Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin

Ion Castravet

doi:doi:10.11648/j.wjac.20170203.17

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Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin

Ion Castravet

Published in World Journal of Applied Chemistry (Volume 2, Issue 3)

Received: 31 July 2017 Accepted: 16 August 2017 Published: 4 September 2017

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Abstract

This study evaluates the ability of obtaining and of analysis of the binary systems of juglone with β-cyclodextrin using the simplest method of complexation - the kneading method. The purpose of this paper is to obtain and to investigate the binary systems of juglone with β-cyclodextrin. The obtained systems were analyzed with the spectrometric method in IR. In its turn, the given purpose gave the formulation of the following research objectives: a) the creation of a binary system that could reduce the toxic properties of juglone and enhance its antiseptic properties; b) the analysis of the influence of the quantity of water in the obtaining of the complex compounds by the method of kneading; c) the applying of the spectrometric method in IR in order to evaluate the efficiency of the research. Thus, it was found that the complexation process of juglone with β-cyclodextrin is more efficient with the use of water acting as facilitator of the formation of the proposed complex system, both substances being hydrophobic they tend to form a common complex.

Published in	World Journal of Applied Chemistry (Volume 2, Issue 3)
DOI	10.11648/j.wjac.20170203.17
Page(s)	116-119
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Analysis, Binary Systems, β-Cyclodextrin, Complexation Reaction, Juglone

References

[1]	K. Aithal, S. Kumar, “Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells,” J. Cell Biology International, 33: 1039-1049, 2009.
[2]	V. Boldescu, I. Bratu, Gh. Borodi, I. Kasco, A. Bende, Gh. Duca, F. Macaev, S. Pogrebnoi, Z. Ribkovskaia, “Study of binary systems of -cyclodextrin with a highly potential anti-mycobacterial drug,” J. Incl. Phenom. Macrocycl. Chem., 74(1-4): 129-135, 2012.
[3]	S. Chao, A. Greenleaf, D. Price, “Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin 1, also directly blocks transcription,” J. Oxford. Nucleic Acids Research, 29 (3): 767-773, 2001.
[4]	B. Evrard, P. Chiap, P. DeTullio, “Oral bioavailability in sheep of albendazole from a suspension and from a solution containing β-cyclodextrin,” J. Control Release, 85: 45-50, 2002.
[5]	A. Hejl, F. Einhellig, J. Rasmussen, “Effects of juglone on growth, photosynthesis and respiration,” J. Chemical Ecology, 559-568, 2003.
[6]	Xu Hua-Li, Yu Xiao-Feng, “Anti-proliferative effect of juglone on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway,” J. European Journal of Pharmacology, 645: 14-22, 2010.
[7]	F. Macaev, V. Boldescu, A. Geronikaki, N. Sucman, “Recent advances in the use of cyclodextrins in antifungal formulations,” J. Curr. Top. Med. Chem., 13 (21): 2677-2683, 2013.
[8]	G. Junghietu, L. Vlad, “Juglone and the homologues of 1,4-naftaquinone,” ed. Science, Chișinău, 19‐57, 1978.
[9]	Ji Yu-Bin, Qu Zhong-Yuan, “Juglone – induced apoptosis in human gastric cancer SGC-7901 cells via mitochondrial pathway,” J. Experimental and Toxicologic Pathology, 63: 69-78, 2011.
[10]	https://ibn.idsi.md/sites/default/files/imag_file/Compusi%20complecsi%20de%20incluziune%20ai%20amantadinelor_0.pdf, accessed 2016.
[11]	http://14.139.47.15/bitstream/123456789/15483/1/IJCA%2039A%288%29%20889-895.pdf, accessed 2016.
[12]	http://www.washingtoncitypaper.com/articles/47564/if-juglone-can-induce-cell-death-in-humans-how-are, accessed 2016.

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APA Style

Ion Castravet. (2017). Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin. World Journal of Applied Chemistry, 2(3), 116-119. https://doi.org/10.11648/j.wjac.20170203.17

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ACS Style

Ion Castravet. Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin. World J. Appl. Chem. 2017, 2(3), 116-119. doi: 10.11648/j.wjac.20170203.17

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AMA Style

Ion Castravet. Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin. World J Appl Chem. 2017;2(3):116-119. doi: 10.11648/j.wjac.20170203.17

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@article{10.11648/j.wjac.20170203.17,
  author = {Ion Castravet},
  title = {Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin},
  journal = {World Journal of Applied Chemistry},
  volume = {2},
  number = {3},
  pages = {116-119},
  doi = {10.11648/j.wjac.20170203.17},
  url = {https://doi.org/10.11648/j.wjac.20170203.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20170203.17},
  abstract = {This study evaluates the ability of obtaining and of analysis of the binary systems of juglone with β-cyclodextrin using the simplest method of complexation - the kneading method. The purpose of this paper is to obtain and to investigate the binary systems of juglone with β-cyclodextrin. The obtained systems were analyzed with the spectrometric method in IR. In its turn, the given purpose gave the formulation of the following research objectives: a) the creation of a binary system that could reduce the toxic properties of juglone and enhance its antiseptic properties; b) the analysis of the influence of the quantity of water in the obtaining of the complex compounds by the method of kneading; c) the applying of the spectrometric method in IR in order to evaluate the efficiency of the research. Thus, it was found that the complexation process of juglone with β-cyclodextrin is more efficient with the use of water acting as facilitator of the formation of the proposed complex system, both substances being hydrophobic they tend to form a common complex.},
 year = {2017}
}

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TY  - JOUR
T1  - Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin
AU  - Ion Castravet
Y1  - 2017/09/04
PY  - 2017
N1  - https://doi.org/10.11648/j.wjac.20170203.17
DO  - 10.11648/j.wjac.20170203.17
T2  - World Journal of Applied Chemistry
JF  - World Journal of Applied Chemistry
JO  - World Journal of Applied Chemistry
SP  - 116
EP  - 119
PB  - Science Publishing Group
SN  - 2637-5982
UR  - https://doi.org/10.11648/j.wjac.20170203.17
AB  - This study evaluates the ability of obtaining and of analysis of the binary systems of juglone with β-cyclodextrin using the simplest method of complexation - the kneading method. The purpose of this paper is to obtain and to investigate the binary systems of juglone with β-cyclodextrin. The obtained systems were analyzed with the spectrometric method in IR. In its turn, the given purpose gave the formulation of the following research objectives: a) the creation of a binary system that could reduce the toxic properties of juglone and enhance its antiseptic properties; b) the analysis of the influence of the quantity of water in the obtaining of the complex compounds by the method of kneading; c) the applying of the spectrometric method in IR in order to evaluate the efficiency of the research. Thus, it was found that the complexation process of juglone with β-cyclodextrin is more efficient with the use of water acting as facilitator of the formation of the proposed complex system, both substances being hydrophobic they tend to form a common complex.
VL  - 2
IS  - 3
ER  -

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Author Information

Ion Castravet

Student at the Faculty of Medicine, University of Montpellier, Montpellier, France

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APA Style

Ion Castravet. (2017). Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin. World Journal of Applied Chemistry, 2(3), 116-119. https://doi.org/10.11648/j.wjac.20170203.17

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ACS Style

Ion Castravet. Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin. World J. Appl. Chem. 2017, 2(3), 116-119. doi: 10.11648/j.wjac.20170203.17

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AMA Style

Ion Castravet. Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin. World J Appl Chem. 2017;2(3):116-119. doi: 10.11648/j.wjac.20170203.17

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@article{10.11648/j.wjac.20170203.17,
  author = {Ion Castravet},
  title = {Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin},
  journal = {World Journal of Applied Chemistry},
  volume = {2},
  number = {3},
  pages = {116-119},
  doi = {10.11648/j.wjac.20170203.17},
  url = {https://doi.org/10.11648/j.wjac.20170203.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20170203.17},
  abstract = {This study evaluates the ability of obtaining and of analysis of the binary systems of juglone with β-cyclodextrin using the simplest method of complexation - the kneading method. The purpose of this paper is to obtain and to investigate the binary systems of juglone with β-cyclodextrin. The obtained systems were analyzed with the spectrometric method in IR. In its turn, the given purpose gave the formulation of the following research objectives: a) the creation of a binary system that could reduce the toxic properties of juglone and enhance its antiseptic properties; b) the analysis of the influence of the quantity of water in the obtaining of the complex compounds by the method of kneading; c) the applying of the spectrometric method in IR in order to evaluate the efficiency of the research. Thus, it was found that the complexation process of juglone with β-cyclodextrin is more efficient with the use of water acting as facilitator of the formation of the proposed complex system, both substances being hydrophobic they tend to form a common complex.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Obtaining & Analysis of the Binary Systems of Juglone with β-Cyclodextrin
AU  - Ion Castravet
Y1  - 2017/09/04
PY  - 2017
N1  - https://doi.org/10.11648/j.wjac.20170203.17
DO  - 10.11648/j.wjac.20170203.17
T2  - World Journal of Applied Chemistry
JF  - World Journal of Applied Chemistry
JO  - World Journal of Applied Chemistry
SP  - 116
EP  - 119
PB  - Science Publishing Group
SN  - 2637-5982
UR  - https://doi.org/10.11648/j.wjac.20170203.17
AB  - This study evaluates the ability of obtaining and of analysis of the binary systems of juglone with β-cyclodextrin using the simplest method of complexation - the kneading method. The purpose of this paper is to obtain and to investigate the binary systems of juglone with β-cyclodextrin. The obtained systems were analyzed with the spectrometric method in IR. In its turn, the given purpose gave the formulation of the following research objectives: a) the creation of a binary system that could reduce the toxic properties of juglone and enhance its antiseptic properties; b) the analysis of the influence of the quantity of water in the obtaining of the complex compounds by the method of kneading; c) the applying of the spectrometric method in IR in order to evaluate the efficiency of the research. Thus, it was found that the complexation process of juglone with β-cyclodextrin is more efficient with the use of water acting as facilitator of the formation of the proposed complex system, both substances being hydrophobic they tend to form a common complex.
VL  - 2
IS  - 3
ER  -

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