| Peer-Reviewed

Medicinal Importance of Some Metal Cluster Compounds

Received: 7 January 2016     Accepted: 11 January 2016     Published: 29 January 2016
Views:       Downloads:
Abstract

Metal clusters are very interesting materials with highly active metal sites. Active metal sites are important for interaction with biological targets. In this review article we have summarized medicinal/biological importance of metal clusters compounds. We have presented the collection metal clusters having potential for the treatment of different fetal diseases like Cancer, Diabetic, Alzheimer, Cardiovascular disease, Hypertension, and Anemia etc. Thus the metal clusters are now getting prominence share in modern medicines.

Published in Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 1)
DOI 10.11648/j.jddmc.20160201.11
Page(s) 1-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Metal Clusters, Cancer, Medicines, Metal Carbonyls, Organometallics

References
[1] Mingos, D. M. P.; Wales, D. J. Introduction to cluster chemistry: Prentice Hall; 1990.
[2] Huheey, J. E.; Keiter, E. A.; Keiter, R. L.; Medhi, O. K. Inorganic chemistry: principles of structure and reactivity: Pearson Education India; 2006.
[3] Kravtsova, A. N.; Lomachenko, K. A.; Soldatov, A. V.; Meyer, J.; Niedner-Schatteburg, G.; Peredkov, S.; Eberhardt, W.; Neeb, M.; Journal of Electron Spectroscopy and Related Phenomena. 2014, 195, 189-94.
[4] Allardyce, C. S.; Dyson, P. J.; Journal of Cluster Science. 2001, 12, 563-9.
[5] Szczepanowski, R. H.; Filipek, R.; Bochtler, M.; Journal of Biological Chemistry. 2005, 280, 22006-11.
[6] Dahms, S. O.; Kuester, M.; Streb, C.; Roth, C.; Straeter, N.; Than, M. E.; Acta Crystallographica Section D: Biological Crystallography. 2013, 69, 284-97.
[7] Gomis-RuÈth, F. X.; Coll, M.; Acta Crystallographica Section D: Biological Crystallography. 2001, 57, 800-5.
[8] Pacchioni, G.; Krüger, S.; Rösch, N.; Metal Clusters in Chemistry. 1999, 1392-433.
[9] Turner, J. A.; Science. 2004, 305, 972-4.
[10] Lippert, B. Cisplatin: chemistry and biochemistry of a leading anticancer drug: Wiley-vch; 1999.
[11] Takahara, P. M.; Frederick, C. A.; Lippard, S. J.; Journal of the American Chemical Society. 1996, 118, 12309-21.
[12] Stevens, R. C.; Nature structural & molecular biology. 2004, 11, 293-5.
[13] Hotze, A. C.; van der Geer, E. P.; Kooijman, H.; Spek, A. L.; Haasnoot, J. G.; Reedijk, J.; European journal of inorganic chemistry. 2005, 2005, 2648-57.
[14] Dorcier, A.; Ang, W. H.; Bolano, S.; Gonsalvi, L.; Juillerat-Jeannerat, L.; Laurenczy, G.; Peruzzini, M.; Phillips, A. D.; Zanobini, F.; Dyson, P. J.; Organometallics. 2006, 25, 4090-6.
[15] Schluga, P.; Hartinger, C. G.; Egger, A.; Reisner, E.; Galanski, M.; Jakupec, M. A.; Keppler, B. K.; Dalton Transactions. 2006, 1796-802.
[16] Therrien, B.; Ang, W. H.; Cherioux, F.; Vieille-Petit, L.; Juillerat-Jeanneret, L.; Süss-Fink, G.; Dyson, P. J.; Journal of Cluster Science. 2007, 18, 741-52.
[17] Herman, A.; Tanski, J. M.; Tibbetts, M. F.; Anderson, C. M.; Inorganic chemistry. 2008, 47, 274-80.
[18] Page, S. M.; Boss, S. R.; Barker, P. D.; Future medicinal chemistry. 2009, 1, 541-59.
[19] Vincent, J. B.; Love, S.; Biochimica et Biophysica Acta (BBA)-General Subjects. 2012, 1820, 362-78.
[20] Meißner, T.; Bergmann, R.; Oswald, J.; Rode, K.; Stephan, H.; Richter, W.; Zänker, H.; Kraus, W.; Emmerling, F.; Reck, G.; Transition metal chemistry. 2006, 31, 603-10.
[21] Shestopalov, M. A.; Mironov, Y. V.; Brylev, K. A.; Kozlova, S. G.; Fedorov, V. E.; Spies, H.; Pietzsch, H.-J.; Stephan, H.; Geipel, G.; Bernhard, G.; Journal of the American Chemical Society. 2007, 129, 3714-21.
[22] Stephan, H.; Kubeil, M.; Emmerling, F.; Müller, C. E.; European journal of inorganic chemistry. 2013, 2013, 1585-94.
[23] Pricker, S. P.; Gold bulletin. 1996, 29, 53-60.
[24] Allardyce, C. S.; Dyson, P. J.; Ellis, D. J.; Salter, P. A.; Scopelliti, R.; Journal of organometallic chemistry. 2003, 668, 35-42.
[25] Rehder, D. Vanadium. Its role for humans. Interrelations between Essential Metal Ions and Human Diseases: Springer; 2013. p. 139-69.
[26] Chen, J.; Wang, D.; Xi, J.; Au, L.; Siekkinen, A.; Warsen, A.; Li, Z.-Y.; Zhang, H.; Xia, Y.; Li, X.; Nano letters. 2007, 7, 1318-22.
[27] Rhodes, M. D.; Sadler, P. J.; Scawen, M. D.; Silver, S.; Journal of inorganic biochemistry. 1992, 46, 129-42.
[28] Khan E.; Khan U. A.; Badshah A.; Tahir M.N.; Altaf A. A.;.Journal of Molecular Structure. 2014, 1060, 150-55.
[29] Girgis, L.; Conaghan, P. G.; Brooks, P.; Current opinion in rheumatology. 1994, 6, 252-61.
[30] Jain, P. K.; Huang, X.; El-Sayed, I. H.; El-Sayed, M. A.; Accounts of Chemical Research. 2008, 41, 1578-86.
[31] Hindi, K. M.; Siciliano, T. J.; Durmus, S.; Panzner, M. J.; Medvetz, D. A.; Reddy, D. V.; Hogue, L. A.; Hovis, C. E.; Hilliard, J. K.; Mallet, R. J.; Tessier, C. A.; Cannon, C. L.; Youngs, W. J.; Journal of Medicinal Chemistry. 2008, 51, 1577-83.
[32] Clarke, E. G. C. Isolation and identification of drugs in Pharmaceuticals, body fluids, and post-mortem material. Vol. 2: The Pharmaceutical Press, 17 Bloomsbury Square, London WC1A2NN.; 1975.
[33] Warrell, R. P.; Coonley, C. J.; Straus, D. J.; Young, C. W.; Cancer. 1983, 51, 1982-7.
[34] Roy, S.; Westmaas, J. A.; Hagen, K. D.; van Wezel, G. P.; Reedijk, J.; Journal of inorganic biochemistry. 2009, 103, 1288-97.
[35] Echeverría, C.; Becerra, A.; Nuñez-Villena, F.; Muñoz-Castro, A.; Stehberg, J.; Zheng, Z.; Arratia-Perez, R.; Simon, F.; Ramírez-Tagle, R.; New journal of chemistry. 2012, 36, 927-32.
[36] Orto, P. J.; Nichol, G. S.; Okumura, N.; Evans, D. H.; Arratia-Pérez, R.; Ramirez-Tagle, R.; Wang, R.; Zheng, Z.; Dalton Transactions. 2008, 4247-53.
[37] Schmidt, K.; Jung, M.; Keilitz, R.; Schnurr, B.; Gust, R.; Inorganica Chimica Acta. 2000, 306, 6-16.
[38] Roth, T.; Eckert, C.; Fiebig, H.-H.; Jung, M.; Anticancer research. 2001, 22, 2281-4.
[39] Motterlini, R.; Otterbein, L. E.; Nature reviews Drug discovery. 2010, 9, 728-43.
[40] Thorup, C.; Jones, C. L.; Gross, S. S.; Moore, L. C.; Goligorsky, M. S.; American Journal of Physiology-Renal Physiology. 1999, 277, F882-F9.
[41] Motterlini, R.; Biochemical Society Transactions. 2007, 35, 1142-6.
[42] Shtemenko, A. V.; Collery, P.; Shtemenko, N. I.; Domasevitch, K. V.; Zabitskaya, E. D.; Golichenko, A. A.; Dalton Transactions. 2009, 5132-6.
[43] Zuris, J. A.; Harir, Y.; Conlan, A. R.; Shvartsman, M.; Michaeli, D.; Tamir, S.; Paddock, M. L.; Onuchic, J. N.; Mittler, R.; Cabantchik, Z. I.; Proceedings of the National Academy of Sciences. 2011, 108, 13047-52.
Cite This Article
  • APA Style

    Ataf Ali Altaf, Muhammad Hafeez, Sumbal Arshad, Nayab Saher, Amin Badshah. (2016). Medicinal Importance of Some Metal Cluster Compounds. Journal of Drug Design and Medicinal Chemistry, 2(1), 1-9. https://doi.org/10.11648/j.jddmc.20160201.11

    Copy | Download

    ACS Style

    Ataf Ali Altaf; Muhammad Hafeez; Sumbal Arshad; Nayab Saher; Amin Badshah. Medicinal Importance of Some Metal Cluster Compounds. J. Drug Des. Med. Chem. 2016, 2(1), 1-9. doi: 10.11648/j.jddmc.20160201.11

    Copy | Download

    AMA Style

    Ataf Ali Altaf, Muhammad Hafeez, Sumbal Arshad, Nayab Saher, Amin Badshah. Medicinal Importance of Some Metal Cluster Compounds. J Drug Des Med Chem. 2016;2(1):1-9. doi: 10.11648/j.jddmc.20160201.11

    Copy | Download

  • @article{10.11648/j.jddmc.20160201.11,
      author = {Ataf Ali Altaf and Muhammad Hafeez and Sumbal Arshad and Nayab Saher and Amin Badshah},
      title = {Medicinal Importance of Some Metal Cluster Compounds},
      journal = {Journal of Drug Design and Medicinal Chemistry},
      volume = {2},
      number = {1},
      pages = {1-9},
      doi = {10.11648/j.jddmc.20160201.11},
      url = {https://doi.org/10.11648/j.jddmc.20160201.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20160201.11},
      abstract = {Metal clusters are very interesting materials with highly active metal sites. Active metal sites are important for interaction with biological targets. In this review article we have summarized medicinal/biological importance of metal clusters compounds. We have presented the collection metal clusters having potential for the treatment of different fetal diseases like Cancer, Diabetic, Alzheimer, Cardiovascular disease, Hypertension, and Anemia etc. Thus the metal clusters are now getting prominence share in modern medicines.},
     year = {2016}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Medicinal Importance of Some Metal Cluster Compounds
    AU  - Ataf Ali Altaf
    AU  - Muhammad Hafeez
    AU  - Sumbal Arshad
    AU  - Nayab Saher
    AU  - Amin Badshah
    Y1  - 2016/01/29
    PY  - 2016
    N1  - https://doi.org/10.11648/j.jddmc.20160201.11
    DO  - 10.11648/j.jddmc.20160201.11
    T2  - Journal of Drug Design and Medicinal Chemistry
    JF  - Journal of Drug Design and Medicinal Chemistry
    JO  - Journal of Drug Design and Medicinal Chemistry
    SP  - 1
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2472-3576
    UR  - https://doi.org/10.11648/j.jddmc.20160201.11
    AB  - Metal clusters are very interesting materials with highly active metal sites. Active metal sites are important for interaction with biological targets. In this review article we have summarized medicinal/biological importance of metal clusters compounds. We have presented the collection metal clusters having potential for the treatment of different fetal diseases like Cancer, Diabetic, Alzheimer, Cardiovascular disease, Hypertension, and Anemia etc. Thus the metal clusters are now getting prominence share in modern medicines.
    VL  - 2
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Jalal Pur Jatta Road, Gujrat, Pakistan

  • Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan

  • Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Jalal Pur Jatta Road, Gujrat, Pakistan

  • Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Jalal Pur Jatta Road, Gujrat, Pakistan

  • Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan

  • Sections