There is a wide spectrum of syndromes that include dental, oral and craniofacial disorders as localized abnormality or a part of a generalized pathology. Care of individuals with syndromes affecting craniofacial and dento-alveolar structures is mostly treated by an interdisciplinary team who becomes more frequently involved in the refined diagnostic and etiological processes of these patients. Early diagnosis is often crucial for the effective treatment of functional and developmental aspects. However, not all syndromes can be clinically identified early, especially in cases of absence of known family history. Moreover, the treatment of these patients is often complicated because of insufficient medical knowledge and because of the dento-alveolar and craniofacial developmental variations. Clinical phenotyping together with reviewed data and evidence-based conclusions will ultimately pave the way for preventive strategies and therapeutic options in the future. This will improve the prognosis for better functional and aesthetic outcome for these patients and lead to a better quality of life, not only for the patients themselves but also for their families.

The proposed issue is inspected to update recent advances in diagnosis clarity and interdisciplinary management of different syndromes affecting craniofacial and dento-alveolar structures. Although the existing literature does not provide considerable insight into the topic, this special issue aims to provide compressive information via literature reviews and case reports for the interdisciplinary team. The main target is to promote interdisciplinary interaction and mutual understanding among all specialists involved in the diagnosis and therapeutic guidance of patients with syndromal conditions in order to provide optimal personalized care in an integrated approach including medical and dental specialists’ collaboration.

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