Background: RT-QuIC (Real-Time QuIC) is a clinical diagnostic method that detects trace proteins in samples through protein amplification. According to the international CJD diagnostic criteria, RT-QuIC provides diagnostic evidence that is second only to that of pathology. Presently, this approach remains underutilized in China. Case Report: A 76-year-old female patient was admitted to the hospital for a period of two weeks, characterized by a general slowing of her cognitive responses. A physical examination revealed elevated levels of cognitive impairment, as indicated by a Mini-Mental State Examination (MMSE) score of 12 and a Montreal Cognitive Assessment (MoCA) score of 8. An electroencephalogram (EEG) revealed moderate abnormalities, characterized by intermittent high-amplitude delta waves (frequency 3–3.5 Hz) across multiple leads and short-range rhythmic discharges in several leads. A magnetic resonance imaging (MRI) scan revealed the presence of ribbon-like changes in the parietal and temporal cortical regions on diffusion-weighted imaging (DWI) sequences. CSF testing for 14-3-3 protein yielded a negative result, while RT-QuIC testing produced a positive result. Treatment: The primary management strategy encompassed the provision of supportive care and the management of symptoms. The clinical outcome is as follows: The treatment response was unsatisfactory, with a rapid disease progression over a 52-day period. The patient exhibited a progressive deterioration in visuospatial function, accompanied by the emergence of myoclonus, tremor, urinary and fecal incontinence, and motor mutism. Conclusion: RT-QuIC testing has the potential to enhance diagnostic specificity and sensitivity in patients suspected of having Creutzfeldt-Jakob disease (CJD).
| Published in | Science Discovery (Volume 13, Issue 6) |
| DOI | 10.11648/j.sd.20251306.16 |
| Page(s) | 139-142 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2025. Published by Science Publishing Group |
Creutzfeldt-Jakob Disease, 14-3-3 Protein, RT-QuIC, Cortical Ribbon Sign
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APA Style
Jia, Z., Geng, J. (2025). A Case of Sporadic Creutzfeldt-Jakob Disease (sCJD) with Lightning-like Progression. Science Discovery, 13(6), 139-142. https://doi.org/10.11648/j.sd.20251306.16
ACS Style
Jia, Z.; Geng, J. A Case of Sporadic Creutzfeldt-Jakob Disease (sCJD) with Lightning-like Progression. Sci. Discov. 2025, 13(6), 139-142. doi: 10.11648/j.sd.20251306.16
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Download@article{10.11648/j.sd.20251306.16,
author = {Zhengchang Jia and Jinfeng Geng},
title = {A Case of Sporadic Creutzfeldt-Jakob Disease (sCJD) with Lightning-like Progression
},
journal = {Science Discovery},
volume = {13},
number = {6},
pages = {139-142},
doi = {10.11648/j.sd.20251306.16},
url = {https://doi.org/10.11648/j.sd.20251306.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20251306.16},
abstract = {Background: RT-QuIC (Real-Time QuIC) is a clinical diagnostic method that detects trace proteins in samples through protein amplification. According to the international CJD diagnostic criteria, RT-QuIC provides diagnostic evidence that is second only to that of pathology. Presently, this approach remains underutilized in China. Case Report: A 76-year-old female patient was admitted to the hospital for a period of two weeks, characterized by a general slowing of her cognitive responses. A physical examination revealed elevated levels of cognitive impairment, as indicated by a Mini-Mental State Examination (MMSE) score of 12 and a Montreal Cognitive Assessment (MoCA) score of 8. An electroencephalogram (EEG) revealed moderate abnormalities, characterized by intermittent high-amplitude delta waves (frequency 3–3.5 Hz) across multiple leads and short-range rhythmic discharges in several leads. A magnetic resonance imaging (MRI) scan revealed the presence of ribbon-like changes in the parietal and temporal cortical regions on diffusion-weighted imaging (DWI) sequences. CSF testing for 14-3-3 protein yielded a negative result, while RT-QuIC testing produced a positive result. Treatment: The primary management strategy encompassed the provision of supportive care and the management of symptoms. The clinical outcome is as follows: The treatment response was unsatisfactory, with a rapid disease progression over a 52-day period. The patient exhibited a progressive deterioration in visuospatial function, accompanied by the emergence of myoclonus, tremor, urinary and fecal incontinence, and motor mutism. Conclusion: RT-QuIC testing has the potential to enhance diagnostic specificity and sensitivity in patients suspected of having Creutzfeldt-Jakob disease (CJD).
},
year = {2025}
}
TY - JOUR T1 - A Case of Sporadic Creutzfeldt-Jakob Disease (sCJD) with Lightning-like Progression AU - Zhengchang Jia AU - Jinfeng Geng Y1 - 2025/12/24 PY - 2025 N1 - https://doi.org/10.11648/j.sd.20251306.16 DO - 10.11648/j.sd.20251306.16 T2 - Science Discovery JF - Science Discovery JO - Science Discovery SP - 139 EP - 142 PB - Science Publishing Group SN - 2331-0650 UR - https://doi.org/10.11648/j.sd.20251306.16 AB - Background: RT-QuIC (Real-Time QuIC) is a clinical diagnostic method that detects trace proteins in samples through protein amplification. According to the international CJD diagnostic criteria, RT-QuIC provides diagnostic evidence that is second only to that of pathology. Presently, this approach remains underutilized in China. Case Report: A 76-year-old female patient was admitted to the hospital for a period of two weeks, characterized by a general slowing of her cognitive responses. A physical examination revealed elevated levels of cognitive impairment, as indicated by a Mini-Mental State Examination (MMSE) score of 12 and a Montreal Cognitive Assessment (MoCA) score of 8. An electroencephalogram (EEG) revealed moderate abnormalities, characterized by intermittent high-amplitude delta waves (frequency 3–3.5 Hz) across multiple leads and short-range rhythmic discharges in several leads. A magnetic resonance imaging (MRI) scan revealed the presence of ribbon-like changes in the parietal and temporal cortical regions on diffusion-weighted imaging (DWI) sequences. CSF testing for 14-3-3 protein yielded a negative result, while RT-QuIC testing produced a positive result. Treatment: The primary management strategy encompassed the provision of supportive care and the management of symptoms. The clinical outcome is as follows: The treatment response was unsatisfactory, with a rapid disease progression over a 52-day period. The patient exhibited a progressive deterioration in visuospatial function, accompanied by the emergence of myoclonus, tremor, urinary and fecal incontinence, and motor mutism. Conclusion: RT-QuIC testing has the potential to enhance diagnostic specificity and sensitivity in patients suspected of having Creutzfeldt-Jakob disease (CJD). VL - 13 IS - 6 ER -
Department of Neurology, Jinzhong Second People's Hospital, Jinzhong, China
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