Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is one of the independent risk factors for multiple systemic diseases, with the most significant impact on cardiovascular and cerebrovascular diseases. There are many causes of atrial fibrillation, including hypertension and coronary heart disease, among which OSAHS is often overlooked. However, atrial fibrillation caused by OSAHS is very common in clinical practice. Objective: To observe the clinical efficacy of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSAHS complicated by atrial fibrillation. Additionally, to explore the mechanisms and treatment methods for atrial fibrillation in patients with OSAHS. Methods: A total of 60 patients with moderate to severe OSAHS complicated by atrial fibrillation who visited our hospital from January 2024 to January 2025 were selected and randomly divided into a treatment group and a control group. The treatment group received conventional medication and CPAP treatment, while the control group received only conventional medication. After 10 days of treatment, polysomnography (PSG) and 24-hour Holter monitoring were performed to observe the clinical efficacy, apnea-hypopnea index (AHI), average nocturnal oxygen saturation, oxygen desaturation index, and the number of nocturnal atrial fibrillation episodes in both groups. Results: After 10 days of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, with a statistically significant difference. In the treatment group, AHI returned to normal after CPAP treatment, the oxygen desaturation index decreased, the average nocturnal blood oxygen saturation normalized, and the number of nocturnal atrial fibrillation episodes significantly decreased, all with statistically significant differences. Conclusion: On the basis of conventional medication, the addition of CPAP can effectively treat moderate to severe OSAHS complicated by atrial fibrillation and reduce the incidence of cardiovascular diseases. It was also found that hypoxia is the main mechanism for the occurrence of nocturnal atrial fibrillation in patients with OSAHS.
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Sleep breathing disorders are generally divided into three types: inability to wake up, inability to sleep, and poor sleep. Among them, obstructive sleep apnea hypopnea syndrome (OSAHS, commonly known as "snoring") is one of the most common sleep breathing disorders.Patients may present with poor sleep, which can lead to changes in blood pressure
[1]
CHEN Lian, et al.Correlation between SAHS and nocturnal hypotension with non-arteritic anterior ischemic optic neuropathy [J]. International Journal of Ophthalmology, 2019, 19(10): 1672-1675.
. OSAHS is primarily associated with partial or complete obstruction or narrowing of the upper airway in patients, resulting in recurrent hypoventilation or apnea. This leads to a clinical syndrome characterized by pathological and physiological changes such as hypercapnia, hypoxemia, and arousal
[2]
JU Shande, et al.Study on the impact of obstructive sleep apnea-hypopnea syndrome on non-arteritic anterior ischemic optic neuropathy [J]. Journal of Clinical Medicine and Pharmacy, 2023, 27(18): 49-51.
. The prevalence of OSAHS in adults ranges from 9%to 38%, with a higher incidence in males than in females, at 13%to 33%
[3]
SHE Liping, WU Yafeng, LI Shaoman, et al. Application of comprehensive nursing intervention in second-generation cryoballoon ablation for elderly patients with atrial fibrillation [J]. PracticalGeriatrics, 2021, 35(11): 1203-1206.
. With the aging of society becoming more and more obvious, the incidence rate of atrial fibrillation (AF) also increases with age, and the prevalence rate of people over 70 years old reaches 10%. AF affects about 1% of the world's population, which is one of the most common arrhythmias in clinical practice. It has a high disability rate and mortality rate
[4]
WANG Shan, et al.Analysis of the safety and nursing characteristics of green electrophysiological radiofrequency ablation in patients with atrial fibrillation [J]. Chinese Journal of Practical Nursing, 2021, 37(33): 2584-2588.
[4]
. In China, the incidence rate of atrial fibrillation is about 0.7%~2.8%, which has become a "cardiovascular epidemic", significantly higher than the international average level
[5]
FENG Xiaoyan, LI Xiaotong.Nursing coordination of cryoablation combined with radiofrequency ablation and left atrial appendage closure in patients with atrial fibrillation [J]. Journal of Nursing Science, 2021, 36(16): 50-52.
. The incidence of atrial fibrillation in OSAHS patients reaches 5%, while the incidence of atrial fibrillation in non OSAHS patients is only 1%
[6]
DAVIES, et al.Factors influencing recurrence after ablation in elderly patients with atrial fibrillation [J]. China Medical Herald, 2024, 21(17): 29-31.
. The incidence rate of atrial fibrillation caused by OSAHS is four times that of ordinary people. So treating atrial fibrillation must also treat OSAHS, and the two are closely related. This study aims to observe whether there is a difference in the efficacy of conventional medication combined with non-invasive positive pressure ventilation therapy and conventional medication alone in treating OSAHS with atrial fibrillation, providing further evidence for clinical treatment. At the same time, it was found that the main mechanism of atrial fibrillation in OSAHS patients is hypoxia.
2. Materials and Methods
2.1. Research Object and Grouping
The research subjects were 60 patients diagnosed with moderate to severe OSAHS complicated with atrial fibrillation through 24-hour dynamic electrocardiogram and polysomnography analysis at the Department of Cardiology, Fenyang Hospital, Shanxi Province from January 2024 to January 2025. There were 45 males and 15 females aged 40-75 years, with an average age of (58±6.8) years. They were randomly divided into a treatment group and a control group, with 30 patients in each group.
2.1.1. Inclusion Criteria
1) Meet the diagnostic criteria for moderate to severe OSAHS: AHI≥ 15 times/h; 2) Patients with atrial fibrillation were diagnosed using a 24-hour dynamic electrocardiogram analyzer.
2.1.2. Exclusion Criteria
1) Patients with non obstructive sleep apnea syndrome; 2) Patients with acute coronary heart disease and other severe conditions; 3) Individuals with severe liver and kidney dysfunction; 4) Individuals who are contraindicated to taking medications for the treatment of atrial fibrillation.
2.1.3. Ethics
This study complies with ethical standards and has been approved by our hospital's ethics department (approval number: 2024020). Both the subjects and their families have signed informed consent forms.
2.2. Instruments and Reagents
Non invasive ventilator (Resmay ventilator, Australia, S10, SN22232481307); Multi channel sleep monitoring (EMBLETA, Polysomnography, PSG) and 24-hour dynamic electrocardiogram (Merrill Lynch 12 lead dynamic electrocardiograph, Holter).
2.3. Research Methods
The treatment group received conventional medication and non-invasive ventilator treatment (ventilator mode: Auto-CPAP, Pressure of 4-20cmH2O); The control group was only given conventional drug treatment. 10 days after treatment, multi-channel sleep monitoring and 24-hour dynamic electrocardiogram examination were performed to observe the clinical efficacy, Apnea hypopnea index (AHI), nighttime mean oxygen saturation, arousal index, and frequency of atrial fibrillation occurrence in both groups.
2.3.1. Criteria for Evaluating the Efficacy of Atrial Fibrillation
According to the 2010 European Society of Cardiology guidelines for atrial fibrillation and the 8-year textbook of internal medicine in general higher education institutions, the efficacy evaluation criteria are: significant effect is the restoration of sinus rhythm, and clinical symptoms and signs have basically disappeared. Effective for resting with a heart rate of less than 70 beats per minute, mild activity with a heart rate of less than 90 beats per minute, mild symptoms, and no impact on daily activities; Clinical symptoms and signs have improved. Invalid: resting heart rate greater than or equal to 70 beats per minute, slight activity heart rate greater than or equal to 90 beats per minute, severe symptoms, and daily activities affected; There is no significant improvement or deterioration in clinical symptoms and signs. Total effective rate=(number of significantly effective cases+number of effective cases)/number of evaluable cases x 100%.
2.3.2. OSAHS Interpretation Criteria
Apnea refers to the disappearance or significant reduction of airflow between the mouth and nose during sleep (a decrease of ≥ 90% from baseline), with a duration of ≥ 10 seconds; Hypoventilation refers to a decrease in respiratory airflow signal by 30% for a duration of ≥ 10 seconds, accompanied by a decrease in blood oxygen saturation of ≥ 3% and/or wakefulness.
2.4. Statistical Methods
SPSS 26.0 statistical software was used for data processing. The metric data of normal distribution is represented by (x ± s) and compared using t-test; Count data is expressed in terms of rate or composition ratio, and a chi square test is used. P<0.05 indicates statistical difference.
3. Results
3.1. Comparison of Clinical Efficacy Between Two Groups
After 10 days of treatment, the total effective rate of the treatment group was significantly higher than that of the control group, with statistical differences (χ 2=10.425, P<0.05), as shown in Table 1.
Table 1. Comparison of clinical efficacy between two groups [n (%)].
Group
examples
Significant
effectiveness
ineffective
overall effectiveness
Control group
30
12(40.0)
8(26.67)
10(33.33)
20(66.7)
Treatment group
30
24(80.0)
4(13.33)
2(6.67)
28(93.3)#
Note#: Compared with the control group, χ2=10.425, P<0.05.
3.2. The Treatment Group was Compared Before and After CPAP Treatment
After CPAP treatment, the treatment group had a normal AHI, a reduced oxygen desaturation index, normal mean nocturnal blood oxygen saturation (SaO2), and a significant decrease in the number of atrial fibrillation episodes at night, with statistically significant differences (P<0.05). The number of nocturnal atrial fibrillation episodes showed a statistically significant difference when compared with the control group after treatment (P<0.05). See Table 2.
Table 2. Comparison of AHI, Oxygen Desaturation Index, Mean Nocturnal Blood Oxygen Saturation, and Number of Nocturnal Atrial Fibrillation Episodes in 30 Patients Before and After CPAP Treatment (x±s).
Group
AHI (Times/h)
Arousal Index (Times/h)
SaO2
Number of atrial fibrillation episodes at night
Control
Treatment
Before treatment
35.5±5.3
32.3±4.8
75.6±6.8
30
30
after treatment
3.8±2.1
2.5±1.4
93.8±3.2
10
02*
P
0.02
0.03
0.04
0.02
0.004
Note*: Indicates P<0.05 when compared with the control group after treatment.
4. Discussion
OSAHS is one of the independent risk factors for various systemic diseases, especially cardiovascular and cerebrovascular diseases, which pose the greatest harm. This study treated the treatment group with conventional medication combined with non-invasive mechanical ventilation, while the control group received only conventional medication treatment. After 10 days of treatment, both groups underwent multi-channel sleep monitoring and 24-hour dynamic electrocardiogram examination. It was observed that there were statistically significant differences in clinical efficacy, sleep apnea hypopnea index, nighttime average oxygen saturation, arousal index, and frequency of nighttime atrial fibrillation between the two groups. The apnea hypopnea index is closely related to the severity of atrial fibrillation. It can be seen that non-invasive ventilator therapy plays a significant role in patients with moderate to severe obstructive sleep apnea hypopnea syndrome complicated with atrial fibrillation. At the same time, it was found that hypoxia is the main mechanism of atrial fibrillation in OSAHS patients at night.
With the increasing trend of global aging, atrial fibrillation will become one of the most common cardiovascular diseases in the next 50 years. We have found that there are many reasons that can cause atrial fibrillation, including hypertension, coronary heart disease, heart failure, cardiomyopathy, and so on. Among them, sleep apnea and hypopnea are often overlooked. However, in clinical practice, atrial fibrillation caused by OSAHS is very common. Fully understanding the mechanism of OSAHS induced atrial fibrillation and developing effective treatment strategies are currently the focus of medical research. The mechanisms of atrial fibrillation in patients with sleep apnea hypopnea currently include atrial remodeling, inflammatory response, and changes in intrathoracic pressure. Increased negative pressure in the chest cavity, overactivation of the autonomic nervous system, chronic intermittent hypoxia, and cardiac remodeling can all lead to atrial fibrillation in OSAHS patients. Chronic intermittent hypoxia caused by OSAHS can directly affect the electrical activity of myocardial cells, including mechanisms such as AERP shortening. OSAHS can cause hypoxemia and hypercapnia in the body, and patients themselves are prone to arrhythmia
[7]
LIU Hui, MA Xianli, SHANG Tongtong. Application of integrated nursing in patients with atrial fibrillation undergoing radiofrequency ablation [J]. Nursing Journal of Qilu, 2021, 27(3): 88-90.
[7]
. Due to poor sleep at night in OSAHS patients, the sympathetic nervous system is stimulated, which can lead to atrial fibrillation. Moreover, systemic inflammatory response indicators are also related to OSAHS disease, such as the increased incidence of atrial fibrillation in OSAHS patients under the influence of C-reactive protein
[8]
YAO Yufei, CHEN Hongwu, WANG Lin, et al. Discussion on the relationship between gastrointestinal symptoms and quality of life after different radiofrequency ablation procedures in patients with atrial fibrillation [J]. Chinese Journal of General Practice, 2021, 19(9): 1584-1588.
. On the contrary, atrial fibrillation can also induce the occurrence of OSAHS disease. Studies have shown
[9]
XU Bin, WANG Yanchao, MA Jun.Therapeutic effect of modified Morrow procedure for obstructive hypertrophic cardiomyopathy and perioperative nursing points [J]. Chinese Journal of Trauma and Repair(Electronic Edition), 2021, 16(1): 85-88.
[9]
that atrial tachycardia pacing can effectively reduce the occurrence of OSAHS disease in patients with sinus node dysfunction. Atrial fibrillation and sleep apnea hypopnea share the same underlying diseases and risk factors. Intermittent hypoxia, repeated awakenings, and chest pressure fluctuations are all involved in the occurrence and development of cardiovascular disease in patients with sleep apnea hypopnea, and the two interact with each other. OSAHS, as an independent risk factor for the occurrence and development of atrial fibrillation
[10]
TRAAEN G M, et al.Prevalence, risk factors, and type of sleep apnea in patients with paroxysmal atrial fibrillation [J]. International Journal of Cardiology Heart & Vascular, 2020, 26: 100447.
, not only affects the effectiveness of radiofrequency ablation treatment for atrial fibrillation, but also increases the risk of atrial fibrillation recurrence after cardioversion
[11]
SHE Liping, et al.Application of comprehensive nursing intervention in second-generation cryoballoon ablation for elderly patients with atrial fibrillation [J]. Practical Geriatrics, 2021, 35(11): 1203-1206.
. So, OSAHS can serve as a new risk factor for the occurrence and development of atrial fibrillation, which deserves our attention.
In clinical practice, cardiovascular physicians often encounter patients with poor drug control and severe clinical symptoms of atrial fibrillation. At this time, we should actively monitor their sleep and screen for sleep apnea hypopnea syndrome. If OSAHS is diagnosed with atrial fibrillation, as long as continuous positive airway pressure ventilation is used for treatment, most patients will have good results. After OSAHS correction, some patients may no longer need to take treatment drugs for atrial fibrillation, which is of great significance for atrial fibrillation patients. There are studies showing that electric cardioversion is an effective treatment for atrial fibrillation, but when used in OSAHS patients who develop atrial fibrillation, the risk doubles. On the contrary, after treatment with positive pressure ventilation through a ventilator, the risk significantly decreases
[12]
JIANG Chunxia, WU Yahui, ZHANG Youqin, et al.Impact of continuous nursing on self-management ability and follow-up compliance in patients after thyroid microwave ablation [J]. Journal of Navy Medicine, 2020, 41(5): 586-588, 602.
[12]
. There are also studies showing that non-invasive ventilator therapy can not only prevent the occurrence of nocturnal atrial fibrillation in OSAHS patients, but also facilitate the maintenance of sinus rhythm in atrial fibrillation patients after cardioversion. This reduced the incidence of atrial fibrillation in OSAHS patients (from 18.3% to 8.6%). On the contrary, if non-invasive positive pressure ventilation is not used in a timely manner, the patient's arrhythmia cannot be effectively corrected, which will have a great impact on the patient's family, economy, and psychology.
In summary, in clinical practice, high attention should be paid to patients with atrial fibrillation, and OSAHS screening should be done well to diagnose and treat OSAHS as early as possible. Although there are many disease-related associations between OSAHS and atrial fibrillation, the prevalence of atrial fibrillation in OSAHS patients is still not very clear. We need to expand the sample size, continue to observe and summarize, and analyze from multiple perspectives in our future work.
Abbreviations
CPAP
Continuous Positive Airway Pressure
OSAHS
Obstructive Sleep Apnea Hypopnea Syndrome
AF
Atrial Fibrillation
PSG
Polysomnography
AHI
Apnea Hypopnea Index
Funding
Shanxi Provincial Health Commission Project (2024226); Lvliang Municipal Science and Technology Bureau Project (2024SHFZ24); Shanxi Provincial FenYang Hospital Project (2024025).
Conflicts of Interest
The authors declares that there is no conflict of interest.
References
[1]
CHEN Lian, et al.Correlation between SAHS and nocturnal hypotension with non-arteritic anterior ischemic optic neuropathy [J]. International Journal of Ophthalmology, 2019, 19(10): 1672-1675.
JU Shande, et al.Study on the impact of obstructive sleep apnea-hypopnea syndrome on non-arteritic anterior ischemic optic neuropathy [J]. Journal of Clinical Medicine and Pharmacy, 2023, 27(18): 49-51.
SHE Liping, WU Yafeng, LI Shaoman, et al. Application of comprehensive nursing intervention in second-generation cryoballoon ablation for elderly patients with atrial fibrillation [J]. PracticalGeriatrics, 2021, 35(11): 1203-1206.
WANG Shan, et al.Analysis of the safety and nursing characteristics of green electrophysiological radiofrequency ablation in patients with atrial fibrillation [J]. Chinese Journal of Practical Nursing, 2021, 37(33): 2584-2588.
[5]
FENG Xiaoyan, LI Xiaotong.Nursing coordination of cryoablation combined with radiofrequency ablation and left atrial appendage closure in patients with atrial fibrillation [J]. Journal of Nursing Science, 2021, 36(16): 50-52.
DAVIES, et al.Factors influencing recurrence after ablation in elderly patients with atrial fibrillation [J]. China Medical Herald, 2024, 21(17): 29-31.
LIU Hui, MA Xianli, SHANG Tongtong. Application of integrated nursing in patients with atrial fibrillation undergoing radiofrequency ablation [J]. Nursing Journal of Qilu, 2021, 27(3): 88-90.
[8]
YAO Yufei, CHEN Hongwu, WANG Lin, et al. Discussion on the relationship between gastrointestinal symptoms and quality of life after different radiofrequency ablation procedures in patients with atrial fibrillation [J]. Chinese Journal of General Practice, 2021, 19(9): 1584-1588.
XU Bin, WANG Yanchao, MA Jun.Therapeutic effect of modified Morrow procedure for obstructive hypertrophic cardiomyopathy and perioperative nursing points [J]. Chinese Journal of Trauma and Repair(Electronic Edition), 2021, 16(1): 85-88.
[10]
TRAAEN G M, et al.Prevalence, risk factors, and type of sleep apnea in patients with paroxysmal atrial fibrillation [J]. International Journal of Cardiology Heart & Vascular, 2020, 26: 100447.
SHE Liping, et al.Application of comprehensive nursing intervention in second-generation cryoballoon ablation for elderly patients with atrial fibrillation [J]. Practical Geriatrics, 2021, 35(11): 1203-1206.
JIANG Chunxia, WU Yahui, ZHANG Youqin, et al.Impact of continuous nursing on self-management ability and follow-up compliance in patients after thyroid microwave ablation [J]. Journal of Navy Medicine, 2020, 41(5): 586-588, 602.
Caiping, Z., Xiaofei, Z. (2025). The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF. World Journal of Public Health, 10(3), 325-329. https://doi.org/10.11648/j.wjph.20251003.23
Caiping, Z.; Xiaofei, Z. The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF. World J. Public Health2025, 10(3), 325-329. doi: 10.11648/j.wjph.20251003.23
Caiping Z, Xiaofei Z. The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF. World J Public Health. 2025;10(3):325-329. doi: 10.11648/j.wjph.20251003.23
@article{10.11648/j.wjph.20251003.23,
author = {Zhang Caiping and Zhang Xiaofei},
title = {The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF
},
journal = {World Journal of Public Health},
volume = {10},
number = {3},
pages = {325-329},
doi = {10.11648/j.wjph.20251003.23},
url = {https://doi.org/10.11648/j.wjph.20251003.23},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20251003.23},
abstract = {Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is one of the independent risk factors for multiple systemic diseases, with the most significant impact on cardiovascular and cerebrovascular diseases. There are many causes of atrial fibrillation, including hypertension and coronary heart disease, among which OSAHS is often overlooked. However, atrial fibrillation caused by OSAHS is very common in clinical practice. Objective: To observe the clinical efficacy of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSAHS complicated by atrial fibrillation. Additionally, to explore the mechanisms and treatment methods for atrial fibrillation in patients with OSAHS. Methods: A total of 60 patients with moderate to severe OSAHS complicated by atrial fibrillation who visited our hospital from January 2024 to January 2025 were selected and randomly divided into a treatment group and a control group. The treatment group received conventional medication and CPAP treatment, while the control group received only conventional medication. After 10 days of treatment, polysomnography (PSG) and 24-hour Holter monitoring were performed to observe the clinical efficacy, apnea-hypopnea index (AHI), average nocturnal oxygen saturation, oxygen desaturation index, and the number of nocturnal atrial fibrillation episodes in both groups. Results: After 10 days of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, with a statistically significant difference. In the treatment group, AHI returned to normal after CPAP treatment, the oxygen desaturation index decreased, the average nocturnal blood oxygen saturation normalized, and the number of nocturnal atrial fibrillation episodes significantly decreased, all with statistically significant differences. Conclusion: On the basis of conventional medication, the addition of CPAP can effectively treat moderate to severe OSAHS complicated by atrial fibrillation and reduce the incidence of cardiovascular diseases. It was also found that hypoxia is the main mechanism for the occurrence of nocturnal atrial fibrillation in patients with OSAHS.},
year = {2025}
}
TY - JOUR
T1 - The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF
AU - Zhang Caiping
AU - Zhang Xiaofei
Y1 - 2025/08/08
PY - 2025
N1 - https://doi.org/10.11648/j.wjph.20251003.23
DO - 10.11648/j.wjph.20251003.23
T2 - World Journal of Public Health
JF - World Journal of Public Health
JO - World Journal of Public Health
SP - 325
EP - 329
PB - Science Publishing Group
SN - 2637-6059
UR - https://doi.org/10.11648/j.wjph.20251003.23
AB - Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is one of the independent risk factors for multiple systemic diseases, with the most significant impact on cardiovascular and cerebrovascular diseases. There are many causes of atrial fibrillation, including hypertension and coronary heart disease, among which OSAHS is often overlooked. However, atrial fibrillation caused by OSAHS is very common in clinical practice. Objective: To observe the clinical efficacy of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSAHS complicated by atrial fibrillation. Additionally, to explore the mechanisms and treatment methods for atrial fibrillation in patients with OSAHS. Methods: A total of 60 patients with moderate to severe OSAHS complicated by atrial fibrillation who visited our hospital from January 2024 to January 2025 were selected and randomly divided into a treatment group and a control group. The treatment group received conventional medication and CPAP treatment, while the control group received only conventional medication. After 10 days of treatment, polysomnography (PSG) and 24-hour Holter monitoring were performed to observe the clinical efficacy, apnea-hypopnea index (AHI), average nocturnal oxygen saturation, oxygen desaturation index, and the number of nocturnal atrial fibrillation episodes in both groups. Results: After 10 days of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, with a statistically significant difference. In the treatment group, AHI returned to normal after CPAP treatment, the oxygen desaturation index decreased, the average nocturnal blood oxygen saturation normalized, and the number of nocturnal atrial fibrillation episodes significantly decreased, all with statistically significant differences. Conclusion: On the basis of conventional medication, the addition of CPAP can effectively treat moderate to severe OSAHS complicated by atrial fibrillation and reduce the incidence of cardiovascular diseases. It was also found that hypoxia is the main mechanism for the occurrence of nocturnal atrial fibrillation in patients with OSAHS.
VL - 10
IS - 3
ER -
Caiping, Z., Xiaofei, Z. (2025). The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF. World Journal of Public Health, 10(3), 325-329. https://doi.org/10.11648/j.wjph.20251003.23
Caiping, Z.; Xiaofei, Z. The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF. World J. Public Health2025, 10(3), 325-329. doi: 10.11648/j.wjph.20251003.23
Caiping Z, Xiaofei Z. The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF. World J Public Health. 2025;10(3):325-329. doi: 10.11648/j.wjph.20251003.23
@article{10.11648/j.wjph.20251003.23,
author = {Zhang Caiping and Zhang Xiaofei},
title = {The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF
},
journal = {World Journal of Public Health},
volume = {10},
number = {3},
pages = {325-329},
doi = {10.11648/j.wjph.20251003.23},
url = {https://doi.org/10.11648/j.wjph.20251003.23},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20251003.23},
abstract = {Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is one of the independent risk factors for multiple systemic diseases, with the most significant impact on cardiovascular and cerebrovascular diseases. There are many causes of atrial fibrillation, including hypertension and coronary heart disease, among which OSAHS is often overlooked. However, atrial fibrillation caused by OSAHS is very common in clinical practice. Objective: To observe the clinical efficacy of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSAHS complicated by atrial fibrillation. Additionally, to explore the mechanisms and treatment methods for atrial fibrillation in patients with OSAHS. Methods: A total of 60 patients with moderate to severe OSAHS complicated by atrial fibrillation who visited our hospital from January 2024 to January 2025 were selected and randomly divided into a treatment group and a control group. The treatment group received conventional medication and CPAP treatment, while the control group received only conventional medication. After 10 days of treatment, polysomnography (PSG) and 24-hour Holter monitoring were performed to observe the clinical efficacy, apnea-hypopnea index (AHI), average nocturnal oxygen saturation, oxygen desaturation index, and the number of nocturnal atrial fibrillation episodes in both groups. Results: After 10 days of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, with a statistically significant difference. In the treatment group, AHI returned to normal after CPAP treatment, the oxygen desaturation index decreased, the average nocturnal blood oxygen saturation normalized, and the number of nocturnal atrial fibrillation episodes significantly decreased, all with statistically significant differences. Conclusion: On the basis of conventional medication, the addition of CPAP can effectively treat moderate to severe OSAHS complicated by atrial fibrillation and reduce the incidence of cardiovascular diseases. It was also found that hypoxia is the main mechanism for the occurrence of nocturnal atrial fibrillation in patients with OSAHS.},
year = {2025}
}
TY - JOUR
T1 - The Clinical Significance of CPAP Treatment for Severe OSAHS Combined with AF
AU - Zhang Caiping
AU - Zhang Xiaofei
Y1 - 2025/08/08
PY - 2025
N1 - https://doi.org/10.11648/j.wjph.20251003.23
DO - 10.11648/j.wjph.20251003.23
T2 - World Journal of Public Health
JF - World Journal of Public Health
JO - World Journal of Public Health
SP - 325
EP - 329
PB - Science Publishing Group
SN - 2637-6059
UR - https://doi.org/10.11648/j.wjph.20251003.23
AB - Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is one of the independent risk factors for multiple systemic diseases, with the most significant impact on cardiovascular and cerebrovascular diseases. There are many causes of atrial fibrillation, including hypertension and coronary heart disease, among which OSAHS is often overlooked. However, atrial fibrillation caused by OSAHS is very common in clinical practice. Objective: To observe the clinical efficacy of continuous positive airway pressure (CPAP) treatment in patients with moderate to severe OSAHS complicated by atrial fibrillation. Additionally, to explore the mechanisms and treatment methods for atrial fibrillation in patients with OSAHS. Methods: A total of 60 patients with moderate to severe OSAHS complicated by atrial fibrillation who visited our hospital from January 2024 to January 2025 were selected and randomly divided into a treatment group and a control group. The treatment group received conventional medication and CPAP treatment, while the control group received only conventional medication. After 10 days of treatment, polysomnography (PSG) and 24-hour Holter monitoring were performed to observe the clinical efficacy, apnea-hypopnea index (AHI), average nocturnal oxygen saturation, oxygen desaturation index, and the number of nocturnal atrial fibrillation episodes in both groups. Results: After 10 days of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, with a statistically significant difference. In the treatment group, AHI returned to normal after CPAP treatment, the oxygen desaturation index decreased, the average nocturnal blood oxygen saturation normalized, and the number of nocturnal atrial fibrillation episodes significantly decreased, all with statistically significant differences. Conclusion: On the basis of conventional medication, the addition of CPAP can effectively treat moderate to severe OSAHS complicated by atrial fibrillation and reduce the incidence of cardiovascular diseases. It was also found that hypoxia is the main mechanism for the occurrence of nocturnal atrial fibrillation in patients with OSAHS.
VL - 10
IS - 3
ER -