Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases

Sajjad Hussain Sumrra; Muhammad Ibrahim; Sabahat Ambreen; Muhammad Imran; Muhammad Naveed Zafar; Muhammad Faizan Nazar; Fouzia Sultana Rehmani

doi:doi:10.11648/j.jddmc.20160203.11

Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases

Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, Muhammad Faizan Nazar, Fouzia Sultana Rehmani

Published in Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 3)

Received: 4 March 2016 Accepted: 3 June 2016 Published: 30 June 2016

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Abstract

A new series of bidentate nitrogen donor type Schiff bases (L¹)-(L³) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.

Published in	Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 3)
DOI	10.11648/j.jddmc.20160203.11
Page(s)	26-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Nitrogen Donor Schiff Bases, Bidentate Ligands, Metal(II) Complexes, Antibacterial and Antifungal Activities

References

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APA Style

Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, et al. (2016). Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. Journal of Drug Design and Medicinal Chemistry, 2(3), 26-34. https://doi.org/10.11648/j.jddmc.20160203.11

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ACS Style

Sajjad Hussain Sumrra; Muhammad Ibrahim; Sabahat Ambreen; Muhammad Imran; Muhammad Naveed Zafar, et al. Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. J. Drug Des. Med. Chem. 2016, 2(3), 26-34. doi: 10.11648/j.jddmc.20160203.11

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AMA Style

Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, et al. Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. J Drug Des Med Chem. 2016;2(3):26-34. doi: 10.11648/j.jddmc.20160203.11

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@article{10.11648/j.jddmc.20160203.11,
  author = {Sajjad Hussain Sumrra and Muhammad Ibrahim and Sabahat Ambreen and Muhammad Imran and Muhammad Naveed Zafar and Muhammad Faizan Nazar and Fouzia Sultana Rehmani},
  title = {Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {2},
  number = {3},
  pages = {26-34},
  doi = {10.11648/j.jddmc.20160203.11},
  url = {https://doi.org/10.11648/j.jddmc.20160203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20160203.11},
  abstract = {A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.},
 year = {2016}
}

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TY  - JOUR
T1  - Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases
AU  - Sajjad Hussain Sumrra
AU  - Muhammad Ibrahim
AU  - Sabahat Ambreen
AU  - Muhammad Imran
AU  - Muhammad Naveed Zafar
AU  - Muhammad Faizan Nazar
AU  - Fouzia Sultana Rehmani
Y1  - 2016/06/30
PY  - 2016
N1  - https://doi.org/10.11648/j.jddmc.20160203.11
DO  - 10.11648/j.jddmc.20160203.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 26
EP  - 34
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20160203.11
AB  - A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.
VL  - 2
IS  - 3
ER  -

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Author Information

Sajjad Hussain Sumrra

Department of Chemistry, University of Gujrat, Gujrat, Pakistan
Muhammad Ibrahim

Department of Applied Chemistry, Govt. College University, Faisalabad, Pakistan
Sabahat Ambreen

Department of Chemistry, University of Karachi, Karachi, Pakistan
Muhammad Imran

Department of Chemistry, Ghazi University, Dera Ghazi Khan, Pakistan
Muhammad Naveed Zafar

Department of Chemistry, Quaid-e-Azam University, Islamabad, Pakistan
Muhammad Faizan Nazar

Department of Chemistry, University of Gujrat, Gujrat, Pakistan
Fouzia Sultana Rehmani

Department of Chemistry, University of Karachi, Karachi, Pakistan

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APA Style

Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, et al. (2016). Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. Journal of Drug Design and Medicinal Chemistry, 2(3), 26-34. https://doi.org/10.11648/j.jddmc.20160203.11

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ACS Style

Sajjad Hussain Sumrra; Muhammad Ibrahim; Sabahat Ambreen; Muhammad Imran; Muhammad Naveed Zafar, et al. Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. J. Drug Des. Med. Chem. 2016, 2(3), 26-34. doi: 10.11648/j.jddmc.20160203.11

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AMA Style

Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, et al. Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. J Drug Des Med Chem. 2016;2(3):26-34. doi: 10.11648/j.jddmc.20160203.11

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@article{10.11648/j.jddmc.20160203.11,
  author = {Sajjad Hussain Sumrra and Muhammad Ibrahim and Sabahat Ambreen and Muhammad Imran and Muhammad Naveed Zafar and Muhammad Faizan Nazar and Fouzia Sultana Rehmani},
  title = {Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {2},
  number = {3},
  pages = {26-34},
  doi = {10.11648/j.jddmc.20160203.11},
  url = {https://doi.org/10.11648/j.jddmc.20160203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20160203.11},
  abstract = {A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.},
 year = {2016}
}

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TY  - JOUR
T1  - Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases
AU  - Sajjad Hussain Sumrra
AU  - Muhammad Ibrahim
AU  - Sabahat Ambreen
AU  - Muhammad Imran
AU  - Muhammad Naveed Zafar
AU  - Muhammad Faizan Nazar
AU  - Fouzia Sultana Rehmani
Y1  - 2016/06/30
PY  - 2016
N1  - https://doi.org/10.11648/j.jddmc.20160203.11
DO  - 10.11648/j.jddmc.20160203.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 26
EP  - 34
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20160203.11
AB  - A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.
VL  - 2
IS  - 3
ER  -

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