A 47 years old woman presented with darkening skins on exposed and frictional areas for more than one year, in addition to fatigue, loss of appetite and weight loss for 2 months. One year ago, there was no inducement of pigmentation on the back of the hand, and it spread to the elbow. Then, the skin of the chest, lower limbs, abdomen, neck, forehead, and internal eyelids also gradually appeared diffuse dark spots. Meanwhile she had low 24-hour urinary excretion of 17-hydroxy steroid and increased ACTH. X-ray test showed point-like calcification shadow on bilateral lungs; CT test showed increased adrenal gland volume, substantially uninformed density, and multiple stippled calcification. Histopathological results: Chromatophilic cells and macrophages that were arranged in nests, scattered and pigment-laden can see subepidermally. Diagnosis: Addison’s disease. After 6 months anti-TB and glucocorticoid hormone replacement therapy, the patient had a good general condition, disappeared clinical symptoms as well as laboratory and imaging test results returned to normal. Now no drugs have been administrated except for 2.5mg of prednisone tablets to take at a draught every morning. The patient is still traced and observed. The study in this case suggests that clinicians should be highly vigilant against Addison's disease in patients who are treated with multiple skin progressive pigmentation.
| Published in | Asia-Pacific Journal of Medicine (Volume 1, Issue 1) |
| Page(s) | 10-13 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Skins Darkening, ACTH, Tuberculosis, Addison’s Disease
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APA Style
Lingji Zeng, Zhongye Chen. (2019). A Case of Addison's Disease with Only Progressive Skin Pigmentation. Asia-Pacific Journal of Medicine, 1(1), 10-13.
ACS Style
Lingji Zeng; Zhongye Chen. A Case of Addison's Disease with Only Progressive Skin Pigmentation. Asia-Pac. J. Med. 2019, 1(1), 10-13.
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Download@article{10033497,
author = {Lingji Zeng and Zhongye Chen},
title = {A Case of Addison's Disease with Only Progressive Skin Pigmentation},
journal = {Asia-Pacific Journal of Medicine},
volume = {1},
number = {1},
pages = {10-13},
url = {https://www.sciencepublishinggroup.com/article/10033497},
abstract = {A 47 years old woman presented with darkening skins on exposed and frictional areas for more than one year, in addition to fatigue, loss of appetite and weight loss for 2 months. One year ago, there was no inducement of pigmentation on the back of the hand, and it spread to the elbow. Then, the skin of the chest, lower limbs, abdomen, neck, forehead, and internal eyelids also gradually appeared diffuse dark spots. Meanwhile she had low 24-hour urinary excretion of 17-hydroxy steroid and increased ACTH. X-ray test showed point-like calcification shadow on bilateral lungs; CT test showed increased adrenal gland volume, substantially uninformed density, and multiple stippled calcification. Histopathological results: Chromatophilic cells and macrophages that were arranged in nests, scattered and pigment-laden can see subepidermally. Diagnosis: Addison’s disease. After 6 months anti-TB and glucocorticoid hormone replacement therapy, the patient had a good general condition, disappeared clinical symptoms as well as laboratory and imaging test results returned to normal. Now no drugs have been administrated except for 2.5mg of prednisone tablets to take at a draught every morning. The patient is still traced and observed. The study in this case suggests that clinicians should be highly vigilant against Addison's disease in patients who are treated with multiple skin progressive pigmentation.},
year = {2019}
}
TY - JOUR T1 - A Case of Addison's Disease with Only Progressive Skin Pigmentation AU - Lingji Zeng AU - Zhongye Chen Y1 - 2019/01/04 PY - 2019 T2 - Asia-Pacific Journal of Medicine JF - Asia-Pacific Journal of Medicine JO - Asia-Pacific Journal of Medicine SP - 10 EP - 13 PB - Science Publishing Group UR - http://www.sciencepg.com/article/10033497 AB - A 47 years old woman presented with darkening skins on exposed and frictional areas for more than one year, in addition to fatigue, loss of appetite and weight loss for 2 months. One year ago, there was no inducement of pigmentation on the back of the hand, and it spread to the elbow. Then, the skin of the chest, lower limbs, abdomen, neck, forehead, and internal eyelids also gradually appeared diffuse dark spots. Meanwhile she had low 24-hour urinary excretion of 17-hydroxy steroid and increased ACTH. X-ray test showed point-like calcification shadow on bilateral lungs; CT test showed increased adrenal gland volume, substantially uninformed density, and multiple stippled calcification. Histopathological results: Chromatophilic cells and macrophages that were arranged in nests, scattered and pigment-laden can see subepidermally. Diagnosis: Addison’s disease. After 6 months anti-TB and glucocorticoid hormone replacement therapy, the patient had a good general condition, disappeared clinical symptoms as well as laboratory and imaging test results returned to normal. Now no drugs have been administrated except for 2.5mg of prednisone tablets to take at a draught every morning. The patient is still traced and observed. The study in this case suggests that clinicians should be highly vigilant against Addison's disease in patients who are treated with multiple skin progressive pigmentation. VL - 1 IS - 1 ER -
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