Magnesium Enhances the Antidiabetic Activity of <i>Lippia multiflora</i> Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats

Yapo Fulgence Allo; Brou Andre Konan; Ziehi Fidele Kpahe; Yao Jacques Datte

doi:doi:10.11648/j.ijpc.20220805.12

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Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats

Yapo Fulgence Allo, Brou Andre Konan, Ziehi Fidele Kpahe, Yao Jacques Datte

Published in International Journal of Pharmacy and Chemistry (Volume 8, Issue 5)

Received: 29 September 2022 Accepted: 14 October 2022 Published: 28 October 2022

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Abstract

Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous extract supplemented with magnesium (LiMAE-Mg) on blood glucose, lipid profile and cardiovascular parameters in streptozotocin-diabetic rats and compared with diabetic and drug-treated rats. Methods: Diabetes was induced in adult male Wistar rats by intraperitoneal administration of streptozotocin (10 mg/kg). 7 groups of 5 STZ-diabetic rats were treated daily for 10 days with Glucophage (Glu 10 mg/kg), Lippia multiflora leaves aqueous extract (LiMAE 200, 400 and 600 mg/kg) and LiMAE-Mg (200, 400 and 600 mg/kg). One group of untreated diabetic rats (uDR) and one group of healthy rats (HeR) were the controls. After 10 days of treatment, some biological parameters were measured in 12 hr-fasted rats. Results: Diabetic rats had elevated levels of blood glucose (379.76%), glycosylated hemoglobin (HbA_1c), LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and decreased levels of blood insulin and HDL-cholesterol. Like Glu 10 mg/kg, LiMAE and LiMAE-Mg significantly (p < 0.05) reduced the disturbances caused by STZ in a dose-dependent manner. When diabetic rats were treated separately with LiMAE-Mg and LiMAE, a significant reduction in blood glucose (9.72 to 73.76%), HbA_1c, LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and an elevation in blood insulin and HDL-cholesterol were observed. However, the effects induced by LiMAE-Mg were greater at p < 0.05 than those of LiMAE, the extract of Lippia multiflora without magnesium. Conclusion: Supplementation with magnesium significantly increased the antidiabetic effects of Lippia multiflora leaves aqueous extract in streptozotocin-diabetic rats. However, future studies should be carried out on body weight, transaminases of regulatory organs, redox status and hematological parameters. Ultimately, these works will make it possible to better appreciate the beneficial effect of supplementation with magnesium of this medicinal plant extract in diabetic.

Published in	International Journal of Pharmacy and Chemistry (Volume 8, Issue 5)
DOI	10.11648/j.ijpc.20220805.12
Page(s)	57-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Lippia multiflora, Diabetes, Magnesium, Streptozotocin, Antidiabetic Effect

References

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Yapo Fulgence Allo, Brou Andre Konan, Ziehi Fidele Kpahe, Yao Jacques Datte. (2022). Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats. International Journal of Pharmacy and Chemistry, 8(5), 57-66. https://doi.org/10.11648/j.ijpc.20220805.12

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Yapo Fulgence Allo; Brou Andre Konan; Ziehi Fidele Kpahe; Yao Jacques Datte. Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats. Int. J. Pharm. Chem. 2022, 8(5), 57-66. doi: 10.11648/j.ijpc.20220805.12

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Yapo Fulgence Allo, Brou Andre Konan, Ziehi Fidele Kpahe, Yao Jacques Datte. Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats. Int J Pharm Chem. 2022;8(5):57-66. doi: 10.11648/j.ijpc.20220805.12

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@article{10.11648/j.ijpc.20220805.12,
  author = {Yapo Fulgence Allo and Brou Andre Konan and Ziehi Fidele Kpahe and Yao Jacques Datte},
  title = {Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {8},
  number = {5},
  pages = {57-66},
  doi = {10.11648/j.ijpc.20220805.12},
  url = {https://doi.org/10.11648/j.ijpc.20220805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20220805.12},
  abstract = {Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous extract supplemented with magnesium (LiMAE-Mg) on blood glucose, lipid profile and cardiovascular parameters in streptozotocin-diabetic rats and compared with diabetic and drug-treated rats. Methods: Diabetes was induced in adult male Wistar rats by intraperitoneal administration of streptozotocin (10 mg/kg). 7 groups of 5 STZ-diabetic rats were treated daily for 10 days with Glucophage (Glu 10 mg/kg), Lippia multiflora leaves aqueous extract (LiMAE 200, 400 and 600 mg/kg) and LiMAE-Mg (200, 400 and 600 mg/kg). One group of untreated diabetic rats (uDR) and one group of healthy rats (HeR) were the controls. After 10 days of treatment, some biological parameters were measured in 12 hr-fasted rats. Results: Diabetic rats had elevated levels of blood glucose (379.76%), glycosylated hemoglobin (HbA1c), LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and decreased levels of blood insulin and HDL-cholesterol. Like Glu 10 mg/kg, LiMAE and LiMAE-Mg significantly (p ) reduced the disturbances caused by STZ in a dose-dependent manner. When diabetic rats were treated separately with LiMAE-Mg and LiMAE, a significant reduction in blood glucose (9.72 to 73.76%), HbA1c, LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and an elevation in blood insulin and HDL-cholesterol were observed. However, the effects induced by LiMAE-Mg were greater at p  than those of LiMAE, the extract of Lippia multiflora without magnesium. Conclusion: Supplementation with magnesium significantly increased the antidiabetic effects of Lippia multiflora leaves aqueous extract in streptozotocin-diabetic rats. However, future studies should be carried out on body weight, transaminases of regulatory organs, redox status and hematological parameters. Ultimately, these works will make it possible to better appreciate the beneficial effect of supplementation with magnesium of this medicinal plant extract in diabetic.},
 year = {2022}
}

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TY  - JOUR
T1  - Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats
AU  - Yapo Fulgence Allo
AU  - Brou Andre Konan
AU  - Ziehi Fidele Kpahe
AU  - Yao Jacques Datte
Y1  - 2022/10/28
PY  - 2022
N1  - https://doi.org/10.11648/j.ijpc.20220805.12
DO  - 10.11648/j.ijpc.20220805.12
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 57
EP  - 66
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20220805.12
AB  - Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous extract supplemented with magnesium (LiMAE-Mg) on blood glucose, lipid profile and cardiovascular parameters in streptozotocin-diabetic rats and compared with diabetic and drug-treated rats. Methods: Diabetes was induced in adult male Wistar rats by intraperitoneal administration of streptozotocin (10 mg/kg). 7 groups of 5 STZ-diabetic rats were treated daily for 10 days with Glucophage (Glu 10 mg/kg), Lippia multiflora leaves aqueous extract (LiMAE 200, 400 and 600 mg/kg) and LiMAE-Mg (200, 400 and 600 mg/kg). One group of untreated diabetic rats (uDR) and one group of healthy rats (HeR) were the controls. After 10 days of treatment, some biological parameters were measured in 12 hr-fasted rats. Results: Diabetic rats had elevated levels of blood glucose (379.76%), glycosylated hemoglobin (HbA1c), LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and decreased levels of blood insulin and HDL-cholesterol. Like Glu 10 mg/kg, LiMAE and LiMAE-Mg significantly (p ) reduced the disturbances caused by STZ in a dose-dependent manner. When diabetic rats were treated separately with LiMAE-Mg and LiMAE, a significant reduction in blood glucose (9.72 to 73.76%), HbA1c, LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and an elevation in blood insulin and HDL-cholesterol were observed. However, the effects induced by LiMAE-Mg were greater at p  than those of LiMAE, the extract of Lippia multiflora without magnesium. Conclusion: Supplementation with magnesium significantly increased the antidiabetic effects of Lippia multiflora leaves aqueous extract in streptozotocin-diabetic rats. However, future studies should be carried out on body weight, transaminases of regulatory organs, redox status and hematological parameters. Ultimately, these works will make it possible to better appreciate the beneficial effect of supplementation with magnesium of this medicinal plant extract in diabetic.
VL  - 8
IS  - 5
ER  -

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Yapo Fulgence Allo

Laboratory of Biology and Health, Felix Houphouet-Boigny University, Abidjan, Ivory Coast
Brou Andre Konan

Laboratory of Biology and Health, Felix Houphouet-Boigny University, Abidjan, Ivory Coast
Ziehi Fidele Kpahe

Laboratory of Biodiversity and Tropical Ecology, Jean Lorougnon Guede University, Daloa, Ivory Coast
Yao Jacques Datte

Laboratory of Biology and Health, Felix Houphouet-Boigny University, Abidjan, Ivory Coast

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Yapo Fulgence Allo, Brou Andre Konan, Ziehi Fidele Kpahe, Yao Jacques Datte. (2022). Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats. International Journal of Pharmacy and Chemistry, 8(5), 57-66. https://doi.org/10.11648/j.ijpc.20220805.12

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Yapo Fulgence Allo; Brou Andre Konan; Ziehi Fidele Kpahe; Yao Jacques Datte. Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats. Int. J. Pharm. Chem. 2022, 8(5), 57-66. doi: 10.11648/j.ijpc.20220805.12

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Yapo Fulgence Allo, Brou Andre Konan, Ziehi Fidele Kpahe, Yao Jacques Datte. Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats. Int J Pharm Chem. 2022;8(5):57-66. doi: 10.11648/j.ijpc.20220805.12

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@article{10.11648/j.ijpc.20220805.12,
  author = {Yapo Fulgence Allo and Brou Andre Konan and Ziehi Fidele Kpahe and Yao Jacques Datte},
  title = {Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {8},
  number = {5},
  pages = {57-66},
  doi = {10.11648/j.ijpc.20220805.12},
  url = {https://doi.org/10.11648/j.ijpc.20220805.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20220805.12},
  abstract = {Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous extract supplemented with magnesium (LiMAE-Mg) on blood glucose, lipid profile and cardiovascular parameters in streptozotocin-diabetic rats and compared with diabetic and drug-treated rats. Methods: Diabetes was induced in adult male Wistar rats by intraperitoneal administration of streptozotocin (10 mg/kg). 7 groups of 5 STZ-diabetic rats were treated daily for 10 days with Glucophage (Glu 10 mg/kg), Lippia multiflora leaves aqueous extract (LiMAE 200, 400 and 600 mg/kg) and LiMAE-Mg (200, 400 and 600 mg/kg). One group of untreated diabetic rats (uDR) and one group of healthy rats (HeR) were the controls. After 10 days of treatment, some biological parameters were measured in 12 hr-fasted rats. Results: Diabetic rats had elevated levels of blood glucose (379.76%), glycosylated hemoglobin (HbA1c), LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and decreased levels of blood insulin and HDL-cholesterol. Like Glu 10 mg/kg, LiMAE and LiMAE-Mg significantly (p ) reduced the disturbances caused by STZ in a dose-dependent manner. When diabetic rats were treated separately with LiMAE-Mg and LiMAE, a significant reduction in blood glucose (9.72 to 73.76%), HbA1c, LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and an elevation in blood insulin and HDL-cholesterol were observed. However, the effects induced by LiMAE-Mg were greater at p  than those of LiMAE, the extract of Lippia multiflora without magnesium. Conclusion: Supplementation with magnesium significantly increased the antidiabetic effects of Lippia multiflora leaves aqueous extract in streptozotocin-diabetic rats. However, future studies should be carried out on body weight, transaminases of regulatory organs, redox status and hematological parameters. Ultimately, these works will make it possible to better appreciate the beneficial effect of supplementation with magnesium of this medicinal plant extract in diabetic.},
 year = {2022}
}

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TY  - JOUR
T1  - Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Extract on Glycemia, Lipid Profile and Cardiovascular Parameters in Streptozotocin-diabetic Rats
AU  - Yapo Fulgence Allo
AU  - Brou Andre Konan
AU  - Ziehi Fidele Kpahe
AU  - Yao Jacques Datte
Y1  - 2022/10/28
PY  - 2022
N1  - https://doi.org/10.11648/j.ijpc.20220805.12
DO  - 10.11648/j.ijpc.20220805.12
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 57
EP  - 66
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20220805.12
AB  - Background & Aims: According to studies, magnesium would have beneficial effects in the treatment of diabetes which prompted studies on the supplementation of medicinal substances with magnesium for the treatment of this disease. This work is situated in this context. It was conducted to investigate the effects of Lippia multiflora leaves aqueous extract supplemented with magnesium (LiMAE-Mg) on blood glucose, lipid profile and cardiovascular parameters in streptozotocin-diabetic rats and compared with diabetic and drug-treated rats. Methods: Diabetes was induced in adult male Wistar rats by intraperitoneal administration of streptozotocin (10 mg/kg). 7 groups of 5 STZ-diabetic rats were treated daily for 10 days with Glucophage (Glu 10 mg/kg), Lippia multiflora leaves aqueous extract (LiMAE 200, 400 and 600 mg/kg) and LiMAE-Mg (200, 400 and 600 mg/kg). One group of untreated diabetic rats (uDR) and one group of healthy rats (HeR) were the controls. After 10 days of treatment, some biological parameters were measured in 12 hr-fasted rats. Results: Diabetic rats had elevated levels of blood glucose (379.76%), glycosylated hemoglobin (HbA1c), LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and decreased levels of blood insulin and HDL-cholesterol. Like Glu 10 mg/kg, LiMAE and LiMAE-Mg significantly (p ) reduced the disturbances caused by STZ in a dose-dependent manner. When diabetic rats were treated separately with LiMAE-Mg and LiMAE, a significant reduction in blood glucose (9.72 to 73.76%), HbA1c, LDL-cholesterol, total cholesterol, triglycerides and cardiovascular parameters and an elevation in blood insulin and HDL-cholesterol were observed. However, the effects induced by LiMAE-Mg were greater at p  than those of LiMAE, the extract of Lippia multiflora without magnesium. Conclusion: Supplementation with magnesium significantly increased the antidiabetic effects of Lippia multiflora leaves aqueous extract in streptozotocin-diabetic rats. However, future studies should be carried out on body weight, transaminases of regulatory organs, redox status and hematological parameters. Ultimately, these works will make it possible to better appreciate the beneficial effect of supplementation with magnesium of this medicinal plant extract in diabetic.
VL  - 8
IS  - 5
ER  -

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