriy Aleksandrovich Zhukovsky

Department of Urology and Nephrology, Odessa National Medical University, Odessa, Ukraine
Natalya Vladimirovna Shmatkova

Department of General Chemistry and Polymers, Odessa I. I. Mechnikov National University, Odessa, Ukraine

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APA Style

Ruslan Valerievich Savchuk, Dmitriy Aleksandrovich Zhukovsky, Natalya Vladimirovna Shmatkova. (2017). Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro. International Journal of Pharmacy and Chemistry, 3(5), 62-66. https://doi.org/10.11648/j.ijpc.20170305.11

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ACS Style

Ruslan Valerievich Savchuk; Dmitriy Aleksandrovich Zhukovsky; Natalya Vladimirovna Shmatkova. Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro. Int. J. Pharm. Chem. 2017, 3(5), 62-66. doi: 10.11648/j.ijpc.20170305.11

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AMA Style

Ruslan Valerievich Savchuk, Dmitriy Aleksandrovich Zhukovsky, Natalya Vladimirovna Shmatkova. Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro. Int J Pharm Chem. 2017;3(5):62-66. doi: 10.11648/j.ijpc.20170305.11

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@article{10.11648/j.ijpc.20170305.11,
  author = {Ruslan Valerievich Savchuk and Dmitriy Aleksandrovich Zhukovsky and Natalya Vladimirovna Shmatkova},
  title = {Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {3},
  number = {5},
  pages = {62-66},
  doi = {10.11648/j.ijpc.20170305.11},
  url = {https://doi.org/10.11648/j.ijpc.20170305.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20170305.11},
  abstract = {Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3- (dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.},
 year = {2017}
}

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TY  - JOUR
T1  - Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro
AU  - Ruslan Valerievich Savchuk
AU  - Dmitriy Aleksandrovich Zhukovsky
AU  - Natalya Vladimirovna Shmatkova
Y1  - 2017/10/17
PY  - 2017
N1  - https://doi.org/10.11648/j.ijpc.20170305.11
DO  - 10.11648/j.ijpc.20170305.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 62
EP  - 66
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20170305.11
AB  - Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3- (dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.
VL  - 3
IS  - 5
ER  -

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